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Are EPB41 and alpha-synuclein diagnostic biomarkers of sport-related concussion?Findings from the NCAA and Department of Defense CARE Consortium

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Journal of Sport and health Science 2023年第3期12卷 379-387页

作者： Rany Vorn Christina Devoto Timothy B.Meier Chen Lai Sijung Yun Steven P.Broglio Sara Mithani Thomas W.McAllister Christopher C.Giza hyung-Suk Kim Daniel huber Jaroslaw harezlak Kenneth L.Cameron Gerald McGinty Jonathan Jackson Kevin M.Guskiewicz Jason P.Mihalik Alison Brooks Stefan Duma Steven Rowson Lindsay D.Nelson Paul Pasquina Michael A.McCrea jessica M.Gill the CARE Consortium Investigators Johns hopkins School of Nursing and Medicine BaltimoreMD 21205USA National Institutes of health BethesdaMD 20892USA Department of Neurosurgery Medical College of WisconsinMilwaukeeWI 53226USA Predictiv Care Inc.Mountain ViewCA 94086USA Michigan Concussion Center University of MichiganAnn ArborMI 48109USA Department of Psychiatry Indiana University School of MedicineIndianapolisIN 46202USA Departments of Pediatrics and Neurosurgery University of California at Los Angeles(UCLA)Los AngelesCA 90024USA Department of Epidemiology and Biostatistics School of Public health–Bloomington Indiana UniversityBloomingtonIN 47405USA John A.Feagin Sports Medicine Fellowship Keller Army Community HospitalWest PointNY 10996USA United States Air Force Academy Colorado SpringsCO 80840USA Mathew Gfeller Center Department of Exercise and Sport ScienceUniversity of North Carolina at Chapel HillChapel HillNC 27514USA Department of Orthopedics Division of Sports MedicineSchool of Medicine and Public HealthUniversity of WisconsinMadisonWI 53705USA Department of Biomedical Engineering and Mechanics Virginia TechBlacksburgVA 24061USA Center for Neuroscience&Regenerative Medicine Uniformed Services UniversityBethesdaMD 20814USA 不详 Current affiliation:School of Nursing University of Texas Health Science Center San AntonioSan AntonioTX 78229USA

Background:Current protein biomarkers are only moderately predictive at identifying individuals with mild traumatic brain injury or ***,more accurate diagnostic markers are needed for sport-related ***:This was a multicenter,prospective,case-control study of athletes who provided blood samples and were diagnosed with a concussion or were a matched non-concussed control within the National Collegiate Athletic Association-Department of Defense Concussion Assessment,Research,and Education Consortium conducted between 2015 and *** blood was collected within 48 h of injury to identify protein abnormalities at the acute and subacute *** with concussion were divided into 6 h post-injury(0-6 h post-injury)and after 6 h postinjury(7-48 h post-injury)*** applied a highly multiplexed proteomic technique that used a DNA aptamers assay to target 1305proteins in plasma samples from athletes with and without sport-related ***:A total of 140 athletes with concussion(79.3%males;aged 18.71±1.10 years,mean±SD)and 21 non-concussed athletes(76.2%males;19.14±1.10 years)were included in this *** identified 338 plasma proteins that significantly differed in abundance(319 upregulated and 19 downregulated)in concussed athletes compared to non-concussed *** top 20 most differentially abundant proteins discriminated concussed athletes from non-concussed athletes with an area under the curve(AUC)of 0.954(95%confidence interval:0.922-0.986).Specifically,after 6 h of injury,the individual AUC of plasma erythrocyte membrane protein band 4.1(EPB41)and alpha-synuclein(SNCA)were 0.956 and 0.875,*** combination of EPB41 and SNCA provided the best AUC(1.000),which suggests this combination of candidate plasma biomarkers is the best for diagnosing concussion in athletes after 6 h of ***:Our data suggest that proteomic profiling may provide novel diagnostic protein markers and that a combina

关键词： Biomarkers College athletes Concussion Mild traumatic brain injury Sport injury

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Prevalence of helicobacter pylori vacA,cagA,dupA and oipA Genotypes in Patients with Gastric Disease

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Advances in Microbiology 2017年第1期7卷 1-9页

作者： Mayara Luciana Sallas jessica Lima Melchiades Luanna Munhoz Zabaglia Juliana Ribeiro do Prado Moreno Wilson Aparecido Orcini Elizabeth Suchi Chen Marilia de Arruda Cardoso Smith Spencer Luiz Marques Payao Lucas Trevizani Rasmussen Sagrado Coracao University(USC) BauruBrazil Federal University of Sao Paulo(UNIFESP) Sao PauloBrazil

