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Respond to the New Accounting Standards,International Taxation Rules and Business Models

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Belt and Road Initiative Tax Journal 2023年第1期4卷 82-93页

作者： Stef van Weeghel jessica ma PwC PwC Hong Kong China

This article discusses some major changes and developments in ac-counting standards(*** 15 and IFRS 16)and international taxation rules(*** Two-Pillar solution under BEPS 2.0)and new business models(*** and Non-Fungible Tokens)which may have significant impact on taxpayers and pose challenges to tax administrations on how to provide tax certainty and better taxpayer *** article briefly analyses the impact of these developments on taxpayers and makes suggestions for tax policymakers and tax administrations in the Belt *** Road jurisdictions.

关键词： Accounting standards BEPS 2.0 Crypto assets

APIR: Aggregating Universal Proteomics Database Search Algorithms for Peptide Identification with FDR Control

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GENOMICS PROTEOMICS & BIOINFORmaTICS 2024年第2期22卷 qzae042页

作者： Chen, Yiling Elaine Ge, Xinzhou Woyshner, Kyla McDermott, Meilu manousopoulou, Antigoni Ficarro, Scott B. marto, Jarrod A. Li, Kexin Wang, Leo David Li, Jingyi jessica Univ Calif Los Angeles Dept Stat & Data Sci Los Angeles CA 90095 USA Univ Calif Los Angeles Bioinformat Interdept Program Los Angeles CA 90095 USA Univ Calif Los Angeles Dept Human Genet Los Angeles CA 90095 USA Univ Calif Los Angeles Dept Computat Med Los Angeles CA 90095 USA Univ Calif Los Angeles Dept Biostat Los Angeles CA 90095 USA City Hope Natl Med Ctr Beckman Res Inst Dept Immuno Oncol Duarte CA 91010 USA Univ Southern Calif Dept Quantitat & Computat Biol Los Angeles CA 90007 USA City Hope Natl Med Ctr Dept Pediat Duarte CA 91010 USA Brigham & Womens Hosp Dept Canc Biol Boston MA 02215 USA Brigham & Womens Hosp Dana Farber Canc Inst Blais Prote Ctr Dept Pathol Boston MA 02215 USA Harvard Med Sch Boston MA 02215 USA

Advances in mass spectrometry (MS) have enabled high-throughput analysis of proteomes in biological systems. The state-of-the-art MS data analysis relies on database search algorithms to quantify proteins by identifying peptide-spectrum matches (PSMs), which convert mass spectra to peptide sequences. Different database search algorithms use distinct search strategies and thus may identify unique PSMs. However, no existing approaches can aggregate all user-specified database search algorithms with a guaranteed increase in the number of identified peptides and a control on the false discovery rate (FDR). To fill in this gap, we proposed a statistical framework, Aggregation of Peptide Identification Results (APIR), that is universally compatible with all database search algorithms. Notably, under an FDR threshold, APIR is guaranteed to identify at least as many, if not more, peptides as individual database search algorithms do. Evaluation of APIR on a complex proteomics standard dataset showed that APIR outpowers individual database search algorithms and empirically controls the FDR. Real data studies showed that APIR can identify disease-related proteins and post-translational modifications missed by some individual database search algorithms. The APIR framework is easily extendable to aggregating discoveries made by multiple algorithms in other high-throughput biomedical data analysis, e.g., differential gene expression analysis on RNA sequencing data. The APIR R package is available at https://***/yiling0210/APIR.

关键词： Shotgun proteomics Peptide-spectrum match Peptide identification Aggregation of lists FDR control PROTEIN IDENTIFICATION BRCA2 MUTATIONS CELL-CYCLE TANDEM TARGET CANCER PREVALENCE EXPRESSION GENE APOPTOSIS

Vonoprazan 10 mg or 20 mg *** 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis:A randomized controlled trial

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Chinese Medical Journal 2024年第8期137卷 962-971页

