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Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism

World Journal of Gastroenterology 2011年第26期17卷 3117-3125页

作者： jesper ab strickertsson Kristina BV DΦssing Anna JM Aabakke Hans-Olof Nilsson Thomas VO Hansen Ulrich Knigge Andreas Kjr Torkel Wadstrm Lennart Friis-Hansen Genomic Medicine Department of Clinical BiochemistryRigshospitaletUniversity of Copenhagen Department of Basic Animal and Veterinary Sciences Faculty of Life SciencesUniversity of Copenhagen Department of Microbiology University of Lund Department of Gastro-Intestinal Surgery RigshospitaletUniversity of Copenhagen Department of Clinical Physiology RigshospitaletUniversity of Copenhagen

AIM- To investigate if and how the proinflammatory cytokine interferon γ （IFNγ） affects ghrelin expression in mice. METHODS： The plasma concentration of ghrelin, and gastric ghrelin and somatostatin expression, were ex- amined in wild-type mice and mice infected with Helico- bacter pylori （H. pylorO. Furthermore, ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth. To study the effect of IFNγ, alone, mice were given a subcutaneous infusion of IFNγ, for 7 d. Finally, the influ- ence of IFNγ, and somatostatin on the ghrelin promoter was characterized. RESULTS： H. py/ori infection was associated with a 50% reduction in ghrelin expression and plasma concentration. Suppression of ghrelin expression was in- versely correlated with gastric inflammation in achlorh- dyric mouse models. Subcutaneous infusion of IFNγ, suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations. Finally, we showed that the ghrelin promoter operates under the control of soma- tostatin but not under that of IFNγ. CONCLUSION： Gastric infection and inflammation is associated with increased IFNγ, expression and reduced ghrelin expression. IFNγ, does not directly control ghre- lin expression but inhibits it indirectly via somatostatin.

关键词： Ghrelin Interferon-γ Somatostatin Inflam-matory diseases He/icobacterpy/ori

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Complex Ga_(2)O_(3) polymorphs explored by accurate and general-purpose machine-learning interatomic potentials

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npj Computational Materials 2023年第1期9卷 666-675页

作者： Junlei Zhao jesper Byggmästar Huan He Kai Nordlund Flyura Djurabekova Mengyuan Hua Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Physics University of HelsinkiP.O.Box 43FI-00014 HelsinkiFinland FCAI:Finnish Center for Artificial Intelligence University of HelsinkiP.O.Box 43FI-00014 HelsinkiFinland School of Nuclear Science and Technology Xi’an Jiaotong UniversityXi’anShaanxi 710049China Helsinki Institute of Physics University of HelsinkiP.O.Box 43FI-00014 HelsinkiFinland

Ga_(2)O_(3) is a wide-band gap semiconductor of emergent importance for applications in electronics and ***,vital information of the properties of complex coexisting Ga_(2)O_(3) polymorphs and low-symmetry disordered structures is *** develop two types of machine-learning Gaussian approximation potentials(ML-GAPs)for Ga_(2)O_(3) with high accuracy forβ/κ/α/δ/γpolymorphs and generality for disordered stoichiometric *** release two versions of interatomic potentials in parallel,namely soapGAP and tabGAP,for high accuracy and exceeding speedup,*** potentials can reproduce the structural properties of all the five polymorphs in an exceptional agreement with ab initio results,meanwhile boost the computational efficiency with 5×102 and 2×105 computing speed increases compared to density functional theory,***,the Ga_(2)O_(3) liquid-solid phase transition proceeds in three different *** experimentally unrevealed complex dynamics can be understood in terms of distinctly different mobilities of O and Ga sublattices in the interfacial layer.

关键词： disordered exceptional exceeding

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WARA-PS:a research arena for public safety demonstrations and autonomous collaborative rescue robotics experimentation

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Autonomous Intelligent Systems 2021年第1期1卷 104-134页

作者： Olov Andersson Patrick Doherty Mårten Lager Jens-Olof Lindh Linnea Persson Elin A.Topp jesper Tordenlid Bo Wahlberg Department of Computer and Information Science Linköping UniversityLinköpingSweden Saab Kockums MalmöSweden Division of Decision and Control Systems School of Electrical Engineering and Computer ScienceKTH Royal Institute of TechnologyStockholmSweden Department of Computer Science Lund UniversityLundSweden Saab Combitech ab LinköpingSweden Division of Automatic Control Department of Electrical EngineeringLinköping UniversityLinköpingSweden

A research arena(WARA-PS)for sensing,data fusion,user interaction,planning and control of collaborative autonomous aerial and surface vehicles in public safety applications is *** objective is to demonstrate scientific discoveries and to generate new directions for future research on autonomous systems for societal *** enabler is a computational infrastructure with a core system architecture for industrial and academic *** includes a control and command system together with a framework for planning and executing tasks for unmanned surface vehicles and aerial *** motivating application for the demonstration is marine search and rescue operations.A state-of-art delegation framework for the mission planning together with three specific applications is also *** first one concerns model predictive control for cooperative rendezvous of autonomous unmanned aerial and surface *** second project is about learning to make safe real-time decisions under uncertainty for autonomous vehicles,and the third one is on robust terrain-aided navigation through sensor fusion and virtual reality tele-operation to support a GPS-free positioning system in marine *** research results have been experimentally evaluated and demonstrated to industry and public sector audiences at a marine test *** would be most difficult to do experiments on this large scale without the WARA-PS research ***,these demonstrator activities have resulted in effective research dissemination with high public visibility,business impact and new research collaborations between academia and industry.

