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Clinicopathological alterations in wild mammals from the reservoir system of Trypanosoma cruzi:a scoping review

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Animal Diseases 2024年第1期4卷 48-58页

作者： Ricardo sanchez Pérez JoséManuel Aranda-Coello Joséantonio De fuentes Vicente Oscar Rico Chavez Facultad de Estudios superiores Cuautitlan Universidad Nacional Autonoma deMexicoCuautitlan lzcalliEstadodeMexicoMexico El Colegio de la Frontera sur-Unidad Campeche CampecheCampecheMexico Instituto de Ciencias Biologicas-Universidad de Ciencias y Artes de Chiapas Tuxtla GutierrezChiapasMexico Facultad de Medicina Veterinaria y Zootecnia-Universidad Nacional Autonoma deMexico Ciudad deMexicoMexico

Trypanosoma cruzi is the etiologic agent of Chagas *** flagellated protozoan is transmitted to humans as well as different species of domestic and wild animals via vectors from the Reduviidae family(known as"kissing bugs").Despite the fact that hundreds of species of wild mammals are part of the reservoir system,the morphologi-cal changes and clinical manifestations resulting from the pathogenesis of the infection have been largely *** aim of this review is to systematically compile the available information regarding clinicopathological altera-tions in wild mammals due to natural infection by *** was obtained from six online bibliographic data search platforms,resulting in the identification of 29 publications that met the inclusion *** was the most common clinical manifestation,cardiac damage was the main finding at necropsy,and lymphoplas-macytic inflammation was the most frequent microscopic ***,regardless of its role as a reservoir,*** has the potential to affect the health status of wild mammals,a situation that highlights the need for further research to analyze,measure,and compare its effects at both the individual and population levels.

关键词： Trypanosoma cruzi Chagas disease American trypanosomiasis Clinicopathological alterations Natural infection Wild mammals

Potential seed germination-enhancing plant growth-promoting rhizobacteria for restoration of Pinus chiapensis ecosystems

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Journal of Forestry Research 2021年第5期32卷 2143-2153页

作者： Cristina Domínguez-Castillo Julia María Alatorre-Cruz Dolores Castañeda-antonio Jose antonio Munive Xianwu Guo jesús Francisco López-Olguín Luis Ernesto fuentes-Ramírez Ricardo Carreño-López Centro de Investigaciones en Ciencias Microbiológicas Instituto de CienciasBenemérita Universidad Autónoma de PueblaPueblaMéxico Universidad Autónoma de Querétaro QuerétaroMéxico Centro de Biotecnología Genómica Instituto Politécnico NacionalReynosaTamaulipasMéxico

Rhizosphere soil samples of three Pinus chiapensis sites were analyzed for their physicochemical properties,soil bacteria isolated and screened in vitro for growthpromoting *** isolates that showed promise were identified to five genera Dyella,Luteimonas,Euterobacter,Paraburkholderia and Bacillus based on the sequences of16 s rRNA *** the strains were isolated from nondisturbed *** bacteria significantly decreased germination time and increased sprout *** acetic acid and gibberellin production and phosphate solubilisation were *** indicate that these biochemicals could be essential for *** distribution and suggest the possibility that PGPR inoculation on *** seeds prior to planting could improve germination and possibly seedling development.

关键词： Pinus chiapensis Plant growth-promoting rhizobacteria Dyella Luteimonas Enterobacter

Preclinical models of idiosyncratic drug-induced liver injury(iDILI):Moving towards prediction

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Acta Pharmaceutica sinica B 2021年第12期11卷 3685-3726页

作者： antonio segovia-Zafra Daniel E.Di Zeo-sanchez Carlos Lopez-Gomez Zeus Perez-Valdes Eduardo garcıa-fuentes Raul J.Andrade M.Isabel Lucena Marina Villanueva-Paz Unidad de Gestio´n Clı´nica de Gastroenterologı´a Servicio de Farmacologıa ClınicaInstituto de Investigacio´n Biomedica de Malaga-IBIMAHospital Universitario Virgen de la VictoriaUniversidad de MalagaMalaga 29071Spain Centro de Investigacion Biomedica en Red en el Area Tematica de Enfermedades Hepaticas y Digestivas(CIBERehd) Madrid 28029Spain Platform IsCIII de Ensayos Clınicos UICEC-IBIMAMalaga 29071Spain Unidad de Gestion Clınica de Aparato Digestivo Instituto de Investigacion Biomedica de Malaga(IBIMA)Hospital Universitario Virgen de la VictoriaMalaga 29010Spai