作者： Yinglian Xiao Jiaming Qian Shutian Zhang Ning Dai Hoon Jai Chun Chengtang Chiu Chui Fung Chong Nobuo Funao Yuuichi Sakurai jessica D.Eisner Li Xie Minhu Chen Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510062China Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100006China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Gastroenterology Sir Run Run Shaw HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310020China Department of Internal Medicine Korea University Anam HospitalKorea University College of Medicine73 Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Department of Gastroenterology&Hepatology Linkou Medical CenterChang Gung Memorial HospitalTaoyuanTaiwan 33353China College of Medicine Chang Gung UniversityTaoyuanTaiwan 33353China Takeda Development Center Asia Singapore 018981Singapore Takeda Pharmaceutical Company Chuo-kuOsaka 540-8645Japan Takeda Pharmaceuticals International Company CambridgeMA02142 USA China Medical Team Takeda ChinaBeijing 100027China Hoffmann-La Roche Basel4070 Switzerland Abbott Laboratories Lake ForestIL 60045USA

Background:Erosive esophagitis(EE)is a gastroesophageal reflux disease characterized by mucosal breaks in the *** pump inhibitors are widely used as maintenance therapy for EE,but many patients still *** this trial,we evaluated the noninferiority of vonoprazan *** as maintenance therapy in patients with healed ***:We performed a double-blind,double-dummy,multicenter,phase 3 clinical trial among non-Japanese Asian adults with endoscopically confirmed healed EE from April 2015 to February *** from China,South Korea,and malaysia were randomized to vonoprazan 10 mg or 20 mg once daily or lansoprazole 15 mg once daily for 24 *** primary endpoint was endoscopically confirmed EE recurrence rate over 24 weeks with a noninferiority margin of 10%using a two-sided 95%confidence interval(CI).Treatment-emergent adverse events(TEAEs)were ***:Among 703 patients,EE recurrence was observed in 24/181(13.3%)and 21/171(12.3%)patients receiving vonoprazan 10 mg or 20 mg,respectively,and 47/184(25.5%)patients receiving lansoprazole(differences:-12.3%[95%CI,-20.3%to-4.3%]and-13.3%[95%CI,-21.3%to-5.3%],respectively),meeting the primary endpoint of noninferiority to lansoprazole in preventing EE recurrence at 24 *** of superiority(upper bound of 95%CImaintenance therapy was well-tolerated and noninferior to lansoprazole for preventing EE recurrence i

关键词： Erosive esophagitis Lansoprazole maintenance therapy Potassium-competitive acid blockers Vonoprazan

The role of RAS effectors in BCR/ABL induced chronic myelogenous leukemia

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Frontiers of Medicine 2013年第4期7卷 452-461页

作者： jessica Fredericks Ruibao Ren State Key Laboratory for Medical Genomics Shanghai Institute of HematologyRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Rosenstiel Basic Medical Sciences Research Center and Department of Biology Brandeis UniversityWalthamMA 02454USA EMD Millipore Corporation 17 Cherry Hill DriveDanversMA 01923USA

BCR/ABL is the causative agent of chronic myelogenous leukemia(CML).Through structure/function analysis,several protein motifs have been determined to be important for the development of ***177 of BCR is a Grb2 binding site required for BCR/ABL-induced CML in *** the current study,we use a mouse bone marrow transduction/transplantation system to demonstrate that addition of oncogenic NRAS(NRASG12D)to a vector containing a BCR/ABL^(Y177F)mutant“rescues”the CML phenotype rapidly and *** further narrow down the pathways downstream of RAS that are responsible for this rescue effect,we utilize well-characterized RAS effector loop mutants and determine that the RAL pathway is important for rapid induction of *** of this pathway by a dominant negative RAL is capable of delaying disease *** from the present study support the notion of RAL inhibition as a potential therapy for BCR/ABL-induced CML.

关键词： BCR/ABL chronic myelogenous leukemia(CML) RAS RAL

Metallurgy at the Crossroads: New Analyses of Copper-based Objects at Tianshanbeilu, Eastern Xinjiang, China

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Acta Geologica Sinica(English Edition) 2020年第3期94卷 594-602页

作者： LIU Cheng LIU Ruiliang ZHOU Pengcheng LU Chun YANG Zengxin A.mark POLLARD Peter HOMMEL ma Jian CUI Jianfeng Peter BRAY TONG Jianyi jessica RAWSON School of Cultural Heritage Northwest UniversityXi’an 710069China Research Center of material Science and Archaeology NPU Institute of Culture and HeritageNorthwestern Polytechnical UniversityXi’an 710072China School of Archaeology University of OxfordOxfordUK(OX13TG Xi’an Museum Xi’an 710068China Shandong University of Finance and Economics Library Jinan 250012China School of Electronic Engineering Xidian UniversityXi’an 710068China Department of Archaeology Classics and EgyptologyUniversity of LiverpoolLiverpoolUK(L77BD School of Archaeology and Museology Peking UniversityBeijing 100871China British Museum LondonUK(WC1B 3DG Department of Archaeology University of ReadingReadingUK(RG66AB

