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低剂量左旋布比卡因3mg复合芬太尼10μg脊髓麻醉在妇科门诊腹腔镜手术中的应用

麻醉与镇痛 2012年第1期8卷 27-33页

作者： jesus de santiago, desa, md Javier Santos,Yglesias, md Jorge Giron, md Frandsco Montes de Oca, md Alejandro Jimenez, PhDl Pilar Diaz, PhD departments of Anesthesiology ＊Gynaecology Hospital USP La Colina SC de Tenerife Research Unit Hospital Universitario de Canarias-University of La Laguna department ofPharmacy Hospital Universitario Nuestra Se~ora de La Candelaria SC de Tenerife Tenerife Spain

背景对于妇科门诊腹腔镜这种短时手术来说，选择利多卡因进行脊髓麻醉是十分有效的。本研究中，我们对比了利多卡因．芬太尼与左旋布比卡因-芬太尼脊髓麻醉在短时妇科腹腔镜手术中的麻醉效果、麻醉恢复时间和患者满意度。方法在这项双... 详细信息

背景对于妇科门诊腹腔镜这种短时手术来说，选择利多卡因进行脊髓麻醉是十分有效的。本研究中，我们对比了利多卡因．芬太尼与左旋布比卡因-芬太尼脊髓麻醉在短时妇科腹腔镜手术中的麻醉效果、麻醉恢复时间和患者满意度。方法在这项双盲研究中，52例拟行输卵管绝育术的健康妇女被随机分为组Ⅰ（椎管内注射2％利多卡因10mg加芬太尼10μg）和组Ⅱ（椎管内注射0．5％左旋布比卡因3mg加芬太尼10μg），每组药物用灭菌水稀释至3ml。术中需要监测以下指标：麻醉起效时间、是否需要补充麻醉一镇痛药物、镇静深度、手术条件以及血流动力学方面的事件。术后，通过测试运动阻滞情况、本体感觉、振动觉、轻触觉和进行Romberg试验来评估患者是否可以不去麻醉恢复室并独立行走。麻醉给药后5、10、15分钟测试感觉阻滞平面，之后每15分钟测试一次直至感觉完全恢复。感觉阻滞恢复时间的差异达25分钟被认为在临床上是有意义的。结果两组的麻醉起效时间和术中条件相同。没有患者需要全身麻醉来完成手术。所有两组患者都不需要去麻醉恢复室。组Ⅰ患者在27分钟（18-45分钟）后可行走，组Ⅱ30分钟（18。56分钟）后可行走（P=0．24）。脊髓麻醉完全恢复组Ⅰ需要93分钟（65-120分钟），组Ⅱ需要105分钟（78-150分钟）（P=0．019）；然而，出院时间两组没有区别，组Ⅰ为185分钟（150-300分钟），组Ⅱ为188分钟（125-300分钟）（P=0．62）。两组患者的总体满意度也相似。结论左旋布比卡因3mg复合芬太尼10μg可以替代利多卡因10mg复合芬太尼10μg用于短时手术的脊髓麻醉。前者在临床中可以达到与后者相当的感觉阻滞恢复时间、术中条件和患者满意度。

关键词：左旋布比卡因复合芬太尼妇科腹腔镜脊髓麻醉妇科门诊手术中低剂量 Romberg试验

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A novel supplement with yeast b-glucan, prebiotic, minerals and Silybum marianum synergistically modulates metabolic and inflammatory pathways and improves steatosis in obese mice

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Journal of Integrative Medicine 2021年第5期19卷 439-450页

