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Muscle force and movement variability before and after total knee arthroplasty: A review

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World Journal of Orthopedics 2014年第2期5卷 69-79页

作者： Jessica W Smith jesse c.christensen Robin L Marcus Paul c LaStayo Department of Bioengineering University of Utah Salt Lake City UT 84108-1290 United States Department of Physical Therapy University of Utah Salt Lake City UT 84108-1290 United States Department of Orthopedics University of Utah Salt Lake City UT 84108-1290 United States Department of Exercise and Sport Science University of Utah Salt Lake City UT 84108-1290 United States

Variability in muscle force output and movement variability are important aspects of identifying individuals with mobility deficits, central nervous system impairments, and future risk of falling. This has been investigated in elderly healthy and impaired adults, as well as in adults with osteoarthritis(OA), but the question of whether the same correlations also apply to those who have undergone a surgical intervention such as total knee arthroplasty(TKA) is still being investigated. While there is a growing body of literature identifying potential rehabilitation targets for individuals who have undergone TKA, it is important to first understand the underlying post-operative impairments to more efficiently target functional deficits that may lead to improvedlong-term outcomes. The purpose of this article is to review the potential role of muscle force output and movement variability in TKA recipients. The narrative review relies on existing literature in elderly healthy and impaired individuals, as well as in those with OA before and following TKA. The variables that may predict longterm functional abilities and deficits are discussed in the context of existing literature in healthy older adults and older adults with OA and following TKA, as well as the role future research in this field may play in providing evidence-based data for improved rehabilitation targets.

关键词： Osteoarthritis Elderly Total knee arthroplasty Movement variability

Deep learning for exploring ultra-thin ferroelectrics with highly improved sensitivity of piezoresponse force microscopy

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npj computational Materials 2023年第1期9卷 2066-2073页

作者： Panithan Sriboriboon Huimin Qiao Owoong Kwon Rama K.Vasudevan Stephen jesse Yunseok Kim School of Advanced Materials and Engineering Sungkyunkwan University(SKKU)SuwonRepublic of Korea Research center for Advanced Materials Technology Core Research InstituteSuwonRepublic of Korea center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTNUSA

Hafnium oxide-based ferroelectrics have been extensively studied because of their existing ferroelectricity,even in ultra-thin film ***,studying the weak response from ultra-thin film requires improved measurement *** general,resonance-enhanced piezoresponse force microscopy(PFM)has been used to characterize ferroelectricity by fitting a simple harmonic oscillation model with the resonance ***,an iterative approach,such as traditional least squares(LS)fitting,is sensitive to noise and can result in the misunderstanding of weak *** this study,we developed the deep neural network(DNN)hybrid with deep denoising autoencoder(DDA)and principal component analysis(PcA)to extract resonance *** DDA/PcA-DNN improves the PFM sensitivity down to 0.3 pm,allowing measurement of weak piezoresponse with low excitation voltage in 10-nm-thick Hf_(0.5)Zr_(0.5)O_(2) thin *** hybrid approaches could provide more chances to explore the low piezoresponse of the ultra-thin ferroelectrics and could be applied to other microscopic techniques.

关键词： spectrum ferroelectric excitation

Shape-dependence in seeded-growth of Pd-cu solid solution from Pd nanostructure towards methanol oxidation electrocatalyst

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Nano Research 2023年第7期16卷 9116-9124页

作者： Lianxi Si Hui Li Yu Zhang Donghao Zhang Xiaowei An Mengmeng Yao Yuanyuan Shao jesse Zhu Shi Hu School of chemical Engineering and Technology Tianjin UniversityTianjin 300072China Department of chemistry School of ScienceTianjin Key Laboratory of Molecular Optoelectronic ScienceTianjin UniversityTianjin 300072China college of Environmental Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China

Ultrathin Pd nanosheets(NSs)have great advantages in catalysis due to their large specific surface area and high percentage of under-coordinated ***,the electrochemical performance still can be improved via composition-controllable growth of their solid ***,seeded alloying strategy was proposed to synthesize Pd-cu solid solution from Pd NSs and Pd-cu nanostructures with tunable molar ratios obtained by changing the amount of cu *** compared to the pristine Pd NSs,the Pd-cu solid solution shows significantly enhanced methanol oxidation reaction(MOR)performance over those of Pd NSs and homemade Pd/c as the incorporation of cu weakens the adsorption of cO intermediate on Pd in the MOR *** choice of template is pivotal to the growth,as a shape-dependent behavior could be identified in the alloying of cu with Pd nanosheets enclosed by{111}and{100}facets,Pd nanocubes enclosed by{100}facet,and Pd nano-tetrahedrons enclosed by{111}*** Pd-cu solid solution with tunable composition can only be obtained from Pd NSs and the shape-dependent alloying process is mainly determined by the diffusion barrier and the minimum diffusion depth of the different facets.

