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脾脏在肝癌合并肝硬化中的临床价值

外科理论与实践 2023年第4期28卷 394-398页

作者： chang jessica 陈旭晓陈拥军上海交通大学医学院附属瑞金医院普外科上海200025

脾脏作为人体最大的淋巴器官,可通过门静脉系统影响肝脏的免疫微环境。肝癌病人往往因为肝硬化和门静脉高压而出现脾功能亢进(脾亢)和脾肿大。脾脏功能失调不仅诱发肝脏纤维化,还改变肝脏的免疫调节,加速肝硬化和抑制肝脏再生能力,且使... 详细信息

脾脏作为人体最大的淋巴器官,可通过门静脉系统影响肝脏的免疫微环境。肝癌病人往往因为肝硬化和门静脉高压而出现脾功能亢进(脾亢)和脾肿大。脾脏功能失调不仅诱发肝脏纤维化,还改变肝脏的免疫调节,加速肝硬化和抑制肝脏再生能力,且使肝内微环境和免疫系统趋向“促肿瘤生成”与“肿瘤耐受”的状态。脾脏切除术已被证实在术后短期内可改善肝癌病人的一般状态、肝功能,甚至免疫力。因此,脾脏切除术可能提高肝癌病人术后抗癌治疗的耐受性。但对于合并门静脉高压和脾亢的肝癌病人选择进行肝脾联合切除是否存在远期效益或提高生存率仍有争议。

关键词：肝癌脾脏门静脉高压肝硬化

Vonoprazan 10 mg or 20 mg *** 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis:A randomized controlled trial

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Chinese Medical Journal 2024年第8期137卷 962-971页

作者： Yinglian Xiao Jiaming Qian Shutian Zhang Ning Dai Hoon Jai Chun Chengtang Chiu Chui Fung Chong Nobuo Funao Yuuichi Sakurai jessica D.Eisner Li Xie Minhu Chen Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510062China Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100006China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Gastroenterology Sir Run Run Shaw HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310020China Department of Internal Medicine Korea University Anam HospitalKorea University College of Medicine73 Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Department of Gastroenterology&Hepatology Linkou Medical CenterChang Gung Memorial HospitalTaoyuanTaiwan 33353China College of Medicine Chang Gung UniversityTaoyuanTaiwan 33353China Takeda Development Center Asia Singapore 018981Singapore Takeda Pharmaceutical Company Chuo-kuOsaka 540-8645Japan Takeda Pharmaceuticals International Company CambridgeMA02142 USA China Medical Team Takeda ChinaBeijing 100027China Hoffmann-La Roche Basel4070 Switzerland Abbott Laboratories Lake ForestIL 60045USA

Background:Erosive esophagitis(EE)is a gastroesophageal reflux disease characterized by mucosal breaks in the *** pump inhibitors are widely used as maintenance therapy for EE,but many patients still *** this trial,we evaluated the noninferiority of vonoprazan *** as maintenance therapy in patients with healed ***:We performed a double-blind,double-dummy,multicenter,phase 3 clinical trial among non-Japanese Asian adults with endoscopically confirmed healed EE from April 2015 to February *** from China,South Korea,and Malaysia were randomized to vonoprazan 10 mg or 20 mg once daily or lansoprazole 15 mg once daily for 24 *** primary endpoint was endoscopically confirmed EE recurrence rate over 24 weeks with a noninferiority margin of 10%using a two-sided 95%confidence interval(CI).Treatment-emergent adverse events(TEAEs)were ***:Among 703 patients,EE recurrence was observed in 24/181(13.3%)and 21/171(12.3%)patients receiving vonoprazan 10 mg or 20 mg,respectively,and 47/184(25.5%)patients receiving lansoprazole(differences:-12.3%[95%CI,-20.3%to-4.3%]and-13.3%[95%CI,-21.3%to-5.3%],respectively),meeting the primary endpoint of noninferiority to lansoprazole in preventing EE recurrence at 24 *** of superiority(upper bound of 95%CI<0%)was also *** 12 weeks,endoscopically confirmed EE recurrence was observed in 5/18,2/20,and 7/20 of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** were experienced by 66.8%(157/235),69.0%(156/226),and 65.3%(158/242)of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** most common TEAE was upper respiratory tract infection in 12.8%(30/235)and 12.8%(29/226)patients in vonoprazan 10 mg and 20 mg groups,respectively and 8.7%(21/242)patients in lansoprazole ***:Vonoprazan maintenance therapy was well-tolerated and noninferior to lansoprazole for preventing EE recurrence i

