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World Journal of Gastroenterology 2006年第21期12卷 3406-3409页

作者： jesus K Yamamoto-Furusho Takeshi Takahashi-Monroy Omar Vergara-Fernandez Edgardo Reyes Luis Uscanga Departments of Gastroenterology. Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Mexico City Mexico Departments of Surgery. Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Mexico City Mexico Departments of Pathology. Institute Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Mexico City Mexico

AIM： To assess the prevalence and clinical value of p-ANCA in a sample of Mexican ulcerative colitis （UC） patients. METHODS： In a prospective, IRB-approved protocol, p-ANCA was determined in 80 patients with UC （mean age, 32 ± 12.9 years）. The severity and extension of disease were determined by clinical methods, searching a statistical association with p-ANCA status. RESULTS： p-ANCA were detected in 41 （51%） patients. Severity of disease was the only clinical variable statistically associated with their presence （P 〈 0.0001; OR = 9; CI 95% = 3.2-24.7）. CONCLUSION： The prevalence of p-ANCA was similar to that reported in other countries. Their presence was associated to UC severity, but offered no more information than the obtained by clinical methods.

关键词： Ulcerative colitis Inflammatory bowel disease Perinuclear anti-neutrophil cytoplasmic antibodies

Prevalence of and risk factors for severe malaria caused by Plasmodium and dengue virus co-infection: a systematic review and meta-analysis

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Infectious Diseases of Poverty 2020年第5期9卷 120-121页

作者： Manas Kotepui Kwuntida Uthaisar Kotepui Giovanni De jesus Milanez Frederick Ramirez Masangkay Medical Technology School of Allied Health SciencesWalailak UniversityTha SalaNakhon Si ThammaratThailand 不详

Background:Co-infection with both Plasmodium and dengue virus(DENV)infectious species could have serious and fatal outcomes if left undiagnosed and without timely *** present study aimed to determine the pooled prevalence estimate of severe malaria among patients with co-infection,the risk of severe diseases due to co-infection,and to describe the complications of severe malaria and severe dengue among patients with ***:Relevant studies published between databases between 12 September 1970 and 22 May 2020 were identified and retrieved through a search of the ISI Web of Science,Scopus,and *** pooled prevalence and 95%confidence interval(CI)of severe malaria among patients with Plasmodium and DENV co-infection was estimated with a random-effects model to take into account the between-study heterogeneity of the included *** risks of severe malaria and severe diseases due to co-infection were estimated with the pooled odds ratio(OR)and 95%CI with a random-effects ***:Of the 5653 articles screened,13 studies were included in the systematic review and *** results demonstrated that the pooled prevalence estimate of severe malaria among patients with co-infection was 32%(95%CI:18-47%,I 2=92.3%).Patients with co-infection had a higher risk of severe diseases than those with DENV mono-infection(odds ratio[OR]=3.94,95%CI:1.96-7.95,I 2=72%).Patients with co-infection had a higher risk of severe dengue than those with DENV mono-infection(OR=1.98,95%CI:1.08-3.63,I 2=69%).The most severe complications found in severe dengue were bleeding(39.6%),jaundice(19.8%),and shock/hypotension(17.9%),while the most severe complications found in severe malaria were severe bleeding/bleeding(47.9%),jaundice(32.2%),and impaired consciousness(7.43%).Conclusions:The present study found that there was a high prevalence of severe malaria among patients with Plasmodium and DENV *** in endemic areas where these two di

关键词： Plasmodium Malaria Dengue Severe complications Severity

Alcohol consumption on pancreatic diseases

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World Journal of Gastroenterology 2013年第5期19卷 638-647页

作者： Marta Herreros-Villanueva Elizabeth Hijona jesus Maria Baales Angel Cosme Luis Bujanda Schulze Center for Novel Therapeutics Division of Oncology ResearchDepartment of MedicineMayo ClinicRochesterMA 55905United States Department of Gastroenterology Center for Biomedical Research in Digestive and Liver Diseases Network(CIBERehd)Donostia HospitalUniversity of the Basque UPV/EHU20010 San SebastianSpain

