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Male Drosophila melanogaster learn to prefer an arbitrary trait associated with female mating status

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Current Zoology 2015年第6期61卷 1036-1042页

作者： Machteld N. VERZIJDEN jessica K. ABBOTT Anne C. von PHIlIPSBORI~ Volker lOESCHCKE Aarhus Institute for Advanced Studies Aarhus University Denmark Department of Biology Section for Evolutionary Ecology Lund University Sweden Dandrite Department of Molecular Biology and Genetics Aarhus University Denmark Department of Bioscience Section for Genetics Ecology and Evolution Aarhus University Denmark

Although males are generally less discriminating than females when it comes to choosing a mate, they still benefit from distinguishing between mates that are receptive to courtship and those that are not, in order to avoid wasting time and ener- gy. It is known that males of Drosophila melanogaster are able to learn to associate olfactory and gustatory cues with female re- ceptivity, but the role of more arbitrary, visual cues in mate choice learning has been overlooked to date in this species. We there- fore carried out a series of experiments to determine： 1） whether males had a baseline preference for female eye color （red versus brown）, 2） if males could learn to associate an eye color cue with female receptivity, and 3） whether this association disappeared when the males were unable to use this visual cue in the dark. We found that naive males had no baseline preference for females of either eye color, but that males which were trained with sexually receptive females of a given eye color showed a preference for that color during a standard binary choice experiment. The learned cue was indeed likely to be truly visual, since the prefe- rence disappeared when the binary choice phase of the experiment was carried out in *** is, to our knowledge l） the first evidence that male D. melanogaster can use more arbitrary cues and 2） the first evidence that males use visual cues during mate choice learning. Our findings suggest that that D. melanogaster has untapped potential as a model system for mate choice learning.

关键词： Mate choice learning Male Drosophila Visual trait

Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms

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Stroke & Vascular Neurology 2018年第3期3卷 169-175页

作者： Bowen Jiang Matthew T Bender Erick M Westbroek jessica K Campos li-Mei lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander l Coon Department of Neurosurgery Johns Hopkins University School of MedicineBaltimoreMarylandUSA Department of Neurosurgery University of CaliforniaIrvine School of MedicineOrangeCaliforniaUSA Department of Neurosurgery University of CaliforniaLos AngelesLos AngelesCaliforniaUSA

background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and *** is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic *** is limited knowledge on whether procedural complexity influences these *** Data were collected retrospectively on 742 consecutive PED cases at a single *** with intraprocedural acute thrombosis were compared with patients without these *** A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous *** two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm *** was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two *** in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,pling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,plinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of *** Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are asso

关键词： P2Y12 matched balloon

Comment on“In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells”

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light(Science & Applications) 2021年第10期10卷 1998-1999页

作者： Amber l.Williams jessica E.Fitzgerald Fernando Ivich Eduardo DSontag Mark Niedre Department of Bioengineering Northeastern UniversityBostonMAUSA Department of Electrical and Computer Engineering Northeastern UniversityBostonMAUSA laboratory of Systems Pharmacology Harvard Medical SchoolBostonMAUSA

Dear Editor,Circulating tumor cells(CTCs)are instrumental in hematogenous metastasis and are widely studied using liquid biopsy *** involve analysis and characterization of CTCs from fractionally small blood samples drawn from *** biopsy implicitly assumes that the number and phenotypical distribution of CTCs in small blood samples is representative of the full peripheral blood volume,and furthermore that CTC numbers are approximately constant over the days and hours surrounding the blood draw.

关键词： biopsy metastasis furthermore

Hepatic pseudotumor associated with Strongyloides infection:A case report

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World Journal of Hepatology 2023年第12期15卷 1338-1343页

作者： jessica P Gialanella Tyler Steidl Kokkola Korpela Miral S Grandhi Russell C langan H Richard Alexander Rachel M Hudacko Brett l Ecker Department of Surgical Oncology Rutgers Cancer Institute of New JerseyNew BrunswickNJ 08901United States Rutgers New Jersey Medical School NewarkNJ 07103United States Department of Infectious Disease Cooperman Barnabas Medical CenterLivingstonNJ 07039United States Department of Pathology and labratory Medicine Rutgers Robert Wood Johnson Medical SchoolNew BrunswickNJ 08901United States

BACKGROUND Strongyloides sterocoralis is a parasitic infection caused by a roundworm that is transmitted through soil contaminated with *** can infrequently cause hepatic abscesses in immunocompromised patients and is rarely reported to form hepatic lesions in immunocompetent *** SUMMARY We present a case study of a 45-year-old female who presented with right upper quadrant abdominal pain and constitutional symptoms for several *** imaging identified several malignant-appearing liver *** investigation,including serological testing and histopathologic examination,revealed the presence of serum Strongyloides antibodies and hepatic granulomas with extensive *** treatment with ivermectin for 2 wk,there was complete resolution of the liver lesions and associated *** This case highlights the importance of considering parasitic infections,such as Strongyloides,in the differential diagnosis of hepatic *** recognition and appropriate treatment can lead to a favorable outcome and prevent unnecessary invasive *** awareness among clinicians is crucial to ensure the timely diagnosis and management of such cases.