作者： Victor Abou Nehmi Gilson Masahiro Murata Ruan Carlos Macêdo de Moraes Gabriely Cristina AlvesLima Danielle Araujo de Miranda Katrin Radloff Raquel Galvao Figuerêdo Costa Joyce de Cassia Rosade jesus Jéssica Alves de Freitas Nayara Izabel Viana Ruan Pimenta Katia Ramos Moreira Leite JoséPinhata Otoch Ana Flávia Marcal Pessoa Laboratory of Medical Investigation(LIM-26) Department of SurgeryUniversity of Sao Paulo Medical SchoolSao PauloSP 01246903Brazil Laboratory of Medical Investigation(LIM-29) Clinic Medical DepartmentUniversity of Sao Paulo Medical SchoolSao PauloSP 01246903Brazil department of Physiology Escola Paulista de Medicina/Universidade Federal de Sao PauloSP 04023062Brazil Max Rubner-Institut Federal Research Institute of Nutrition and FoodKarlsruheBW 76131Germany Cancer and Inflammation Program Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892United States Laboratory of Medical Investigation(LIM-55) Urology DepartmentUniversity of Sao Paulo Medical SchoolSao PauloSP 01246903Brazil D'Or Institute for Research and Education RJ 22281-100Brazil Program in Anesthesiology Surgical Sciencesand Perioperative MedicineUniversity of Sao PauloSao PauloSP 01246903Brazil Brazilian Academic Consortium for Integrative Health(CABSIN) Natural Products CommitteeSao PauloSP 05449-070Brazil

Objective: To evaluate the synergic effects of a novel oral supplement formulation, containing prebiotics,yeast b-glucans, minerals and silymarin(Silybum marianum), on lipid and glycidic metabolism, inflammatory and mitochondrial proteins of the liver, in control and high-fat diet-induced obese ***: After an acclimation period, 32 male C57 BL/6 mice were divided into the following groups:nonfat diet(NFD) vehicle, NFD supplemented, high-fat diet(HFD) vehicle and HFD supplemented. The vehicle and experimental formulation were administered orally by gavage once a day during the last four weeks of the diet(28 consecutive days). We then evaluated energy homeostasis, inflammation, and mitochondrial protein expression in these groups of ***: After four weeks of supplementation, study groups experienced reduced glycemia, dyslipidemia,fat, and hepatic fibrosis levels. Additionally, proliferator-activated receptor-α, AMP-activated protein kinase-1α, peroxisome proliferator-activated receptor γ co-activator-1α, and mitochondrial transcription factor A expression levels were augmented;however, levels of inhibitor of nuclear factor-κB kinase subunit a and p65 nuclear factor-κB expression, and oxidative markers were reduced. Notably, the cortisol/C-reactive protein ratio, a well-characterized marker of the hypothalamic–pituitary–adrenal axis immune interface status, was found to be modulated by the ***: We discovered that the novel supplement was able to modify different antioxidant, metabolic and inflammatory pathways, improving the energy homeostasis and inflammatory status, and consequently alleviated hepatic steatosis.

关键词： Supplement Silymarin Prebiotic Obese Mice Steatosis Inflammation Mitochondrial biogenesis

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Non-invasive delivery of levodopa-loaded nanoparticles to the brain via lymphatic vasculature to enhance treatment of Parkinson’s disease

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Nano Research 2021年第8期14卷 2749-2761页

作者： Tianqi Nie Zhiyu He Jinchang Zhu Kuntao Chen Gregory P.Howard jesus Pacheco-Torres II Minn Pengfei Zhao Zaver M.Bhujwalla Hai-Quan Mao Lixin Liu Yongming Chen School of Materials Science and Engineering Key Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationSun Yat-sen UniversityGuangzhou 510275China Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100China department of Materials Science and Engineering Johns Hopkins University BaltimoreMD 21218USA department of Biomedical Engineering Johns Hopkins School of Medicine BaltimoreMD 21205USA Institute for NanoBioTechnology Johns Hopkins UniversityBaltimoreMD 21218USA Division of Nuclear Medicine and Molecular Imaging department of Radiology and Radiological Science Johns Hopkins School of MedicineBaltimoreMD 21205USA Translational Tissue Engineering Center Johns Hopkins School of MedicineBaltimoreMD 21287USA

