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阿里安娜·赫芬顿:“新媒体女皇”成功路

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疯狂英语（新悦读） 2016年第1期1卷 18-21页

作者： jessica harris 蓝蓝

这个访谈的语速不算太快，其中一人有些许口音，但不影响理解。这段交谈中使用的语言较规范，对提高口语有参考价值。

关键词：成功路新媒体安娜阿里参考价值语速

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Exploration of Methane Mitigation Efficacy Using Asparagopsis-Derived Bioactives Stabilized in Edible Oil Compared to Freeze-Dried Asparagopsis in Vitro

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American Journal of Plant Sciences 2022年第7期13卷 1023-1041页

作者： Robert D. Kinley Siong Tan Jemima Turnbull Shane Askew jessica harris Breanna M. Roque FutureFeed Pty Ltd. Townsville Australia Agriculture and Food Commonwealth Scientific and Industrial Research Organisation (CSIRO) Townsville Australia College of Public Health Medical and Veterinary Sciences Douglas Campus James Cook University (JCU) Townsville Australia Advanced Analytical Centre (AAC) Douglas Campus James Cook University (JCU) Townsville Australia

Asparagopsis oil products are of interest due to the stabilizing effects of the Asparagopsis-derived antimethanogenic bioactive compound bromoform (CHBr3). The objective of this in vitro series is to characterize antimethanogenic efficacy of freeze-dried Asparagopsis (FD-Asp) and Asparagopsis oil (Asp-Oil) and compare relative antimethanogenic response over time at multiple levels of CHBr3 delivery. Relative methane (CH4) emissions (mL/g) are based on in vitro apparent feed digested dry matter (IVDDM) after 24, 48, and 72 h of fermentation. CHBr3 contained in FD-Asp was included at 95, 191, and 286 mg/kg, and CHBr3 contained in Asp-Oil was included at 78, 117, and 175 mg/kg, to produce the Low, Mid, and High inclusions, respectively. Low FD-Asp had no significant impact on CH4 emissions, Mid FD-Asp demonstrated 91%, 44%, and 37% reductions, and the High FD-Asp demonstrated complete inhibition of CH4, after 24, 48, and 72 h of fermentation, respectively. Comparatively, Low Asp-Oil demonstrated a 46%, 28%, and 18% CH4 reduction, Mid Asp-Oil resulted in 99%, 92%, and 73% reductions, and the High Asp-Oil demonstrated complete inhibition of CH4 after 24, 48, and 72 h of fermentation, respectively. IVDDM and total volatile fatty acid (tVFA) production were not changed by the inclusion of FD-Asp and Asp-Oil. The results from this study show that Asparagopsis is not only a compelling CH4 mitigating feed supplement but is also able to be delivered in edible oil forms which will strengthen its applicability to on-farm use. This study is promising for the utility of Asp-Oil, and in vivo trials are essential to demonstrate the extent of efficacy of Asp-Oil in ruminant animals because FD-Asp has consistently demonstrated greater antimethanogenic efficacy in vivo compared to in vitro.

关键词： Asparagopsis Edible Oil Methane Greenhouse Gas Mitigation In Vitro

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Immuno-oncology combinations： raising the tail of the survival curve

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Cancer Biology & Medicine 2016年第2期13卷 171-193页

作者： Samuel J. harris jessica Brown Juanita Lopez Timothy A. Yap Drug Development Unit Royal Marsden Hospital and The Institute of Cancer Research London SM2 5PT UK Lung Unit Royal Marsden Hospital and The Institute of Cancer Research London SM2 5PT UK

There have been exponential gains in immuno-oncology in recent times through the development of immune checkpoint inhibitors. Already approved by the U.S. Food and Drug Administration for advanced melanoma and non-small cell lung cancer,immune checkpoint inhibitors also appears to have significant antitumor activity in multiple other tumor types. An exciting component of immunotherapy is the durability of antitumor responses observed, with some patients achieving disease control for many years. Nevertheless, not all patients benefit, and efforts should thus now focus on improving the efficacy of immunotherapy through the use of combination approaches and predictive biomarkers of response and resistance. There are multiple potential rational combinations using an immunotherapy backbone, including existing treatments such as radiotherapy, chemotherapy or molecularly targeted agents, as well as other immunotherapeutics. The aim of such antitumor strategies will be to raise the tail on the survival curve by increasing the number of long term survivors, while managing any additive or synergistic toxicities that may arise with immunotherapy combinations. Rational trial designs based on a clear understanding of tumor biology and drug pharmacology remain paramount. This article reviews the biology underpinning immuno-oncology, discusses existing and novel immunotherapeutic combinations currently in development, the challenges of predictive biomarkers of response and resistance and the impact of immuno-oncology on early phase clinical trial design.

