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Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

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Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria Martinelli jessica Mandrioli Andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari Cecilia Simonini Francesco Cavallieri Franco Valzania Department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental Medicine Ph.D.Program University of Modena and Reggio EmiliaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory SOD1 superoxide dismutase 1 urinary vocal cord palsy

GaAs/AlGaAs heterostructure nanowires studied by cathodoluminescence

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Nano Research 2014年第4期7卷 473-490页

作者： jessica.bolinsson Martin Ek Johanna Tragardh Kilian Mergenthaler Daniel Jacobsson Mats-Erik Pistol Lars Samuelson Anders Gustafsson Solid State Physics and the Nanometer Structure Consortium Lund University Box 118 SE-221 00 Lund Sweden Polymer and Materials Chemistry Lund University Box 124 SE-221 00 Lund Sweden

In this report we explore the structural and optical properties of GaAs/A1GaAs heterostructure nanowires grown by metalorganic vapour phase epitaxy using gold seed-particles. The optical studies were done by low-temperature cathodo- luminescence （CL） in a scanning electron microscope （SEM）. We perform a systematic investigation of how the nanowire growth-temperature affects the total photon emission, and variations in the emission energy and intensity along the length of the nanowires. The morphology and crystal structures of the nanowires were investigated using SEM and transmission electron microscopy （TEM）. In order to correlate specific photon emission characteristics with variations in the nanowire crystal structure directly, TEM and spatially resolved CL measurements were performed on the same individual nanowires. We found that the main emission energy was located at around 1.48 eV, and that the emission intensity was greatly enhanced when increasing the GaAs nanowire core growth temperature. The data strongly suggests that this emission energy is related to rotational twins in the GaAs nanowire core. Our measurements also show that radial overgrowth by GaAs on the GaAs nanowire core can have a deteriorating effect on the optical quality of the nanowires. Finally, we conclude that an in situ pre-growth annealing step at a sufficiently high temperature significantly improves the optical quality of the nanowires.

关键词： GaAs/AlGaAs core shellnanowires metalorganic vapourphase epitaxy (MOVPE) cathodoluminescence twin defects transmission electronmicroscopy

A Comparative Study of the Effect of Gold Seed Particle Preparation Method on Nanowire Growth

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Nano Research 2010年第7期3卷 506-519页

作者： Maria E.Messing Karla Hillerich jessica.bolinsson Kristian Storm Jonas Johansson Kimberly A.Dick Knut Deppert Solid State Physics Lund UniversityBox 118S-22100 LundSweden Polymer&Materials Chemistry Lund UniversityBox 124S-22100 LundSweden

Highly controlled particle-assisted growth of semiconductor nanowires has been performed for many years,and a number of novel nanowire-based devices have been *** control of the epitaxial growth is required to optimize the performance of devices,and gold seed particles are known to provide the most controlled *** nanowire growth from gold particles generated and deposited by various different methods has been reported,but no investigation has yet been performed to compare the effects of gold particle generation and deposition methods on nanowire *** this article we present a direct comparative study of the effect of the gold particle creation and deposition methods on nanowire growth characteristics and nanowire crystal structure,and investigate the limitations of the different generation and deposition methods used.

关键词： Nanowire growth nanoparticles gold epitaxy electron microscopy

Ecology and management of Bactericera cockerelli and Candidatus Liberibacter solanacearum in New Zealand

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Journal of Integrative Agriculture 2020年第2期19卷 333-337页

作者： jessica VEREIJSSEN Applied Entomology the New Zealand Institute for Plant and Food Research Limited

The psyllid Bactericera cockerelli was first reported in New Zealand in 2006 and spread quickly throughout all potato growing *** 2009,*** was associated with the plant pathogenic bacterium Candidatus Liberibacter solanacearum,the putative causal agent of zebra chip disease in *** the psyllid and the bacterium have non-crop host plants which can serve as reservoirs when the crop is not *** apply different management strategies that fit integrated pest management programmes to manage *** and subsequently lower incidence of zebra chip disease in potato *** best management efforts,complete control of *** and zero incidence of zebra chip disease are not achievable at the current time.

关键词： Bactericera cockerelli Candidatus Liberibacter solanacearum potato insect vector

Erratum regarding missing ethics approval and consent to participate statements in previously published articles

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Bioactive Materials 2024年第10期40卷 I0010-I0015页

作者： jessica Wang

The publisher would like to draw the reader’s attention to the following *** approval and consent to participate statements were not included in the published version of the following articles that appeared in previous issues of Bioactive *** authors were contacted after publication to request ethics approval and consent to participate statements for the following *** appropriate ethics approval and consent to participate statements,provided by the authors,are included below.