关键词： Hepatic tumor liver mass Strongyloides sterocoralis Parasitology Case report

Release of interleukin-10 and neurotrophic factors in the choroid plexus：possible inductors of neurogenesis following copolymer-1 immunization after cerebral ischemia

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Neural Regeneration Research 2018年第10期13卷 1743-1752页

作者： Yolanda Cruz Edna E.García jessica V.Gálvez Stella V.Arias-Santiago Horacio G.Carvajal Raúl Silva-García Herlinda Bonilla-Jaime Julio Rojas-Castaneda Antonio Ibarra Centro de Investigación en Ciencias de la Salud (CICSA) FCSUniversidad Anáhuac México Norte Huixquilucan Estado de México México lab. De Biologia de la reproducción UAMI. Ciudad de México México Hospital de Pediatría CMN Siglo XXI. Ciudad de México México Subdirección de Medicina Experimental Instituto Nacional de PediatríaCiudad de México México Doctorado en Ciencias Biológicas División de Ciencias Biológicas y de la SaludUniversidad Autónoma MetropolitanaUnidad Iztapalapa.Ciudad de México México

Copolymer-1（Cop-1） is a peptide with immunomodulatory properties, approved by the Food and Drug Administration of United States in the treatment of multiple sclerosis. Cop-1 has been shown to exert neuroprotective effects and induce neurogenesis in cerebral ischemia models. Nevertheless, the mechanism involved in the neurogenic action of this compound remains unknown. The choroid plexus（CP） is a network of cells that constitute the interphase between the immune and central nervous systems, with the ability to mediate neurogenesis through the release of cytokines and growth factors. Therefore, the CP could play a role in Cop-1-induced neurogenesis. In order to determine the participation of the CP in the induction of neurogenesis after Cop-1 immunization, we evaluated the gene expression of various growth factors（brain-derived neurotrophic factor, insulin-like growth factor 1, neurotrophin-3） and cytokines（tumor necrosis factor alpha, interferon-gamma, interleukin-4（Il-4）, Il-10 and Il-17）, in the CP at 14 days after ischemia. Furthermore, we analyzed the correlation between the expression of these genes and neurogenesis. Our results showed that Cop-1 was capable of stimulating an upregulation in the expression of the genes encoding for brain-derived neurotrophic factor, insulin-like growth factor 1, neurotrophin-3 and Il-10 in the CP, which correlated with an increase in neurogenesis in the subventricular and subgranular zone. As well, we observed a downregulation of Il-17 gene expression. This study demonstrates the effect of Cop-1 on the expression of growth factors and Il-10 in the CP, in the same way, presents a possible mechanism involved in the neurogenic effect of Cop-1.

关键词： choroid plexus growth factors immunomodulation protective autoimmunity Cop-1 Copaxone stroke glatiramer acetate t MCAo focal cerebral ischemia

Effect of land Use Change on Carbon Content and CO<sub>2</sub>Flux of Cloud Forest Soils, Santa Elena, Costa Rica

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Open Journal of Soil Science 2014年第2期4卷 64-71页

作者： lawrence H. Tanner David l. Smith jessica Curry Justin Twist Department of Biological Sciences Le Moyne College Syracuse USA Pottstown Memorial Medical Center Pottstown USA

We investigated the effects of land-use changes on soil carbon storage and soil CO2 flux by comparing soils from mature cloud forest and 31-year-old secondary forest, both in the Santa Elena Forest Reserve, a municipallyowned reserve at an elevation of 1600 to 1700 m near the town of Monteverde, and a clear-cut pasture near the reserve. Soils in the mature forest exhibit only weak horizonation but typically thick A horizons;they also consistently yield the highest carbon contents in the upper 30 cm. Soil CO2 flux was the highest in these soils, but also displayed the highest spatial variability. Secondary forest soils contain substantially less soil carbon than mature forest soils, but more than pasture soils. CO2 flux in the secondary forest soils was more similar to that of the mature forest, but displayed lower spatial variability. The pasture soils contain less soil carbon and produced lower CO2 flux levels than either of the forest soils. The pasture soils typically contain a well-defined coarse sandy layer 10 to 20 cm below the surface that we interpret as a sediment layer deposited across much of the landscape following a widespread erosion event, likely a consequence of the clear-cutting. Soil nitrogen concentrations are more than an order of magnitude lower than soil carbon concentrations, and display no trends between the different landscapes examined. Our preliminary results suggest that reforestation does restore soil carbon to clear-cut landscapes, but returning soil carbon levels to pre-land use levels occurs at a time scale of centuries, rather than decades.

