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长距离水平定向钻进穿越阿萨巴斯卡河案例分析

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非开挖技术 2017年第4期 23-28页

作者： Sam Wilson Brent Goerz jesse Bajnok 彭博

TransCanada公司提出了北方快速管道项目（NCP）的设计和施工方案、、管道工程包括七条大型河流穿越和一条主要通道穿越，其中七条河流穿越每条长度均超过700m.穿越距离最大的是位于FortMackay，Alberta的阿萨巴斯卡河、该项目穿越长度... 详细信息

TransCanada公司提出了北方快速管道项目（NCP）的设计和施工方案、、管道工程包括七条大型河流穿越和一条主要通道穿越，其中七条河流穿越每条长度均超过700m.穿越距离最大的是位于FortMackay，Alberta的阿萨巴斯卡河、该项目穿越长度达2196m（7205ft），钻孔直径1．37m（54in），在北美HDD施工历史中具有里程碑式的意义，由于该项目规模大，技术复杂，需要进行详细的预先规划，以评估可行性，并考虑穿越相关的问题。HDD施工需要使用一些新的工程技术，施工工法和固定技术来实现最终目标，达到管道的预期功能。客户，工程团队和HDD承包商在施工阶段共同合作，顺利完成穿越任务本文将讨论在设计阶段面，临的挑战以及HDD穿越阿萨巴斯卡河施工过程中遇到的风险。

关键词：水平定向钻进长距离穿越管线铺设非开挖

Soluble Structure of CLIC and S100 Proteins Investigated by Atomic Force Microscopy

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医学遗传科住院医师规范化培训中伦理学教育的现状及实施述评

Journal of Biomaterials and Nanobiotechnology（生物材料与纳米技术） 2011年第1期

作者： Stella M. Valenzuela Mark Berkahn Alexander Porkovich Thuan Huynh jesse Goyette Donald K. Martin Carolyn L. Geczy

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中华医学遗传学杂志 2021年第11期38卷 1037-1040页

作者：张竹王和李岭张雪梅刘洪倩胡婷王婧祝茜赖怡刘珊玲四川大学华西第二医院医学遗传科四川大学出生缺陷与相关妇儿疾病教育部重点实验室成都610041 四川大学华西医院生物治疗国家重点实验室《中华医学遗传学杂志》编辑部成都610041

医学遗传学的临床应用涉及利用各种遗传学技术和手段对遗传病进行检测和诊断,并进行后续的咨询和相关治疗。将遗传学知识应用于临床实践时,必须充分考虑伦理学的原则。因此,伦理学教育是医学遗传科住院医师规范化培训不可或缺的内容。... 详细信息

医学遗传学的临床应用涉及利用各种遗传学技术和手段对遗传病进行检测和诊断,并进行后续的咨询和相关治疗。将遗传学知识应用于临床实践时,必须充分考虑伦理学的原则。因此,伦理学教育是医学遗传科住院医师规范化培训不可或缺的内容。本院在建立了医学遗传科医师培训基本体系的基础上,通过包括专题讲座、网络教学、案例教学、情景教学以及教学门诊等多种形式的教学实践,对住院医师培训中的伦理学教学进行了初步探索,以期提升学员的伦理学知识、职业素养及临床沟通能力,将医学伦理学贯穿于医疗实践的始终。

关键词：医学遗传学医学伦理学规范化培训

吗啡为主的麻醉对心脏择期手术后患者的早期恢复更优于芬太尼

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麻醉与镇痛 2011年第1期7卷 29-38页

作者： Glenn S. Murphy Joseph W. Szokol jesse H. Marymont Steven B. Greenberg Michael J. Avram Jeffery S. Vender Saadia S. Sherwani Margarita Nisman Victoria Doroski 朱娟(译) 崔苏扬(校) Department of Anesthesiology North Shore University Health System Evanston Illinois 不详

背景实验研究和临床资料显示吗啡具有独特的心脏保护和抗炎特性。本临床研究主要探讨手术中阿片类药物（吗啡或芬太尼）的选择是否会影响心脏手术后患者的早期恢复。方法90例行体外循环心脏手术的患者被随机分为两组，分别用40mg吗啡或6... 详细信息

