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Liquid biopsy for gastric cancer:Techniques,applications,and future directions

World Journal of Gastroenterology 2024年第12期30卷 1680-1705页

作者： Cristina Díaz del Arco m jesús Fernández Aceñero Luis Ortega medina Department of Surgical Pathology Health Research Institute of the Hospital Clínico San CarlosHospital Clínico San CarlosMadrid 28040Spain Department of Legal medicine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28040Spain

After the study of circulating tumor cells in blood through liquid biopsy(LB),this technique has evolved to encompass the analysis of multiple materials originating from the tumor,such as nucleic acids,extracellular vesicles,tumor-educated platelets,and other ***,research has extended to include the examination of samples other than blood or plasma,such as saliva,gastric juice,urine,or *** techniques are diverse,intricate,and *** must be highly sensitive,and pre-analytical,patient,and tumor-related factors significantly influence the detection threshold,diagnostic method selection,and potential ***,the implementation of LB in clinical practice still faces several *** potential applications of LB range from early cancer detection to guiding targeted therapy or immunotherapy in both early and advanced cancer cases,monitoring treatment response,early identification of relapses,or assessing patient *** the other hand,gastric cancer(GC)is a disease often diagnosed at advanced *** recent advances in molecular understanding,the currently available treatment options have not substantially improved the prognosis for many of these *** application of LB in GC could be highly valuable as a non-invasive method for early diagnosis and for enhancing the management and outcomes of these *** this comprehensive review,from a pathologist’s perspective,we provide an overview of the main options available in LB,delve into the fundamental principles of the most studied techniques,explore the potential utility of LB application in the context of GC,and address the obstacles that need to be overcome in the future to make this innovative technique a game-changer in cancer diagnosis and treatment within clinical practice.

关键词： Liquid biopsy Gastric cancer Circulating tumor cells Cell-free DNA Circulating tumor DNA molecular

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Synthesis and applications of lanthanoid complexes of pentadentate and hexadentate N_(5) and N_(6) macrocycles:A review

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Journal of Rare Earths 2024年第1期42卷 1-15,I0001页

作者： Julio Corredoira-Vázquez Cristina González-Barreira Paula Oreiro-martínez Ana m.García-Deibe jesús Sanmartín-matalobos matilde Fondo Departamento de Química Inorganica Facultade de QuímicaUniversidade de Santiago de CompostelaCampus Vida15782Santiago de CompostelaSpain Phantom-g CICECO-Aveiro Institute of MaterialsDepartment of PhysicsUniversity of Aveiro3810-193AveiroPortugal Institute of materials(imATUS) Universidade de Santiago de Compostela15782Santiago de CompostelaSpain

In this paper,the lanthanoid complexes of N_(5) and N_(6) macrocycle ligands,without pendant arms or additional heteroatoms,are *** review covers the period from 2015 to the current date,since in 2014 Schiff base macrocyclic ligands incorporating the pyridine moiety,and their complexes,were revised,and in 2015 the chemistry of pentaaza macrocycle ligands with rare earth metals was also *** and phthalocyanine ligands are not included in this review,which primarily focuses on complexes with Schiff bases and amines without pendant arms or any additional donor other than *** synthetic methods,structural characterization,based on single X-ray crystal data,and properties of the lanthanoid complexes,with special attention to magneto-structural correlations,are presented herein.

关键词： Lanthanoid N_(5),N_(6)macrocycle Coordination chemistry Chirality Biological activity molecule magnet

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measuring Impact of Lean manufacturing Tools for Continuous Improvement on Economic Sustainability

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Journal of Systems Science and Systems Engineering 2024年第4期33卷 452-474页

作者： Luis Javier márquez Figueroa Jorge Luis García-Alcaraz Ahmed I.Osman Alfonso jesús Gil López Yashar Aryanfar mika Sillanpää mamdouh El Haj Assad Department of Electrical Engineering and Computer Science Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico Department of Industrial Engineering and manufacturing Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico School of Chemistry and Chemical Engineering Queens UniversityBelfastNorthern IrelandUK Department of Economic and managerial Sciences University of La RiojaLa RiojaSpain Department of Chemical Engineering University of JohannesburgJohannesburgSouth Africa Department of Sustainable and Renewable Energy Engineering University of SharjahSharjahUAE

Using Lean manufacturing(Lm)tools in production processes is crucial for companies’economic,environmental,and social sustainability *** study shows a structural equation model(SEm)that shows the relationship between Lm Tools like Kaizen(KAI),Gemba(GEm),Value Stream mapping(VSm)and Key Performance Indicator(KPI)with Economic Sustainability(ECS).Seven hypotheses were evaluated with data from 179 responses to a questionnaire about the mexican maquiladora industry,showing that these variables are *** a 95%confidence level,the model was evaluated using the partial least squares *** findings indicate that the relationships between KAI and GEm and KAI and VSm have the strongest relationship,followed by VSm and ECS;however,VSm has the strongest effect on *** on these findings,it is recommended that managers adopt a continuous improvement(KAI)approach based on working directly on the shop floor(GEm and VSm)to support their decisions regarding economic growth(ECS).

