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Vonoprazan 10 mg or 20 mg *** 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis:A randomized controlled trial

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Chinese Medical Journal 2024年第8期137卷 962-971页

作者： Yinglian Xiao Jiaming Qian Shutian Zhang Ning dai Hoon Jai Chun Chengtang Chiu Chui Fung Chong Nobuo Funao Yuuichi Sakurai jessica d.eisner Li Xie Minhu Chen department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510062China department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100006China department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China department of Gastroenterology Sir Run Run Shaw HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310020China department of Internal Medicine Korea University Anam HospitalKorea University College of Medicine73 Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea department of Gastroenterology&Hepatology Linkou Medical CenterChang Gung Memorial HospitalTaoyuanTaiwan 33353China College of Medicine Chang Gung UniversityTaoyuanTaiwan 33353China Takeda development Center Asia Singapore 018981Singapore Takeda Pharmaceutical Company Chuo-kuOsaka 540-8645Japan Takeda Pharmaceuticals International Company CambridgeMA02142 USA China Medical Team Takeda ChinaBeijing 100027China Hoffmann-La Roche Basel4070 Switzerland Abbott Laboratories Lake ForestIL 60045USA

Background:Erosive esophagitis(EE)is a gastroesophageal reflux disease characterized by mucosal breaks in the *** pump inhibitors are widely used as maintenance therapy for EE,but many patients still *** this trial,we evaluated the noninferiority of vonoprazan *** as maintenance therapy in patients with healed ***:We performed a double-blind,double-dummy,multicenter,phase 3 clinical trial among non-Japanese Asian adults with endoscopically confirmed healed EE from April 2015 to February *** from China,South Korea,and Malaysia were randomized to vonoprazan 10 mg or 20 mg once daily or lansoprazole 15 mg once daily for 24 *** primary endpoint was endoscopically confirmed EE recurrence rate over 24 weeks with a noninferiority margin of 10%using a two-sided 95%confidence interval(CI).Treatment-emergent adverse events(TEAEs)were ***:Among 703 patients,EE recurrence was observed in 24/181(13.3%)and 21/171(12.3%)patients receiving vonoprazan 10 mg or 20 mg,respectively,and 47/184(25.5%)patients receiving lansoprazole(differences:-12.3%[95%CI,-20.3%to-4.3%]and-13.3%[95%CI,-21.3%to-5.3%],respectively),meeting the primary endpoint of noninferiority to lansoprazole in preventing EE recurrence at 24 *** of superiority(upper bound of 95%CIdoscopically confirmed EE recurrence was observed in 5/18,2/20,and 7/20 of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** were experienced by 66.8%(157/235),69.0%(156/226),and 65.3%(158/242)of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** most common TEAE was upper respiratory tract infection in 12.8%(30/235)and 12.8%(29/226)patients in vonoprazan 10 mg and 20 mg groups,respectively and 8.7%(21/242)patients in lansoprazole ***:Vonoprazan maintenance therapy was well-tolerated and noninferior to lansoprazole for preventing EE recurrence i

关键词： Erosive esophagitis Lansoprazole Maintenance therapy Potassium-competitive acid blockers Vonoprazan

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith jessica L.Williams department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

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Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria Martinelli jessica Mandrioli Andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari Cecilia Simonini Francesco Cavallieri Franco Valzania department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental Medicine Ph.d.Program University of Modena and Reggio EmiliaModenaItaly department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOd1)mutations represent a minority of ALS cases,the SOd1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOd1(SOd1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOd1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOd1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory SOd1 superoxide dismutase 1 urinary vocal cord palsy

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Translational Bioinformatics: Past, Present, and Future

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Genomics, Proteomics & Bioinformatics 2016年第1期14卷 31-41页

作者： jessica d.Tenenbaum department of Biostatistics and Bioinformatics Duke University School of Medicine

Though a relatively young discipline, translational bioinformatics （TBI） has become a key component of biomedical research in the era of precision medicine. development of high-throughput technologies and electronic health records has caused a paradigm shift in both healthcare and biomedical research. Novel tools and methods are required to convert increasingly voluminous datasets into information and actionable knowledge. This review provides a definition and contex- tualization of the term TBI, describes the discipline＇s brief history and past accomplishments, as well as current loci, and concludes with predictions of future directions in the field.

关键词： Translational bioinformatics Biomarkers Genomics Precision medicine Personalized medicine

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Large-diameter trees and deadwood correspond with belowground ectomycorrhizal fungal richness

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Ecological Processes 2023年第1期12卷 31-45页

作者： Joseph d.Birch James A.Lutz Soren Struckman jessica R.Miesel Justine Karst department of Plant Soil and Microbial SciencesMichigan State University1066 Bogue StreetEast LansingMI 48824USA department of Wildland Resources and the Ecology Center Utah State University5230 Old Main HillLoganUT 84322-5230USA department of Renewable Resources University of Alberta751 General Services BuildingEdmontonAB T6G 2H1Canada

