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Targeted prostate biopsy： value of multiparametric magnetic resonance imaging in detection of localized cancer

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Asian Journal of Andrology 2014年第4期16卷 522-529页

作者： jesse D Le Jiaoti Huang Leonard s Marks Departments of Urology University of California Los Angeles USA. Pathology University of California Los Angeles USA.

Prostate cancer is the second most common cancer in men, with 1.1 million new cases worldwide reported by the World Health Organization in one recent year. Transrectal ultrasound （TRUs）-guided biopsy has been used for the diagnosis of prostate cancer for over 2 decades, but the technique is usually blind to cancer location. Moreover, the false negative rate of TRUs biopsy has been reported to be as high as 47%. Multiparametric magnetic resonance imaging （mp-MRI） includes T1- and T2-weighted imaging as well as dynamic contrast-enhanced （DCE） and diffusion-weighted imaging （DWI）. mp-MRI is a major advance in the imaging of prostate cancer, enabling targeted biopsy of suspicious lesions. Evolving targeted biopsy techniquesmincluding direct in-bore biopsy, cognitive fusion and software-based MRI-ultrasound （MRI-Us） fusion--have led to a several-fold improvement in cancer detection compared to the earlier method. Importantly, the detection of clinically significant cancers has been greatly facilitated by targeting, compared to systematic biopsy alone. Targeted biopsy via MRI-Us fusion may dramatically alter the way prostate cancer is diagnosed and managed.

关键词： fusion biopsy magnetic resonance imaging (MRI) prostate biopsy prostate cancer targeted biopsy ultrasound

Fast raycasting using a compound deep image for virtual point light range determination

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Computational Visual Media 2019年第3期5卷 257-265页

作者： jesse Archer Geoff Leach Pyarelal Knowles school of science RMIT University

The concept of using multiple deep images,under a variety of different names, has been explored as a possible acceleration approach for finding raygeometry intersections. We leverage recent advances in deep image processing from order independent transparency for fast building of a compound deep image(CDI) using a coherent memory format well suited for raycasting. We explore the use of a CDI and raycasting for the problem of determining distance between virtual point lights(VPLs) and geometry for indirect lighting,with the key raycasting step being a small fraction of total frametime.

关键词： deep image indirect lighting raycasting

Improving flow and fluidization quality of fine and ultrafine particles via nanoparticle modulation

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Nano Research 2023年第10期16卷 12013-12025页

作者： Jiaying Wang Yuanyuan shao jesse Zhu Department of Chemical and Biochemical Engineering The University of Western OntarioLondonOntario N6A 3K7Canada school of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China Beacons of Excellence Research and Innovation Institute University of NottinghamNingbo 315100China

Fine and ultrafine particles possess great potential for industrial applications ascribed from their huge specific surface area and ability to provide good gas–solid ***,these powders are inherently cohesive,making it challenging to achieve smooth flow and *** challenge can be well-resolved by nanoparticle modulation(nano-modulation),where a small amount of nanoparticles is uniformly mixed with the cohesive fine/ultrafine *** nano-modulation,the fluidization system of cohesive powders exhibits distinguishable minimum fluidization velocity,enlarged bed expansion ratio(particularly the dense phase expansion),and scarcer,smaller,and slower moving bubbles,indicating improved flow and fluidization *** purpose of the current work is to systematically summarize the state-of-the-art progress in the fluidization and utilization of fine and ultrafine particles via the nanoparticle modulation ***,a broader audience can be enlightened regarding this promising fine/ultrafine particle fluidization technology,so as to provoke their attention and encourage interdisciplinary integration and industry-academia collaborative research.

关键词： fine particle ultrafine particle cohesive powder flowability fluidization nanoparticle modulation

special Issue for the Future Chemical Engineering scholars of Global Chinese Chemical Engineering symposium

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Frontiers of Chemical science and Engineering 2022年第6期16卷 775-776页

作者： jesse Zhu Junwu Wang Particle Technology Research Centre Western UniversityLondonOntario N6A 5B9Canada state Key Laboratory of Multiphase Complex systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

The Global Chinese Chemical Engineering symposium(GCCEs)is a prestigious and world-wide platform for the communication and academic exchange of chemical science and *** addition to its key roles in international academic exchanges and collaborations,as well as cross-disciplinary integration and industrial-academic co-operation,the GCCEs strongly promotes the professional development of young Chinese chemical engineers and scientists by founding series of special forums for the winners of the Excellent Postgraduate Academic Forum,the Young Researchers Forum,the Future Chemical Engineering scholars,and the International Award for Outstanding Young Chemical Engineers.

关键词： founding Global scholars

special Issue for the 14th Global Chinese Chemical Engineering symposium

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Frontiers of Chemical science and Engineering 2023年第10期17卷 1321-1322页

The Global Chinese Chemical Engineering symposium(GCCEs)is a prestigious and world-wide platform for the communication and academic exchange of chemical science and *** special issue is a collection of the keynote lectures presented by the winners of Future Chemical Engineering scholars,the Global Award for Outstanding Young Female Chemical Engineers,and the International Award for Outstanding Young Chemical Engineers,selected by the International scientific Committee of the GCCEs.

关键词： engineering. Global Engineers

Nitrogen distribution in the products from the hydrothermal liquefaction of Chlorella sp. and spirulina sp.