关键词： Lean manufacturing economic sustainability structural equation model quality improvement

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Risk scores for allograft failure: Are they still useful in liver recipients from donation after circulatory death?

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World Journal of Transplantation 2024年第4期14卷 95-100页

作者： mohamed H mohamed Chairi mónica mogollón González Jennifer Triguero Cabrera Inmaculada Segura Jiménez maria T Villegas Herrera jesús m Villar del moral Transplant Surgery Division Department of SurgeryVirgen de las Nieves University HospitalGranada 18013AndalusiaSpain

BACKGROUND Liver grafts from donation after circulatory death(DCD)are associated with a higher risk of early graft dysfunction,determined by the warm ischemia and cold ischemia *** is essential to have precise criteria to identify this complication in order to guide therapeutic *** To validate different graft and recipient survival scores in patients undergoing liver transplantation(LT)with DCD *** A retrospective and observational unicentric study was conducted on 65 LT patients with grafts obtained from controlled DCD donors from November 2013 to November *** United Kingdom(UK)risk score,early allograft dysfunction(EAD)Olthoff score,and model for early allograft function(mEAF)score were used to evaluate the risk of graft and recipient survival *** survival analysis purposes,we used the Kaplan-meier method,and the differences between subgroups were compared using the log-rank(mantel-Cox)*** Sixty-five patients were included in the *** UK risk score did not demonstrate predictive capacity for recipient or graft ***,in donors aged over 70 years old(18.4%),it significantly predicted graft survival(Pmeier survival curves,graft survival rates at 6 months,2 years,and 5 years in the futility group dramatically decreased to 50%compared to the other groups(log-rank 8.806,PmEAF scores did not demonstrate predictive capacity for recipient or graft *** on Kaplan-meier survival curves,patients with a mEAF score≥7 had a lower graft survival rate at 6 months,2 years,and 5 years compared to patients with a lower mEAF score(log-rank 4.667,PmEAF score showed predictive capability for graft survival.

关键词： Liver transplantation Donation after circulatory death Early allograft dysfunction Risk scores Graft surviva

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Novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance

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Neural Regeneration Research 2024年第2期19卷 289-295页

作者： Dina medina-Vera Antonio jesús López-Gambero Juan Antonio Navarro Carlos Sanjuan Elena Baixeras Juan Decara Fernando Rodríguez de Fonseca Instituto de Investigación Biomédica de málaga y Plataforma en Nanomedicina-IBImA Plataforma BIONAND UGC Salud MentalMálagaSpain Facultad de Ciencias Universidad de MálagaMálagaSpain CIBER Enfermedades Cardiovasculares(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra S.L.Calle Johannes Kepler MálagaSpain Departamento de Bioquímica y Biología molecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s *** pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau *** the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug *** present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.

关键词： Alzheimer’s disease cyclin-dependent kinase 5 diabetes D-Pinitol inositols insulin resistance kinases phosphorylation PI3K/Akt tau

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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-merz Jorge Hernández-Campano Sergei A.Kirov jesús m.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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morphometry and mineral Content in the Seeds and Soil of Two Species of Argemone L.(Papaveraceae)in the Central Part of the Chihuahuan Desert

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Phyton-International Journal of Experimental Botany 2024年第2期93卷 371-386页

作者： Perla Patricia Ochoa-García Jaime Sánchez-Salas Ricardo Trejo-Calzada jesús JosafathQuezada-Rivera Fabián García-González Unidad Regional Universitaria de ZonasÁridas BermejilloUniversidad Autónoma ChapingoDurango35230México Facultad de Ciencias Biológicas Universidad Juárez del Estado de DurangoGómez PalacioDurango35010México

The genus Argemone L.(Papaveraceae)is found widely distributed in mexico’s Chihuahuan Desert(CD).Some species of this genus are of phytochemical or ethnobotanical *** are inedible plants considered as *** date they have not been broadly studied;thus,their ecology is,to our knowledge,*** present work was centered around carrying out a morphometric analysis and the determination of minerals in the soil and seeds of the wild populations of Argemone at sites belonging to two ecoregions of the CD in *** April 2021 and April 2022,seeds of Argemone spp.,and soil samples were collected at 10 sites of the *** seeds were selected under a randomized design,and weight,length,diameter,thickness,buoyancy,and mineral content were *** soil samples were obtained under the mexican regulation NOm-021-RECNAT-2000,and determinations of mineral content,electrical conductivity,apparent density,and soluble anions were *** information obtained was grouped by variable,species,and place of *** statistical tests consisted of an ANOVA,Tukey means tests considering p≤0.05,and a Principal Components *** pleiacantha exhibited differences in terms of weight(F=54.79,p=0.001),length(F=90.83,p=0.001),thickness(F=104.89,p=0.001),and diameter(F=155.82,p=0.001),and the differences in Argemone mexicana were in weight(F=46.71,p=0.001),thickness(F=187.49,p=0.001),length(F=191.56,p=0.001),and diameter(F=215.83,p=0.001).The evaluated seeds reached their maximal imbibition velocity at 24 h of *** content of the micro-and macro-nutrients analyzed in the seeds and soil suggest a tight relation with the morphometric characteristics of the seeds.

