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Dual-targeted lung cancer therapy via inhalation delivery of UCNP-siRNA-As1411 nanocages

Cancer Biology & medicine 2022年第7期19卷 1047-1060页

作者： Yu Han Yuming Yang Qiuyang sun Bin Li Caixia Yue Yanlei Liu Jesús M.de la fuente Daxiang Cui Institute of Nano Biomedicine and Engineering Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of EducationShanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentDepartment of Instrument Science&EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China National Engineering Center for Nanotechnology Collaborative Innovational Center for System BiologyShanghai 200241China department of Neurosurgery Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 200092China school of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Instituto de Nanociencia de Aragon(INA) Universidad de ZaragozaZaragoza 50018Spain

Objective:Although great progress has been m.de in the field of siRNA gene therapy,safe,efficient,and targeted delivery of siRNA are still major challenges in siRNA therapeutics.methods:We developed an up-conversion nanoparticle-based nanocage system.This system protected the siRNA from being degraded by nucleases in organisms and selectively delivered the siRNAs to the tumor sites,due to modifications of targeted molecules on the surfaces of nanocages and local inhalation.Results:The siRNAs delivered by the up-conversion nanoparticle nanocages were protected from.degradation in transit to the tumor sites,where they accumulated.Compared with the passive target and control groups,the up-conversion nanoparticles based on the nanocage system showed a tumor suppressive effect after approximately 3 weeks of treatment.Conclusions:The up-conversion nanoparticle nanocages efficiently delivered vascular endothelial growth factor siRNAs to tumor sites.mice with lung tumors treated with tumors targeting up-conversion nanoparticle nanocages showed steady body weight changes,high tumor inhibition ratios,and longer survival times.

关键词： Nanomaterials VEGF siRNA lung cancer gene therapy siRNA delivery

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Artificial intelligence in theranostics of gastric cancer, a review

Medical Review

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medical Review 2023年第3期3卷 214-229页

作者： Yiqian Zha Cuili Xue Yanlei Liu Jian Ni jesus m.de la fuente Daxiang Cui Institute of Nano Biomedicine and Engineering Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment InstrumentSchool of Sensing Science and EngineeringShanghai Jiao Tong UniversityShanghaiChina National Engineering Research Center for Nanotechnology ShanghaiChina Institute of Aragon Nanoscience University of ZaragozaZaragozaSpain

Gastric cancer (GC) is one of the commonestcancers with high morbidity and mortality in the world.How to realize precise diagnosis and therapy of GC ownsgreat clinical requirement. In recent years, artificial intelligence (AI) has been actively explored to apply to earlydiagnosis and treatment and prognosis of gastric carcinoma. Herein, we review recent advance of AI in earlyscreening, diagnosis, therapy and prognosis of stomachcarcinoma. Especially AI combined with breath screeningearly GC system improved 97.4 % of early GC diagnosisratio, AI m.del on stomach cancer diagnosis system of salivabiomarkers obtained an overall accuracy of 97.18 %, speci-ficity of 97.44 %, and sensitivity of 96.88 %. We also discussconcept, issues, approaches and challenges of AI applied instomach cancer. This review provides a comprehensive viewand roadmap for readers working in this field, with the aimof pushing application of AI in theranostics of stomachcancer to increase the early discovery ratio and curativeratio of GC patients.

关键词： artificial intelligence diagnosis gastric cancer prognosis screening therapy

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subjective experience and visual attention to a historic building:A real-world eyetracking study

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Frontiers of Architectural Research 2020年第4期9卷 774-804页

作者： Luis Alfonso de la fuente suarez Architecture school Universidad Autonoma de Nuevo LeonSon Nicolos de los Garza(Monterrey)66455Mexico

The objective of this exploratory study is to discover the relations between visual attention to an architectural work and the subjective experiences produced during its observation.A subjective experience with a building is the specific manner in which an architectural element or the building as a whole are presented to a person.The qualities of the element as how they are perceived and the inner world of the observer are both considered in this subjective experience.The aims of this study are to describe the experience that a building generates in people,pinpoint what has attracted the participant's attention during each view of the building in an itinerary;and understand which aspects of this selected case study have m.de it an object of attend on.An eye-tracking study was carried out using a portable eye tracker.This tool allowed the participants to walk freely around the exterior of a historic train station in the city of monterrey,mexico.Two groups of participants,with routes starting from opposite sides of the building,contemplated it while using the eye tracker.Eye tracking allowed for the identification of the architectural elements that were objects of attention,the lengths of observation,and the points of view from which the elements were observed.Other data collection techniques,such as the think-aloud protocol and a special type of survey,were used to deeply understand the experiences that accompanied the visual exploration of the historic building.Results suggest that the participants observed the different architectural elements for a time that was neither influenced by the route used to explore the building nor the point where that route was initiated.The architectural elements identified as examples of high-quality architecture and perceived as aesthetically pleasing by the participants during the itinerary were observed for longer times.