关键词： Cloud Forest Secondary Succession Soil Carbon Soil Nitrogen Soil CO2 Flux

Flow diversion covering the M1 origin as a last resort

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Stroke & Vascular Neurology 2019年第3期4卷 141-147页

作者： li-Mei lin Matthew T Bender Geoffrey P Colby Bowen Jiang jessica K Campos David A Zarrin Robert W C Young Risheng Xu Justin M Caplan Judy Huang Rafael J Tamargo Alexander l Coon Department of Neurosurgery University of California IrvineOrangeCaliforniaUSA Department of Neurosurgery Johns Hopkins University School of MedicineBaltimoreMarylandUSA Department of Neurosurgery University of California Los AngelesLos AngelesCaliforniaUSA

Introduction Internal carotid artery termination(ICAT)and proximal A1 aneurysms can be challenging for open surgical clipping or endovascular *** with flow diversion covering the middle cerebral artery(MCA),an end vessel supplying a terminal circulation,has not been *** A prospective,Institutional Review Board-approved database was analysed for patients with pipeline embolisation device(PED)placement from the anterior cerebral artery(ACA)to the ICA during cerebral aneurysm *** Nine cases were identified,including five proximal A1,three posterior communicating artery and one ICAT aneurysm *** aneurysm size was 8.3 mm(range 3-17),with 67%saccular and 78%*** indication for treatment was significant dome irregularity(44%),recurrence or enlargement(33%),underlying collagen vascular disorder(11%)and traumatic pseudoaneurysm(11%).Preservation of the ipsilateral ACA(with PED placed in A1)was performed when the anterior communicating artery(67%)or contralateral A1(33%)were absent on *** coiling was done in four cases(44%).There was one major stroke leading to mortality(11%)and one minor stroke(11%).Clinical follow-up was 27 months on ***-up digital subtraction angiography(average interval 15 months)showed complete aneurysm obliteration(88%)or dome occlusion with entry remnant(12%).The jailed MCA showed minimal or mild delay(primarily anterograde flow)in 75%of cases and significant delay(reliance primarily on ACA and external carotid artery collaterals)in 25%.Conclusions Covering the MCA with a flow diverting stent should be reserved for select rare *** attention to blood pressure augmentation during the periprocedural period is necessary to minimise potential ischaemic compromise.

关键词： primarily resort sided

A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure

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Journal of Genetics and Genomics 2016年第5期43卷 307-318页

作者： Jason Ear jessica Hsueh Melinda Nguyen QingHua Zhang Victoria Sung Rajesh Chopra Kathleen M.Sakamoto Shuo lin Department of Molecular Cell and Developmental Biology University of California Los Angeles Los Angeles CA 90095 USA Celgene Corporation San Francisco 94158 USA Celgene Corporation Summit NJ 07901 USA Division of Hematology/Oncology Department of Pediatrics Stanford University School of Medicine Stanford CA 94304 USA

5q-syndrome is a distinct form of myelodysplastic syndrome（MDS） where a deletion on chromosome 5 is the underlying *** is characterized by bone marrow failures,including macrocytic *** mapping and studies using various models support the notion that ribosomal protein S14（RPS14） is the candidate gene for the erythroid *** disruption of RPS14 causes an increase in p53 activity and p53-mediated apoptosis,similar to what is observed with other ribosomal ***,due to the higher risk for cancer development in patients with ribosome deficiency,targeting the p53 pathway is not a viable treatment *** better understand the pathology of RPS14 deficiency in 5q-deletion,we generated a zebrafish model harboring a mutation in the RPS14 *** model mirrors the anemic phenotype seen in ***,the anemia is due to a late-stage erythropoietic defect,where the erythropoietic defect is initially p53-independent and then becomes ***,we demonstrate the versatility of this model to test various pharmacological agents,such as RAP-011,l-leucine,and dexamethasone in order to identify molecules that can reverse the anemic phenotype.

关键词： 5q-syndrome RPS14 Ribosomopathy Myelodysplastic syndrome

Raman spectra and vibrational analysis of CsPbI3:A fast and reliable technique to identify lead halide perovskite polymorphs

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Journal of Materiomics 2021年第1期7卷 127-135页

作者： jessica Satta Claudio Melis Carlo Maria Carbonaro Andrea Pinna Manuel Salado Daniel Salazar Pier Carlo Ricci Department of Physics University of CagliariS.p.No.8 Km 0.70009042MonserratoCAItaly Department of Mechanical Chemical and Materials EngineeringCINSAINSTMUniversity of CagliariVia Marengo 2CagliariI-09123Italy BCMaterials Basque Center for MaterialsApplications and NanostructuresUPV/EHU Science Park48940LeioaSpain

A major issue in the development of lead halide perovskites is the assessment of the crystal structure of the samples,due to their typically limited time-stability,and the understanding of the role of external factors that can induce a crystal phase transformation(such as humidity,intense light flux,temperature,etc.).In this perspective,it is of utmost importance to have at disposal a fast and reliable experimental tool able to give an immediate indication of the polymorph of the sample with the possibility to integrate in-situ measurements for constant *** this paper we propose Raman spectroscopy as the ideal technique to solve this *** vibrational analysis of CsPbI3 in the a-phase and 5-phase and of the Cs4PbI6 secondary phase is reported and all the vibrational modes are assigned by comparing experimental spectra of the phases to Raman modes calculated within the DFT ***,the mechanism of laser induced phase degradation was studied using in-situ Raman measurements providing new insights on the secondary phase generated during the process.

关键词： Raman spectroscopy CsPb13 Inorganic lead halide perovskites Phase transformation