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Effects of 3 months of full-court and half-court street basketball training on health profile in untrained men

Journal of Sport and Health Science 2018年第2期7卷 132-138页

作者： Morten B.Randers Marie Hagman Jonathan Brix jesper F.christensen Mogens T.Pedersen Jens J.Nielsen Peter Krustrup Department of Sports Science and Clinical Biomechanies SDU Sport and Health Sciences Cluster (SHSC) University of Southern Denmark Odense 5230 Denmark Department of Nutrition Exercise and Sports University of Copenhagen Copenhagen 2200 Denmark Centre oflnflammation and Metabolism (CIM) and Centre for Physical Activity Research (CFAS) Rigshospitalet Faculty of Health Science Copenhagen University Hospital 7641 University of Copenhagen Copenhagen 2100 Denmark Sport and Health Sciences University of Exeter Exeter EX1 2LU UK

Purpose: The aim of the present study was to investigate whether street basketball organized as 3 v 3 on either a half court(HC) with 1 basket or a full court(FC) with 2 baskets could improve fitness and health profiles of untrained men after 3 months of supervised ***: Thirty-five untrained men(aged 20—42 years) completed the pre-and post-intervention testing(FC: n = 13, HC: n = 12, CO(control):n = 10). The training attendance was 2.0 ± 0.4 and 1.9 ± 0.3 times per week in FC and HC, respectively. Mean heart rate(HR) was 83.8 ± 6.0 percent of maximal heart rate(%HR_(max)) and 84.5 ± 2.9 %HR_(max) in FC and HC, ***: The 3 months of street basketball training on an FC with 2 baskets increased maximal oxygen uptake(2.4 mL/min/kg(95% confidence interval(CI): 1.0—3.9)), time to exhaustion(47 s(95%CI: 26—67)), lean body mass(0.8 kg(95%CI: 0.1—1.5)), and bone mineral density(0.021 g/cm^2(95%CI: 0.011—0.031)), whereas mean arterial pressure(—5.6 mm Hg(95%CI: —7.5 to 3.7)), body fat percentage(—1.6%,(95%CI: —2.5 to —0.7)), heart rate(—18 bpm(95%CI: —24 to —12)), and blood lactate(median: —1.4 mmol/L(interquartile range: —1.5 to —0.6)) during submaximal running were lowered. The changes were less pronounced after the training period when playing on an HC with 1 basket, but increases in maximal oxygen uptake(1.6 mL/min/kg(95%CI: —0.1 to 3.3)), time to exhaustion(28 s(95%CI: 9—47)), lean body mass(1.3 kg(95%CI: 0.3—2.4)), and lower body fat percentage(—0.9%(95%CI: —1.9 to —0.1)) were observed in this ***: Three months of 3 v 3 street basketball training improved fitness and led to broad-spectrum improvements in variables related to overall health profile, with the most marked effects observed when playing on an FC with 2 baskets.

关键词： Blood pressure Body composition Cardiovascular fitness Maximal oxygen uptake Muscoloskeletal fitness Physical demands Small-sided games Team sport

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Deregulation of tumor suppressive ASXL1−PTEN/AKT axis in myeloid malignancies

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Journal of Molecular Cell Biology 2020年第9期12卷 688-699页

作者： Lei Cao Xianyou Xia Yu Kong Fengqin Jia Bo Yuan Rui Li Qian Li YuxinWang Mingrui Cui Zhongye Dai Huimin Zheng jesper christensen Yuan Zhou Xudong Wu Collaborative Innovation Center of Tianjin for Medical Epigenetics Tianjin Key Laboratory of Medical EpigeneticsKey Laboratory of Immune Microenvironment and Disease(Ministry of Education)Department of Cell BiologyTianjin Medical UniversityTianjin 300070China National Demonstration Center for Experimental Basic Medical Science Education Tianjin Medical UniversityTianjin 300070China Department of Prosthodontics School and Hospital of StomatologyTianjin Medical UniversityTianjin 300070China Biotech Research and Innovation Centre and Centre for Epigenetics University of Copenhagen2200 CopenhagenDenmark State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin 300020China