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Frontiers of Chemical science and Engineering 2022年第6期16卷 985-995页

作者： Tianyi Bao Yuanyuan shao Haiping Zhang jesse Zhu school of Chemical Engineering of Technology Tianjin UniversityTianjin 300072China Tianjin Key Laboratory of Membrane science and Desalination Technology Tianjin 300072China Department of Chemical&Biochemical Engineering The University of Western OntarioOntario N6A 3K7Canada

The high contents of nitrogen-containing organic compounds in biocrude obtained from hydrothermal liquefaction of microalgae are one of the most concerned issues on the applications and *** the project,Chlorella *** spirulina *** selected as raw materials to investigate the influence of different reaction conditions(i.e.,reaction temperature,residence time,solid loading rate)on the distribution of nitrogen in the oil phase and aqueous *** main forms of nitrogen-containing organic compounds including nitrogen-heterocyclic compounds,amide,and amine were detected in *** contents of nitrogen-heterocyclic compounds decreased with temperature while amide kept *** effect of residence time on the components of nitrogen-containing organic compounds was similar with that of ***,the influence of solid loading rate was ***,it was also found that the differences of amino acids in the protein components in the two microalgae might affect the nitrogen distribution in *** example,nitrogen in basic amino acids of spirulina *** to go into the aqueous phase comparing with the nitrogen in neutral amino acids of Chlorella *** summary,a brief reaction map was proposed to describe the nitrogen pathway during microalgae hydrothermal liquefaction.

关键词： microalgae hydrothermal liquefaction biocrude nitrogen distribution

Micro-flow structure at regime transition from bubbling to turbulent fluidization in a fluidized bed

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Particuology 2024年第6期89卷 117-130页

作者： Chaoyu Yan Yue Yuan Xiaoyang Wei jesse Zhu state Key Laboratory of Heavy Oil Processing Beijing Key Laboratory of Process Fluid Filtration and SeparationCollege of Mechanical and Transportation EngineeringChina University of PetroleumBeijing 102249China China Beacons Institute The University of NottinghamNingbo315100China Department of Chemical and Biochemical Engineering University of Western OntarioLondonOntarioN6A 5B9Canada

Gas-solid fluidized beds have found extensive utilization in frontline manufacturing,in particular as low-velocity *** fluidization status,the bubbling or turbulent flow regime and the transition in between,determine the system performance in practical *** the convoluted hydrodynamics are quantitively evaluated through numerous data-processing methodologies,none of them alone can reflect all the critical information to identify the transition from the bubbling to the turbulent ***,this study was to exploit a coupling data processing methodology,in the combination of standard deviation,power spectrum density,probability density function,wavelet transform,and wavelet multiresolution method,to jointly explain the micro-flow structure at the regime transition from bubbling to turbulent *** transient differential pressure fluctuation was measured for the evaluation in a fluidized bed(0.267 m i.d.×2.5 m height)with FCC catalysts(d_(p)=65μm,ρ_(p)=1780kg/m^(3))at different superficial gas velocities(0.02–1.4 m/s).The results show that the onset of turbulent fluidization starts earlier in the top section of the bed than in the bottom *** wavelet decomposition displays that the fluctuation of differential pressure mainly concentrates on the sub-signals with an intermediate frequency *** sub-signals could be synthesized into three types of scales(micro-scale,meso-scale,and macro-scale),representing the multi-scale hydrodynamics in the fluidized *** micro-scale signal has the characteristic information of bubbling fluidization,and the characteristic information of turbulent fluidization is mainly represented by the meso-scale *** work provides a systematic comprehension of fluidization status assessment and serves as an impetus for more coupling analysis in this sector.

关键词： Flow regime transition Bubbling fluidization Turbulent fluidization Micro-flow structure Differential pressure fluctuation

Innovative manufacturing technology enabling light weighting with steel in commercial vehicles

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Advances in Manufacturing 2015年第1期3卷 3-18页

作者： Hardy Mohrbacher Marius spottl jesse Paegle NiobelCon bvba SchildeBelgium WIsCO Lasertechnik GmbH RavensburgGermany Gestamp Sao PauloBrazil

Improved manufacturing technology is often needed when working with high strength steel. In this re- spect manufacturing technology has to adapt to the altered （and typically reduced） formability and weldability of modern high strength steel. However, this is a rather passive approach from a manufacturing point of view. An indeed much more powerful approach is to generate synergies between innovative manufacturing technology, design and material enabling additional weight savings and efficiency gains. Laser-based material processing, in particular laser welding, offers a wide range of opportunities in this sense. Furthermore, hot stamping and roll forming open up new possibilities for advanced manufacturing of commercial vehicle components. Applications and examples of these technologies will be given in terms of producing innovative semi-products as well as final components.

关键词： Commercial vehicles . Light weightingstrength steel . Roll forming - Press forming - Hotstamping . Tailor-welded blanks .Tailor-welded coils

The current landscape for the treatment of mitochondrial disorders

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Journal of Genetics and Genomics 2018年第2期45卷 71-77页

作者： jesse slone Baoheng Gui Taosheng Huang Division of Human Genetics Cincinnati Children's Hospital Medical Center 3333 Burnet Avenue Cincinnati OH 45229 USA Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region Nanning 530002 China Human Aging Research Institute Nanchang University Nanchang 330031 China

The mitochondrial organelle is crucial to the energy metabolism of the eukaryotic cell. Defects in mitochondrial function lie at the core of a wide range of disorders, including both rare primary mitochondrial disorders and more common conditions such as Parkinson＇s disease and diabetes. Inherited defects in mitochondrial function can be found in both the nuclear genome and the mitochondrial genome, with the latter creating unique challenges in the treatment and understanding of disease passed on through the mitochondrial genome. In this review, we will describe the limited treatment regimens currently used to alleviate primary mitochondrial disorders, as well as the potential for emerging technologies（in particular, those involving direct manipulation of the mitochondrial genome） to more decisively treat this class of disease. We will also emphasize the critical parallels between primary mitochondrial disorders and more common ailments such as cancer and diabetes.

关键词： Mitochondrial disease Genetic disorders Therapy