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Engineered smart materials for RNA based molecular therapy to treat Glioblastoma

Bioactive Materials 2024年第3期33卷 396-423页

作者： Ravi raj Singh Indranil Mondal Taskeen janjua Amirali Popat Ritu Kulshreshtha Department of Biochemical Engineering and Biotechnology Indian Institute of Technology DelhiNew DelhiIndia School of Pharmacy The University of QueenslandBrisbaneQLD4072Australia Department of Functional Materials and Catalysis Faculty of ChemistryUniversity of ViennaWahringer Straße 421090 ViennaAustria University of Queensland-IIT Delhi Academy of Research(UQIDAR)

Glioblastoma(GBM)is an aggressive malignancy of the central nervous system(CNS)that remains incurable despite the multitude of improvements in cancer *** conventional chemo and radiotherapy post-surgery have only been able to improve the prognosis slightly;however,the development of resistance and/or tumor recurrence is almost *** is a pressing need for adjuvant molecular therapies that can successfully and efficiently block tumor *** the last few decades,non-coding RNAs(ncRNAs)have emerged as key players in regulating various hallmarks of cancer including that of *** levels of many ncRNAs are dysregulated in cancer,and ectopic modulation of their levels by delivering antagonists or overexpression constructs could serve as an attractive option for cancer *** therapeutic potential of several types of ncRNAs,including miRNAs,lncRNAs,and circRNAs,has been validated in both in vitro and in vivo models of ***,the delivery of these RNA-based therapeutics is highly challenging,especially to the tumors of the brain as the blood-brain barrier(BBB)poses as a major obstacle,among ***,since RNA is extremely fragile in nature,careful considerations must be met while designing a delivery *** this review we have shed light on how ncRNA therapy can overcome the limitations of its predecessor conventional therapy with an emphasis on smart nanomaterials that can aide in the safe and targeted delivery of nucleic acids to treat ***,critical gaps that currently exist for successful transition from viral to non-viral vector delivery systems have been ***,we have provided a perspective on the future directions,potential pathways,and target areas for achieving rapid clinical translation of,RNA-based macromolecular therapy to advance the effective treatment of GBM and other related diseases.

关键词： Glioblastoma(GBM) Non-coding RNAs(ncRNA) Nucleic acid therapy Oligonucleotide therapy Nanocarriers Nanoparticles RNA delivery system Gene therapy

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Ethoxylated molybdenum disulphide based nanofluid for enhanced oil recovery

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Petroleum Science 2024年第5期21卷 3417-3427页

作者： Infant raj Zhuo Lu ji-Rui Hou Yu-Chen Wen Li-Xiao Xiao Unconventional Petroleum Research Institute China University of Petroleum(Beijing)Beijing102249China

Despite advances in renewable energy sources, the world's current infrastructure and consumption patterns still heavily depend on crude oil. Enhanced oil recovery(EOR) is a crucial method for significantly increasing the amount of crude oil extracted from mature and declining oil fields. Nanomaterials have shown great potential in improving EOR methods due to their unique properties, such as high surface area, tunable surface chemistry, and the ability to interact at the molecular level with fluids and rock surfaces. This study examines the potential use of incorporating ethoxylated molybdenum disulfide with a unique three-dimensional flower-like morphology for overcoming the challenges associated with oil recovery from reservoirs characterized by complex pore structures and low permeability. The synthesized nanomaterial features a chemical composition that encompasses a polar ethoxy group linking molybdenum disulfide nanosheets and an alkylamine chain. The ethoxy group promotes interactions with water molecules through hydrogen bonding and electrostatic forces, disrupting the cohesive forces among water molecules and reduction surface tension at the oil-water interface. As a result, the nanomaterial achieves an ultra-low interfacial tension of 10^(-3) mN/m. Core flooding experiments demonstrate a significant oil recovery of approximately 70% at a concentration as low as 50 ppm. This research paves the way for the design and synthesis of advanced extended surfactant-like nanomaterials,offering a promising avenue for enhancing oil recovery efficiency.

