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Neural Regeneration Research 2018年第2期13卷 211-221页

作者： jessica m.hogestyn David J.mock margot mayer-Proschel Department of Neuroscience University of Rochester Department of Biomedical Genetics University of Rochester

Human herpesviruses （HVs） have developed ingenious mechanisms that enable them to traverse the defenses of the central nervous system （CNS）. The ability of HVs to enter a state of latency, a defining char- acteristic of this viral family, allows them to persist in the human host indefinitely. As such, HVs represent the most frequently detected pathogens in the brain. Under constant immune pressure, these infections are largely asymptomatic in healthy hosts. However, many neurotropic HVs have been directly connected with CNS pathology in the context of other stressors and genetic risk factors. In this review, we discuss the potential mechanisms by which neurotropic HVs contribute to neurodegenerative disease （NDD） patholo- gy by highlighting two prominent members of the HV family, herpes simplex virus 1 （HSV-1） and human herpesvirus 6 （HHV-6）. We （i） introduce the infectious pathways and replicative cycles of HSV-1 and HHV-6 and then （ii） review the clinical evidence supporting associations between these viruses and the NDDs Alzheimer＇s disease （AD） and multiple sclerosis （mS）, respectively. We then （iii） highlight and dis- cuss potential mechanisms by which these viruses exert negative effects on neurons and glia. Finally, we （iv） discuss how these viruses could interact with other disease-modifying factors to contribute to the initiation and/or progression of NDDs.

关键词： herpes simplex virus 1 human herpesvirus 6 central nervous system neurodegeneration demyelination Alzheimer's disease multiple sclerosis viral latency viral reactivation

Application of DInSAR for short period monitoring of initial subsidence due to longwall mining in the mountain west United States

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International Journal of mining Science and Technology 2020年第1期30卷 33-37页

作者： jessica m.Wempen Department of mining Engineering University of UtahSalt Lake City 84112USA

Differential Interferometric Synthetic Aperture Radar(DInSAR),a satellite-based remote sensing technique,has application for monitoring subsidence with high resolution over short *** uses radar images to measure centimeter-level surface *** the images,ground resolution can be relatively high,with each data point(pixel)representing the average displacement over an area of several square *** image data are acquired regularly which allows subsidence to be monitored sequentially over short periods;imaging periods typically range from weeks to *** subsidence over short periods with high spatial resolution has potential to provide insight into the dynamics of subsidence and into relationships between mine advance and *** this study,for three longwall mines in the western United States,initial subsidence occurring at the start of longwall advance is quantified over short periods(12–72 days).C-band interferometric wide swath Synthetic Aperture Radar(SAR)images from the Sentinel satellites are used to quantify the ***,the data show initial development of subsidence,expansion of the subsidence trough,and the advance of subsidence in the direction of mining.

关键词： Longwall mining Interferometry Subsidence

Quantifying relationships between subsidence and longwall face advance using DInSAR

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International Journal of mining Science and Technology 2021年第1期31卷 91-94页

作者： Bailey S.Simmons jessica m.Wempen Department of mining Engineering University of UtahUT 84112United States

Surface subsidence that results from longwall mining can be large magnitude and can affect significant *** methods for subsidence monitoring include leveling,global positioning system(GPS),and photogrammetric *** sensing techniques including,aerial LiDAR,terrestrial laser scanning,and satellite-based Differential Interferometric Synthetic Aperture Radar(DInSAR),are also used to measure deformation associated with *** data are different than data from conventional subsidence *** capture data over large areas(hundreds of kilometers),and each pixel(data point)in an image quantifies the average displacement over an area of square *** data can have fairly high time resolution;imaging periods typically range from weeks to *** data can be useful to monitor subsidence sequentially over short *** monitoring subsidence may help define if caving is progressing normally and can establish relationships between surface deformation and longwall face advance,which has potential to help quantify possible risks to mine *** this study,subsidence at a longwall trona mine is monitored over short periods,typically 12 days,as the longwall face is advanced through a panel.C-band interferometric wide swath synthetic aperture radar(SAR)images from the sentinel satellites are used to quantify the *** onset of subsidence occurs close in time to the beginning of the longwall face advance,and overall,the development of subsidence closely follows the longwall face advance.

关键词： DInSAR Subsidence monitoring Longwall Trona

Circadian rhythms and inflammatory diseases of the liver and gut

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Liver Research 2023年第3期7卷 196-206页

作者： jessica m.Ferrell Department of Integrative medical Sciences Northeast Ohio Medical UniversityRootstownOHUSA

Circadian rhythms play a central role in maintaining metabolic homeostasis and orchestrating interorgan *** evidence indicates that disruption to rhythms,which occurs through shift work,chronic sleep disruption,molecular clock polymorphisms,or the consumption of alcohol or highfat diets,can influence inflammatory status and disrupt timing between the brain and periphery or between the body and the external *** the liver and gut,circadian rhythms direct the timing of glucose and lipid homeostasis,bile acid and xenobiotic metabolism,and nutrient absorption,making these systems particularly susceptible to the effects of disrupted *** this review,the impacts of circadian disruption will be discussed with emphasis on inflammatory conditions affecting the liver and gut,and the potential for chronotherapy for these conditions will be explored.