Gastric diseases such as chronic gastritis and gastric cancer are most commonly caused by virulence factors of helicobacter pylori (h. pylori), such as the vacA, cagA, dupA and oipA genes. Therefore, this study investigated the prevalence and the combination of these virulence factors from patients with gastric diseases. The endoscopic biopsies were obtained from 516 patients with gastric symptoms, 101 of which were from patients with normal gastric tissue, 365 of which were from patients with chronic gastritis, and 50 of which were from patients with gastric cancer. h. pylori and the virulence factors were detected by PCR. The oipA gene exhibited an increased risk for chronic gastritis (p = 0.0296), and the vacA gene demonstrated a risk for gastric cancer from chronic gastritis (p = 0.0002). Based on the combination of the virulence factors, cagA, vacA, dupA and oipA genes exhibited a high prevalence in patients with chronic gastritis and gastric cancer. The cagA+/dupA+ genotype demonstrated a significant correlation in patients with normal gastric mucosa (p = 0.0278). In the chronic gastritis group, a significant association was observed between the cagA+ and the vacA s1m1 genotypes (p cagA+/dupA+ genotypes (p = 0.0183), the dupA+/oipA+ genotypes (p cagA, vacA, dupA, and oipA genes, which contributed to the risk of developing gastroduodenal diseases. Furthermore, this is the first study to reveal a high prevalence of the oipA gene in h. pylori isolates in Brazil.

关键词： helicobacter pylori Virulence Factors cagA dupA oipA vacA

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Impact of 1,7-malaria reactive community-based testing and response(1,7-mRCTR)approach on malaria prevalence inTanzania

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Infectious Diseases of Poverty 2023年第6期12卷 103-104页

作者： Wei Chang jessica Cohen Duo‑Quan Wang Salim Abdulla Muhidin Kassim Mahende Tegemeo Gavana Valerie Scott hajirani M.Msuya Mary Mwanyika‑Sando Ritha John ANjau Shen‑Ning Lu Silas Temu honorati Masanja Wilbald Anthony Maru Aregawi W Naveen Sunder Tang Kun Katia Bruxvoort Jovin Kitau Fadhila Kihwele Godlove Chila Mihayo Michael Marcia Castro Nicolas AMenzies Sein Kim Xiao Ning Xiao‑Nong Zhou Prosper Chaki Yeromin P.Mlacha Department of Global health and Population Harvard T.H. Chan School of Public Health Boston USA Chinese Center for Disease Control and Prevention National Institute of Parasitic Diseases Shanghai People’s Republic of China School of Global health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Chinese Center for Tropical Diseases Research Shanghai People’s Republic of China WhO Collaborating Centre for Tropical Diseases Shanghai People’s Republic of China Ifakara health Institute Dar es Salaam United Republic of Tanzania Africa Academy for Public health Dar es Salaam Tanzania Muhimbili University of health and Allied Sciences Dar es Salaam Tanzania National Center for International Research on Tropical Diseases Ministry of Science and Technology Shanghai People’s Republic of China Global Malaria Programme World Health Organization Geneva Switzerland Bentley University Waltham USA Vanke School of Public health Tsinghua University Beijing People’s Republic of China School of Public health University of Alabama at Birmingham Birmingham USA The Pan-African Mosquito Control Association (PAMCA) KEMRI Headquarters Nairobi Kenya

Background Progress in malaria control has stalled in recent years and innovative surveillance and response approaches are needed to accelerate malaria control and elimination eforts in endemic areas of ***‑ing on a previous China-UK-Tanzania pilot study on malaria control,this study aimed to assess the impact of the 1,7-malaria Reactive Community-Based Testing and Response(1,7-mRCTR)approach implemented over two years in three districts of *** The 1,7-mRCTR approach provides community-based malaria testing via rapid diagnostic tests and treat‑ment in villages with the highest burden of malaria incidence based on surveillance data from health *** used a diference-in-diferences quasi-experimental design with linear probability models and two waves of crosssectional household surveys to assess the impact of 1,7-mRCTR on malaria *** conducted sensitivity analyses to assess the robustness of our results,examined how intervention efects varied in subgroups,and explored alternative explanations for the observed *** Between October 2019 and September 2021,244,771 community-based malaria rapid tests were com‑pleted in intervention areas,and each intervention village received an average of 3.85 rounds of *** prevalence declined from 27.4%at baseline to 11.7%at endline in the intervention areas and from 26.0%to 16.0%in the control areas.1,7-mRCTR was associated with a 4.5-percentage-point decrease in malaria prevalence(95%confdence interval:−0.067,−0.023),equivalent to a 17%reduction from the *** Rufji,a district characterized by lower prevalence and where larviciding was additionally provided,1,7-mRCTR was associated with a 63.9%decline in malaria *** The 1,7-mRCTR approach reduced malaria *** implementation interruptions due to the COVID-19 pandemic and supply chain challenges,the study provided novel evidence on the efectiveness of community-based reactive approache