关键词： Erosive esophagitis Lansoprazole Maintenance therapy Potassium-competitive acid blockers Vonoprazan

Helper T Cell(CD4^(+))Targeted Tacrolimus Delivery Mediates Precise Suppression of Allogeneic Humoral Immunity

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Research 2022年第3期2022卷 189-203页

作者： Jia Shen chang Liu Pengpeng Yan Meifang Wang Luying Guo Shuaihui Liu Jianghua Chen jessica MRosenholm Hongfeng Huang Rending Wang Hongbo Zhang Kidney Disease Center The First Affiliated HospitalCollege of MedicineZhejiang UniversityKey Laboratory of Kidney Disease Prevention and Control TechnologyZhejiang ProvinceChina Pharmaceutical Sciences Laboratory Faculty of Science and EngineeringÅbo Akademi UniversityTurku 20520Finland Turku Bioscience Centre University of Turku andÅbo Akademi UniversityTurku 20520Finland Organ Donation and Coordination Office The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Antibody-mediated rejection(ABMR)is a major cause of dysfunction and loss of transplanted *** current treatments for ABMR involve nonspecific inhibition and clearance of T/B cells or plasma ***,the prognosis of patients following current treatment is poor.T follicular helper cells(Tfh)play an important role in allograft-specific antibodies secreting plasma cell(PC)*** cells are therefore considered to be important therapeutic targets for the treatment of antibody hypersecretion disorders,such as transplant rejection and autoimmune ***(Tac),the primary immunosuppressant,prevents rejection by reducing T cell ***,its administration should be closely monitored to avoid serious side *** this study,we investigated whether Tac delivery to helper T(CD4^(+))cells using functionalized mesoporous nanoparticles can block Tfh cell differentiation after alloantigen *** showed that Tac delivery ameliorated humoral rejection injury in rodent kidney graft by suppressing Tfh cell development,PC,and donor-specific antibody(DSA)generation without causing severe side effects compared with delivery through the drug administration *** study provides a promising therapeutic strategy for preventing humoral rejection in solid organ *** specific and controllable drug delivery avoids multiple disorder risks and side effects observed in currently used clinical approaches.

关键词： Tacrolimus treatment donor

Disrupted Maturation of Prefrontal Layer 5 Neuronal Circuits in an Alzheimer’s Mouse Model of Amyloid Deposition

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Neuroscience Bulletin 2023年第6期39卷 881-892页

作者： chang Chen Jing Wei Xiaokuang Ma Baomei Xia Neha Shakir jessica K.Zhang Le Zhang Yuehua Cui Deveroux Ferguson Shenfeng Qiu Feng Bai Department of Neurology Affiliated Drum Tower HospitalMedical School of Nanjing UniversityNanjing210008China Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZ85004USA

Mutations in genes encoding amyloid precursor protein(APP)and presenilins(PSs)cause familial forms of Alzheimer’s disease(AD),a neurodegenerative disorder strongly associated with *** is currently unknown whether and how AD risks affect early brain development,and to what extent subtle synaptic pathology may occur prior to overt hallmark AD *** mutant APP/PS1 over-expression mouse lines are key tools for studying the molecular mechanisms of AD *** these lines,the 5XFAD mice rapidly develop key features of AD pathology and have proven utility in studying amyloid plaque formation and amyloidβ(Aβ)-induced *** reasoned that transgenic mutant APP/PS1 over-expression in 5XFAD mice may lead to neurodevelopmental defects in early cortical neurons,and performed detailed synaptic physiological characterization of layer 5(L5)neurons from the prefrontal cortex(PFC)of 5XFAD and wild-type littermate controls.L5 PFC neurons from 5XFAD mice show early APP/Aβ***-cell patch-clamp recording at an early post-weaning age(P22–30)revealed functional impairments;although 5XFAD PFC-L5 neurons exhibited similar membrane properties,they were intrinsically less *** addition,these neurons received smaller amplitude and frequency of miniature excitatory synaptic *** functional disturbances were further corroborated by decreased dendritic spine density and spine head volumes that indicated impaired synapse *** biotinylation followed by Western blot analysis of PFC-L5 tissue revealed that 5XFAD mice showed reduced synaptic AMPA receptor subunit GluA1 and decreased synaptic NMDA receptor subunit *** with this,patch-clamp recording of the evoked L23>L5 synaptic responses revealed a reduced AMPA/NMDA receptor current ratio,and an increased level of AMPAR-lacking silent *** results suggest that transgenic mutant forms of APP/PS1 overexpression in 5XFAD mice leads to early deve