Levodopa(L-DOPA),a precursor of dopamine,is commonly prescribed for the treatment of the Parkinson’s disease(PD).However,oral administration of levodopa results in a high level of homocysteine in the peripheral circulation,thereby elevating the risk of cardiovascular disease,and limiting its clinical ***,we report a non-invasive method to deliver levodopa to the brain by delivering L-DOPA-loaded sub-50 nm nanoparticles via brain-lymphatic *** hydrophilic L-DOPA was successfully encapsulated into nanoparticles of tannic acid(TA)/polyvinyl alcohol(PVA)via hydrogen bonding using the flash nanocomplexation(FNC)process,resulting in a high L-DOPA-loading capacity and uniform size in a scalable *** analysis in a PD rat model demonstrated that the levels of dopamine and tyrosine hydroxylase,which indicate the dopaminergic neuron functions,were increased by 2-and 4-fold,*** disorders and cerebral oxidative stress of the rats were significantly *** formulation exhibited a high degree of biocompatibility as evidenced by lack of induced inflammation or other pathological changes in major *** antioxidative and drug-delivery platform administered through the brain-lymphatic vasculature shows promise for clinical treatment of the PD.

关键词： levodopa brain delivery cerebral lymphatic vasculature Parkinson’s disease

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Mitogenome and phylogenetic analyses support rapid diversification among species groups of small-eared shrews genus Cryptotis(Mammalia:Eulipotyphla:Soricidae)

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Zoological Research 2021年第6期42卷 739-745页

作者： Kai He Xing Chen Yin-Bin Qiu Zhu Liu Wen-Zhi Wang Neal Woodman jesus E.Maldonado Xinghua Pan department of Biochemistry and Molecular Biology School of Basic Medical Sciencesand Guangdong Provincial Key aboratory of Single Cell Technology and ApplicationSouthern Medical UniversityGuangzhouGuangdong 510515China Wildlife Forensic Science Service KunmingYunnan 650223China School of Zoology Faculty of Life sciencesTel Aviv UniversityTel Aviv 6997801 Israel College of Life Science and Technology Mudanjiang Normal UniversityMudanjiangHeilongjiang 157012China Guizhou Academy of Testing and Analysis GuiyangGuizhou 550002China U.S.Geological Survey Eastern Ecological Science CenterLaurelMD 20708USA Division of Mammals Department of Vertebrate ZoologyNational Museum of Natural HistorySmithsonian InstitutionWashingtonDC 20560USA Center for Conservation Genomics Smithsonian Conservation Biology InstituteWashingtonDC 20008USA

The small-eared shrew genus Cryptotis is the third largest in the family Soricidae and occurs in North,Central,and northern South *** Mexico and Central and South America,most species inhabit geographically isolated moist,montane habitats at middle and high elevations in a typical sky-island *** 49 recognized species have been partitioned into as many as six species groups based on morphological and molecular phylogenetic *** relationships among these species groups are poorly resolved,and their evolutionary histories,including migration patterns and locomotor adaptations,remain ***,we provide a new phylogeny incorporating complete mitochondrial genomes(mitogenomes)and supermatrix *** compared different evolutionary scenarios using approximately unbiased(AU),Kishino-Hasegawa(KH),and Shimodaira-Hasegawa(SH)statistical *** phylogenetic hypothesis based on mitogenomes revealed novel relationships supporting a basal position for the Cryptotis parvusgroup in the genus,and a close relationship between *** and one clade of the *** former relationship is consistent with the least derived humerus morphology and northern distribution of the *** latter relationship i mplies multiple migrations between Central and South *** lack of fine resolution for the species group relationships may be due partly to the lack of taxon *** contrast,multi-approach analyses suggest that the unresolved relationships may be a result of rapid diversification during the early stages of Cryptotis evolution.

关键词： Cryptotis Capture hybridization Hard polytomy Mitochondrial genome Rapid diversification Soricidae

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