关键词： Malaria Surveillance and response Incidence rate Community-health worker health facility Communitybased testing and treatment 1,7-mRCTR Tanzania

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LIM-domain-only 4(LMO4)enhances CD8^(+)T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling

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Signal Transduction and Targeted Therapy 2024年第9期9卷 4066-4078页

作者： Roland C.Schelker jessica Fioravanti Fabio Mastrogiovanni Jeremy G.Baldwin Nisha Rana Peng Li Ping Chen Timea Vadász Rosanne Spolski Christoph heuser-Loy Dragana Slavkovic-Lukic Pedro Noronha Giuseppe Damiano Laura Raccosta Daniela Maggioni Sree Pullugula Jian-Xin Lin Jangsuk Oh Patrick Grandinetti Mario Lecce Leo hesse Emilia Kocks Azucena Martín-Santos Claudia Gebhard William G.Telford Yun Ji Nicholas P.Restifo Vincenzo Russo Michael Rehli Wolfgang herr Warren J.Leonard Luca Gattinoni Division of Functional Immune Cell Modulation Leibniz Institute for ImmunotherapyRegensburgGermany Center for Cancer Research National Cancer InstituteNational Institutes of HealthBethesdaMDUSA Laboratory of Molecular Immunology and the Immunology Center National HeartLung and Blood InstituteNational Institutes of HealthBethesdaMDUSA Department of Internal MedicineⅢ University Hospital RegensburgRegensburgGermany Next Generation Sequencing Core Leibniz Institute for ImmunotherapyRegensburgGermany Immuno-Biotherapy of Melanoma and Solid Tumors Unit Division of Experimental OncologyIRCCS Scientific Institute San RaffaeleMilanItaly Vita-Salute San Raffaele University MilanItaly University of Regensburg RegensburgGermany National Center for Tumor Diseases WERA SiteWürzburg-Erlangen-Regensburg-AugsburgGermany Center for Immunomedicine in Transplantation and Oncology University Hospital RegensburgRegensburgGermany

high frequencies of stem-like memory T cells in infusion products correlate with superior patient outcomes across multiple T cell therapy ***,we analyzed a published CRISPR activation screening to identify transcriptional regulators that could be harnessed to augment stem-like behavior in CD8^(+)T *** IFN-γproduction as a proxy for CD8^(+)T cell terminal differentiation,LMO4 emerged among the top hits inhibiting the development of effectors ***,we found that Lmo4 was downregulated upon CD8^(+)T cell activation but maintained under culture conditions facilitating the formation of stem-like T *** employing a synthetic biology approach to ectopically express LMO4 in antitumor CD8^(+)T cells,we enabled selective expansion and enhanced persistence of transduced cells,while limiting their terminal differentiation and ***4 overexpression promoted transcriptional programs regulating stemness,increasing the numbers of stem-like CD8^(+)memory T cells and enhancing their polyfunctionality and recall *** tested in syngeneic and xenograft tumor models,LMO4 overexpression boosted CD8^(+)T cell antitumor immunity,resulting in enhanced tumor *** than directly modulating gene transcription,LMO4 bound to JAK1 and potentiated STAT3 signaling in response to IL-21,inducing the expression of target genes(Tcf7,Socs3,Junb,and Zfp36)crucial for memory ***/Cas9-deletion of Stat3 nullified the enhanced memory signature conferred by LMO4,thereby abrogating the therapeutic benefit of LMO4 *** results establish LMO4 overexpression as an effective strategy to boost CD8^(+)T cell stemness,providing a new synthetic biology tool to bolster the efficacy of T cell-based immunotherapies.

