检索结果-南通市图书馆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

晚清百态中的乡土文化

美术大观 2024年第5期 10-23页

作者： [英]霍吉淑陈怡(译) 大英博物馆中国馆中央美术学院

作者从物质文化的视角,探讨晚清以来地方士绅、底层人民及女性群体的生活痕迹,分别从农村人群、城市生活、城市人群、城市住宅、家居装饰、服装、社交中心—寺庙、娱乐、美食九个面向,考察平民的生活处境、营生态度和价值观念。其所勾... 详细信息

作者从物质文化的视角,探讨晚清以来地方士绅、底层人民及女性群体的生活痕迹,分别从农村人群、城市生活、城市人群、城市住宅、家居装饰、服装、社交中心—寺庙、娱乐、美食九个面向,考察平民的生活处境、营生态度和价值观念。其所勾勒出来的人民形象,贯通时代的思想观念、行为表现与社会样貌,更具全面性和立体感。本文别具洞察之眼,重新揭露晚清复杂的社会面貌及丰富的社会活动,开启了一个新的物质文化研究路径。

关键词：物质物文化身份效仿文化塑造

Conceptualizing Individual and Household Disaster Preparedness:The Perspective from Cameroon

在线全文

学校读者我要写书评

暂无评论

International Journal of Disaster Risk Science 2020年第3期11卷 333-346页

作者： Emmanuel Nzengung Nojang jessica Jensen Department of Political Science and Public Affairs/Homeland Security and Emergency Management Program(PSPA/HSEM) Savannah State UniversitySavannahGA 31404USA Department of Emergency Management North Dakota State UniversityFargoND 58105USA

This research explored the basic issue of what preparedness means and entails to people in Fako Division,Cameroon—a place threated by many hazards and that has experienced many *** from the analysis of the 33 interviews conducted in this study indicate that preparedness is a dynamic state of readiness that is dependent on context,a social process,and a process of completing activities to save lives and minimize the effects of *** addition,the research determined that Cameroonians view a wholly prepared person as someone who would:(1)have knowledge about hazards and what to do about them;(2)engage others,including their families and neighbors,in discussions about activities related to hazards;and(3)participate in activities to minimize loss from hazards,sustain themselves in the face of hazards,and flee from *** findings from the interview data synchronize to a large extent with what is implied,but not clearly stated,in the existing research *** article addresses this synchrony,posits a definition of preparedness,and identifies the theoretical components of preparedness.

关键词： Disaster theory Emergency management Hazards preparedness Individuals and households Risk management

A new bioinformatics tool to recover missing gene expression in single-cell RNA sequencing data

在线全文

学校读者我要写书评

暂无评论

Journal of Molecular Cell Biology 2021年第1期13卷 1-2页

作者： Jingyi jessica Li Department of Statistics University of CaliforniaLos AngelesCA 90095-1554USA

Single-cell RNA sequencing (ScRNA-seq) is a burgeoning field where experi-mental techniques and computationalmethods have been under rapid evolution in the past 6 *** techno-logicaladvances haveallowedbiomedical researchers to identify newcell types, delineate cell sub-populations, and infer cell differentiationtrajectories in various tissue *** the important features extract-able from scRNA-seq data, the predomi-nant onesare individualgenes'expression levels in single cells.

关键词： cell allowed advances

Pharmacotherapy in autism spectrum disorders,including promising older drugs warranting trials

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2023年第6期13卷 262-277页

作者： jessica Hellings Department of Psychiatry University of Missouri-Kansas CityLee's SummitMO 64063United States

Available pharmacotherapies for autism spectrum disorders(ASD)are reviewed based on clinical and research experience,highlighting some older drugs with emerging *** medications show efficacy in ASD,though controlled studies in ASD are largely *** risperidone and aripiprazole have Federal Drug Administration approval in the United ***(MPH)studies showed lower efficacy and tolerability for attention deficit hyperactivity disorder(ADHD)than in the typically developing(TD)population;atomoxetine demonstrated lower efficacy but comparable tolerability to TD *** improved hyperactivity in ASD comparably to *** promises greater efficacy than MPH in *** medications reduce impulsive aggression in youth,and may also be key for this in *** trials of the selective serotonin reuptake inhibitors citalopram and fluoxetine demonstrated poor tolerability and lack of efficacy for repetitive *** of antiseizure medications in ASD remain inconclusive,however clinical trials may be warranted in severely disabled individuals showing bizarre *** identified drugs treat ASD core symptoms;oxytocin lacked *** and loxapine however,show *** at 5-10 mg daily resembled an atypical antipsychotic in positron emission tomography studies,but may be *** at approximately 1 mg/kg/day used cautiously,shows efficacy for sleep,anxiety,impulsivity and ADHD,repetitive behaviors,and *** drugs have promising neurotrophic properties.

