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Food Bioscience 2022年第3期47卷 91-110页

作者： sandra Peñaloza Cornelio Delesma jesús muñiz López-Ortiz A. Instituto de Energías Renovables Universidad Nacional Autónoma de MéxicoPriv.Xochicalco s/nCol.CentroTemixco62580MorelosMexico

This review is intended to cover the works related to the anthocyanin behavior in food that is subjected to *** experimental and theoretical results available in scientific literature are *** increase in anthocyanin concentration has been observed upon thermal ***,a conclusive explanation is still *** accessible studies suggest an increase in concentration during maturations,which could be related to the enzymatic *** possible enzymes involved in such a procedure have also been covered,including their role played in the *** possible activation mechanisms and the related factors such as temperature,pH,oxygen contents and the presence of UV-light irradiation were also ***,the metabolic pathways were also explored including experimental evaluation and theoretical models based on atomistic methodologies such as density functional theory(DFT).This review is aimed to provide a comprehensive overview of the probable mechanisms behind the increase of anthocyanin concentration during drying.

关键词： Anthocyanin Metabolic pathway PAL CHs UFGT HPLC Theoretical model

Interactivity software tools for teaching in ophthalmology

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Annals of Eye science 2024年第1期9卷 10-23页

作者： jesús Barrio-Barrio Department of Ophthalmology Navarra University Clinic HospitalNavarra Institute for Health ResearchIdiSNAPamplonaSpain

The use of interactive audience software,such as audience response systems(ARs),in medical education has become increasingly popular in recent *** technology allows instructors to engage students in real time,encouraging active participation and promoting effective *** benefits of interactive audience software in medical education include increased student engagement,promotion of active learning,and enhanced learning ***,there are also several challenges to its implementation,including technical difficulties,careful planning and preparation,over-reliance on technology,and ethical concerns related to privacy and data *** cost of implementing interactive audience software may also be a barrier for some *** paper specifically reviews six interactive software platforms,including socrative,Quizizz,Pear Deck,slido,Wooclap and *** platforms allow for real-time assessment of student understanding,feedback,and *** also enable instructors to adjust their teaching strategies based on student responses and ***,interactive audience software has shown great potential to enhance learning and engagement in medical *** is important for instructors to carefully consider the benefits and challenges of its *** the cost of implementing interactive audience software may be a barrier for some institutions,there are free and low-cost options available.

关键词： Interactive audience software mobile software audience response systems(ARs) medical education

soil resilience assessment using soil profile descriptions and Analytic Hierarchy Process in Mediterranean mountains considering diverse fire occurrences

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Journal of Mountain science 2024年第8期21卷 2517-2532页

作者： jesús RODRIGO-COMINO Departamento de Análisis Geográfico Regional y Geografía Física Facultad de Filosofía y LetrasCampus Universitario de CartujaUniversidad de GranadaGranada 18071Spain

Wildfires are complex natural phenomena that exert significant impacts on landscapes,societies,and *** the concept of resilience is crucial in mitigating its possible negative impacts,as it involves preparing for,responding to,and recovering from *** research aims to demonstrate the utility of in situ soil profile description in assessing land use resilience using an Analytic Hierarchy Process(AHP)through an expert panel *** study examines a catchment located in the Balearic Islands,considering two fire occurrences(once and twice),comparing abandoned agricultural terraces and natural *** results demonstrated that the priority ranking of variables to assess soil profile resilience against wildfires,determined by a panel of 10 experts,identified horizon depth(25.1%),slope inclination(21.5%),and hydrological connectivity(16.6%)as the most crucial *** variables,such as number and size of roots,structure of pedal soil material,size class structure,and rock fragments,also contributed to resilience but to a lesser extent,with scores ranging from 5.7%to 9.6%.Analyzing the priorities established by the experts using AHP,the results showed that the least resilient soil horizon was H1 of the control hillslope,especially under high and low connectivity processes,which aligned with the loss of superficial soil horizons after one and two *** showed greater changes in resilience after occurring wildfires compared to terraces,with the most significant alterations occurring after the second wildfire *** study addresses a significant knowledge gap in the field by highlighting the interconnectedness of wildfires,resilience,and land use,providing insights into land management strategies for wildfire-prone regions.

关键词： soil profiles soil geography Wildfires AHP Land management Expert panel survey

Myelin histology:a key tool in nervous system research

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Neural Regeneration Research 2024年第2期19卷 277-281页

作者： Óscar Darío García-García Víctor Carriel jesús Chato-Astrain Department of Histology Tissue Engineering GroupUniversity of Granada&Instituto de Investigación Biosanitaria ibs.GRANADAGranadaSpain

The myelin sheath is a lipoprotein-rich,multilayered structure capable of increasing conduction velocity in central and peripheral myelinated nerve *** to the complex structure and composition of myelin,various histological techniques have been developed over the centuries to evaluate myelin under normal,pathological or experimental ***,methods to assess myelin integrity or content are key tools in both clinical diagnosis and neuroscience *** this review,we provide an updated summary of the composition and structure of the myelin sheath and discuss some histological procedures,from tissue fixation and processing techniques to the most used and practical myelin histological staining *** the lipoprotein nature of myelin,the main features and technical details of the different available methods that can be used to evaluate the lipid or protein components of myelin are described,as well as the precise ultrastructural techniques.