关键词： STAT3 immunity LMO4

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Ursolic Acid Derivatives Induced Apoptosis and Reduces the NF-κB in human Lung Adenocarcinoma Cells

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Journal of Cancer Therapy 2019年第10期10卷 863-876页

作者： Elaine Carlos Scherrer Ydia Mariele Valadares Caio Cesar Souza Alves Gabriella Freitas Ferreira Marcela Pereira Leao jessica Aline Soares Fernando Sa Silva Alessandra Paula Carli Oswaldo Cardoso Jr. Fabiana Simao Machado Sandra Bertelli Ribeiro Castro Life Sciences Institute Federal University of Juiz de ForaGovernador ValadaresMGBrazil Faculty of Medicine Federal University of the Valleys of Jequitinhonha and MucuriTeofilo OtoniMGBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo HorizonteMGBrazil

Lung cancer is the major cause of death in the neoplastic diseases. In spite of the advances in the chemotherapy, the lung cancer treatments are still complex and costly, being necessary the seeking of new drugs. In this context, the ursolic acid (UA) becomes the target of studies that investigate its antitumor potential and, thus, structural modifications can enhance its biological activities. Eight UA semisynthetic derivative compounds (UAD1-8) were synthesized and evaluated their cytotoxic activity against human alveolar adenocarcinoma cells (A549). UAD1, UAD3, UAD5, UAD6 and UAD8 were able to reduce the viability of the A549 cells. Only UAD1 and UAD6 reduced the viability at 24 h, and only UAD3 didn’t reduce the NF-κB expression. The compound UAD1 showed the greater apoptosis induction. Moreover, the compound UAD1 showed better results than UA in all assays. The present study shows, for the first time, the action of these compounds in the apoptotic effect, in the expression of NF-κB and in the A549 cell line. The ursolic acid derivatives showed substantial results in the apoptosis, cytotoxicity and NF-κB inhibition of A549 cells, and further studies are necessary for the development of possible new therapeutic drugs.

关键词： Ursolic Acid Apoptosis NF-κB A549 Cells Tumoral

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Buffer Standards for the Biochemical ph of the Zwitterionic Buffer <i>N</i>-Tris-(hydroxymethyl) Methyl-2-Aminoethanesulfonic Acid (TES) from 5℃ to 55℃

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Open Journal of Physical Chemistry 2012年第1期2卷 41-46页

作者： Rabindra N. Roy Lakshmi N. Roy Blake M. Bodendorfer Zachary M. Downs Stephen D. Rocchio Joshua T. Wollen jessica M. Stegner Isaac B. henson Nicholas W. Grove Lauren A. Dieterman hoffman Department of Chemistry Drury University Springfield USA

The authors have undertaken the determination of ph values for one buffer solution of TES without NaCl and nine buffer solutions with NaCl yielding an ionic strength I = ***-1. similar to that of blood. These buffer solutions have been evaluated in the temperature range of 5℃ to 55℃ using an extended version of the Debye-hückel equation. The ph values are reported using 1) the Debye-hückel extension of the Bates-Guggenheim convention in the tempera- ture range 5℃ to 55℃ and 2) with and without liquid junction correction at 25℃ and 37℃. These TES buffer solutions are recommended as secondary standard references for ph measurements in the range of ph 7.2 to 7.5 for physiological application with an ionic strength of I = 0.16 ***-1.

关键词： Ionic Strength Liquid Junction Potentials Second Dissociation Constant Buffer Solutions Activity Coefficients

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你们哪里懂周杰伦

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小作家选刊（时文素材） 2008年第4期 57-57页

作者： jessica

卡拉OK必点歌:潘玮柏、Twins、S.h.E、张韶涵。初见周杰伦,自然是因为那首《简单爱》。MTV里他的容颜青春且沉静,即便是那么活泼的情歌,他也唱得那么不动声色。惊鸿一瞥,料定此人绝非泛泛之辈。很多人对他的评价是:"吐词含糊,口齿不清,

关键词：周杰伦张韶涵潘玮柏鸿一口齿不清一轮明月冬夜我们这代人第二年这个世界

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Associations between health-related fitness and patient-reported symptoms in newly diagnosed breast cancer patients

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Journal of Sport and health Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso Myriam Filion Spencer J.Allen Stephanie M.Ntoukas Gordon J.Bell jessica McNeil Qinggang Wang Margaret L.McNeely Jeff K.Vallance Lin Yang S.Nicole Culos-Reed Leanne Dickau John R.Mackey Christine M.Friedenreich Kerry S.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation Medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of Medicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience symptoms that may affect their quality of life,treatment outcomes,and *** and managing breast cancer-related symptoms soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(hRF)and patient-reported symptoms in newly diagnosed breast cancer ***:This study utilized baseline data from the Alberta Moving Beyond Breast Cancer Cohort Study that were collected within 90 days of *** measures included peak cardiopulmonary fitness(peak volume of oxygen consumption(VO_(2peak))),maximal muscular strength and endurance,flexibility,and body *** measures included depression,sleep quality,and *** multivariable logistic regression was performed for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported moderate *** multivariable-adjusted models,lower relative VO_(2peak)was independently associated with a greater likelihood of all symptom measures,including moderate depression(phreshold associations with all symptom measures such that all 3 lower quartiles exhibited similar elevated risk compared to the highest *** strength of the threshold associations varied by the symptom measure with odds ratios ranging from-1.5 for poor sleep quality to-3.0 for moderate depression and multiple ***,lower relative upper body muscular endurance was also independently associated with fatigue in a dose-response manner(p=0.001),and higher body weight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:Relative VO_(2peak)appears to be a critical hRF component associated with multiple patient-reported symptoms in newly diag