关键词： Alzheimer’s disease Mouse model Synaptic plasticity Long-term potentiation Cortical circuit Electrophysiology Learning and memory

Intravascular large B-cell lymphoma presenting with altered mental status: A case report

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World Journal of Clinical Oncology 2019年第12期10卷 402-408页

作者： Christopher Robert D’Angelo Kimberly Ku jessica Gulliver Julie chang Department of Medicine Section of Hematology/OncologyUniversity of Wisconsin School of Medicine and Public HealthMadisonWI 53792United States Department of Pathology University of Wisconsin School of Medicine and Public HealthMadisonWI 53792United States

BACKGROUND Intravascular large B-cell lymphoma(IVLBCL)is a rare and aggressive subtype of non-Hodgkin lymphoma with a varied presentation and no pathognomonic *** diagnosis is critical to altering the disease course as early treatment with chemoimmunotherapy is required to prevent a rapidly fatal *** including improved awareness of this clinical entity through publication of cases with unique presentations are essential to prompt consideration of IVLBCL early in the disease ***,we present a case of IVLBCL presenting with altered mental status and systemic organ *** SUMMARY A 61-year-old male patient presented with flu-like symptoms and a high *** experienced rapid clinical deterioration with liver,kidney failure,and shock despite rapid antibiotic administration and supportive care.A broad infectious workup was *** imaging revealed nonspecific changes to the corpus callosum suspicious for *** biopsy was *** further progression of his symptoms,the family elected to withdraw care and the patient died shortly ***-mortem analysis revealed clear multi-organ involvement by IVLBCL,prompting re-examination of the ante-mortem renal biopsy that also identified IVLBCL *** IVLBCL is a rare *** with specialties and early biopsy is critical to establishing the diagnosis and initiating therapy.

关键词： Intravascular lymphoma Altered mental status Case report

Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy

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Chronic Diseases and Translational Medicine 2019年第4期5卷 258-266页

作者： Amin Zargar Samantha chang Ankita Kothari Antoine M.Snijders Jian-Hua Mao jessica Wang Amanda C.Hernandez Jay D.Keasling Trever G.Bivona Joint BioEnergy Institute Lawrence Berkeley National LaboratoryEmeryvilleCA 94608USA QB3 Institute University of California-Berkeley174 Stanley HallBerkeleyCA 94720USA Biological Systems and Engineering Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Chemical&Biomolecular Engineering Department of BioengineeringUniversity of CaliforniaBerkeleyCA 94720USA Helen Diller Family Comprehensive Cancer Center University of CaliforniaSan FranciscoCA 94143USA Department of Cellular and Molecular Pharmacology University o f CaliforniaSan FranciscoCA 94143USA

Despite tremendous efforts to fight cancer,it remains a major public health problem and a leading cause of death *** increased knowledge of cancer pathways and improved technological platforms,precision therapeutics that specifically target aberrant cancer pathways have improved patient ***,a primary cause of unsuccessful cancer therapy remains cancer drug *** this review,we summarize the broad classes of resistance to cancer therapy,particularly pharmacokinetics,the tumor microenvironment,and drug resistance ***,we describe how bacterial-mediated cancer therapy,a bygone mode of treatment,has been revitalized by synthetic biology and is uniquely suited to address the primary resistance mechanisms that confound traditional *** genetic engineering,we discuss how bacteria can be potent anticancer agents given their tumor targeting potential,anti-tumor activity,safety,and coordinated delivery of anti-cancer drugs.