关键词： Pd-cu alloy nanosheets tunable composition methanol oxidation reaction optimized electronic structure weakened cOadsorption

Time scales and length scales in magma ?ow pathways and the origin ofmagmatic Ni-cu-PGE ore deposits

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Geoscience Frontiers 2019年第1期10卷 77-87页

作者： Stephen J.Barnes jesse c.Robertson cSIRO Mineral Resources

Ore forming processes involve the redistribution of heat, mass and momentum by a wide range of processes operating at different time and length scales. The fastest process at any given length scale tends to be the dominant control. Applying this principle to the array of physical processes that operate within magma flow pathways leads to some key insights into the origins of magmatic Ni-cu-PGE sulfide ore deposits. A high proportion of mineralised systems, including those in the super-giant Noril'sk-Talnakh camp, are formed in small conduit intrusions where assimilation of country rock has played a major role. Evidence of this process is reflected in the common association of sulfides with varitextured contaminated host rocks containing xenoliths in varying stages of assimilation. Direct incorporation of S-bearing country rock xenoliths is likely to be the dominant mechanism for generating sulfide liquids in this setting. However, the processes of melting or dissolving these xenoliths is relatively slow compared with magma flow rates and, depending on xenolith lithology and the composition of the carrier magma, slow compared with settling and accumulation rates. chemical equilibration between sulfide droplets and silicate magma is slower still, as is the process of dissolving sulfide liquid into initially undersaturated silicate magmas. Much of the transport and deposition of sulfide in the carrier magmas may occur while sulfide is still incorporated in the xenoliths, accounting for the common association of magmatic sulfide-matrix ore breccias and contaminated "taxitic" host rocks. Effective upgrading of so-formed sulfide liquids would require repetitive recycling by processes such as reentrainment, back flow or gravity flow operating over the lifetime of the magma transport system as a whole. In contrast to mafic-hosted systems, komatiite-hosted ores only rarely show an association with externally-derived xenoliths, an observation which is partially due to the pre

关键词： Magmatic ore deposits Assimilation Intrusions Nickel Norilsk Komatiites

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Description of two new species of Hemiphyllodactylus(Reptilia: Gekkonidae) from karst landscapes in Yunnan, china, highlights complex conservation needs

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Zoological Research 2022年第5期43卷 767-786页

作者： Ade Prasetyo Agung Ada chornelia L.Lee Grismer jesse L.Grismer Evan S.H.Quah Jian-Mei Lu Kyle W.Tomlinson Alice c.Hughes Landscape Ecology Group Center for Integrative ConservationXishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunMenglaYunnan 666303China University of chinese Academy of Sciences Beijing 101408China Herpetology Laboratory Department of BiologyLa Sierra UniversityRiversideCalifornia 92515USA Institute for Tropical Biology and conservation Universiti Malaysia SabahJalan UMSKota KinabaluSabah 88400Malaysia Lee Kong chian Natural History Museum National University of SingaporeSingapore 117377Singapore community Ecology and conservation Group Center for Integrative ConservationXishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunMenglaYunnan 666303China School of Biological Sciences University of Hong KongPokfulamHong Kong SARChina

Karst habitats are hotspots of diversity and endemism. Their naturally fragmented distributions across broad geographic landscapes have led to the complex array of smaller evolutionary ecosystems that present unique challenges from a conservation *** assessments of karst habitats have revealed that these ecosystems contain an almost unparalleled level of endemism, and many site-restricted species remain undescribed, thus posing considerable challenges for effective conservation *** rock-dwelling species, such as geckos, may be particularly prone to such isolation. In this paper, we discuss one such genus, i.e.,Hemiphyllodactylus, and explore its diversity across karst landforms in Yunnan Province, southwestern china. Based on morphological and genetic data, we describe two new species of Hemiphyllodactylus from karst habitats in Simao District and Yanshan county. A phylogenetic tree for Hemiphyllodactylus was constructed using 1?039 base pairs(bp) of the mitochondrial NADH dehydrogenase subunit 2 gene(ND2). The Simao and Yanshan specimens can be distinguished from all other congeners within their respective subclades based on uncorrected genetic pairwise distances greater than 6.3% and 4.3%respectively, as well as significant morphological differences. The discovery and description of these two new species brings the total number of described Hemiphyllodactylus species in china to 14and indicates many more undescribed species from unsurveyed karst regions await *** findings suggest that karst ecosystems in Yunnan support a higher diversity of Hemiphyllodactylus than previously *** study also highlights the importance of karst ecosystems as refugia for sitespecific endemic species and the need for heightened conservation efforts.