背景实验研究和临床资料显示吗啡具有独特的心脏保护和抗炎特性。本临床研究主要探讨手术中阿片类药物（吗啡或芬太尼）的选择是否会影响心脏手术后患者的早期恢复。方法90例行体外循环心脏手术的患者被随机分为两组，分别用40mg吗啡或600Ixg芬太尼联合异氟烷进行复合麻醉。在手术前以及手术后第1至第3天分别使用QoR-40调查问卷评估恢复情况，在手术后前3天使用100mm视觉模拟评分法（VAS）测定疼痛程度，记录各种静脉以及口服用药（吗啡或对乙酰氨基酚／羟考酮）的用量。同时评估血流动力学参数、气管插管保留时间、手术后发热反应情况、器官受损情况、ICU入住天数和住院时间。结果在不同时间点，吗啡组患者的QoR-40评分均高于芬太尼组，平均值分别为：手术后第1天（173与160，P〈0．0001），第2天（174与164，P〈0．0001），第3天（177与167，P〈0．001）。两组之间的差异主要表现在QoR-40量表中的情绪状态、身体舒适度以及疼痛等方面（P〈0．01。0．0001）。吗啡组患者的手术后VAS评分、ICU及手术室内疼痛药物用量以及手术后发热反应均较芬太尼组明显降低（均为P〈0．01）。气管插管保留时间、ICU以及总住院时间、手术后并发症等方面，两组间无明显差异。结论做为复合麻醉的一部分，手术中使用40mg吗啡对于择期行体外循环心脏手术的患者手术后生活质量以及疼痛的改善等方面较芬太尼更为优越。

关键词：术后患者心脏保护复合麻醉早期恢复芬太尼吗啡择期体外循环心脏手术

46,XY,t(6;13)(p11.2;q21.2)伴身材矮小一例

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中华医学遗传学杂志 2020年第4期37卷 396-396页

作者：平慧李守霞郭红霞邯郸市中心医院检验科河北056001

患者男,10岁,因身材矮小来我院内分泌科就诊。垂体磁共振成像、肝胆肾B超检查均未见异常,心脏彩超示三尖瓣轻度反流,生长激素水平及其他检查未见异常。3年前曾做腹股沟疝气手术。患者有一姐,14岁,体健。父母表型均正常,系非近亲结婚,母... 详细信息

患者男,10岁,因身材矮小来我院内分泌科就诊。垂体磁共振成像、肝胆肾B超检查均未见异常,心脏彩超示三尖瓣轻度反流,生长激素水平及其他检查未见异常。3年前曾做腹股沟疝气手术。患者有一姐,14岁,体健。父母表型均正常,系非近亲结婚,母亲孕期无患病及服药史,无毒物和放射线接触史,无不良孕产史。

关键词：身材矮小非近亲结婚内分泌科服药史放射线接触史母亲孕期磁共振成像不良孕产史

Author Correction:Manifold learning of four-dimensional scanning transmission electron microscopy

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npj Computational Materials 2020年第1期6卷 1073-1073页

作者： Xin Li Ondrej E.Dyck Mark P.Oxley Andrew R.Lupini Leland McInnes John Healy Stephen jesse Sergei V.Kalinin Center for Nanophase Materials Sciences Oak Ridge National Laboratory Oak Ridge USA Institute for Functional Imaging of Materials Oak Ridge National Laboratory Oak Ridge USA Tutte Institute for Mathematics and Computing Ottawa Canada

The original version of the published Article had a mistake in the Acknowledgements *** Acknowledgments have been updated to the following:This research was supported by the US Department of Energy,Basic Energy Sciences,Materials Sciences and Engineering Division(M.P.O.,A.R.L.,S.V.K.)and conducted at the Center for Nanophase Materials Sciences,which is a US DOE Office of Science User Facility(X.L.,O.E.D.,S.J.).*** *** support from Tutte Institute for Mathematics and Computing,Canada.