Mutations of epigenetic regulators are pervasive in human ***1 is frequently mutated in myeloid *** previously found that ASXL1 forms together with BAP1 a complex that can deubiquitinylate mono-ubiquitinylated lysine 119 on histone H2A(H2AK119ub1),a Polycomb repressive ***,a complete mechanistic understanding of ASXL1 in transcriptional regulation and tumor suppression remains to be ***,we find that depletion of Asxl1 confers murine 32D cells to IL3-independent growth at least partly due to sustained activation of PI3K/AKT ***,Asxl1 is critical for the transcriptional activation of Pten,a key negative regulator of AKT *** we confirm that Asxl1 is specifically enriched and required for H2AK119 deubiquitylation at the Pten ***,ASXL1 and PTEN expression levels are positively correlated in human blood cells and ASXL1 mutations are associated with lower expression levels of PTEN in human myeloid ***,malignant cells with ASXL1 downregulation or mutations exhibit higher sensitivity to the AKT inhibitor ***,this study has linked the PTEN/AKT signaling axis to deregulated epigenetic changes in myeloid *** also provides a rationale for mechanism-based therapy for patients with ASXL1 mutations.

关键词： tumor suppressor Polycomb H2A ubiquitylation PTEN AKT

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Bone Loss in Women with Type 1 Diabetes

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Journal of Diabetes Mellitus 2015年第4期5卷 252-257页

作者： Maj-Britt Tanderup Jorgensen jesper Olund christensen Ole Lander Svendsen Department of Endocrinology I Bispebjerg University HospitalCopenhagenDenmark Steno Diabetes Center GentofteDenmark Center for Clinical and Basic Research BallerupDenmark

Background: Although osteoporosis has been investigated and debated in the diabetic population over the past decades, very little is known about the spontaneous changes in bone mineral density (BMD) and biochemical markers of bone turnover in pre- and postmenopausal type 1 diabetic (T1DM) women over time. Aim: To measure spontaneous changes in BMD and biochemical markers of bone turnover in pre- and postmenopausal T1DM women. Subjects: 53 T1DM women (31 premenopausal and 22 postmenopausal) from the outpatient clinic were enrolled in the study in 1993 and 35 (22 premenopausal, 13 postmenopausal) were reexamined in 1997. Method: BMD was measured at femoral neck (f.n.), spine (L2 - L4), total body and forearm with DXA or SXA in 53 T1DM women. 4 years later a re-scan was carried out on 35 T1DM. Results: In premenopausal subjects a yearly decrease less than 1% at f.n., spine, forearm and total body was observed, though only statistically significant (s.s.) at f.n., p ≤ 0.05. In postmenopausal subjects a s.s. decrease less than 2% was observed at f.n., forearm and total body, p ≤ 0.05. In general, osteopenic or osteoporotic values were observed at the measured skeletal sites. Only at f.n. a lower s.s. BMD compared to age-matched reference women was seen. Conclusion: Small or non-significant changes in BMD and biochemical markers of bone turnover were observed in pre- and postmenopausal T1DM subjects after a 4-year period.

关键词： Bone Turnover Bone Mineral Density Biochemical Markers of Bone Turnover Premenopausal Postmenopausal

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Deregulation of H2A monoubiquitylation in cancers

Deregulation of H2A monoubiquitylation in cancers

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第十一次全国基因功能与表观遗传调控学术研讨会

作者： Xudong Wu Yan Qi jesper christensen Kasper Dindler Rasmussen Juri Rappsilber Kristian Helin Department of Cell Biology Tianjin Medical University Biotech Research and Innovation Centre Centre for Epigenetics University of CopenhagenDenmark

Epigenetic changes are now recognized to be as important to cancer formation as are gene ***,ASXL1 mutations have been reported in patients with diverse tumors especially hematological *** its importance in tumorigene...