关键词： Autism Pharmacotherapy Dextroamphetamine Loxapine Amitriptyline Minimally verbal Neurotrophic

Identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第9期14卷 4028-4044页

作者： Chris Chun-Yiu Chan Qian Guo Jasper Fuk-Woo Chan Kaiming Tang Jian-Piao Cai Kenn Ka-Heng Chik Yixin Huang Mei Dai Bo Qin Chon Phin Ong Allen Wing-Ho Chu Wan-Mui Chan Jonathan Daniel Ip Lei Wen jessica Oi-Ling Tsang Tong-Yun Wang Yubin Xie Zhenzhi Qin Jianli Cao Zi-Wei Ye Hin Chu Kelvin Kai-Wang To Xing-Yi Ge Tao Ni Dong-Yan Jin Sheng Cui Kwok-Yung Yuen Shuofeng Yuan State Key Laboratory of Emerging Infectious Diseases Carol Yu Centre for InfectionDepartment of MicrobiologySchool of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China Department of Infectious Diseases and Microbiology the University of Hong Kong-Shenzhen HospitalShenzhen 518000China Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong Kong SAR 999077China Academician Workstation of Hainan Province Hainan Medical University-the University of Hong Kong Joint Laboratory of Tropical Infectious DiseasesHaikou 571100China School of Biomedical Sciences Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen Biology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China College of Biology Hunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha 410082China

There are only eight approved small molecule antiviral drugs for treating *** them,four are nucleotide analogues(remdesivir,JT001,molnupiravir,and azvudine),while the other four are protease inhibitors(nirmatrelvir,ensitrelvir,leritrelvir,and simnotrelvir-ritonavir).Antiviral resistance,unfavourable drug‒drug interaction,and toxicity have been reported in previous *** there is a dearth of new treatment options for *** this work,a three-tier cell-based screening was employed to identify novel compounds with anti-SARS-CoV-2 *** compound,designated 172,demonstrated broad-spectrum antiviral activity against multiple human pathogenic coronaviruses and different SARS-CoV-2 variants of *** studies validated by reverse genetics showed that compound 172 inhibits the 3-chymotrypsin-like protease(3CLpro)by binding to an allosteric site and reduces 3CLpro dimerization.A drug synergistic checkerboard assay demonstrated that compound 172 can achieve drug synergy with nirmatrelvir in *** vivo studies confirmed the antiviral activity of compound 172 in both Golden Syrian Hamsters and K18 humanized ACE2 ***,this study identified an alternative druggable site on the SARS-CoV-23CLpro,proposed a potential combination therapy with nirmatrelvir to reduce the risk of antiviral resistance and shed light on the development of allosteric protease inhibitors for treating a range of coronavirus diseases.

关键词： SARS-CoV-2 High throughput screening Broad-spectrum antiviral treatment 3CLpro inhibitor Allosteric-site inhibitor Animal models Chemical genetics Reverse genetics

Leptogenesis via a varying Weinberg operator:a semi-classical approach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2019年第3期43卷 22-28页

作者： Silvia Pascoli jessica Turner Ye-Ling Zhou Institute for Particle Physics Phenomenology Department of PhysicsDurham UniversitySouth RoadDurham DH1 3LEUnited Kingdom Theoretical Physics Department Fermi National Accelerator LaboratoryP.O.Box 500BataviaIL 60510USA

In this paper, we introduce leptogenesis via a varying Weinberg operator from a semi-classical *** mechanism is motivated by the breaking of an underlying symmetry which triggers a phase transition that causes the coupling of the Weinberg operator to become dynamical. Consequently, a lepton anti-lepton asymmetry arises from the interference of the Weinberg operator at two different spacetime points. Using the semi-classical approach,we treat the Higgs as a background field and show that a reflection asymmetry between leptons and anti-leptons is generated in the vicinity of the bubble wall. We solve the equations of motion of the lepton and anti-lepton quasiparticles to obtain the final lepton asymmetry.

关键词： leptogenesis Weinberg operator phase transition

Colorectal cancer in inflammatory bowel disease:What is the real magnitude of the risk?