Idiosyncratic drug-induced liver injury(iDILI) encompasses the unexpected harms that prescription and non-prescription drugs,herbal and dietary supplements can cause to the *** remains a major public health problem and a major cause of drug *** the lack of biomarkers for iDILI prediction,diagnosis and prognosis,searching new models to predict and study mechanisms of iDILI is *** of the major limitations of iDILI preclinical assessment has been the lack of correlation between the markers of hepatotoxicity in animal toxicological studies and clinically significant ***,major advances in the understanding of iDILI susceptibility and pathogenesis have come from the study of well-phenotyped iDILI ***,there are many gaps for explaining all the complexity of iDILI susceptibility and ***,there is a need to optimize preclinical human in vitro models to reduce the risk of iDILI during drug ***,the current experimental models and the future directions in iDILI modelling are thoroughly discussed,focusing on the human cellular models available to study the pathophysiological mechanisms of the disease and the most used in vivo animal iDILI *** also comment about in silico approaches and the increasing relevance of patient-derived cellular models.

关键词： Drug-induced liver injury Preclinical models Mechanisms Oxidative stress Mitochondrial damage Immune response Personalized medicine

Acceptance of living liver donation among medical students: A multicenter stratified study from spain

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World Journal of Gastroenterology 2016年第25期22卷 5800-5813页

作者： antonio Ríos Ana Isabel López-Navas Ana Isabel López-López Francisco Javier Gómez Jorge Iriarte Rafael Herruzo Gerardo Blanco Francisco Javier Llorca Angel Asunsolo Pilar sánchez-Gallegos Pedro Ramón Gutiérrez Ana Fernández María Teresa de jesús Laura Martínez-Alarcón Alberto Lana Lorena fuentes Juan Ramón Hernández Julio Virseda José Yelamos José antonio Bondía antonio Miguel Hernández Marco antonio Ayala Pablo Ramírez Pascual Parrilla International Collaborative Donor Project ('Proyecto Colaborativo Internacional Donante' 30007 Casillas Murcia Spain Department of surgery Paediatrics Obstetrics and Gynaecology University of Murcia Avenida de las Fuerzas Armadas 30800 Espinardo Murcia Spain Transplant Unit Surgery Service IMIB - Virgen de la Arrixaca University Hospital Carretera Madrid-Cartagena s/n 30120 El Palmar Murcia Spain Regional Transplant Centre Consejeria de Sanidad y Consumo de la Region de Murcia 30008 Ronda de Levante Murcia Spain Hospital Clinico Universitario Virgen de la Arrixaca Departamento de Cirugia General y del Aparato Digestivo Unidad de Trasplantes 30007 Casillas Murcia Spain Department of Psychology Universidad Catolica San Antonio (UCAM) Avenida de los Jeronimos 30107 Guadalupe Murcia Spain Department of Urology San Juan University Hospital of Alicante 03010 Calle Pintor Baeza Alicante Spain Universidad de Granada Avenida del Hospicio s/n 18010 Granada Spain Universidad de Navarra Campus Universitario 31080 Pamplona Navarra Spain Universidad Autonoma de Madrid Ciudad Universitaria de cantoblanco 28049 Madrid Spain servicio de Cirugia HBP y Trasplante Hepatico Complejo Hospitalario Universitario de Badajoz Hospital Infanta Cristina Avenida Elvas s/n 06006 Badajoz Spain Universidad de Cantabria Avenida los Castros s/n 39005 Santander Cantabria Spain Departamento de Cirugia Ciencias Medicas y Sociales Facultad de Medicina y Ciencias de la Salud Universidad de Alcala Campus Cientifico-Tecnologico Plaza de San Diego s/n 28801 Alcala de Henares Madrid Spain Facultad de Medicina Universidad de Malaga 29071 Avenida de Cervantes Malaga Spain servicio de Urologia (Complejo Hospitalario Universitario de Canarias CHUC) y Departamento de Cirugia (Universidad de La Laguna ULL) Calle Molinos de Agua s/n 38207 San Cristobal de La Laguna Santa Cruz de Tenerife Spain Departamento de Ciencias Biomedicas Basicas Facultad de Ciencias Biomedicas Universidad Europea de

AIM: To analyze the attitude of spanish medical students toward living liver donation (LLD) and to establish which factors have an influence on this ***: study type: A sociological, interdisciplinary, multicenter and observational study. study population: Medical students enrolled in spain (n = 34000) in the university academic year 2010-2011. sample size: A sample of 9598 students stratified by geographical area and academic year. Instrument used to measure attitude: A validated questionnaire (PCID-DVH RIOs) was self-administered and completed anonymously. Data collection procedure: Randomly selected medical schools. The questionnaire was applied to each academic year at compulsory sessions. statistical analysis: student´s t test, χsup>2sup> test and logistic regression ***: The completion rate was 95.7% (n = 9275). 89% (n = 8258) were in favor of related LLD, and 32% (n = 2937) supported unrelated LLD. The following variables were associated with having a more favorable attitude: (1) age (P = 0.008); (2) sex (P ssibility of needing a transplant oneself in the future (P sed donation (P segment from a family member if one were needed (P scussed the subject with one’s family (P s (P s opinion about the subject (P s of an altruistic nature; and (12) fear of the possible mutilation of the body after donation (P sION: spanish medical students have a favorable attitude toward LLD.