关键词： Combination drug therapy oncology clinical trials PD-1 PD-L1 CTLA4 biomarkers immunotherapy

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Endoscopic ultrasound staging for early esophageal cancer: Are we denying patients neoadjuvant chemo-radiation?

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World Journal of Gastroenterology 2017年第46期23卷 8193-8199页

作者： Carrie Luu Marisa Amaral Jason Klapman Cynthia harris Khaldoun Almhanna Sarah Hoffe jessica Frakes Jose M Pimiento Jacques P Fontaine Department of Thoracic Oncology H. Lee Moffitt Cancer Center and Research Institute Department of Gastrointestinal Oncology H. Lee Moffitt Cancer Center and Research Institute Department of Radiation Oncology H. Lee Moffitt Cancer Center and Research Institute

AIM To evaluate the accuracy of endoscopic ultrasound(EUS) in early esophageal cancer(EC) performed in a highvolume tertiary cancer center. METHODS A retrospective review of patients undergoing esophagectomy was performed and patients with c T1 N0 and c T2 N0 esophageal cancer by EUS were evaluated. Patient demographics, tumor characteristics, and treatment were reviewed. EUS staging was compared to surgical pathology to determine accuracy of EUS. Descriptive statistics was used to describe the cohort. Student's t test and Fisher's exact test or χ~2 test was used to compare variables. Logistic regression analysis was used to determine if clinical variables such as tumor location and tumor histology were associated with EUS *** Between 2000 and 2015, 139 patients with clinical stage Ⅰ or Ⅱ?A esophageal cancer undergoing esophagectomy were identified. There were 25(18%) female and 114(82%) male patients. The tumor location included the middle third of the esophagus in 11(8%) and lower third and gastroesophageal junction in 128(92%) patients. Ninety-three percent of patients had adenocarcinoma. Preoperative EUS matched the final surgical pathology in 73/139 patients for a concordance rate of 53%. Twenty-nine patients(21%) were under-staged by EUS; of those, 19(14%) had unrecognized nodal disease. Positron emission tomography(PET) was used in addition to EUS for clinical staging in 62/139 patients. Occult nodal disease was only found in 4 of 62 patients(6%) in whom both EUS and PET were negative for nodal involvement. CONCLUSION EUS is less accurate in early EC and endoscopic mucosal resection might be useful in certain settings. The addition of PET to EUS improves staging accuracy.

关键词： Esophageal cancer Endoscopic ultrasound Staging Early esophageal cancer Endoscopic mucosal resection

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Assessment of resting energy expenditure in patients with cirrhosis

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World Journal of Hepatology 2022年第4期14卷 802-811页

作者： Shaiane Ferreira Cláudio Augusto Marroni jessica Taina Stein Roberta Rayn Ana Cristhina Henz Natália P Schmidt Randhall B Carteri Sabrina Alves Fernandes Postgraduate Program in Hepatology Federal University of Health Sciences of Porto Alegre(UFCSPA)Porto Alegre 90050-170Brazil Department of Nutrition Centro Universitário Metodista-IPAPorto Alegre 90420-060Brazil Department of Health and Behavior Catholic University of PelotasPelotas 96015-560Brazil

BACKGROUND Malnutrition affects 20%to 50%of patients with *** may be associated with serious complications and has a direct impact on *** energy expenditure(REE)is an important parameter to guide the optimization of therapy and recovery of nutritional status in patients with ***,the REE of patients with cirrhosis is still unclear,casting doubt upon the optimal nutritional management *** To identify the best method that predicts the REE of cirrhotic patients,using indirect calorimetry(IC)as the gold *** An observational study was performed on 90 patients with *** was assessed by IC,bioelectrical impedance analysis(BIA),and predictive formulas,which were compared using Bland-Altman plots and the Student’s *** REE values measured by IC(1607.72±257.4 kcal)differed significantly from those determined by all other methods(BIA:1790.48±352.1 kcal;harris&Benedict equation:2373.54±254.9 kcal;IOM equation:1648.95±185.6 kcal;Cunningham equation:1764.29±246.2 kcal),except the Food and Agriculture Organization of the United Nations,World Health Organization,and United Nations University(FAO/WHO/UNU)(1616.07±214.6 kcal)and McArdle(1611.30±241.8 kcal)*** found no significant association when comparing IC and 24-h dietary recall among different Child-Pugh classes of *** The IOM and FAO/WHO/UNU equations have the best agreement with the *** results indicate a possibility of different tools for the clinical practice on cirrhotic patients.

关键词： Liver cirrhosis Calorimetry Indirect Energy metabolism Malnutrition

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