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Circadian rhythm dysfunction and psychopathology in the offspring of parents with bipolar disorder:a highrisk study in the Chinese population

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General Psychiatry 2024年第3期37卷 388-400页

作者： Binbin Lei Hongliang Feng Lulu Yang Jing Wang Jie Chen Weidong Song Chao Jiang Kun Zhang Qunfeng Wang jessie Chi Ching Tsang Ngan Yin Chan Yaping Liu Joey W.Y.Chan Jiyang Pan Bin Zhang Tao Li Kathleen Ries Merikangas Jihui Zhang Yun Kwok Wing Guangdong Cardiovascular Institute Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdongChina Guangdong Mental Health Center Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdongChina Li Chiu Kong Family Sleep Assessment Unit Department of PsychiatryFaculty of MedicineThe Chinese University of Hong KongHong KongChina Center for Sleep and Circadian Medicine The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Psychiatry Faculty of MedicineThe Chinese University of Hong KongNew TerritoriesHong KongChina Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou Medical UniversityGuangzhouGuangdongChina Shenzhen Nanshan Center for Chronic Diseases Control(Shenzhen Nanshan Mental Health Center) ShenzhenChina Department of Clinical Psychology Shenzhen Fuyong People's HospitalShenzhenChina Department of Mental Illness Prevention and Treatment Shenzhen Longgang Center for Chronic Diseases ControlShenzhenChina Department of Neurology Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina Sleep Medical Center The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdongChina Department of Psychiatry Nanfang HospitalSouthern Medical UniversityGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired IntelligenceGuangzhouGuangdongChina Department of Neurobiology Affiliated Mental Health Center&Hangzhou Seventh People's HospitalZhejiang University School of MedicineHangzhouZhejiangChina Genetic Epidemiology Research Branch Intramural Research ProgramNational Institute of Mental HealthBethesdaMarylandUSA

Background Understanding the evolution of circadian rhythm dysfunction and psychopathology in the high-risk population has important implications for the prevention of bipolar ***,some of the previous studies on the emergence of psychopathologies and circadian dysfunction among high-risk populations were inconsistent and *** To examine the prevalence rates of sleep and circadian dysfunctions,mental disorders and their symptoms in the offspring of parents with(O-BD)and without bipolar disorder(O-control).Methods The study included 191 O-BD and 202 O-control subjects aged 6-21 years from the Greater Bay Area,*** diagnoses and symptoms of sleep/circadian rhythm and mental disorders were assessed by the Diagnostic Interview for Sleep Patterns and Disorders,and the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version,*** estimating equations and shared frailty proportional hazards models of survival analysis were applied to compare the outcomes in the *** Adjusting for age,sex and region of recruitment,there was a significantly higher risk of delayed sleep phase symptoms(9.55%vs 2.58%,adjusted OR:4.04)in O-BD than in O-control.O-BD had a nearly fivefold higher risk of mood disorders(11.70%vs 3.47%,adjusted OR:4.68)and social anxiety(6.28%vs 1.49%,adjusted OR:4.70),a fourfold higher risk of depressive disorders(11.17%vs 3.47%,adjusted OR:3.99)and a threefold higher risk of mood symptoms(20.74%vs 10.40%,adjusted OR:2.59)than *** analysis revealed that O-BD children(aged under 12 years)had a nearly 2-fold higher risk of any mental and behavioural symptoms than O-control,while there was a nearly 4-fold higher risk of delayed sleep phase symptoms,a 7.5-fold higher risk of social anxiety and a 3-fold higher risk of mood symptoms in O-BD adolescents(aged 12 years and over).Conclusions There was an increase in delayed sleep phase symptoms in O-BD

关键词： prevention dysfunction bipolar

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The Phantom Menace:latest findings on effector biology in the rice blast fungus

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aBIOTECH 2023年第2期4卷 140-154页

作者： jessie Fernandez Department of Microbiology and Cell Science at University of Florida-Institute of Food and Agricultural Science GainesvilleFL 32611USA

Magnaporthe oryzae is a hemibiotrophic fungus responsible for the economically devastating and recalcitrant rice blast ***,the blast fungus is not only restricted to rice plants as it can also infect wheat,millet,and other *** previous outstanding discoveries aimed to understand and control the disease,the fungus remains one of the most important pathogens that threatens global food *** cause disease,*** initiates morphological changes to attach,penetrate,and colonize rice cells,all while suppressing plant immune defenses that would otherwise hinder its *** such,*** actively secretes a battery of small proteins called“effectors”to manipulate host *** this review,we summarize the latest findings in effector identification,expression,regulation,and *** review the most studied effectors and their roles in ***,we discern the current methodologies to structurally catalog effectors,and we highlight the importance of climate change and its impact on the future of rice blast disease.

关键词： Rice blast Effector Secretion Computational analysis Plant immunity Climate change

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高山密林寻冷杉

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少儿科学周刊(少年版) 2024年第5期 16-16页

作者： jessie 张智动漫画屋

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Embracing oligodendrocyte diversity in the context of perinatal injury

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Neural Regeneration Research 2017年第10期12卷 1575-1585页

作者： jessie Newville Lauren L.Jantzie Lee Anna Cunningham Department of Neurosciences University of New Mexico Health Sciences CenterAlbuquerqueNMUSA Department of Pediatrics University of New Mexico Health Sciences CenterAlbuquerqueNMUSA

Emerging evidence is fueling a new appreciation of oligodendrocyte diversity that is overturning the traditional view that oligodendrocytes are a homogenous cell *** of distinct origins,maturational stages,and regional locations may differ in their functional capacity or susceptibility to *** of the most unique qualities of the oligodendrocyte is its ability to produce *** abnormalities have been ascribed to a remarkable array of perinatal brain injuries,with concomitant oligodendrocyte *** this review,we discuss new insights into the diversity of the oligodendrocyte lineage and highlight their relevance in paradigms of perinatal brain *** therapeutic development will be informed by comprehensive knowledge of oligodendrocyte pathophysiology that considers the particular facets of heterogeneity that this lineage exhibits.