关键词： Molybdenum disulfide Nanofluid Flow in porous media Core flooding Interfacial tension

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Microencapsulation of betacyanin from dragon fruit peel by complex coacervation:Physicochemical characteristics,thermal stability,and release profile of microcapsules

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Food Bioscience 2022年第5期49卷 1072-1083页

作者： G.V.S.Bhagya raj Kshirod K.Dash Department of Food Engineering and Technology Tezpur UniversityTezpurAssam784028India Department of Food Processing Technology Ghani Khan Choudhury Institute of Engineering and Technology(GKCIET)MaldaWest Bengal732141India

Dragon fruit peel contains phytochemicals and natural pigment *** crude extract was extracted from the freeze-dried dragon fruit(Hylocereus undatus)peel powder using ultrasonication and betacyanin was isolated by aqueous two-phase *** pigment betacyanin extracted from the dragon fruit peels,was encapsulated using the complex coacervation *** encapsulation,four distinct carrier agents,namely maltodextrin,gum arabic,xanthan gum,and gelatin were mixed with sodium alginate to form the wall *** betacyanin microcapsule using gum arabic as the wall material had the highest encapsulation efficiency(92.265%),followed by maltodextrin(88.365%),xanthan gum(84.655%),and gelatin(80.526%).The hygroscopicity,swelling index,and solubility of the formulated four betacyanin microcapsules were in the range of 7.581-9.462 g/100 g,120.155-153.545%,and 54.645-65.216%,*** thermal stability of four microcapsules treated at 80◦C and pH 7 was revealed to have a half-life period of 55-110 *** release behaviour of microcapsules in terms of betacyanin content in simulated gastric juice were fitted with Higuchi,Korsmeyer-Peppas,Weibull,and Peppas-Sahalin *** findings support the concept that microencapsulation enables the formulation of a stable product containing functional components.

关键词： Dragon fruit peel Extraction Encapsulation Complex coacervation Betacyanin

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Electrochemical determination of an anti-hyperlipidimic drug pitavastatin at electrochemical sensor based on electrochemically pre-treated polymer film modified GCE

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journal of Pharmaceutical Analysis 2017年第4期7卷 258-264页

作者： Umar j.Pandit Gowhar A.Naikoo Mehraj Ud Din Sheikh Gulzar A.Khan K.K.raj S.N.Limaye Department of Chemistry Dr. Harisingh Gour UniversitySagarM.P.India Department of Mathematics and Sciences College of Arts and Applied SciencesDofar UniversitySalalahOman

An electrochemically pretreated silver macroporous(Ag MP) multiwalled carbon nanotube modified glassy carbon electrode(PAN-Ag MP-MWCNT-GCE) was fabricated for the selective determination of an antihyperlipidimic drug, pitavastatin(PST). The fabricated electrochemical sensor was characterized by cyclic voltammetry(CV) and electrochemical impedance spectroscopy(EIS). The fabricated electrode was employed in quantifying and determining PST through differential pulse adsorptive stripping voltammetry(DPAdSV) and CV. The electrode fabrication proceeded with remarkable sensitivity to the determination of PST. The effect of various optimized parameters such as pH, scan rate(ν), accumulation time(t_(acc)), accumulation potential(U_(acc))and loading volumes of Ag MP-MWCNT suspension were investigated to evaluate the performance of synthesized electrochemical sensor and to propose a simple, accurate, rapid and economical procedure for the quantification of PST in pharmaceutical formulations and biological fluids. A linear response of PST concentration in the range 2.0×10^(-7)–1.6×10^(-6)M with low detection(LOD) and quantification(LOQ) limits of 9.66 ± 0.04 nM and 32.25 ± 0.07 nM, respectively, were obtained under these optimized conditions.

关键词： Pitavastatin Electrochemical sensor Adsorptive stripping voltammetry Biological fluids Pharmaceutical formulations

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Seeing the Beat generation

Seeing the Beat generation

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作者： raj Chandarlapaty.