关键词： micronutrients agricultural area semiarid zone ecoregion buoyancy

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Predicting the clothing insulation through machine learning algorithms:A comparative analysis and a practical approach

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Building Simulation 2024年第5期17卷 839-855页

作者： Pablo Aparicio-Ruiz Elena Barbadilla-martin Jose Guadix jesus munuzuri Grupo de Ingenieria de Organizacion Escuela Tecnica Superior de IngenieriaUniversidad de SevillaCamino de los Descubrimientos S/N41092SevilleSpain

Since indoor clothing insulation is a key element in thermal comfort models,the aim of the present study is proposing an approach for predicting it,which could assist the occupants of a building in terms of recommendations regarding their *** that,a systematic analysis of input variables is exposed,and 13 regression and 12 classification machine learning algorithms were developed and *** results are based on data from 3352 questionnaires and 21 input variables from a field study in mixed-mode office buildings in *** temperature at 6 a.m.,indoor air temperature,indoor relative humidity,comfort temperature and gender were the most relevant features for predicting clothing *** comparing machine learning algorithms,decision tree-based algorithms with Boosting techniques achieved the best *** proposed model provides an efficient method for forecasting the clothing insulation level and its application would entail optimising thermal comfort and energy efficiency.

关键词： clothing insulation simulation adaptive thermal comfort behavioural adaptive actions machine learning

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Impact of device resistances in the performance of graphene-based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期 89-99页

作者： óscar Castelló Sofía m.López Baptista Kenji Watanabe Takashi Taniguchi Enrique Diez jesús Enrique Velázquez-Pérez Yahya m.meziani José m.Caridad Juan A.Delgado-Notario Department of Applied Physics University of Salamanca Unidad de Excelencia en Luz y materia Estructurada(LUmES) University of Salamanca Research Center for Electronic and Optical materials National Institute for Materials Science Research Center for materials Nanoarchitectonics National Institute for Materials Science Nanotechnology Group USAL–Nanolab University of Salamanca

In recent years, graphene field-effect-transistors(GFETs) have demonstrated an outstanding potential for terahertz(THz) photodetection due to their fast response and high-sensitivity. Such features are essential to enable emerging THz applications, including 6G wireless communications, quantum information, bioimaging and security. However, the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device, so-called access or parasitic resistances. In this work, we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFET detectors. Such dual-gate architectures allow us to fine tune(decrease) the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector, respectively. Our results can be well understood by a series resistance model, as shown by the excellent agreement found between the experimental data and theoretical calculations. These findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

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Identification of Rhizobia Isolated from Nodules of mexican Commercial Soybean Varieties

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American Journal of Plant Sciences 2024年第1期15卷 29-45页

作者： Cecilia Vázquez Rodríguez Lourdes Vital López jesús Gerardo García Olivares Homar Rene Gill Langarica Laboratorio de Biotecnología Vegetal Centro de Biotecnología Genómica Instituto Politécnico Nacional Reynosa México Carrera de mantenimiento Industrial Universidad Tecnológica de Tamaulipas Norte Universidad Tecnológica Reynosa México

Rhizobia, crucial for nitrogen fixation in leguminous plants, play a vital role in soybean cultivation. This study, conducted in mexico, a major soybean importer, aimed to identify bacteria from nodules of five soybean varieties in high-production regions. multilocus sequence analysis (mLSA) was employed for enhanced species resolution. The study identified six Bradyrhizobium species: Bradyrhizobium japonicum USDA 110, Bradyrhizobium japonicum USDA 6, Bradyrhizobium elkanii USDA 76, Bradyrhizobium neotropicale, Bradyrhizobium lablabi, and Bradyrhizobium icense. Bradyrhizobium japonicum USDA 110 predominated in the soils, displaying symbiotic preference for the Huasteca 400 variety. However, phylogenetic analysis didn't reveal a clear association between strains, soil, and soybean variety. This research sheds light on the diversity of rhizobia in mexican soybean cultivation, contributing to the understanding of symbiotic relationships in soybean production systems.

关键词： Nodules Soybean Housekeeping Genes mLSA Rhizobia Bradyrhizobium Nitrogen Fixation Symbiosis Phylogenetic Analysis

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