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Effects of Changed Climate Conditions on Tropospheric Ozone over Three Centuries

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Atmospheric and Climate Sciences 2012年第4期2卷 546-561页

作者： Gitte Brandt Hedegaard jesper Heile christensen Camilla Geels Allan Gross Kaj Mantzius Hansen Wilhelm May Azimeh Zare Jorgen Brandt Department of Environmental Science Aarhus UniversityRoskildeDenmark Danish Climate Centre Danish Meteorological InstituteCopenhagenDenmark Centre for Environmental and Climate Research Lund UniversityLundSweden Institute of Geophysics University of TehranTehranIran

The ozone chemistry in four decades (1890s, 1990s, 2090s and 2190s) representing the changes over three centuries has been simulated using the chemistry version of the atmospheric long-range transport model: the Danish Eulerian Hemispheric Model (DEHM) forced with meteorology projected by theECHAM5/MPI-OM coupled Atmosphere-Ocean General Circulation Model. The largest changes in meteorology, ozone and its precursors are found in the 21st century, however, also significant changes are found in the 22nd century. At surface level the ozone concentration is projected to increase due to climate change in the areas where substantial amounts of ozone precursors are emitted. Elsewhere a significant decrease is projected at the surface. In the free troposphere a general increase is found in the entire Northern Hemisphere except in the tropics, where the ozone concentration is decreasing. In the Arctic the ozone concentration will increase in the entire air column, which most likely is due to changes in atmospheric transport. Changes in temperature, humidity and the naturally emitted Volatile Organic Compounds (VOCs) are governing the changes in ozone both in the past, present and future century.

关键词： Ozone Climate Change Air Quality Modelling

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Cardiac Structure and Function in Men with Prostate Cancer Receiving Androgen-Deprivation Therapy and the Effects of Recreational Small-Sided Football Training:A Randomized Controlled Trial

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World Journal of Cardiovascular Diseases 2017年第9期7卷 308-322页

作者： Jakob Friis Schmidt Lars Juel Andersen Jacob Uth Therese Hornstrup jesper christensen Julie Midtgaard Klaus Brasso Peter Krustrup Mikael Rorth Peter Riis Hansen Department of Cardiology Copenhagen University HospitalGentofteDenmark Department of Nutrition Exercise and SportsCentre for Team Sport and HealthUniversity of CopenhagenCopenhagenDenmark Department of Cardiology Roskilde HospitalRoskildeDenmark The University Hospitals Centre for Health Care Research(UCSF) Copenhagen University HospitalRigshospitaletDenmark Department of Public Health University of CopenhagenCopenhagenDenmark Copenhagen Prostate Cancer Center Department of UrologyCopenhagen University HospitalRigshospitaletDenmark Sport and Health Sciences University of ExeterExeterGreat Britain Department of Sports Science and Clinical Biomechanics SDU Sport and Health Sciences Cluster(SHSC)University of Southern DenmarkOdenseDenmark Department of Oncology Copenhagen University HospitalRigshospitaletDenmark

Purpose: Androgen deprivation therapy (ADT) is a cornerstone in prostate cancer (PCa) management that prolongs PCa-free and overall survival, but effects of ADT on human cardiac function have not been investigated. We used echocardiography to examine cardiac structure and function in patients with prostate cancer receiving ADT and to determine whether an exercise intervention can elicit cardiac adaptations in these subjects. Methods: Forty-three patients with prostate cancer receiving ADT were randomized to 12 weeks football training (ST group;n = 20) or usual care (control [CO] group;n = 23). Cardiac function was assessed at baseline and after 12 weeks by comprehensive echocardiography. Peak oxygen consumption, blood pressure and peripheral microvascular function was also measured. Results: At baseline, no considerable echocardiographic abnormalities were observed. In the ST group, increases in left ventricular diastolic function variables including E/A ratio (P = 0.03), E’ (P = 0.016), E’TDIcolor (P = 0.040) and in left atrial diameter (P = 0.001) were observed after 12 weeks. In addition, diastolic blood pressure (P = 0.027) and resting heart rate (P 0.001) were reduced after ST. In the CO group, no significant changes were observed in the examined variables after 12 weeks. Despite within group changes in the ST group, no significant differences were observed after 12 weeks between groups in echocardiographic variables, peak oxygen consumption, blood pressure and peripheral microvascular function. Conclusion: In men with prostate cancer receiving ADT, echocardiography showed no abnormalities in cardiac structure and function. Twelve weeks of ST failed to elicit significant cardiovascular adaptations and ADT may blunt cardiovascular adaptations to short-term exercise training.