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Hybrid Bacterial Foraging Optimization with Sparse Autoencoder for Energy Systems

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Computer Systems Science & Engineering 2023年第4期45卷 701-714页

作者： Helen josephine V L Ramchand Vedaiyan V.M.Arul Xavier joy Winston j A.jegatheesan D.Lakshmi joshua Samuel raj Business Analytics School of Business and ManagementChrist UniversityBangalore560029India Department of Computer Science and IT School of SciencesJain Deemed to be UniversityBangalore560027India Department of Computer Science and Engineering Karunya Institute of Technology and SciencesCoimbatore641114India College of Computer Studies University of Technology Bahrain18041Bahrain Institute of Computer Science and Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennai602105India Department of Computer Science and Engineering Panimalar Institute of TechnologyChennai600123India Department of Information Science&Engineering CMR Institute of TechnologyBengaluru560037India

The Internet of Things(IoT)technologies has gained significant interest in the design of smart grids(SGs).The increasing amount of distributed generations,maturity of existing grid infrastructures,and demand network transformation have received maximum *** essential energy storing model mostly the electrical energy stored methods are developing as the diagnoses for its procedure was becoming further *** dynamic electrical energy stored model using Electric Vehicles(EVs)is comparatively standard because of its excellent electrical property and flexibility however the chance of damage to its battery was there in event of overcharging or deep discharging and its mass penetration deeply influences the *** paper offers a new Hybridization of Bacterial foraging optimization with Sparse Autoencoder(HBFOA-SAE)model for IoT Enabled energy *** proposed HBFOA-SAE model majorly intends to effectually estimate the state of charge(SOC)values in the IoT based energy *** accomplish this,the SAE technique was executed to proper determination of the SOC values in the energy ***,for improving the performance of the SOC estimation process,the HBFOA is *** addition,the HBFOA technique is derived by the integration of the hill climbing(HC)concepts with the BFOA to improve the overall *** ensuring better outcomes for the HBFOA-SAE model,a comprehensive set of simulations were performed and the outcomes are inspected under several *** experimental results reported the supremacy of the HBFOA-SAE model over the recent state of art approaches.

关键词： Internet of things energy systems state of charge estimation machine learning deep learning metaheuristics

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Description of a New Species of Amolops Cope, 1865(Amphibia: Ranidae) from Nepal and Nomenclatural Validation of Amolops nepalicus Yang, 1991

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Asian Herpetological Research 2020年第2期11卷 71-94页

作者： janak raj KHATIWADA Guocheng SHU Bin WANG Tian ZHAO Feng XIE jianping jIANG CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China

A new species,Amolops mahabharatensis ***.,is described from Mahabharat range(middle mountain)of *** new species is a member of the *** group and is distinguished from its congeners using morphological and molecular *** new species is diagnosed by having numerous warts on dorsum and flanks,dorsal body greyish olivebrown/light brown,presence of vomerine teeth series,presence of a pair of subgular vocal sacs in males and tadpole withⅢ:5+5/1+1:Ⅱ–labial tooth *** addition,evidenced by the phylogenetic and morphological analyses in this study,Amolops nepalicus is shown to be a valid species.A molecular phylogenetic analysis based on 16 S ribosomal gene for six members of the *** group suggested that the new species is sister to a clade containing *** and *** uncorrected genetic divergences between the new species and its closest congeners ***,*** and *** based on 16 S rRNA gene were 10.5%,11.6%,and 8.6%*** new species showed wide distribution in the Mahabharat range of Nepal.

关键词： A.marmoratus group mahabharat range molecular phylogeny taxonomy

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Growth, Optical, Mechanical, Dielectric and Theoretical Studies on Potassium Pentaborate Tetrahydrate (KB_5O_8·4H_2O) Single Crystal by Modified Sankaranarayanan-Ramasamy Method

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journal of Materials Science & Technology 2009年第6期25卷 745-748页

作者： C. justin raj S. Krishnan S. Dinakaran j. Mary Linet R. Uthrakumar R. Robert S. jerome Das Department of Physics FET Saveetha University Department of Physics RMK Engineering College Department of Physics Loyola College