关键词： Attitude Living liver donation Medical students Transplantation Organ donation Psychosocial variables spain

Comparison of six human anti-transglutaminase ELIsA-tests in the diagnosis of celiac disease in the saharawi population

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World Journal of Gastroenterology 2005年第24期11卷 3762-3766页

作者： Eloy Fernández sabino Riestra Luis Rodrigo Carlos Blanco antonio López-Vázquez Dolores fuentes Maria Moreno Carlos López-Larrea Biochemistry service Gastroenterology service Immunology service

AIM: Celiac disease (CD) is an enteropathic disorder very prevalent in saharawi people. Our aim was to investigate the diagnostic accuracy of six human tissue transglutaminase (tTG) based ELIsA tests in saharawi CD patients. METHODs: Fifty-two CD patients and 23 controls were selected from the saharawi refugee camps in Tinduf. CD patients were divided into two groups according to their anti-endomysium (EmA) status: 41 EmA positive and 11 EmA negative. sera from patients and controls were tested for human tTG using six commercial ELIsA kits. We used receiver operating characteristics (ROC) curves and areas under the curve to compare the diagnostic accuracies of the six assays. REsULTs: In general, there are differences in the sensitivity and specificity of the human tTG ELIsA assays used. Diagnostic accuracy of tests was significantly improved by adjusting the cut-off thresholds according to ROC plot analysis; the correction of the cut-off with the employment of the ROC curve analysis modifies the decision limit in more than 50% in five of the six kits evaluated. CONCLUsION: some of the human tTG ELIsAs used in this study have a diagnostic accuracy similar to EmA determination for diagnosis of CD in saharawi people. However, it is necessary to select the assay with a higher sensitivity and specificity, and recalculate the cut-off threshold using samples from the referral population.

关键词： Anti-transglutaminase tests Comparative study Celiac diagnosis saharawi population

Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOsIMP-B study

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World Journal of Gastroenterology 2017年第41期23卷 7459-7469页

作者： Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier fuentes Martín Prieto Gloria sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa garcía-Buey María Angeles Blanco Javier salmerón María Lucía Bonet Jose antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 Division of Gastroenterology and Hepatology.Hospital Universitario Central de Asturias Unit for the Clinical Management of Digestive Diseases IBISHospital Universitario Virgen del Rocío Liver Transplantation and Hepatology Unit Gastroenterology ServiceHospital Universitario Reina Sofía Digestive Medicine service Hospital Universitario Miguel Servet Hepatology Unit Digestive Medicine ServiceHospital Universitari i Politècnic La Fe Hepatology Unit Hospital Universitario Rio Hortega Liver Unit Hospital Universitario Puerta de Hierro de MajadahondaUniversidad Autónoma de Madrid Digestive Medicine service Hospital Clínico de Santiago de Compostela Liver Unit Hospital Universitario de La Princesa Digestive Medicine service Hospital General Universitario Gregorio Maranon Digestive Medicine Unit Complejo Hospitalario de Granada Digestive Medicine service Hospital Universitario Son Espases Hepatology Unit IMIB Hospital Universitario Virgen de la Arrixaca Digestive Medicine service Hospital Clínico Universitario de Valladolid Pharmacoeconomics and Outcomes Research Iberia Division of Gastroenterology and Hepatology Complejo Asistencial Universitario de León the TENOsIMP-B Research Group

AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with *** This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were *** Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P sION TDF monotherapy proved to be safe

关键词： Tenofovir Lamivudine+Adefovir Efficacy safety Adherence Costs Hepatitis B

Atmospheric-pressure dielectric barrier discharge generation by a full-bridge flying capacitor multilevel inverter

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Plasma science and Technology 2017年第7期19卷 40-49页

作者： Rosendo PE?A-EGUILUZ José A LóPEZ-FERNáNDEZ antonio MERCADO-CABRERA Bethsabet JARAMILLO-sIERRA Régulo LóPEZ-CALLEJAs Benjamín RODRíGUEZ-MéNDEZ Raúl VALENCIA-ALVARADO Allan A FLOREs-fuentes Arturo E MU?OZ-CAsTRO Plasma Physics Laboratory Instituto Nacional de Investigaciones Nucleares Tecnológico de Estudios superiores de Tianguistenco Universidad Autónoma del Estado de México