关键词： fluorescence microscopy histology light microscopy lipid histochemistry metallographic techniques myelin histochemistry myelin immunohistochemistry myelin structure&composition myelin ultrastructural evaluation tissue fixation&processing

Predicting the clothing insulation through machine learning algorithms:A comparative analysis and a practical approach

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Building simulation 2024年第5期17卷 839-855页

作者： Pablo Aparicio-Ruiz Elena Barbadilla-Martin Jose Guadix jesus munuzuri Grupo de Ingenieria de Organizacion Escuela Tecnica Superior de IngenieriaUniversidad de SevillaCamino de los Descubrimientos S/N41092SevilleSpain

since indoor clothing insulation is a key element in thermal comfort models,the aim of the present study is proposing an approach for predicting it,which could assist the occupants of a building in terms of recommendations regarding their *** that,a systematic analysis of input variables is exposed,and 13 regression and 12 classification machine learning algorithms were developed and *** results are based on data from 3352 questionnaires and 21 input variables from a field study in mixed-mode office buildings in *** temperature at 6 a.m.,indoor air temperature,indoor relative humidity,comfort temperature and gender were the most relevant features for predicting clothing *** comparing machine learning algorithms,decision tree-based algorithms with Boosting techniques achieved the best *** proposed model provides an efficient method for forecasting the clothing insulation level and its application would entail optimising thermal comfort and energy efficiency.

关键词： clothing insulation simulation adaptive thermal comfort behavioural adaptive actions machine learning

An optimization-oriented modeling approach using input convex neural networks and its application on optimal chiller loading

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Building simulation 2024年第4期17卷 639-655页

作者： shanshuo Xing Jili Zhang song mu Dalian University of Technology Dalian116024China Guangdong Airport Baiyun Information Technology Co. Ltd.Guangzhou510000China

Optimization for the multi-chiller system is an indispensable approach for the operation of highly efficient chiller *** optima obtained by model-based optimization algorithms are dependent on precise and solvable objective *** classical neural networks cannot provide convex input-output mappings despite capturing impressive nonlinear fitting capabilities,resulting in a reduction in the robustness of model-based *** this paper,we leverage the input convex neural networks(ICNN)to identify the chiller model to construct a convex mapping between control variables and the objective function,which enables the NN-based OCL as a convex optimization problem and apply it to multi-chiller optimization for optimal chiller loading(OCL).Approximation performances are evaluated through a four-model comparison based on an experimental data set,and the statistical results show that,on the premise of retaining prior convexities,the proposed model depicts excellent approximation power for the data set,especially the unseen ***,the ICNN model is applied to a typical OCL problem for a multi-chiller system and combined with three types of optimization *** with conventional and meta-heuristic methods,the numerical results suggest that the gradient-based BFGs algorithm provides better energy-saving ratios facing consecutive cooling load inputs and an impressive convergence speed.

关键词： chiller plant input convex neural network optimal load distribution convex optimization

Liquid biopsy for gastric cancer:Techniques,applications,and future directions

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World Journal of Gastroenterology 2024年第12期30卷 1680-1705页

作者： Cristina Díaz del Arco M jesús Fernández Aceñero Luis Ortega Medina Department of surgical Pathology Health Research Institute of the Hospital Clínico San CarlosHospital Clínico San CarlosMadrid 28040Spain Department of Legal Medicine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28040Spain

After the study of circulating tumor cells in blood through liquid biopsy(LB),this technique has evolved to encompass the analysis of multiple materials originating from the tumor,such as nucleic acids,extracellular vesicles,tumor-educated platelets,and other ***,research has extended to include the examination of samples other than blood or plasma,such as saliva,gastric juice,urine,or *** techniques are diverse,intricate,and *** must be highly sensitive,and pre-analytical,patient,and tumor-related factors significantly influence the detection threshold,diagnostic method selection,and potential ***,the implementation of LB in clinical practice still faces several *** potential applications of LB range from early cancer detection to guiding targeted therapy or immunotherapy in both early and advanced cancer cases,monitoring treatment response,early identification of relapses,or assessing patient *** the other hand,gastric cancer(GC)is a disease often diagnosed at advanced *** recent advances in molecular understanding,the currently available treatment options have not substantially improved the prognosis for many of these *** application of LB in GC could be highly valuable as a non-invasive method for early diagnosis and for enhancing the management and outcomes of these *** this comprehensive review,from a pathologist’s perspective,we provide an overview of the main options available in LB,delve into the fundamental principles of the most studied techniques,explore the potential utility of LB application in the context of GC,and address the obstacles that need to be overcome in the future to make this innovative technique a game-changer in cancer diagnosis and treatment within clinical practice.