关键词： oligodendrogenesis oligodendrocyte progenitor cell myelination central nervous system development ontogenetic origin white matter white matter injury preterm birth glia macroglia

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高山密林寻冷杉

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少儿科学周刊(儿童版) 2024年第5期 16-16页

作者： jessie 张智动漫画屋

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You are what you eat:feeding neurons in nutrient regulation of behavior

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Life Metabolism 2023年第1期2卷 1-2页

作者： jessie C.Morrill Qingchun Tong Department of Animal Science University of NebraskaLincolnLincolnNE 68503USA Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases McGovern Medical School of the University of Texas Health Science Center at HoustonTX 77030USA

In a recent paper published in Life Metabolism,Yuan et *** that deprivation of the essential amino acid,leucine,alleviated depressive behaviors that were induced by chronic ***,the antidepressant effects were shown to be mediated by the activation of agouti-related protein(AgRP)-expressing neurons,which are known for the ability to sense bodily energy status and promote energy intake,revealing a neural basis for the availability of nutrients in controlling mental behaviors.

关键词： behaviors behavior activation

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RNA binding proteins in spermatogenesis： an in depth focus on the Musashi family

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Asian Journal of Andrology 2015年第4期17卷 529-536页

作者： jessie M Sutherland Nicole A Siddall Gary R Hime Eileen A McLaughlin School of Environmental and Life Sciences University of Newcastle Callaghan NSW 2308 Australia Anatomy and Neuroscience University of Melbourne ParkvilleVIC 3010 Australia

Controlled gene regulation during gamete development is vital for maintaining reproductive potential. During the complex process of mammalian spermatogenesis, male germ cells experience extended periods of the inactive transcription despite heavy translational requirements for continued growth and differentiation. Hence, spermatogenesis is highly reliant on mechanisms of posttranscriptional regulation of gene expression, facilitated by RNA binding proteins （RBPs）, which remain abundantly expressed throughout this process. One such group of proteins is the Musashi family, previously identified as critical regulators of testis germ cell development and meiosis in Drosophila, and also shown to be vital to sperm development and reproductive potential in the mouse. This review describes the role and function of RBPs our recent knowledge of the Musashi proteins in spermatogenesis. within the scope of male germ cell development, focusing on The functional mechanisms utilized by RBPs within the cell are outlined in depth, and the significance of sub-cellular localization and stage-specific expression in relation to the mode and impact of posttranscriptional regulation is also highlighted. We emphasize the historical role of the Musashi family of RBPs in stem cell function and cell fate determination, as originally characterized in Drosophila and Xenopus, and conclude with our current understanding of the differential roles and functions of the mammalian Musashi proteins, Musashi-1 and Musashi-2, with a primary focus on our findings in spermatogenesis. This review highlights both the essential contribution of RBPs to posttranscriptional regulation and the importance of the Musashi family as master regulators of male gamete development.

关键词： gene regulation Musashi Musashi-1 Musashi-2 posttranscriptional control RNA binding proteins spermatogenesis splicing testis translation

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Non-small-bowel abnormalities identified during small bowel capsule endoscopy

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World Journal of Gastroenterology 2014年第14期20卷 4025-4029页

作者： Reinier A Hoedemaker jessie Westerhof Rinse K Weersma Jan J Koornstra Department of Gastroenterology and Hepatology University Medical Centre GroningenUniversity of Groningen

AIM: To investigate the incidence of non-small-bowel abnormalities in patients referred for small bowel capsule endoscopy, this single center study was performed.

关键词： Capsule endoscopy Small bowel Findings Colon Stomach

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CONGLOMERATE MERGER CONTROL： FROM THE CONTINENTS TO A SMALL ECONOMY

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Frontiers of Law in China-Selected Publications from Chinese Universities 2013年第2期8卷 304-334页

作者： jessie Xinyu Wang Y. Stephen Chiu Bachelor practising law at Angela Ho & Associates at Faculty of Law University ofHong Kong Hong Kong China Ph.D and Associate Professor at Faculty of Business and Economics University ofHong Kong Hong Kong China.

To condemn a conglomerate merger for the foreclosure effect of post-merger activities, one should examine the anticipated conduct against the same liability rules under the law of agreement and the law of abuse of dominance as if the conduct has been materialized Given the inherent uncertainty of pre-merger assessment, it requires a high standard of proof to satisfy the adjudicator that the merger in question would lead to anticompetitive effect in all the circumstances. Conglomerate merger, which will reinforce market concentration or increase entry barriers, should be stringently scrutinized. Saying so, the pro-efficiency effects of conglomerate merger are appreciated One shouM not take it for granted that agglomeration will be restrained through conglomerate merger control.

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Current AQP research:therapeutic approaches to ischemic and hemorrhagic stroke

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Neural Regeneration Research 2016年第12期11卷 1918-1919页

作者： Linlin Ma Longfei Guan jessie N.Ding Xiaokun Geng China-America Institute of Neuroscience Beijing Luhe HospitalCapital Medical University Department of Neurology Beijing Luhe HospitalCapital Medical University Department of Neurosurgery Wayne State University School of Medicine

The role of aquaporins（AQPs）in the formation of cerebral edema after stroke：Stroke can be classified into either ischemic or hemorrhagic based on their etiological *** edema development often accompanies both ischemic infarct and intracerebral hemorrhage（ICH）.Cerebral edema is differentiated according to their underlying mechanism and time course：cytotoxic and vasogenic.

关键词： AQP Current AQP research

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