Tianshanbeilu is the largest Bronze Age site in eastern Xinjiang, China. Stretching across the entire second millennium BC, it performed a prominent role in connecting the Hexi corridor, Central China and the steppe. A further insight into the metallurgical tradition and the metal supply network is of vital importance to improve our understanding of its multi-connected nature. This paper offers a new set of chemical and isotopic data on the copper-based objects at Tianshanbeilu, including alloying elements, trace elements(impurities) and lead isotopes. Combining the concentrations of arsenic and antimony reveals that arsenic was introduced to copper partially due to the use of specific minerals tethrahedrite-tennantite. Lead isotopes demonstrate that multiple sources of copper were employed at Tianshanbeilu and a majority of them are characterized by common lead, which appears rather different from those of the Central Plains and the Hexi corridor, but highly consistent with local ores. Surprisingly, one object at Tianshanbeilu contains the well-known highly radiogenic lead. This object undoubtedly marks the westernmost boundary of the distribution of the highly radiogenic lead. We also anticipate that more lead isotopic analyses in NW China will further contribute to the study of the highly radiogenic lead in Central China.

关键词： highly radiogenic lead chemical and isotopic analysis metallurgy Tianshanbeilu

Disrupted maturation of Prefrontal Layer 5 Neuronal Circuits in an Alzheimer’s Mouse Model of Amyloid Deposition

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Neuroscience Bulletin 2023年第6期39卷 881-892页

作者： Chang Chen Jing Wei Xiaokuang ma Baomei Xia Neha Shakir jessica K.Zhang Le Zhang Yuehua Cui Deveroux Ferguson Shenfeng Qiu Feng Bai Department of Neurology Affiliated Drum Tower HospitalMedical School of Nanjing UniversityNanjing210008China Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZ85004USA

Mutations in genes encoding amyloid precursor protein(APP)and presenilins(PSs)cause familial forms of Alzheimer’s disease(AD),a neurodegenerative disorder strongly associated with *** is currently unknown whether and how AD risks affect early brain development,and to what extent subtle synaptic pathology may occur prior to overt hallmark AD *** mutant APP/PS1 over-expression mouse lines are key tools for studying the molecular mechanisms of AD *** these lines,the 5XFAD mice rapidly develop key features of AD pathology and have proven utility in studying amyloid plaque formation and amyloidβ(Aβ)-induced *** reasoned that transgenic mutant APP/PS1 over-expression in 5XFAD mice may lead to neurodevelopmental defects in early cortical neurons,and performed detailed synaptic physiological characterization of layer 5(L5)neurons from the prefrontal cortex(PFC)of 5XFAD and wild-type littermate controls.L5 PFC neurons from 5XFAD mice show early APP/Aβ***-cell patch-clamp recording at an early post-weaning age(P22–30)revealed functional impairments;although 5XFAD PFC-L5 neurons exhibited similar membrane properties,they were intrinsically less *** addition,these neurons received smaller amplitude and frequency of miniature excitatory synaptic *** functional disturbances were further corroborated by decreased dendritic spine density and spine head volumes that indicated impaired synapse *** biotinylation followed by Western blot analysis of PFC-L5 tissue revealed that 5XFAD mice showed reduced synaptic AMPA receptor subunit GluA1 and decreased synaptic NMDA receptor subunit *** with this,patch-clamp recording of the evoked L23>L5 synaptic responses revealed a reduced AMPA/NMDA receptor current ratio,and an increased level of AMPAR-lacking silent *** results suggest that transgenic mutant forms of APP/PS1 overexpression in 5XFAD mice leads to early deve

关键词： Alzheimer’s disease Mouse model Synaptic plasticity Long-term potentiation Cortical circuit Electrophysiology Learning and memory

Restoring the gut microbiome for the treatment of inflammatory bowel diseases

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World Journal of Gastroenterology 2014年第13期20卷 3468-3474页