Although the association between alcohol and pancreatic diseases has been recognized for a long time,the impact of alcohol consumption on pancreatitis and pancreatic cancer(PC)remains poorly *** there is not consensus about the epidemiology and the beverage type,dose and duration of alcohol consumption causing these *** objective of this study was to review the epidemiology described in the literature for pancreatic diseases as a consequence of alcoholic behavior trying to understand the association between dose,type and frequency of alcohol consumption and risk of pancreatitis and *** majority of the studies conclude that high alcohol intake was associated with a higher risk of pancreatitis(around 2.5%-3% between heavy drinkers and 1.3%between non drinkers).About 70%of pancreatitis are due to chronic heavy alcohol *** this incidence rate differs between countries,it is clear that the risk of developing pancreatitis increases with increasing doses of alcohol and the average of alcohol consumption vary since 80 to 150 g/d for 10-15 *** regard to PC, the role of alcohol consumption remains less clear,and low to moderate alcohol consumption do not appear to be associated with PC risk,and only chronic heavy drinking increase the risk compared with lightly *** a population of 10%-15%of heavy drinkers, 2%-5%of all PC cases could be attributed to alcohol ***,as only a minority(less than 10%for pancreatitis and 5%for PC)of heavily drinkers develops these pancreatic diseases,there are other predisposing factors besides alcohol *** variability and environmental exposures such as smoking and diet modify the risk and should be considered for further investigations.

关键词： Acute pancreatitis Chronic pancreatitis Alcohol consumption Alcohol metabolism Genetic variability Pancreatic cancer Risk

Drug resistance in cancer immunotherapy:new strategies to improve checkpoint inhibitor therapies

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Cancer Drug Resistance 2019年第4期2卷 980-993页

作者： jesus Rodriguez-Pascual Angel Ayuso-Sacido Cristobal Belda-Iniesta Department of Clinical Oncology HM-CIOCCGrupo HM HospitalesMadrid 28050Spain Fundación de Investigación HM Hospitales(FiHM) Madrid 28015Spain Instituto de Salud Carlos III Madrid 28029Spain

Recent advances in pharmacological immune modulation against tumor cells has dramatically changed the paradigm of cancer *** inhibitor therapy is a form of cancer immunotherapy already in clinical setting but also under active basic and clinical ***,some patients are primary unresponsive or develop ulterior resistance to these family of *** review aims to update the basic molecular mechanism of resistance as well as the current strategies for checkpoint inhibitor selection in order to propose new approaches to individualize the use of these novel therapies.

关键词： Immunotherapy checkpoint inhibitors cytotoxic T-lymphocyte antigen 4 programmed death receptor-1 programmed death ligand-1

AudiWFlow:Confidential,collusion-resistant auditing of distributed workflows

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Blockchain(Research and Applications) 2022年第3期3卷 1-11页

作者： Xiaohu Zhou Antonio Nehme Vitor jesus Yonghao Wang Mark Josephs Khaled Mahbub Ali Abdallah School of Computing and Digital Technology Birmingham City UniversityBirminghamB47XGUK Aston Business School Aston UniversityBirminghamB47ERUK

We discuss the problem of accountability when multiple parties cooperate towards an end result,such as multiple companies in a supply chain or departments of a government service under different *** cases where a fully trusted central point does not exist,it is difficult to obtain a trusted audit trail of a workflow when each individual participant is unaccountable to all *** propose AudiWFlow,an auditing architecture that makes participants accountable for their contributions in a distributed *** scheme provides confidentiality in most cases,collusion detection,and availability of evidence after the workflow *** is based on verifiable secret sharing and real-time peer-to-peer verification of records;it further supports multiple levels of assurance to meet a desired trade-off between the availability of evidence and the overhead resulting from the auditing *** propose and evaluate two implementation approaches for *** first one is fully distributed except for a central auxiliary point that,nevertheless,needs only a low level of *** second one is based on smart contracts running on a public blockchain,which is able to remove the need for any central point but requires integration with a blockchain.

关键词： Auditing Distributed workflows Confidentiality Blockchains Smart contracts

Optimizing the evolution of strength for lime-stabilized rammed soil

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第4期11卷 882-891页

作者： Jair de jesus Arrieta Baldovino Ronaldo Luis dos Santos Izzo Eclesielter Batista Moreira Juliana Lundgren Rose Department of Civil Construction Federal University of Technology-Parana

In the present study,unconfined compressive strength(qu)values of two lime-treated soils(soil 1 and 2)with curing times of 28 d,90 d and 360 d were *** influence of void/lime ratio was represented by the porosity/volumetric lime content ratio(η/Liv)as the main parameter.η/Liv represents the volume of void influenced by compaction effort and lime *** evolution of qu was analyzed for each soil using the coefficient of determination as the optimization *** at providing adjustments to the mechanical resistance values,the η/Liv parameter was modified to η/LivC using the adjustment exponent C(to make qu-η/Liv variation rates compatible).The results show that with the decrease of η/*** increases potentially and the optimized values of C were *** mechanical resistance data show similar trends between qu and η/LivC for the studied silty soil-ground lime mixtures,which were cured at ambient temperature(23±2)℃ with different curing times of 28-360 ***,optimized equations were presented using the normalized strengths and the proposed optimization model,which show 6% error and 95% acceptability on average.