关键词： Discovery Endemism Geckos Reptiles South china

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cluster identification using image processing

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Particuology 2015年第6期13卷 16-24页

作者： Jingsi Yang jesse Zhu Particle Technology Research centre Department of Chemical and Biochemical Engineering University of Western Ontario London Ontario N6A 5B9Canada

By closely examining hue, saturation and value （HSV） images of the solids holdup distribution in a riser, it can be seen that a ＂cluster＂ is the combination of a relatively stable core cluster of the highest solids holdups and constantly changing cluster clouds of solids holdups that are higher than the dilute phase. Based on this analysis, a threshold selection method maximizing the inter-class variance between the background and foreground classes is introduced. A systematic cluster identification process is therefore proposed that：（｜） applies the threshold selection method to obtain the critical solids holdup threshold ~c to discriminate dense and dilute phases and （2） applies the method again in the dense phase regions to obtain the cluster solids holdup threshold Ssct that identifies the core clusters. Using this systematic process, clusters of different shapes and sizes and a relatively clear boundary can be visualized clearly and identified accurately. Using ~sct, the core cluster fraction is calculated by dividing the total number of pixels in the core cluster by the total number of image pixels. The variation of the core cluster fraction according to operating conditions is also discussed.

关键词： cluster identification Image processingcluster fractionRectangular circulating fluidized bed riser

Therapeutic anticoagulation for splanchnic vein thrombosis in acute pancreatitis: A national survey and case-vignette study

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World Journal of Gastroenterology 2023年第21期29卷 3328-3340页

作者： Noor J Sissingh jesse V Groen Hester c Timmerhuis Marc G Besselink Bas Boekestijn Thomas L Bollen Bert A Bonsing Frederikus A Klok Hjalmar c van Santvoort Robert c Verdonk casper H J van Eijck Jeanin E van Hooft Jan Sven D Mieog Department of Gastroenterology and Hepatology Leiden University Medical CentreLeiden 2333 ZANetherlands Department of Research and Development St.Antonius HospitalNieuwegein 3420 EMNetherlands Department of Surgery Leiden University Medical CentreLeiden 2333 ZANetherlands Department of Surgery St.Antonius HospitalNieuwegein 3420 EMNetherlands Department of Surgery Amsterdam UMCLocation University of AmsterdamAmsterdam 1081 HZNetherlands Amsterdam Gastroenterology Endocrinology Metabolism Amsterdam 1105 AZNetherlands Department of Radiology Leiden University Medical CentreLeiden 2333 ZANetherlands Department of Radiology St.Antonius HospitalNieuwegein 3420 EMNetherlands Department of Medicine-Thrombosis and Hemostasis Leiden University Medical CentreLeiden 2333 ZANetherlands Department of Surgery University Medical Centre UtrechtUtrechtUtrecht 3584 CXNetherlands Department of Gastroenterology and Hepatology St.Antonius HospitalNieuwegein 3420 EMNetherlands Department of Surgery Erasmus Medical CentreRotterdam 3015 GDNetherlands

BAcKGROUND Splanchnic vein thrombosis(SVT)is a major complication of moderate and severe acute *** is no consensus on whether therapeutic anticoagulation should be started in patients with acute pancreatitis and *** To gain insight into current opinions and clinical decision making of pancreatologists regarding SVT in acute *** A total of 139 pancreatologists of the Dutch Pancreatitis Study Group and Dutch Pancreatic cancer Group were approached to complete an online survey and case vignette *** threshold to assume group agreement was set at 75%.RESULTS The response rate was 67%(n=93).Seventy-one pancreatologists(77%)regularly prescribed therapeutic anticoagulation in case of SVT,and 12 pancreatologists(13%)for narrowing of splanchnic vein *** most common reason to treat SVT was to avoid complications(87%).Acute thrombosis was the most important factor to prescribe therapeutic anticoagulation(90%).Portal vein thrombosis was chosen as the most preferred location to initiate therapeutic anticoagulation(76%)and splenic vein thrombosis as the least preferred location(86%).The preferred initial agent was low molecular weight heparin(LMWH;87%).In the case vignettes,therapeutic anticoagulation was prescribed for acute portal vein thrombosis,with or without suspected infected necrosis(82%and 90%),and thrombus progression(88%).Agreement was lacking regarding the selection and duration of long-term anticoagulation,the indication for thrombophilia testing and upper endoscopy,and about whether risk of bleeding is a major barrier for therapeutic *** In this national survey,the pancreatologists seemed to agree on the use of therapeutic anticoagulation,using LMWH in the acute phase,for acute portal thrombosis and in the case of thrombus progression,irrespective of the presence of infected necrosis.