关键词： Cancer therapy Synthetic biology Drug resistance Bacterial-mediated therapy

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Afternoon Tea

明日风尚 2013年第3期 172-173页

作者： jessica 戴翔

充满热情是我对他的第一印象那天窗外飘着小雨我在意利咖啡的咖啡大学里听他说了很多故事离开时心是暖暖的感动……他,是意利咖啡中国区总经理张国骏(Gordon chang)先生11年前将意利咖啡带进了中国……MING:对您来说,咖啡意味着什么?Gor... 详细信息

充满热情是我对他的第一印象那天窗外飘着小雨我在意利咖啡的咖啡大学里听他说了很多故事离开时心是暖暖的感动……他,是意利咖啡中国区总经理张国骏(Gordon chang)先生11年前将意利咖啡带进了中国……MING:对您来说,咖啡意味着什么?Gordon:我和很多人一样,会用一杯好咖啡开始每一天。对我来说,它是生活的一部分。开心与家人朋友在一起的时候,我手边会有一杯咖啡;压力大心情沉闷的时候,我也习惯静静地品一杯咖啡。也因为热爱。

关键词：创业家内地市场始甸 Afternoon Tea 明日风尚商业客户就这样企业文化详尽介绍

Probabilistic Modeling of Oil Spills at the Exclusive Economic Zone of Cuba Using Petromar-3D Model

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Journal of Geoscience and Environment Protection 2021年第6期9卷 21-34页

作者： Alejandro Rodríguez Dayron chang Amilcar E. Calzada Dayana Carracedo Dailín Reyes Alexander Lobaina Reinaldo Casals jessica Hernández Javier Cabrales Institute of Meteorology of Cuba Havana Cuba Meteorology Office of Cuban Company for Air Navigation (ECNA - AISMet) Havana Cuba

This article shows the probabilistic modeling of hydrocarbon spills on the surface of the sea, using climatology data of oil spill trajectories yielded by applying the lagrangian model PETROMAR-3D. To achieve this goal, several computing and statistical tools were used to develop the probabilistic modeling solution based in the methodology of Guo. Solution was implemented using a databases approach and SQL language. A case study is presented which is based on a hypothetical spill in a location inside the Exclusive Economic Zone of Cuba. Important outputs and products of probabilistic modeling were obtained, which are very useful for decision-makers and operators in charge to face oil spill accidents and prepare contingency plans to minimize its effects. In order to study the relationship between the initial trajectory and the arrival of hydrocarbons spills to the coast, a new approach is introduced as an incoming perspective for modeling. It consists in storage in databases the direction of movement of the oil slick at the first 24 hours. The probabilistic modeling solution presented is of great importance for hazard studies of oil spills in Cuban coastal areas.

关键词： Oil Spill Modeling Petromar Lagrangian Model Probabilistic Modeling

Kinases: Understanding Their Role in HIV Infection

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World Journal of AIDS 2019年第3期9卷 142-160页

作者： William De Martini Roksana Rahman Eduvie Ojegba Emily Jungwirth Jasmine Macias Frederick Ackerly Mia Fowler jessica Cottrell Tinchun Chu Sulie L. chang Department of Biological Sciences Seton Hall University South Orange NJ USA Institute of NeuroImmune Pharmacology South Orange NJ USA

Antiviral drugs currently on the market primarily target proteins encoded by specific viruses. The drawback of these drugs is that they lack antiviral mechanisms that account for resistance or viral mutation. Thus, there is a pressing need for researchers to explore and investigate new therapeutic agents with other antiviral strategies. Viruses such as the human immunodeficiency virus (HIV) alter canonical signaling pathways to create a favorable biochemical environment for infectivity. We used Qiagen Ingenuity Pathway Analysis (IPA) software to review the function of several cellular kinases and the resulting perturbed signaling pathways during HIV infection such as NF-κB signaling. These host cellular kinases such as ADK, PKR, MAP3K11 are involved during HIV infection at various stages of the life cycle. Additionally IPA analysis indicated that these modified host cellular kinases are known to have interactions with each other especially AKT1, a serine/threonine kinase involved in multiple pathways. We present a list of cellular host kinases and other proteins that interact with these kinases. This approach to understanding the relationship between HIV infection and kinase activity may introduce new drug targets to arrest HIV infectivity.

关键词： HIV AIDS Kinases IPA NF-κB