关键词： Lime-treated soil Void/lime ratio Ground improvement

New approach to assess sperm DNA fragmentation dynamics： Fine-tuning mathematical models

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Journal of Animal Science and Biotechnology 2017年第3期8卷 592-600页

作者： Isabel Ortiz jesus Dorado Jane Morrell Jaime Gosalvez Francisco Crespo Juan M.Jimenez Manuel Hidalgo Veterinary Reproduction Group Department of Animal Medicine and Surgery Faculty of Veterinary Medicine University of Cordoba 14071 Cordoba Spain Department of Clinical Sciences Division of Reproduction Swedish University of Agricultural Sciences Box 7054 SE-75007 Uppsala Sweden Department of Biology Universidad Aut6noma de Madrid 28049 Madrid Spain Department of Reproduction Centro Militar de Cria Caballar (FESCCR-Ministry of Defense) 05005 Avila Spain Department of Chemistry and Physics of Materials University of Salzburg Hellbrunner StraBe 34/111 A-5020 Salzburg Austria

Background： Sperm DNA fragmentation（sDF） has been proved to be an important parameter in order to predict in vitro the potential fertility of a semen sample. Colloid centrifugation could be a suitable technique to select those donkey sperm more resistant to DNA fragmentation after thawing. Previous studies have shown that to elucidate the latent damage of the DNA molecule, sDF should be assessed dynamically, where the rate of fragmentation between treatments indicates how resistant the DNA is to iatrogenic damage. The rate of fragmentation is calculated using the slope of a linear regression equation. However, it has not been studied if s DF dynamics fit this model. The objectives of this study were to evaluate the effect of different after-thawing centrifugation protocols on sperm DNA fragmentation and elucidate the most accurate mathematical model（linear regression, exponential or polynomial） for DNA fragmentation over time in frozen-thawed donkey ***： After submitting post-thaw semen samples to no centrifugation（UDC）, sperm washing（SW） or single layer centrifugation（SLC） protocols, sD F values after 6 h of incubation were significantly lower in SLC samples than in SW or *** of determination（R-2） values were significantly higher for a second order polynomial model than for linear or exponential. The highest values for acceleration of fragmentation（aSDF） were obtained for SW, fol owed by SLC and ***： SLC after thawing seems to preserve longer DNA longevity in comparison to UDC and SW. Moreover,the fine-tuning of models has shown that sDF dynamics in frozen-thawed donkey semen fit a second order polynomial model, which implies that fragmentation rate is not constant and fragmentation acceleration must be taken into account to elucidate hidden damage in the DNA molecule.

关键词： Colloid centrifugation Dynamics Fine-tuning Mathematical models Sperm DNA fragmentation

Soil Physical Quality of Citrus Orchards Under Tillage, Herbicide, and Organic Managements

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Pedosphere 2018年第3期28卷 463-477页

作者： Simone DI PRIMA jesus RODRIGO-COMINO Agata NOVARA Massimo IOVINO Mario PIRASTRU Saskia KEESSTRA Artemi CERDA Dipartimento di Agraria Università degli Studi di Sassari Sassari 07100 Italy Instituto de Geomorfologia y Suelos Department of Geography Mdlaga University Campus of Teatinos sin Mdlaga 29071( Spain) Department of Physical Geography Trier University Trier D-54286( Germany) Dipartimento di Scienze Agrarie Alimentari e Forestali Universita degli Studi di Palermo Palermo 90128( Italy) Team Soil Water and Land Use Wageningen Environmental Research Wageningen UR Droevendaalsesteeg 3 Wageningen 6700 AA(The Netherlands) Civil Surveying and Environmental Engineering The University of Newcastle Callaghan 2308(Australia) Soil Erosion and Degradation Research Group Department of Geography Universitat de Valencia Valencia 46010( Spain)

Soil capacity to support life and to produce economic goods and services is strongly linked to the maintenance of good soil physical quality(SPQ). In this study, the SPQ of citrus orchards was assessed under three different soil managements, namely no-tillage using herbicides, tillage under chemical farming, and no-tillage under organic farming. Commonly used indicators, such as soil bulk density,organic carbon content, and structural stability index, were considered in conjunction with capacitive indicators estimated by the Beerkan estimation of soil transfer parameter(BEST) method. The measurements taken at the L'Alcoleja Experimental Station in Spain yielded optimal values for soil bulk density and organic carbon content in 100% and 70% of cases for organic farming. The values of structural stability index indicated that the soil was stable in 90% of cases. Differences between the soil management practices were particularly clear in terms of plant-available water capacity and saturated hydraulic conductivity. Under organic farming, the soil had the greatest ability to store and provide water to plant roots, and to quickly drain excess water and facilitate root *** practices adopted under organic farming(such as vegetation cover between the trees, chipping after pruning, and spreading the chips on the soil surface) improved the SPQ. Conversely, the conventional management strategies unequivocally led to soil degradation owing to the loss of organic matter, soil compaction, and reduced structural stability. The results in this study show that organic farming has a clear positive impact on the SPQ, suggesting that tillage and herbicide treatments should be avoided.