作者： jessica R Allegretti matthew J Hamilton Division of Gastroenterology Brigham and Women’s Hospital and Harvard Medical SchoolBostonMA 02115United States

Fecal microbiota transplantation (FMT) is considered to be a highly successful therapy for recurrent and refractory Clostridium difficile infection (CDI) based on recent clinical trials. The pathogenesis of inflammatory bowel diseases (IBD) is thought to be due in part to perturbations in the gut microflora that disrupt homeostasis. FMT restores essential components of the microflora which could reverse the inflammatory processes observed in IBD. Case reports and series for the treatment of IBD by FMT have shown promise with regards to treatment success and safety despite the limitations of the reporting. Future studies will determine the optimal delivery and preparation of stool as well as the conditions under which the recipient will derive maximal benefit. The long term consequences of FMT with regards to infection, cancer, auto-immune, and metabolic diseases are not known and will require continued regulation and study. Despite these limitations, FMT may be beneficial for the treatment of ulcerative colitis and Crohn’s disease, particularly those with concurrent CDI or with pouchitis.

关键词： Crohn’ s, Ulcerative colitis, Microbiota, Fecal transplantation, Dysbiosis, Pouchitis, Clostridium difficile, Probiotic

Can we early diagnose metabolic syndrome using brachial-ankle pulse wave velocity in community population？

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Chinese Medical Journal 2014年第17期127卷 3116-3120页

作者： Li Xin Zheng Liang Wu Juanli ma Yunsheng masanori Munakata Oleski jessica Zhang Lijuan Wo Da Wang Jingsong Jiang Qiaoyu Zou Liling Liu Xuebo Li Jue Department of Cardiology Shanghai East Hospital Tongji University Shanghai 200120 China Tongji University Medical School Shanghai 200092 China Department of Cardiology Shanghai Tenth Hospital Tongji University Shanghai 200072 China University of massachusetts Medical School Massachusetts USA Preventive Medical Center Tohoku Rosai Hospital Sendai Japan

Background The prevalence of metabolic syndrome （MetS） increased recently and there was still not a screening index to predict *** aim of this study was to estimate whether brachial-ankle pulse wave velocity （baPVVV）,a novel marker for systemic arterial stiffness,could predict MetS in Chinese community *** A total of 2 191 participants were recruited and underwent medical examination including 1 455 men and 756 women from June 2011 to January *** was diagnosed according to the criteria of the International Diabetes Federation （IDF）.Multiple Logistic regressions were conducted to explore the risk factors of *** operating characteristic （ROC） curve was performed to estimate the ideal diagnostic cutoff point of baPWV to predict *** The mean age was （45.35±8.27） years *** multiple Logistic regression analysis,the gender,baPWV and smoking status were risk factors to MetS after adjusting age,gender,baPWV,walk time and sleeping *** prevalence of MetS was 17.48% in 30-year age population in *** were significant differences （Х^2=96.46,P 〈0.05） between male and female participants on MetS *** to the ROC analyses,the ideal cutoff point of baPWV was 1 358.50 cm/s （AUC=60.20%） to predict MetS among male group and 1 350.00 cm/s （AUC=70.90%） among female *** BaPWV may be considered as a screening marker to predict MetS in community Chinese population and the diagnostic value of 1 350.00 cm/s was more significant for the female group.

关键词： brachial-ankle pulse wave velocity metabolic syndrome receiver operating characteristic curve

Scalable Methods for Device Patterning as an Outstanding Challenge in Translating Paper-Based Microfluidics from the Academic Benchtop to the Point-of-Care

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Journal of Analysis and Testing 2019年第1期3卷 50-60页

作者： jessica C.Brooks Charles R.mace Department of Chemistry Tufts UniversityMedfordMA 02155USA

Paper-based microfluidic devices offer unparalleled adaptability for the development of low-cost,point-of-care analytical *** potential for these devices to drastically improve access to healthcare around the globe is obvious,but very few tests have found success in clinical ***,we identify manufacturing-specifically,methods to pattern paper devices at large scales-as a major barrier to translating prototype paper-based devices from the academic benchtop to the *** introduce current methods used to pattern papers and discuss their utility as means to prototype and manufacture paper-based devices.

关键词： Paper-based microfluidics μPAD Point-of-care Diagnostics manufacturing