关键词： Eye tracking Architecture Attention subjective experience Data visualization

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霍克“暴风”战斗机

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模型世界 2021年第12期 48-59+5页

作者： Tomás de la fuente

强大的霍克"暴风"战斗机可谓是第二次世界大战中最现代化、最令人印象深刻的飞机之一。它由空中野兽——霍克"台风"战斗机发展而来,在登陆后的日子里也有突出的表现。Tomás de la fuente为我们带来了这件细节满满的1/48比例模型,座舱...

强大的霍克"暴风"战斗机可谓是第二次世界大战中最现代化、最令人印象深刻的飞机之一。它由空中野兽——霍克"台风"战斗机发展而来,在登陆后的日子里也有突出的表现。Tomás de la fuente为我们带来了这件细节满满的1/48比例模型,座舱和其中一扇机翼上的弹舱为开启状态,呈现出丰富的直观细节。飞机身披当时英国皇家空军的典型迷彩,这种涂装一直都是表现大量污垢和磨损效果的良好平台。作者将逐步向我们讲述制作过程。

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FW-190 A-5——荷兰第1战斗机联队

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模型世界 2020年第9期 58-71页

作者： Tomás de la fuente

1/32长谷川(Hasegawa) Fw-190 A-5Fw-190是第二次世界大战最传奇的飞机之一。它的设计始于1937年,当时被设计为一线战斗机me-10的继任者。事实上,me-10从未被Fw-190取代,而是随着战争和前线的推进共存。一直到D型为止,它的主要特征是一...

1/32长谷川(Hasegawa) Fw-190 A-5Fw-190是第二次世界大战最传奇的飞机之一。它的设计始于1937年,当时被设计为一线战斗机me-10的继任者。事实上,me-10从未被Fw-190取代,而是随着战争和前线的推进共存。一直到D型为止,它的主要特征是一台14缸的BmW-801D-2径向发动机,拥有2100马力。使用这种径向发动机的机型有三种:A、F和G,

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雅克夫列夫YAK-3

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模型世界 2020年第6期 56-65页

作者： Tomás de la fuente

sPECIAL HOBBY 1/32推出一款1/32的雅克-3在大比例模型圈内的呼声响了很久。该机的1/48比例模型曾由红星(ZVEZDA)和牛魔王(Eduard)出过,但大比例模型仍未出现。终于,special Hobby推出了这套整体而言质量不错的套件,不过轮舱等部位开模...

sPECIAL HOBBY 1/32推出一款1/32的雅克-3在大比例模型圈内的呼声响了很久。该机的1/48比例模型曾由红星(ZVEZDA)和牛魔王(Eduard)出过,但大比例模型仍未出现。终于,special Hobby推出了这套整体而言质量不错的套件,不过轮舱等部位开模过于繁琐。我觉得这款模型并不适合初学者。套件包含6板塑料件,排气管、轮子、无线电收发器等全为树脂件,以及一张预切成型的遮盖纸,一

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梅塞施密特Bf-109 E-4

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模型世界 2018年第2期 66-74页

作者： Tomás de la fuente

Bf-109这一机型的鼎鼎大名早就已经不需要我去做过多的赘述了,所以我在此只介绍BF109家族中极为特殊的于1941年7月8月在Kln-Ostheim(科隆-奥斯特海姆)进行试飞的夜间作战型号。以BF-109 E-4为基础改造而成,通体被涂成了黑色涂装,加装... 详细信息

Bf-109这一机型的鼎鼎大名早就已经不需要我去做过多的赘述了,所以我在此只介绍BF109家族中极为特殊的于1941年7月8月在Kln-Ostheim(科隆-奥斯特海姆)进行试飞的夜间作战型号。以BF-109 E-4为基础改造而成,通体被涂成了黑色涂装,加装了Pei IG IV夜战天线,通过螺线管检测地面的无线电光束来进行导向。两个额外螺线管被加装在了机身底部并分别被一个泪滴状整流罩保护着。为了弥补这些夜战改造所带来的额外重量和对操

关键词：油画颜料螺线管 Bf-109 E-4 组合度 AK 驾驶舱施密特

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利比亚“铁面”