关键词： Beerkan estimation of soil transfer parameter capacitive indicator organic farming soil management soil quality assessment structural stability index

Dog sperm head morphometry： its diversity and .=volution

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Asian Journal of Andrology 2017年第2期19卷 149-153页

作者： Caries Soler Ana Alambiaga Maria A Marti Almudena Garcia-Molina Anthony Valverde jesus Contell Marcos Campos Department of Functional Biology and Physical Anthropology University of Valencia 46100 Burjassot Spain R+D Department Proiser R+D Scientific Park University of Valencia 46980 Paterna Spain 3Technological Institute of Costa Rica San Carlos Campus School of Agronomy 223-21001 Alajuela Costa Rica Department of Medicine and Animal Surgery University CardenaI-Herrera-CEU 46113 Moncada Valencia Spain Global Veterinaria (Reprovalcan) 46500 Sagunto Valencia Spain Clinica Veterinaria Sangueso 46009 Valencia Spain

Dogs have been under strong artificial selection as a consequence of their relationship with man. Differences between breeds are evident that could be reflected in seminal characteristics. The present study was to evaluate differences in sperm head morphometry between seven well-defined breeds of dog： the British Bulldog, Chihuahua, German Shepherd, Labrador Retriever, Spanish Mastiff, Staffordshire Terrier, and Valencian Rat Hunting dog. Semen samples were obtained by masturbation and smears stained with Diff-Quik. Morphometric analysis （CASA-Morph） produced four size and four shape parameters. Length, Ellipticity, and Elongation showed higher differences between breeds. MANOVA revealed differences among all breeds. Considering the whole dataset, principal component analysis （PCA） showed that PC1 was related to head shape and PC2 to size. Procluster analysis showed the British Bulldog to be the most isolated breed, followed by the German Shepherd. The PCA breed by breed showed the Chihuahua, Labrador Retriever, Spanish Mastiff, and Staffordshire Terrier to have PC1 related to shape and PC2 to size, whereas the British Bulldog, Valencia Rat Hunting dog, and German Shepherd had PC1 related to size and PC2 to shape. The dendrogram for cluster groupings and the distance between them showed the British Bulldog to be separated from the rest of the breeds. Future work on dog semen must take into account the large differences in the breeds＇ sperm characteristics. The results provide a base for future work on phylogenetic and evolutionary studies of dogs, based on their seminal characteristics.

关键词： Canis familiaris cluster analysis diversity sperm morphometry

Peptidomic analysis of whey protein hydrolysates and prediction of their antioxidant peptides

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Food Science and Human Wellness 2022年第2期11卷 349-355页

作者： jesus Morales García Chibuike C.Udenigwe Jorge Duitama Andrés Fernando González Barrios Grupo de Diseño de Productos y Procesos(GDPP) Department of Chemical and Food EngineeringUniversidad de los AndesBogotá111711Colombia School of Nutrition Sciences University of OttawaOttawaOntarioK1N 6N5Canada Systems and Computing Engineering Department Universidad de Los AndesBogotá111711Colombia

Enzymatic hydrolysis of proteins is a breakdown process of peptide bond in proteins,releasing some peptides with potential biological *** studies on enzymatic hydrolysis of whey proteins have not identified the complete peptide profiles after *** this study,we reconstructed a profile of peptides from whey hydrolysates with two enzymes and different processing *** also developed an ensemble machine learning predictor to classify peptides obtained from whey hydrolysis.A total of 2572 peptides were identified over three process conditions with two enzymes in duplicate.499 peptides were classified and chosen as potential antioxidant peptides from whey *** peptides classified as antioxidants in the hydrolysates had a proportion of 13.1%-24.5%regarding all peptides *** results facilitate the selection of promising peptides involved in the antioxidant properties during the enzymatic hydrolysis of whey proteins,aiding the discovery of novel antioxidant peptides.

关键词： Whey hydrolysate Antioxidant peptide Peptidomics Prediction