关键词： approval consent statements

Application of DInSAR for short period monitoring of initial subsidence due to longwall mining in the mountain west United States

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International Journal of Mining Science and Technology 2020年第1期30卷 33-37页

作者： jessica M.Wempen Department of Mining Engineering University of UtahSalt Lake City 84112USA

Differential Interferometric Synthetic Aperture Radar(DInSAR),a satellite-based remote sensing technique,has application for monitoring subsidence with high resolution over short *** uses radar images to measure centimeter-level surface *** the images,ground resolution can be relatively high,with each data point(pixel)representing the average displacement over an area of several square *** image data are acquired regularly which allows subsidence to be monitored sequentially over short periods;imaging periods typically range from weeks to *** subsidence over short periods with high spatial resolution has potential to provide insight into the dynamics of subsidence and into relationships between mine advance and *** this study,for three longwall mines in the western United States,initial subsidence occurring at the start of longwall advance is quantified over short periods(12–72 days).C-band interferometric wide swath Synthetic Aperture Radar(SAR)images from the Sentinel satellites are used to quantify the ***,the data show initial development of subsidence,expansion of the subsidence trough,and the advance of subsidence in the direction of mining.

关键词： Longwall mining Interferometry Subsidence

COVID-19:Reducing the risk via diet and lifestyle

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Journal of Integrative Medicine 2023年第1期21卷 1-16页

作者： jessica L.Campbell 160 Goat Island Road LeighAuckland 0985New Zealand

This review shows that relatively simple changes to diet and lifestyle can significantly,and rapidly,reduce the risks associated with coronavirus disease 2019(COVID-19)in terms of infection risk,severity of disease,and even disease-related mortality.A wide range of interventions including regular exercise,adequate sleep,plant-based diets,maintenance of healthy weight,dietary supplementation,and time in nature have each been shown to have beneficial effects for supporting more positive health outcomes with COVID-19,in addition to promoting better overall *** paper brings together literature from these areas and presents the argument that non-pharmaceutical approaches should not be overlooked in our response to *** is noted that,in several cases,interventions discussed result in risk reductions equivalent to,or even greater than,those associated with currently available *** the balance of evidence suggests benefits,and the risk is minimal to none,it is suggested that communicating the power of individual actions to the public becomes morally ***,many lives could be saved,and many harms from the vaccine mandates avoided,if we were willing to embrace this lifestyle-centred approach in our efforts to deal with COVID-19.

关键词： COVID-19 SARS-CoV-2 Exercise Sleep Diet Risk reduction behaviour

Translational Bioinformatics: Past, Present, and Future

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Genomics, Proteomics & Bioinformatics 2016年第1期14卷 31-41页

作者： jessica D.Tenenbaum Department of Biostatistics and Bioinformatics Duke University School of Medicine

Though a relatively young discipline, translational bioinformatics （TBI） has become a key component of biomedical research in the era of precision medicine. Development of high-throughput technologies and electronic health records has caused a paradigm shift in both healthcare and biomedical research. Novel tools and methods are required to convert increasingly voluminous datasets into information and actionable knowledge. This review provides a definition and contex- tualization of the term TBI, describes the discipline＇s brief history and past accomplishments, as well as current loci, and concludes with predictions of future directions in the field.

关键词： Translational bioinformatics Biomarkers Genomics Precision medicine Personalized medicine

The role of RAS effectors in BCR/ABL induced chronic myelogenous leukemia

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Frontiers of Medicine 2013年第4期7卷 452-461页

作者： jessica Fredericks Ruibao Ren State Key Laboratory for Medical Genomics Shanghai Institute of HematologyRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Rosenstiel Basic Medical Sciences Research Center and Department of Biology Brandeis UniversityWalthamMA 02454USA EMD Millipore Corporation 17 Cherry Hill DriveDanversMA 01923USA

BCR/ABL is the causative agent of chronic myelogenous leukemia(CML).Through structure/function analysis,several protein motifs have been determined to be important for the development of ***177 of BCR is a Grb2 binding site required for BCR/ABL-induced CML in *** the current study,we use a mouse bone marrow transduction/transplantation system to demonstrate that addition of oncogenic NRAS(NRASG12D)to a vector containing a BCR/ABL^(Y177F)mutant“rescues”the CML phenotype rapidly and *** further narrow down the pathways downstream of RAS that are responsible for this rescue effect,we utilize well-characterized RAS effector loop mutants and determine that the RAL pathway is important for rapid induction of *** of this pathway by a dominant negative RAL is capable of delaying disease *** from the present study support the notion of RAL inhibition as a potential therapy for BCR/ABL-induced CML.

关键词： BCR/ABL chronic myelogenous leukemia(CML) RAS RAL