关键词： section ledgment Manifold

Global Wheat Head Detection 2021:An Improved Dataset for Benchmarking Wheat Head Detection Methods

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Plant Phenomics 2021年第1期3卷 277-285页

作者： Etienne David Mario Serouart Daniel Smith Simon Madec Kaaviya Velumani Shouyang Liu Xu Wang Francisco Pinto Shahameh Shafiee Izzat SATahir Hisashi Tsujimoto Shuhei Nasuda Bangyou Zheng Norbert Kirchgessner Helge Aasen Andreas Hund Pouria Sadhegi-Tehran Koichi Nagasawa Goro Ishikawa Sébastien Dandrifosse Alexis Carlier Benjamin Dumont Benoit Mercatoris Byron Evers Ken Kuroki Haozhou Wang Masanori Ishii Minhajul ABadhon Curtis Pozniak David Shaner LeBauer Morten Lillemo jesse Poland Scott Chapman Benoit de Solan Frédéric Baret Ian Stavness Wei Guo Arvalis Institut du Végétal3 Rue Joseph et Marie Hackin75116 ParisFrance UMR1114 EMMAH INRAECentre PACABâtiment ClimatDomaine Saint-Paul228 Route de l’AérodromeCS 4050984914 Avignon CedexFrance School of Food and Agricultural Sciences The University of QueenslandGatton4343 QLDAustralia Hiphen SAS 120 Rue Jean DaussetAgroparcBâtiment Technicité84140 AvignonFrance Plant Phenomics Research Center Nanjing Agricultural UniversityNanjingChina Wheat Genetics Resource Center Dep.of Plant PathologyKansas State Univ.4024 Throckmorton Plant Sciences CenterManhattanKansasUSA Global Wheat Program International Maize and Wheat Improvement Centre(CIMMYT)MexicoD.F.Mexico Faculty of Biosciences Norwegian University of Life SciencesP.O.Box 5003NO-1432ÅsNorway Agricultural Research Corporation Wheat Research ProgramP.O.Box 126Wad MedaniSudan Arid Land Research Center Tottori UniversityTottori 680-0001Japan Laboratories of Plant Genetics and Plant Breeding Graduate School of AgricultureKyoto UniversityJapan CSIRO Agriculture and Food Queensland Biosciences Precinct306 Carmody RoadSt Lucia4067 QLDAustralia Institute of Agricultural Sciences ETH ZurichUniversitätstrasse 28092 ZurichSwitzerland Plant Sciences Department Rothamsted ResearchHarpendenUK Institute of Crop Science National Agriculture and Food Research OrganizationJapan Hokkaido Agricultural Research Center National Agriculture and Food Research OrganizationJapan Biosystems Dynamics and Exchanges TERRA Teaching and Research CenterGembloux Agro-Bio TechUniversity of Liège5030 GemblouxBelgium Plant Sciences TERRA Teaching and Research CenterGembloux Agro-Bio TechUniversity of Liège5030 GemblouxBelgium Graduate School of Agricultural and Life Sciences The University of Tokyo1-1-1 Midori-choNishitokyo CityTokyoJapan Department of Computer Science University of SaskatchewanCanada Department of Plant Sciences University of SaskatchewanCanada College of Agriculture and Life Sciences University of ArizonaTucsonArizona

The Global Wheat Head Detection(GWHD)dataset was created in 2020 and has assembled 193,634 labelled wheat heads from 4700 RGB images acquired from various acquisition platforms and 7 countries/*** an associated competition hosted in Kaggle,GWHD_2020 has successfully attracted attention from both the computer vision and agricultural science *** this first experience,a few avenues for improvements have been identified regarding data size,head diversity,and label *** address these issues,the 2020 dataset has been reexamined,relabeled,and complemented by adding 1722 images from 5 additional countries,allowing for 81,553 additional wheat *** now release in 2021 a new version of the Global Wheat Head Detection dataset,which is bigger,more diverse,and less noisy than the GWHD_2020 version.

关键词： Wheat adding release

Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2015年第4期6卷 223-237页

作者： Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler Department of Veterinary Microbiology and Preventive Medicine College of Veterinary Medicine Iowa State University Department of Food Science and Human Nutrition Iowa State University Department of Veterinary Pathology College of Veterinary Medicine Iowa State University Department of Food Science and Technology University of Nebraska-Lincoln

AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulga

关键词： Prunella vulgaris Spontaneous colitis Inflammatory

Description of two new species of Hemiphyllodactylus (Reptilia: Gekkonidae) from karst landscapes in Yunnan,China, highlights complex conservation needs

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