关键词： Autonomous systems Intelligent system architectures Research demonstration arena Autonomous drones Autonomous marine vessels Public safety and security Collaborative robotics

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Study of photocurrent generation in InP nanowire-based p＋-i-n＋ photodetectors

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Nano Research 2014年第4期7卷 544-552页

作者： Vishal Jain Ali Nowzari jesper Wallentin Magnus T. Borgstrom Maria E. Messing Damir Asoli Mariusz Graczyk Bemd Witzigmann Federico Capasso Lars Samuelson Hakan Pettersson Solid State Physics and the Nanometer Structure Consortium Lund University Box 118 5E-221 O0 Lund Sweden Laboratory of Mathematics Physics and Electrical Engineering Halmstad University Box 823 SE-301 - 18 Halmstad Sweden Sol Voltaics ab Ideon Science Park Scheelevagen 17 SE-22370 Lund Sweden Department of Computational Electronics and Photonics University ofKassel Wilhelmshoeher Allee 71 D-34121 Kassel Germany School of Engineering and Applied Sciences Harvard University Cambridge Massachusetts 02138 USA

We report on electrical and optical properties of p＋-i-n＋ photodetectors/solar cells based on square millimeter arrays of InP nanowires （NWs） grown on InP substrates. The study includes a sample series where the p＋-segment length was varied between 0 and 250 nm, as well as solar cells with 9.3% efficiency with similar design. The electrical data for all devices display clear rectifying behavior with an ideality factor between 1.8 and 2.5 at 300 K. From spectrally resolved photocurrent measurements, we conclude that the photocurrent generation process depends strongly on the p^-segment length. Without a p＋-segment, photogenerated carriers funneled from the substrate into the NWs contribute strongly to the photocurrent. Adding a p＋-segment decouples the substrate and shifts the depletion region, and collection of photogenerated carriers, to the NWs, in agreement with theoretical modeling. In optimized solar cells, clear spectral signatures of interband transitions in the zinc blende and wurtzite InP layers of the mixed-phase i-segments are observed. Complementary electroluminescence, transmission electron microscopy （TEM）, as well as measurements of the dependence of the photocurrent on angle of incidence and polarization, support our interpretations.

关键词： nanophotonics nanowires infrared (IR) photodetectors solar cells

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A very energetic supernova associated with the γ-ray burst of 29 March 2003

A very energetic supernova associated with the γ-ray burst ...

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中国天文学会高能分会2004年学术年会

作者： Jens Hjorth jesper Sollerman Palle Mφller Johan P.U.Fynbo Stan E.Woosley Chryssa Kouveliotou Nial R.Tanvir Jochen Greiner Michael I.Andersen Alberto J.Castro-Tirado José María Castro Cerón Andrew S.Fruchter Javier Gorosabel Páll Jakobsson Lex Kaper S Astronomical Observatory NBIfAFG University of Copenhagen Juliane Maries VejDK-2100 Copenhagenφ Denmark Stockholm Observatory Department of Astronomy AlbaNova S-10691 StockholmSweden European Southern Observatory Karl-Schwarzschild-Strasse 2 D-85748 Garchingbei München Germany Department of Physics and Astronomy University of Aarhus Ny MunkegadeDK-8000rhus C Denmark Department of Astronomy and Astrophysics University of California Santa CruzCalifornia 95064 USA NSSTC SD-50 320 Sparkman Drive Huntsville Alabama 35805 USA Department of Physical Sciences University of Hertfordshire College LaneHatfield AL10 9AB UK Max-Planck-Institut für extraterrestrische Physik D-85741 Garching Germany Astrophysikalisches Institut D-14482 Potsdam Germany Instituto de Astrofísica de Andalucía （IAA-CSIC） PO Box 03004 E-18080 GranadaSpain Space Telescope Science Institute 3700 San Martin Drive BaltimoreMaryland 21218 USA Space Telescope Science Institute 3700 San Martin Drive BaltimoreMaryland 21218 USA Space Telescope Science Institute 3700 San Martin Drive BaltimoreMaryland 21218 USA Instituto de Astrofísica de Andalucía （IAA-CSIC） PO Box 03004 E-18080 GranadaSpain Astronomical Observatory NBIfAFG University of Copenhagen Juliane Maries VejDK-2100 Copenhagen φ Denmark Astronomical Institute Anton Pannekoek Kruislaan 403 NL-1098 SJ AmsterdamNetherlands Thüringer Landessternwarte Tautenburg D-07778 Tautenburg Germany Istituto di Astrofisica Spaziale e Fisica Cosmica - Sezione di Bologna CNRvia Gobetti 101 I-40129 Bologna Italy Astronomical Observatory NBIfAFG University of Copenhagen Juliane Maries VejDK-2100 Copenhagen φ Denmark Astronomical Observatory NBIfAFG University of Copenhagen Juliane Maries VejDK-2100 Copenhagen φ Denmark INAF Osservatorio Astronomico di Trieste Via G.B. Tiepolo 11 I-34131 TriesteItaly Istituto di Astrofisica Spaziale e Fisica Cosmica - Sezione di Bologna CNRvia Gobetti 101 I-40129 Bologna Italy Space Telescope Science I

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