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第29期18卷 3839-3848页

作者： jessica K Dyson Matthew D Rutter Gastroenterology North Tyneside General HospitalRake LaneNorth ShieldsTyne and Wear NE29 8NHUnited Kingdom University Hospital of North Tees Hardwick RoadStockton TS19 8PEUnited Kingdom

The association between inflammatory bowel disease(IBD) and colorectal cancer(CRC) has been recognised since 1925 and still accounts for 10%-15% of deaths in ***-associated CRC(IBD-CRC) affects patients at a younger age than sporadic *** prognosis for sporadic CRC and IBD-CRC is similar,with a 5-year survival of approximately 50%.Identifying at risk patients and implementing appropriate surveillance for these patients is central to managing the CRC risk in *** increased risk of colorectal cancer in association with IBD is thought to be due to genetic and acquired *** link between inflammation and cancer is well recognised but the molecular biology,immune pathobiology and genetics of IBD-CRC are areas of much ongoing *** review examines the literature relating to IBD-CRC,focusing on the incidence of IBD-CRC and examining potential risk factors including age at diagnosis,gender,duration and extent of colitis,severity of inflammation,family history of sporadic CRC and co-existent primary sclerosing cholangitis(PSC).Confirmed risk factors for IBD-CRC are duration,severity and extent of colitis,the presence of co-existent PSC and a family history of *** is insufficient evidence currently to support an increased frequency of surveillance for patients diagnosed with IBD at a younger ***-based guidelines advise surveillance colonoscopy for patients with colitis 8 to 10 years after diagnosis,with the interval for further surveillance guided by risk factors(extent of disease,family history of CRC,post-inflammatory polyps,concomitant PSC,personal history of colonic dysplasia,colonic strictures).There is a move away from using random colonic biopsies towards targeted biopsies aimed at abnormal areas identified by newer colonoscopic techniques(narrow band imaging,chromoendoscopy,confocal microendoscopy).

关键词： Colorectal cancer Inflammatory bowel disease Ulcerative colitis Crohn's disease Risk

Climate Change’s Role in Disaster Risk Reduction’s Future:Beyond Vulnerability and Resilience

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Disaster Risk Science 2015年第1期6卷 21-27页

作者： Ilan Kelman JC Gaillard jessica Mercer UCL Institute for Risk and Disaster Reduction and UCL Institute for Global Health University College London Norwegian Institute of International Affairs(NUPI School of Environment The University of Auckland Secure Futures

A seminal policy year for development and sustainability occurs in 2015 due to three parallel processes that seek long-term agreements for climate change, the Sustainable Development Goals, and disaster risk *** reason exists to separate them, since all three examine and aim to deal with many similar processes, including vulnerability and resilience. This article uses vulnerability and resilience to explore the intersections and overlaps amongst climate change, disaster risk reduction, and sustainability. Critiquing concepts such as 'return to normal'and 'double exposure'demonstrate how separating climate change from wider contexts is counterproductive. Climate change is one contributor to disaster risk and one creeping environmental change amongst many, and not necessarily the most prominent or fundamental contributor. Yet climate change has become politically important, yielding an opportunity to highlight and tackle the deep-rooted vulnerability processes that cause 'multiple exposure'to multiple threats. To enhance resilience processes that deal with the challenges, a prudent place for climate changewould be as a subset within disaster risk reduction. Climate change adaptation therefore becomes one of many processes within disaster risk reduction. In turn, disaster risk reduction should sit within development and sustainability to avoid isolation from topics wider than disaster risk. Integration of the topics in this way moves beyond expressions of vulnerability and resilience towards a vision of disaster risk reduction’s future that ends tribalism and separation in order to work together to achieve common goals for humanity.

关键词： Adaptation Climate change Disaster risk reduction Mitigation Resilience Vulnerability

Quantifying relationships between subsidence and longwall face advance using DInSAR

在线全文

学校读者我要写书评

暂无评论

International Journal of Mining Science and Technology 2021年第1期31卷 91-94页

作者： Bailey S.Simmons jessica M.Wempen Department of Mining Engineering University of UtahUT 84112United States

Surface subsidence that results from longwall mining can be large magnitude and can affect significant *** methods for subsidence monitoring include leveling,global positioning system(GPS),and photogrammetric *** sensing techniques including,aerial LiDAR,terrestrial laser scanning,and satellite-based Differential Interferometric Synthetic Aperture Radar(DInSAR),are also used to measure deformation associated with *** data are different than data from conventional subsidence *** capture data over large areas(hundreds of kilometers),and each pixel(data point)in an image quantifies the average displacement over an area of square *** data can have fairly high time resolution;imaging periods typically range from weeks to *** data can be useful to monitor subsidence sequentially over short *** monitoring subsidence may help define if caving is progressing normally and can establish relationships between surface deformation and longwall face advance,which has potential to help quantify possible risks to mine *** this study,subsidence at a longwall trona mine is monitored over short periods,typically 12 days,as the longwall face is advanced through a panel.C-band interferometric wide swath synthetic aperture radar(SAR)images from the sentinel satellites are used to quantify the *** onset of subsidence occurs close in time to the beginning of the longwall face advance,and overall,the development of subsidence closely follows the longwall face advance.

关键词： DInSAR Subsidence Monitoring Longwall Trona