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模型世界 2018年第12期 30-42页

作者： Tomás de la fuente

梅塞施密特Bf 110是二战最为有名的双引擎战斗机之一。它被设计成一种远程重型战斗机,然而它在不列颠之战的表现暴露了许多缺陷。由于缺乏机动性和加速性能,Bf 110跟英国单发战斗机根本无法匹敌。结果就是不仅没法给轰炸机护航,它们自... 详细信息

梅塞施密特Bf 110是二战最为有名的双引擎战斗机之一。它被设计成一种远程重型战斗机,然而它在不列颠之战的表现暴露了许多缺陷。由于缺乏机动性和加速性能,Bf 110跟英国单发战斗机根本无法匹敌。结果就是不仅没法给轰炸机护航,它们自己还得有飞机护航。但在另外一方面,Bf 110在对地攻击和夜间攻击中表现非常优秀。它的最终型号Bf 110 G-4型一直生

关键词：珐琅漆内部细节亮光漆组合度利比亚

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The sound of host-sARs-CoV-2 molecular interactions

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The Innovation 2021年第3期2卷 5-6页

作者： Joséde la fuente Juan J.Pastor Comín Christian Gortázar saBio.Instituto de Investigación en Recursos Cinegéticos IREC-CsIC-UCLm-JCCm Ronda de Toledo s/n13005 Ciudad RealSpain department of Veterinary Pathobiology Center for Veterinary Health SciencesOklahoma State UniversityStillwaterOK 74078USA Centro de Investigación y Documentación musical CIDom-UCLm-CsIC Facultad de Educación de Ciudad RealRonda Calatrava 313071 Ciudad RealSpain

Host-and virus-derived factors are key drivers of the COVID-19 pandemic(Gortázar et al.).1 The interaction between the severe acute respiratory syndrome coronavirus 2(sARs-CoV-2)spike glycoprotein(s)and host cell membrane angiotensin I converting enzyme 2(ACE2)receptor is highly dynamic,mediates virus infection,and is the main target for protective antibody response2.

关键词： ACE2 protective acute

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serum biomarkers and risk of hepatocellular carcinoma recurrence after liver transplantation

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World Journal of Hepatology 2019年第1期11卷 50-63页

作者： maria J Citores Jose L Lucena sara de la fuente Valentin Cuervas-mons department of Internal medicine Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana Liver Transplantation Unit Hospital Universitario Puerta de Hierro-Majadahonda department of surgery Hospital Universitario Puerta de Hierro-Majadahonda Valentin Cuervas-mons Department of Internal Medicine HospitalUniversitario Puerta de Hierro-Majadahonda department of medicine Universidad Autónoma de Madrid

Liver transplantation(LT) is the only potentially curative treatment for selected patients with cirrhosis and hepatocellular carcinoma(HCC) who are not candidates for resection. When the milan criteria are strictly applied, 75% to85%of 3-to 4-year actuarial survival rates are achieved, but up to 20% of the patients experience HCC recurrence after transplantation. The milan criteria are based on the preoperative tumor macromorphology, tumor size and number on computed tomography or magnetic resonance imaging that neither correlate well with posttransplant histological study of the liver explant nor accurately predict HCC recurrence after LT, since they do not include objective measures of tumor biology. Preoperative biological markers, including alpha-fetoprotein, desgamma-carboxiprothrombin or neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio, can predict the risk for HCC recurrence after transplantation.These biomarkers have been proposed as surrogate markers of tumor differentiation and vascular invasion, with varied risk magnitudes depending on the defined cutoffs. Different studies have shown that the combination of one or several biomarkers integrated into prognostic m.dels predict the risk of HCC recurrence after LT more accurately than milan criteria alone. In this review, we focus on the potential utility of these serum biological markers to improve the performance of milan criteria to identify patients at high risk of tumoral Published online: January 27, 2019 recurrence after LT.Liver transplantation(LT) is the only potentially curative treatment for selected patients with cirrhosis and hepatocellular carcinoma(HCC) who are not candidates for resection. When the milan criteria are strictly applied, 75% to85%of 3-to 4-year actuarial survival rates are achieved, but up to 20% of the patients experience HCC recurrence after transplantation. The milan criteria are based on the preoperative tumor macromorphology, tumor size and number on computed tomography or magnetic resonance imaging that nei

关键词： Hepatocellular carcinoma Liver transplantation Recurrence selection criteria Prognostic score Biomarker Alpha-fetoprotein systemic inflammatory marker

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