Background: Large-diameter trees have an outsized influence on aboveground forest dynamics, composition, and structure. Although their influence on aboveground processes is well studied, their role in shaping belowground fungal communities is largely unknown. We sought to test if (i) fungal community spatial structure matched aboveground forest structure;(ii) fungal functional guilds exhibited differential associations to aboveground trees, snags, and deadwood;and (iii) that large-diameter trees and snags have a larger influence on fungal community richness than smaller-diameter trees. We used MiSeq sequencing of fungal communities collected from soils in a spatially intensive survey in a portion of Cedar Breaks National Monument, Utah, USA. We used random forest models to explore the spatial structure of fungal communities as they relate to explicitly mapped trees and deadwood distributed across 1.15 ha of a 15.32-ha mapped subalpine forest. Results: We found 6,177 fungal amplicon sequence variants across 117 sequenced samples. Tree diameter, dead-wood presence, and tree species identity explained more than twice as much variation (38.7% vs. 10.4%) for ectomy-corrhizal composition and diversity than for the total or saprotrophic fungal communities. Species identity and dis-tance to the nearest large-diameter tree (≥ 40.2 cm) were better predictors of fungal richness than were the identity and distance to the nearest tree. Soil nutrients, topography, and tree species differentially influenced the composition and diversity of each fungal guild. Locally rare tree species had an outsized influence on fungal community richness. Conclusions: These results highlight that fungal guilds are differentially associated with the location, size, and species of aboveground trees. Large-diameter trees are implicated as drivers of belowground fungal diversity, particularly for ectomycorrhizal fungi.

关键词： Belowground ecology Ectomycorrhizal fungi Pinus flexilis Pinus longaeva Saprotrophic fungi Smithsonian ForestGEO Spatial dynamics Utah Forest dynamics Plot

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Linking Fish Habitat Modelling and Sediment Transport in Running Waters

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四川大学学报（工程科学版） 2005年第S1期37卷 52-56页

作者： Andreas eisner Silke WIEPRECHT Matthias SCHNEIdER IWS Universitt StuttgartInst.of Hydraulic Eng.Chair of Hydraulic Eng.and Water Recources ManagementPfaffenwaldring 61D-70569 StuttgartGermany Sje-Schneider and Jorde Ecological Eng.GmbH Viereichenweg 12D-70569 StuttgartGermany

The assessment of ecological status for running waters is one of the major issues within an integrated river basin management and plays a key role with respect to the implementation of the European Water Frame- work directive (WFd).One of the tools supporting the development of sustainable river management is physi- cal habitat modeling,e.g.,for fish,because fish population are one of the most important indicators for the e- colngical integrity of *** physical habitat models hydromorphological ...

关键词： morphodynamics sediment transport fish habitat modeling fuzzy logic CASiMiR

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Hepatitis B in healthcare workers: Transmission events and guidance for management

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World Journal of Hepatology 2015年第3期7卷 488-497页

作者： jessica d Lewis Kyle B Enfield Costi d Sifri division of Infectious diseases and International Health Department of Medicine University of Virginia Health System division of Pulmonary and Critical Care Medicine Department of Medicine University of Virginia Health System Office of Hospital Epidemiology/Infection Prevention and Control University of Virginia Health System

Hepatitis B virus(HBV) is the most efficiently transmissible of the bloodborne viruses that are important in healthcare settings. Healthcare workers(HCWs)are at risk for exposure to HBV from infected patients and, if infected, are similarly at risk of transmitting HBV to patients. Published cases of HBV transmission from HCW to patient are relatively rare, having decreased in frequency following the introduction of standard(universal) precautions, adoption of enhanced percutaneous injury precautions such as double-gloving in surgery, and routine HBV vaccination of HCWs. Here we review published cases of HCW-to-patient transmission of HBV, details of which have helped to guide the creation of formal guidelines for the management of HBV-infected HCWs. We also compare the published guidelines for the management of HBV-infected HCWs from various governing bodies, focusing on their differences with regard to vaccination requirements, viral load limits, frequency of monitoring, and restrictions on practice. Importantly, while there are differences among the recommendations from governing bodies, no guidelines uniformly restrict HBV-infected HCWs from performing invasive or exposure-prone procedures.

关键词： Hepatitis B Healthcare worker Blood-bornepathogens Transmission Invasive procedures

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Connecting brain and body:Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression

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World Journal of Psychiatry 2021年第10期11卷 805-820页

作者： Harriet Emma Clare Sharp Hugo d Critchley jessica A Eccles department of Medical Neuroscience Brighton and Sussex Medical SchoolUniversity of SussexBrighton BN19PXEast SussexUnited Kingdom department of Psychiatry Sussex Partnership NHS Foundation TrustWorthingBN133EPWest SussexUnited Kingdom