A nonlinear optical single crystal of potassium pentaborate tetrahydrate （KB5O8·4H2O） has been grown from aqueous solution by using unidirectional crystal growth method of Sankaranarayanan-Ramasamy （SR） with a due modification in the growth assembly. Potassium pentaborate crystal of 60 mm length and 10 mm diameter has been grown along （100） plane with a growth rate of 3 mm per day within a period of 20 days. The grown crystal was subjected to single crystal X-ray diffraction analysis to confirm that the crystal belongs to the orthorhombic system. Some fundamental data such as valance electron plasma energy, Penn gap, Fermi energy and electronic polarizability of the grown crystal were calculated. The presence of borate in the grown crystal was confirmed by Fourier transform infrared （FTIR） spectroscopy. The optical transmission property of the grown crystal was analyzed using ultra violet （UV） visible spectral analysis. Surface morphology of the growth plane was observed using scanning electron microscopy （SEM）. The mechanical strength of the crystals was found out using Vickers microhardness test along the growth axis. Frequency dependent dielectric constant of the grown crystal was studied for various temperatures along （100） plane.

关键词： Crystal growth Characterization Nonlinear optic materials

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Novel therapies for treating atrial fibrillation

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World journal of Cardiovascular Diseases 2012年第4期2卷 242-259页

作者： raj Parikh Philip j. Kadowitz Department of Pharmacology Tulane University School of Medicine New Orleans USA

Atrial fibrillation is the most common cardiac arrhythmia and is a major risk factor for stroke, heart failure, and death. Current treatments focus on anti-coagulation as well as rate-control and rhythm-control strategies. Frequent INR checks associated with warfarin along with several adverse side effects of anti-arrhythmics have propelled investigations into novel treatments for atrial fibrillation. Research is focused not only on pioneering new pharmacological antico- agulation and anti-arrhythmic agents but also on improving surgical techniques in hopes of treating the arrhythmia. Here, we first briefly discuss the current treatment options, both pharmacological and non-pharmacological, for atrial fibrillation. We then present a focused review of recent animal and human investigations that examine the use of novel an-ticoagulation agents, mechanisms of new anti-arrhythmics, analyze potential triggers of atrial fibrillation, and highlight the role of genetics in atrial fibrillation.

关键词： Atrial Fibrillation Atrial Flutter Arrhythmia Anticoagulation Stroke

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Modeling and forecasting of COVID-19 using a hybrid dynamic model based on SEIRD with ARIMA corrections

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Infectious Disease Modelling 2021年第1期6卷 98-111页

作者： Maher Ala’raj Munir Majdalawieh Nishara Nizamuddin Department of Information Systems College of Technological InnovationZayed UniversityDubai19282United Arab Emirates

The outbreak of novel coronavirus(COVID-19)attracted worldwide *** has posed a significant challenge for the global economies,especially the healthcare *** with a robust healthcare system,countries were not prepared for the ramifications of *** statistical,dynamic,and mathematical models of the COVID-19 outbreak including the SEIR model have been developed to analyze the infection its transmission *** objective of this research is to use public data to study the properties associated with the COVID-19 pandemic to develop a dynamic hybrid model based on SEIRD and ascertainment rate with automatically selected *** proposed model consists of two parts:the modified SEIRD dynamic model and ARIMA *** fit SEIRD model parameters against historical values of infected,recovered and deceased population divided by ascertainment rate,which,in turn,is also a parameter of the *** of the first model for infected,recovered,and deceased populations are then corrected using ARIMA *** model can analyze the input data in real-time and provide long-and short-term forecasts with confidence *** model was tested and validated on the US COVID statistics dataset from the COVID Tracking *** validation,we use unseen recent statistical *** use five common measures to estimate model prediction ability:MAE,MSE,MLSE,Normalized MAE,and Normalized *** proved a great model ability to make accurate predictions of infected,recovered,and deceased *** output of the model can be used by the government,private sectors,and policymakers to reduce health and economic risks significantly improved consumer credit scoring.

关键词： COVID 19 Coronavirus SEIRD model ARIMA Hybrid model

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