关键词： Circadian rhythm Liver Gut Inflammation Non-alcoholic fatty liver disease(NAFLD) Alcohol-associated liver disease(AALD)

Comparison of L-band and X-band differential interferometric synthetic aperture radar for mine subsidence monitoring in central Utah

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International Journal of mining Science and Technology 2017年第1期27卷 159-163页

作者： jessica m.Wempen michael K.mcCarter Department of mining Engineering University of UtahSalt Lake City 84112USA

Differential interferometric synthetic aperture radar(DIn SAR), a satellite-based remote sensing technique, has potential application for measuring mine subsidence on a regional scale with high spatial and temporal resolutions. However, the characteristics of synthetic aperture radar(SAR) data and the effectiveness of DIn SAR for subsidence monitoring depend on the radar band(wavelength). This study evaluates the effectiveness of DIn SAR for monitoring subsidence due to longwall mining in central Utah using L-band(24 cm wavelength) SAR data from the advanced land observing satellite(ALOS)and X-band(3 cm wavelength) SAR data from the Terra SAR-X mission. In the Wasatch Plateau region of central Utah, which is characterized by steep terrain and variable ground cover conditions, areas affected by longwall mine subsidence are identifiable using both L-band and X-band DIn ***, using L-band data, subsidence magnitudes are measurable. Compared to X-band, L-band data are less affected by signal saturation due to large deformation gradients and by temporal decorrelation due to changes in the surface conditions over time. The L-band data tend to be stable over relatively long periods(months). Short wavelength X-band data are strongly affected by signal saturation and temporal decorrelation, but regions of subsidence are typically identifiable over short periods(days). Additionally,though subsidence magnitudes are difficult to precisely measure in the central Utah region using X-band data, they can often be reasonably estimated.

关键词： mine subsidence DInSAR Terra SAR-X ALOS Interferometry

mind on statistics jessica m. Utts, Robert F. Heckard 2nd ed.

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Some insights into how barnacles survive as sessile organisms

2004年

作者： jessica m. Utts Robert F. Heckard

来源：畅想之星图书光盘版（南... 评论

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Integrative Zoology 2009年第4期4卷 395-401页

作者： John S.BUCKERIDGE jessica m.REEVES Earth and Oceanic Systems Research Group RMIT UniversityMelbourneAustralia

During routine chemical analyses of the stalked ibliform barnacle Chaetolepas calcitergum Buckeridge&Newman 2006,peaks of more than 7%(by dry mass)of bromine were *** bromine ions occur in seawater(up to 66 ppm),this level of accumulation,in the soft tissue of the barnacle,is *** concentration of bromine compounds occurs in a number of invertebrates,such as algae and sponges,but this is the first record of elevated bromine in goose *** high accumulation of bromine compound(s)is most likely a defense *** present paper includes a review of the mechanisms deployed by barnacles to repel predators.

关键词： bromine Chaetolepas calcitergum Cirripedia defense mechanisms Ibliformes.

Extrinsic inhibitors in axon sprouting and functional recovery after spinal cord injury

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Neural Regeneration Research 2014年第5期9卷 460-461页

作者： jessica m.meves Binhai Zheng Neurosciences Graduate Program Department of Neurosciences University of California San Diego School of Medicine 9500 Gilman DriveMC 0691 La Jolla CA USA

The limited axonal growth after central nervous system （CNS） injury such as spinal cord injury presents a major challenge in promoting repair and recovery. The literature in axonal repair has focused mostly on frank regeneration of injured axons. Here, we argue that sprouting of uninjured axons, an innate repair mech- anism of the CNS, might be more amenable to modulation in order to promote functional repair. Extrinsic inhibitors of axonal growth modulate axon sprouting after injury and may serve as the first group of therapeutic targets to promote functional repair.

关键词： CNS Omgp Extrinsic inhibitors in axon sprouting and functional recovery after spinal cord injury

Glucocorticoids and nervous system plasticity

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Neural Regeneration Research 2016年第1期11卷 37-41页

作者： Kathryn m.madalena jessica K.Lerch Center for Brain and Spinal Cord Repair The Ohio State University Department of Neuroscience Wexner Medical Center at The Ohio State University

Glucocorticoid and glucocorticoid receptor（GC/GR） interactions alter numerous aspects of neuronal function. These consequences（e.g., anti-inflammatory vs. pro-inflammatory） can vary depending on the duration of GC exposure or central nervous system（CNS） injury model. In this review we discuss how GC/GR interactions impact neuronal recovery after a central or peripheral nerve injury and discuss how GC exposure duration can produce divergent CNS neuronal growth responses. Finally we consider how new findings on gender specific immune cell responses after a nerve injury could intersect with GC/GR interactions to impact pain processing.

关键词： glucocorticoids plasticity stress neuropathic pain

Circadian rhythms in liver metabolism and disease

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Acta Pharmaceutica Sinica B 2015年第2期5卷 113-122页

作者： jessica m.Ferrell John Y.L.Chiang Department of Integrative medical Sciences Northeast Ohio Medical University

mounting research evidence demonstrates a significant negative impact of circadian disruption on human health. Shift work, chronic jet lag and sleep disturbances are associated with increased incidence of metabolic syndrome, and consequently result in obesity, type 2 diabetes and ***, these associations are reviewed with respect to liver metabolism and disease.

关键词： Circadian rhythm Liver metabolic syndrome Type 2 diabetes