关键词： Liquid biopsy Gastric cancer Circulating tumor cells Cell-free DNA Circulating tumor DNA Molecular

Traveling Wave Characteristics Based Pilot Protection scheme for Hybrid Cascaded HVDC Transmission Line

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Journal of Modern Power systems and Clean Energy 2024年第3期12卷 971-980页

作者： Dalin mu sheng Lin Xiaopeng Li the school of Electrical Engineering Southwest Jiaotong UniversityChengdu 611756China the state Grid sichuan Electric Power Research Institute Chengdu 610041China

The hybrid cascaded high-voltage direct current(HVDC)transmission system has various operation modes,and some operation modes have sharply increasing requirements for protection rapidity,while the traditional pilot differential protection(PDP)has poor rapidity,and even refuses to operate when faults occur on the DC ***,a novel pilot protection scheme based on traveling wave characteristics is ***,the adaptability of the traditional PDP applied in engineering is analyzed for different operation ***,the expressions of the forward traveling wave(FTW)and backward traveling wave(BTW)on the rectifier side and the inverter side are derived for different fault *** the theoretical derivation,the difference between the BTW and FTW on the rectifier side is less than zero,and the same is true on the inverter ***,in the event of an external fault of DC line,the difference between the BTW and FTW at nearfault terminal protection installation point is greater than ***,by summing over the product of the difference between BTW and FTW of the rectifier side and that of the inverter side,the fault identification criterion is *** simulation results show that the proposed pilot protection scheme can quickly and reliably identify the short-circuit faults of DC line in different operation modes.

关键词： Hybrid cascaded high-voltage direct current(HVDC)transmission system DC line operation mode pilot protection

strong synergy between physical and chemical properties:Insight into optimization of atomically dispersed oxygen reduction catalysts

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Journal of Energy Chemistry 2024年第4期91卷 36-49页

作者： Yifan Zhang Linsheng Liu Yuxuan Li Xueqin mu shichun mu suli Liu Zhihui Dai school of Chemistry and Molecular Engineering Nanjing Tech UniversityNanjing 211816JiangsuChina state Key Laboratory of Advanced Technology for Materials synthesis and Processing Wuhan University of Technology InstitutionWuhan 430070HubeiChina school of Chemistry and Materials science Nanjing Normal UniversityNanjing 210023JiangsuChina

Atomically dispersed catalysts exhibit significant influence on facilitating the sluggish oxygen reduction reaction(ORR)kinetics with high atom economy,owing to remarkable attributes including nearly 100%atomic utilization and exceptional catalytic ***,accurately controlling atomic physical properties including spin,charge,orbital,and lattice degrees of atomically dispersed catalysts can realize the optimized chemical properties including maximum atom utilization efficiency,homogenous active centers,and satisfactory catalytic performance,but remains ***,through physical and chemical insight,we review and systematically summarize the strategies to optimize atomically dispersed ORR catalysts including adjusting the atomic coordination environment,adjacent electronic orbital and site density,and the choice of dual-atom *** the emphasis is on the fundamental understanding of the correlation between the physical property and the catalytic behavior for atomically dispersed ***,an overview of the existing challenges and prospects to illustrate the current obstacles and potential opportunities for the advancement of atomically dispersed catalysts in the realm of electrocatalytic reactions is offered.

关键词： Atomically dispersed catalysts Coordination environment Electronic orbitals Inter-site distance effect Oxygen reduction reaction

sea level rise along China coast from 1950 to 2020

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science China Earth sciences 2024年第3期67卷 802-810页

作者： Dapeng mu Tianhe XU Haoming YAN Institute of space sciences Shandong UniversityWeihai 264209China Innovation Academy for Precision Measurement science and Technology Chinese Academy of SciencesWuhan 430071China Institute of Marine and Antarctic science University of TasmaniaHobartTasmania 7004Australia

Global mean sea level rise has been reconstructed using tide gauges. However, long-term sea level rise along the China coast is unclear. To address this issue, a data assimilation approach is developed to reconstruct sea level rise along the China coast from 1950 to 2020 using a global distribution of tide gauges(TGs). This approach combines climate models and sea level fingerprints. The climate models provide stereodynamic sea level changes. The sea level fingerprints include increases in ocean mass due to global ice melting and changes in water storage on land. The reconstructed global mean sea level rise agrees well with previous studies. We quantify sea level rise at 20 TGs along the China coast. The results suggest that sea level rise along the China coast(1.95±0.33 mm yr^(-1)) is greater than the global mean(1.71±0.17 mm yr^(-1)). We also find that China's coastal sea level rise is more than three times faster after 1980, increasing from 0.84±0.28 mm yr^(-1)for 1950–1980 to3.12±0.21 mm yr^(-1)for 1980–2020. This finding implies a significant sea level acceleration along the China coast. Our results advance the understanding of long-term sea level changes along the China coast.

关键词： sea level rise China coast Tide gauges Data assimilation