The mind is embodied;thoughts and feelings interact with states of physiological arousal and physical integrity of the *** this context,there is mounting evidence for an association between psychiatric presentations and the expression variant connective tissue,commonly recognised as joint *** hypermobility is common,frequently under-recognised,significantly impacts quality of life,and can exist in isolation or as the hallmark of hypermobility spectrum disorders(encompassing joint hypermobility syndrome and hypermobile Ehlers-danlos syndrome).In this narrative review,we appraise the current evidence linking psychiatric disorders across the lifespan,beginning with the relatively well-established connection with anxiety,to *** next consider emerging associations with affective illnesses,eating disorders,alongside less well researched links with personality disorders,substance misuse and *** then review related findings relevant to neurodevelopmental disorders and stress-sensitive medical *** growing understanding of mind-body interactions,we discuss potential aetiopathogenetic contributions of dysautonomia,aberrant interoceptive processing,immune dysregulation and proprioceptive impairments in the context of psychosocial stressors and genetic *** examine clinical implications of these evolving findings,calling for increased awareness amongst healthcare professionals of the transdiagnostic nature of hypermobility and related disorders.A role for early screening and detection of hypermobility in those presenting with mental health and somatic symptoms is further highlighted,with a view to facilitate preventative approaches alongside longer-term holistic management ***,suggestions are offered for directions of future scientific exploration which may be key to further delineating fundamental mind-body-brain interactions.

关键词： Joint hypermobility Hypermobile Ehlers-danlos syndrome Psychopathology Psychiatric disorders Neurodevelopmental disorders Mind-body relations

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deciphering the role of PGC-1α in neurological disorders: from mitochondrial dysfunction to synaptic failure

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Neural Regeneration Research 2022年第2期17卷 237-245页

作者： jessica d.Panes Aline Wendt Oscar Ramirez-Molina Patricio A.Castro Jorge Fuentealba Laboratorio de Screening de Compuestos Neuroactivos(LSCN) Departamento de FisiologiaFacultad de Ciencias BiologicasUniversidad de ConcepcionConcepcionChile Centro de Investigaciones Avanzadas en Biomedicina(CIAB-UdeC) Facultad de Ciencias BiologicasUniversidad de ConcepcionConcepcionChile departamento de Fisiologia Facultad de Ciencias BiologicasUniversidad de ConcepcionConcepcionChile

The onset and mechanisms underlying neurodegenerative diseases remain uncertain. The main features of neurodegenerative diseases have been related with cellular and molecular events like neuronal loss, mitochondrial dysfunction and aberrant accumulation of misfolded proteins or peptides in specific areas of the brain. The most prevalent neurodegenerative diseases belonging to age-related pathologies are Alzheimer's disease, Huntington's disease, Parkinson's disease and amyotrophic lateral sclerosis. Interestingly, mitochondrial dysfunction has been observed to occur during the early onset of several neuropathological events associated to neurodegenerative diseases. The master regulator of mitochondrial quality control and energetic metabolism is the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α). Additionally, it has been observed that PGC-1α appears to be a key factor in maintaining neuronal survival and synaptic transmission. In fact, PGC-1α downregulation in different brain areas(hippocampus, substantia nigra, cortex, striatum and spinal cord) that occurs in function of neurological damage including oxidative stress, neuronal loss, and motor disorders has been seen in several animal and cellular models of neurodegenerative diseases. Current evidence indicates that PGC-1α upregulation may serve as a potent therapeutic approach against development and progression of neuronal damage. Remarkably, increasing evidence shows that PGC-1α deficient mice have neurodegenerative diseases-like features, as well as neurological abnormalities. Finally, we discuss recent studies showing novel specific PGC-1α isoforms in the central nervous system that appear to exert a key role in the age of onset of neurodegenerative diseases and have a neuroprotective function in the central nervous system, thus opening a new molecular strategy for treatment of neurodegenerative diseases. The purpose of this review is to provide an up-t

关键词： Alzheimer's disease amyotrophic lateral sclerosis Huntington's disease mitochondrial dysfunction Parkinson's disease PGC-1α synaptic function vascular dementia

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The role of RAS effectors in BCR/ABL induced chronic myelogenous leukemia

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Frontiers of Medicine 2013年第4期7卷 452-461页

作者： jessica Fredericks Ruibao Ren State Key Laboratory for Medical Genomics Shanghai Institute of HematologyRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Rosenstiel Basic Medical Sciences Research Center and department of Biology Brandeis UniversityWalthamMA 02454USA EMd Millipore Corporation 17 Cherry Hill DriveDanversMA 01923USA

BCR/ABL is the causative agent of chronic myelogenous leukemia(CML).Through structure/function analysis,several protein motifs have been determined to be important for the development of ***177 of BCR is a Grb2 binding site required for BCR/ABL-induced CML in *** the current study,we use a mouse bone marrow transduction/transplantation system to demonstrate that addition of oncogenic NRAS(NRASG12d)to a vector containing a BCR/ABL^(Y177F)mutant“rescues”the CML phenotype rapidly and *** further narrow down the pathways downstream of RAS that are responsible for this rescue effect,we utilize well-characterized RAS effector loop mutants and determine that the RAL pathway is important for rapid induction of *** of this pathway by a dominant negative RAL is capable of delaying disease *** from the present study support the notion of RAL inhibition as a potential therapy for BCR/ABL-induced CML.

关键词： BCR/ABL chronic myelogenous leukemia(CML) RAS RAL

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