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Ursolic Acid Derivatives Induced Apoptosis and Reduces the NF-κB in Human Lung Adenocarcinoma Cells

Journal of Cancer Therapy 2019年第10期10卷 863-876页

作者： Elaine Carlos Scherrer Ydia Mariele Valadares Caio Cesar Souza Alves Gabriella Freitas Ferreira Marcela Pereira Leao jessica aline soares Fernando Sa Silva Alessandra Paula Carli Oswaldo Cardoso Jr. Fabiana Simao Machado Sandra Bertelli Ribeiro Castro Life Sciences Institute Federal University of Juiz de ForaGovernador ValadaresMGBrazil Faculty of Medicine Federal University of the Valleys of Jequitinhonha and MucuriTeofilo OtoniMGBrazil Department of Biochemistry and Immunology Federal University of Minas GeraisBelo HorizonteMGBrazil

Lung cancer is the major cause of death in the neoplastic diseases. In spite of the advances in the chemotherapy, the lung cancer treatments are still complex and costly, being necessary the seeking of new drugs. In this context, the ursolic acid (UA) becomes the target of studies that investigate its antitumor potential and, thus, structural modifications can enhance its biological activities. Eight UA semisynthetic derivative compounds (UAD1-8) were synthesized and evaluated their cytotoxic activity against human alveolar adenocarcinoma cells (A549). UAD1, UAD3, UAD5, UAD6 and UAD8 were able to reduce the viability of the A549 cells. Only UAD1 and UAD6 reduced the viability at 24 h, and only UAD3 didn’t reduce the NF-κB expression. The compound UAD1 showed the greater apoptosis induction. Moreover, the compound UAD1 showed better results than UA in all assays. The present study shows, for the first time, the action of these compounds in the apoptotic effect, in the expression of NF-κB and in the A549 cell line. The ursolic acid derivatives showed substantial results in the apoptosis, cytotoxicity and NF-κB inhibition of A549 cells, and further studies are necessary for the development of possible new therapeutic drugs.

关键词： Ursolic Acid Apoptosis NF-κB A549 Cells Tumoral

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Primary Scientific Project in Evaluating the Quality of Life and Healthy Factors in Medical Students of a Private Brazilian University

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Journal of Pharmacy and Pharmacology 2018年第6期6卷 620-625页

作者： Gabriela Carvalho Monnerat Magalhaes Carolina Padilha Tavares Fernanda Tebaldi Henriques de Queiroz jessica Barone Sangineto Rocha Camilla soares Moreira Mariana Montenegro Banharo Lilian soares da Costa Liga Academica de Ciencias Cardiovasculares - LACCAV Fundacao Tecnico Educacional Souza Marques Medical School Rio de Janeiro 21310-310 Brazil

Introduction： Limited data are available regarding medical students’ habits related to long duration shifts and graduation classes that could negatively impact on their academic performance. The objective of this study is to identify the profile factors related to life quality and cardiovascular risk on medical students of a private university in Brazil. Methods： This study is based on a descriptive analysis of cross-sectional cohort of a sample of 490 students from the first to sixth year of medical school. The data were collected through an anonymous questionnaire. Results： Some of the data were： 81.6% of students reported alcohol ingestion, 5.9% are smokers and 13.9% reported use of illicit drugs, 27.9% informed adding salt to the food, 78.4% reported stress/anxiety. Conclusion： After observing all the collected data, a project was built for a longitudinal analysis of the influence of life style during the medical school years on mental and cardiovascular health, short and long term.

关键词： Medical students health cardiovascular risk stress.

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Agronomic and Productivity Performance for Quinoa Genotypes in an Agroecological and Conventional Production System

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American Journal of Plant Sciences 2018年第4期9卷 880-891页

作者： Cristiani Belmonte Edmar soares de Vasconcelos Claudio Yuji Tsutsumi Eloisa Lorenzetti Camila Hendges jessica Caroline Coppo Alexandra da Silva Martinez Renan Pan Tauane Santos Brito Adriano Mitio Inagaki State University of Western Paraná Marechal Candido Rondon Paraná Brazil

The objective of this research was to evaluate the agronomic performance and productivity of sixteen genotypes of Chenopodium quinoa cultivated in agroecological and conventional production systems. The evaluations were carried out, based on agronomic characteristics and yields of sixteen C. quinoa genotypes, grown in two simultaneous experiments, in an agroecological production and a conventional production system carried out at the town of Entre Rios do Oeste, Paraná, Brazil in the harvest 2015/16. Each experiment was composed of three replicates, following the randomized block design. Number of plants in flowering, number of plants per linear meter, height of insertion of the first panicle, number of days for maturation and productivity were the parameters evaluated. The data were submitted to statistical analysis with the aid of the GENES computational application. Genotype Q13-24 showed a more suitable production for the conventional production system. While the genotype Q13-01, presented the increase of productivity, being more indicated to the system of agroecological production. The characteristics height of plant flowers (HPF) and height of insertion of the first panicle (HIP) had higher values when the plants were cultivated in a conventional system. The number of plants per linear meter (NPLM) was higher in the agroecological crop, when compared to conventional cultivation. The same quinoa genotype can behave differently depending on the area management, being a productivity and the genotype cycle depends on the production system and the genotype used.

关键词： Chenopodium quinoa Cultivation Methods Genotypic Adaptability Genetic Breeding

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