关键词： Prostate Cancer Exercise Rehabilitation Cardiovascular

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Periprocedural complications and one-year outcomes after catheter ablation for treatment of atrial fibrillation in elderly patients:a nationwide Danish cohort study

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Journal of Geriatric Cardiology 2021年第11期18卷 897-907页

作者： jesper Nielsen Kristian Hay Kragholm Sofie Brix christensen Arne Johannessen Christian Torp-Pedersen Steen Buus Kristiansen Peter Karl Jacobsen Peter Steen Hansen Mogens Stig Djurhus Christoffer Polcwiartek Peter Søgaard Anna Margrethe Thøgersen Uffe Jakob Ortved Gang Ole Dan Jørgensen Filip Lyng Lindgren Sam Riahi Department of Cardiology Aalborg University HospitalDenmark Department of Cardiology Gentofte HospitalCopenhagen University HospitalDenmark Department of Clinical Research and Cardiology Nordsjaellands HospitalHillerødDenmark Department of Cardiology Skejby University HospitalDenmark Department of Cardiology RigshospitaletCopenhagen University HospitalDenmark Mølholm Clinic VejleDenmark Department of Cardiology Odense University hospitalDenmark Department of Cardiology Roskilde University HospitalDenmark Department of Thoracic Surgery Odense University HospitalDenmark AF-Study group Aalborg University Hospital Denmark Clinical Institute Aalborg UniversityDenmark

OBJECTIVES To investigate complications within 30-days following first-time ablation for atrial fibrillation(AF),including a composite of cardiac tamponade,hematoma requiring intervention,stroke or death,in patients≥75 years of age,compared to pa-tients aged 65−74 *** addition,one-year all-cause mortality and AF relapse were ***&RESULTS All patients receiving their first catheter ablation for AF between 2012 and 2016 were identified us-ing Danish nationwide *** aged 65−74 years served as the reference group for patients≥75 *** of AF within one year was defined as cardioversion following a three-month blanking period,re-ablation or confirmed relapse within *** composite complication outcome did not differ between the two age groups,with 39/1554(2.8%)in patients 65−74 years of age,versus 5/199(2.5%)in older patients(adjusted HR=0.94),95%CI:0.37−2.39,P=0.896).Patients≥75 years or older had no increased hazard of death within 30 days after the procedure,with an incidence of 3/1554(0.2%)in younger pa-tients and 2/199(1.0%)in patients≥75 years of age(adjusted HR=4.71,95%CI:0.78−28.40,P=0.091).There was no difference in relapse of AF after one year between age groups(≥75 years adjusted HR=1.00,95%CI:0.78-1.26,P=0.969).CONCLUSION In patients≥75 years of age selected for catheter ablation for AF,the incidence of periprocedural complica-tions,as well as one-year freedom from AF showed no statistical difference,when compared to patients 65−74 years of age.

关键词： patients fibrillation atrial

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Inactivation of OslRX10 Leads to Decreased Xylan Content in Rice Culm Cell Walls and Improved Biomass Saccharification

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Molecular Plant 2013年第2期6卷 570-573页

作者： Xuewei Chen Miguel E. Vega-Sanchez Yves Verhertbruggenb Dawn Chiniquy Patrick E. Canlas Alexandra Fagerstrom Lina Prak Ulla christensen Ai Oikawa Mawsheng Chern Shimin Zuo Fan Lin Manfred Auer William G.T. Willats Laura Bartley jesper Harholt Henrik V. Scheller Pamela C. Ronald Department of Plant Pathology and The Genome Center University of California Davis CA 95616 USA Joint BioEnergy Institute Emeryville CA 94608 USA Rice Research Institute Sichuan Agricultural University at Wenjiang Wenjiang Chengdu 611130 China Physical Biosciences Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Department of Plant and Environmental Sciences Faculty of Science University of Copenhagen DK-1871 Frederiksberg Denmark Department of Botany and Microbiology University of Oklahoma Norman OK 73019 USA Department of Plant and Microbial Biology University of California Berkeley CA 94720 USA

Dear Editor, Xylan polysaccharides constitute the major non-cellulosic components in secondary cell walls of dicots and in both primary and secondary cell walls of grasses （Scheller and Ulvskov, 2010）. Xylan is composed of a linear backbone of 13（1-4）-linked xylose （Xyl）. In grasses, the xylan backbone is substituted with 03-1inked and 02-1inked arabinose residues and, to a lesser extent, a（1-3）-Iinked glucuronic acid residues.