关键词： Breast cancer Fatigue Depression Sleep quality Cardiorespiratory fitness

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Latest development status of Qcells *** NEO technology

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第十九届中国太阳级硅及光伏发电研讨会(19th CSPV)

作者： J?rg W.Müller Ansgar Mette Stefan h?rnlein Ingmar h?ger Martin Schaper Kai Petter Matthias Jungh?nel Christian Klenke Anika Weihrauch hans-Christoph Ploigt Ohjin Kwon Antje Sch?nmann Osama Tobail Kyunghun Kim Axel Schwabedissen Maximilian Kauert Klaus Duncker René h?nig Janko Cieslak Florian Stenzel Bj?rn Faulwetter-Quandt jessica Scharf Friederike Kersten Benjamin Lee Sissel Tind Kristensen Olaf Schnelting Carsten Baer Martina Queck Gregor Zimmermann Matthias K?hler Nicole Lampa Britta Pohl-hampel Lorenzo Burtone Larissa Niebergall Matthias Schütze Susanne Schulz Fabian Fertig Stefan Peters Markus Fischer Qcells Thalheim R&D Center(hanwha Q CELLS Gmbh)

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消化道溃疡出血继续用低剂量阿司匹林

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中国全科医学 2010年第26期13卷 2915-2915页

作者： Joseph J.Y.Sung James Y.W.Lau jessica Y.L.Ching 周淑新中国石油中心医院

背景对接受低剂量阿司匹林治疗发生消化道溃疡出血患者,采取内镜下止血治疗后是否应继续使用阿司匹林。目的检验内镜下控制溃疡出血后继续采用阿司匹林与质子泵抑制剂联合治疗并不劣于停用阿司匹林治疗,基于患心血管或脑血管病的成年复... 详细信息

背景对接受低剂量阿司匹林治疗发生消化道溃疡出血患者,采取内镜下止血治疗后是否应继续使用阿司匹林。目的检验内镜下控制溃疡出血后继续采用阿司匹林与质子泵抑制剂联合治疗并不劣于停用阿司匹林治疗,基于患心血管或脑血管病的成年复发性溃疡出血的患者。设计平行随机安慰剂对照试验。试验中患者和临床医生对指定的治疗双盲,从2003—2006年,将计算机生成的编号密封。设施一家三级内镜中心。患者接受低剂量阿司匹林的消化道溃疡出血者。干预78例患者接受阿司匹林80mg/d,78例接受安慰剂8周,立即采取内镜治疗。所有患者输注泮托拉唑(pantoprazole)治疗72h,接着口服泮托拉唑。对所有患者进行跟踪随访。测量初级终点为用内镜确定30日内再发溃疡出血。次极终点为8周内所有原因和特发原因所致的死亡率。结果 56例患者纳入治疗意向分析。3例在做跟踪前退出了试验。阿司匹林组30日内再发溃疡出血的发生率为10.3%,安慰剂组为5.4%〔相差4.9%,95%CI(3.6%～13.4%)〕,所有原因死亡率,接受阿司匹林治疗的患者比用安慰剂的患者要低〔1.3%vs12.9%;相差11.6%,95%CI(3.7%～19.5%)〕。与安慰剂组患者比较,将阿司匹林组患者死亡率较低的原因归因于心血管、脑血管或胃肠道并发症较少〔1.3%vs10.3%,相差9%,95%CI(1.7%～16.3%)〕。局限性样本量相对较小;仅做了低剂量阿司匹林80mg;安慰剂组有2例再发出血患者未做进一步内镜检查。结论接受低剂量阿司匹林治疗者发生消化道溃疡性出血后,继续用阿司匹林治疗可增加再发出血的风险,但有可能减少死亡率。证实这些发现还需做大量的实验研究。

关键词：消化道溃疡出血剂量阿司匹林内镜下止血治疗随机安慰剂出血患者质子泵抑制剂对照试验胃肠道并发症

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