关键词： Acute pancreatitis Splanchnic vein thrombosis Therapeutic anticoagulation Bleeding Recanalization Outcomes

IFN-γ^(+) cytotoxic cD4^(+) T lymphocytes are involved in thepathogenesis of colitis induced by IL-23 and the foodcolorant Red 40

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cellular & Molecular Immunology 2022年第7期19卷 777-790页

作者： Lili chen Zhengxiang He Bernardo S.Reis jesse D.Gelles Jerry Edward chipuk Adrian T.Ting Julie A.Spicer Joseph A.Trapani Glaucia c.Furtado Sergio A.Lira Precision Immunology Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA Laboratory of Mucosal Immunology The Rockefeller UniversityNew YorkNY 10065USA Department of Oncological Sciences Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA The Tisch cancer Institute Icahn School of Medicine at Mount SinaiNew YorkNY 10029USA The Diabetes Obesityand Metabolism InstituteIcahn School of Medicine at Mount SinaiNew YorkNY 10029USA Department of Immunology Mayo ClinicRochesterMN 55905USA Auckland cancer Society Research centre Faculty of Medical and Health SciencesThe University of AucklandPrivate Bag 92019Auckland 1142New Zealand cancer Immunology Program Peter MacCallum Cancer Centre305 Grattan StreetMelbourneVIC 3000Australia

The food colorant Red 40 is an environmental risk factor for colitis development in mice with increased expression of interleukin(IL)-*** immune response is mediated by cD4^(+)T cells,but mechanistic insights into how these cD4^(+)T cells trigger andperpetuate colitis have remained ***,using single-cell transcriptomic analysis,we found that several cD4^(+)T-cell subsetsare present in the intestines of colitic mice,including an interferon(IFN)-γ-producing *** vivo challenge of primed mice withRed 40 promoted rapid activation of cD4^(+)T cells and caused marked intestinal epithelial cell(IEc)apoptosis that was attenuated bydepletion of cD4^(+)cells and blockade of IFN-γ.Ex vivo experiments showed that intestinal cD4^(+)T cells from colitic mice directlypromoted apoptosis of IEcs and intestinal ***4^(+)T cell-mediated cytotoxicity was contact-dependent and required FasL,which promoted caspase-dependent cell death in target *** ablation of IFN-γconstrained IL-23-and Red 40-inducedcolitis development,and blockade of IFN-γinhibited epithelial cell death in *** results advance the understanding of themechanisms regulating colitis development caused by IL-23 and food colorants and identify IFN-γ^(+)cytotoxic cD4^(+)T cells as a newpotential therapeutic target for colitis.

关键词： Allura Red IL23 cytotoxic cD4^(+)T cells cD4^(+)cTL Inflammation Epithelium damage colitis

Dry powder platform for pulmonary drug delivery

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Particuology 2008年第4期6卷 225-238页

作者： Derek Ivan Daniher jesse Zhu Graduate Program in Biomedical Engineering Department of Chemical and Biochemical EngineeringThe University of Western OntarioLondonOntarioCanada

The phenomenon of particle interaction involved in pulmonary drug delivery belongs to a wide variety of disciplines of particle technology, in particular, fluidization. This paper reviews the basic concepts of pulmonary drug delivery with references to fluidization research, in particular, studies on Geldart group c powders. Dry powder inhaler device-formulation combination has been shown to be an effective method for delivering drugs to the lung for treatment of asthma, chronic obstructive pulmonary disease and cystic fibrosis. Even with advanced designs, however, delivery efficiency is still poor mainly due to powder dispersion problems which cause poor lung deposition and high dose variability. Drug particles used in current inhalers must be 1–5 μm in diameter for effective deposition in small-diameter airways and alveoli. These powders are very cohesive, have poor flowability, and are difficult to disperse into aerosol due to cohesion arising from van der Waals attraction. These problems are well known in fluidization research, much of which is highly relevant to pulmonary drug delivery.

关键词： Dry powder inhaler Interparticle forces Aerosol Pulmonary drug delivery carrier particle Fluidization

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