A new configuration of a resonant full-bridge flying capacitor multicell inverter has been designed and constructed with the aim of achieving an extended output voltage frequency range with low harmonic distortion and reduced semiconductor commutation losses. This configuration was tested as a power supply for two different coaxial dielectric barrier discharge reactors, one of them employed for electric characterization and the other one for inorganic compound elimination in an aqueous solution. Two different gas mixtures, 90% Ar-10% 02 and 80% Ar-20% 02, were individually supplied during the experiments; the results showed a high- efficiency removal of meta-cresol （m-cresol） to the order of 98%, which was obtained by adding more oxygen to the plasma gas mixture.

关键词： plasma applications water pollution plasma sources power supply circuits electricdischarges

A charged star with geometric Karmarkar condition

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Communications in Theoretical Physics 2023年第8期75卷 139-149页

作者： Gabino Estevez-Delgado Joaquin Estevez-Delgado Rafael soto-Espitia antonio Rendón Romero Jorge Mauricio Paulin-fuentes Facultad de Químico Farmacobiología de la Universidad Michoacana de san Nicolás de Hidalgo Facultad de Ciencias Físico Matemáticas de la Universidad Michoacana de san Nicolás de Hidalgo Edificio BCiudad Universitaria Facultad de Ingeniería Civil de la Universidad Michoacana de san Nicolás de Hidalgo Edificio A Ciudad Universitaria Facultad de Ingeniería Mecánica de la Universidad Michoacana de san Nicolás de Hidalgo Edificio W Ciudad Universitaria División Académica de Ciencias Básicas de la Universidad Juárez Autónoma de Tabasco

In this paper,we analyse an analytical solution of the Einstein–Maxwell field equations that considers matter with anisotropic pressures in a static and spherically symmetric *** report the manner in which we obtained the solution,which is by means of the Karmarkar *** the model,we assume a state equation that describes the interaction of matter from quarks P=(c^(2)ρ-4B_(g))/3 and we consider the presence of electric charge,which can generate that the radial and tangential pressures are not *** a graphic manner,we analyse the physical properties of the model,taking as the observational data those of mass 1M⊙and radius7.69 km which were reported for the star Her *** charge values are found between 5.57×10^(18)C≤Q≤1.31×10^(20)C and the interval of the Bag constant Bg∈[118.7,122.13]MeV/fm^(3).Also,we show the stability of the configuration by means of the static stability criteria of Harrison–Zeldovich–Novikov((?M)/?ρc>0),as well as in regards to infinitesimal radial adiabatic perturbation,since the adiabatic indexγ>3.3 which guarantees the stability of the solution.

关键词： general relativity exact solutions anisotropic fluid Karmarkar condition

Relativistic charged stellar modeling with a perfect fluid sphere

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Communications in Theoretical Physics 2023年第9期75卷 113-121页

作者： Joaquin Estevez-Delgado Joel Arturo Rodríguez Ceballos Jorge Mauricio Paulin-fuentes JoséVega Cabrera antonio Rendón Romero Facultad de Ciencias Físico Matemáticas de la Universidad Michoacana de san Nicolás de Hidalgo Edificio BCiudad UniversitariaMorelia MichoacánCP 58040Mexico Facultad de Químico Farmacobiología de la Universidad Michoacana de san Nicolás de Hidalgo Tzintzuntzan No.173Col.MatamorosMorelia MichoacánC.P.58240Mexico División Académica de Ciencias Básicas de la Universidad Juárez Autónoma de Tabasco Carretera Cunduacán-Jalpa Km.1Col.La Esmeralda86690CunduacánTabascoMexico Facultad de Ingenieria Mecanica de la Universidad Michoacana de san Nicolás de Hidalgo Edificio W Ciudad UniversitariaCP 58030Morelia MichoacánMexico

In this report we present the generalization of a solution to Einstein's equations with perfect fluid for the case of Einstein–Maxwell with perfect *** effect of the charge is reflected by a parameter,ν,and its interval is determined by the positivity condition from the pressure in the interior of the *** is shown that the solution is stable according to the Zeldovich criteria as well as in relation to the criteria of the adiabatic *** compactness,u=GM/c^(2)R,of this charged model is greater than it is for the chargeless case as a result of the effect of the presence of the *** allows it to represent stars with a high compactness,in particular a graphic analysis is presented for the star sAX J1808.4-3658 with mass M=1.435M_(⊙)and radius R=7.07 *** these data and employing the solution,we obtain that the total maximum charge for the star is Q=2.4085×10^(20)C.

关键词： general relativity exact solutions charged fluid stars models