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乐高之家

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城市环境设计 2019年第2期118卷 62-73页

作者： Snorre Nash Andreas Klok Pedersen Agne Tamasauskaite Annette Birthe Jensen Ariel Joy Norback Wallner Ask Hvas Birgitte Villadsen Chris Falla Christoffer Gotfredsen Daruisz Duong Vu Hong David Zahle Esben Christoffersen Franck Fdida Ioana Fartadi Scurtu Jakob Andreassen Jakob Ohm Laursen Jakob Sand Jakub Matheus Wlodarczyk jesper Bo Jensen jesper Boye Andersen Julia Boromissza Kasper Reimer Hansen Katarzyna Krystyna Siedlecka Katarzyna Stachura Kekoa Charlot Leszek Czaja Lone Fenger Albrechtsen Louise B?geskov Hou Mads Enggaard Stidsen Magnus Algreen Suhr Manon Otto Marta christensen Mathias Bank Stigsen Michael Kepke Ole Dau Mortensen Ryohei Koike Sergiu Calacean S?ren Askehave Stefan Plugaru Stefan Wolf Thomas Jakobsen Randb?ll Tobias Hjortdal Tommy Bj?rnstrup Iwan Baan Kim christensen 陈思瑾

"乐高之屋展现了乐高积木的无限可能性。通过系统的创造力,让所有年龄段的孩子都能够使用这些工具来创造他们自己的世界,并通过游戏的方式生活其中。最棒的是,建筑和乐高游戏都是这样的:使人们能够想象比现状更令人兴奋和更具表现力的... 详细信息

"乐高之屋展现了乐高积木的无限可能性。通过系统的创造力,让所有年龄段的孩子都能够使用这些工具来创造他们自己的世界,并通过游戏的方式生活其中。最棒的是,建筑和乐高游戏都是这样的:使人们能够想象比现状更令人兴奋和更具表现力的新世界,并为他们提供使之成为现实的技能。这就是孩子们每天用乐高积木来做的事情,这也是我们今天用真实的砖石在乐高之屋里完成的事情,使比伦德向真

关键词：乐高积木展览空间

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瑞士巴塞尔老工业混凝土仓房改建

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城市环境设计 2019年第2期118卷 184-197页

作者： Agnete Jukneviciute Alexandra Gustaffson Andreas Johansen Annette Jensen Barbara Srpkova Buster christensen Camila Stadler Dennis Rasmussen Dominic Black Enea Michelesio Erik de Haan Gül Ertekin Franck Fdida Helen Chen Ioannis Gio Jan Magasanik jesper Andersen Lorenzo Boddi Marcelina Kolasinska Teresa Fernandez Martin Voelkle Miao Zhang Michael Sch?nemann Mikkel Marcker Stubgaard Ole Elkj?r-Larsen Ricardo Palma Ryohei Koike Sergiu Calacean Tobias Hjortdal Laurian Ghinitoiu 朱翰林

巴塞尔的Transitlager坐落于Dreispitz的未来城区中心位置,是众多用于美术馆、餐厅和创意产业的新老建筑中的其中一座。它位于设想的Soho区和皇后区的边缘。与城市一样,周围的工业区域也充斥着基础设施的几何形体。通过对原仓库进行新... 详细信息

巴塞尔的Transitlager坐落于Dreispitz的未来城区中心位置,是众多用于美术馆、餐厅和创意产业的新老建筑中的其中一座。它位于设想的Soho区和皇后区的边缘。与城市一样,周围的工业区域也充斥着基础设施的几何形体。通过对原仓库进行新的功能规划和扩建,使其成为一座多功能的建筑,我们设计将艺术、商业、工

关键词：巴塞尔核心筒 UBS

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