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Fatty acid desaturation by stearoyl-coA desaturase-1 controls regulatory T cell differentiation and autoimmunity

cellular & Molecular Immunology 2023年第6期20卷 666-679页

作者： Elien Grajchen Melanie Loix Paulien Baeten Beatriz F.côrte-Real Ibrahim Hamad Sam Vanherle Mansour Haidar Jonas Dehairs Jelle Y.Broos James M.Ntambi Robert Zimmermann Rolf Breinbauer Piet Stinissen Niels Hellings Sanne G.S.Verberk Gijs Kooij Martin Giera Johannes V.Swinnen Bieke Broux Markus Kleinewietfeld jerome J.A.Hendriks Jeroen F.J.Bogie Department of Immunology and Infection Biomedical Research InstituteHasselt UniversityDiepenbeekBelgium University MS center Hasselt PeltBelgium Neuro-Immune connections and Repair Lab Department of Immunology and InfectionBiomedical Research InstituteHasselt UniversityDiepenbeekBelgium VIB Laboratory of Translational Immunomodulation VIB Center for Inflammation ResearchHasselt UniversityDiepenbeekBelgium Department of Oncology Laboratory of Lipid Metabolism and CancerLKI–Leuven Cancer InstituteKU Leuven-University of LeuvenLeuvenBelgium Department of Molecular cell Biology and Immunology Amsterdam University Medical CenterVrije Universiteit AmsterdamAmsterdam NeuroscienceMS Center AmsterdamAmsterdamThe Netherlands center for Proteomics and Metabolomics Leiden University Medical CenterLeidenThe Netherlands Department of Biochemistry Department of Nutritional SciencesUniversity of Wisconsin-MadisonMadisonUSA Institute of Molecular Biosciences University of GrazGrazAustria BioTechMed-Graz GrazAustria Institute of Organic chemistry Graz University of TechnologyGrazAustria cardiovascular Research Institute Maastricht Department of Internal MedicineMaastricht UniversityMaastrichtThe Netherlands

The imbalance between pathogenic and protective T cell subsets is a cardinal feature of autoimmune disorders such as multiple sclerosis(MS).Emerging evidence indicates that endogenous and dietary-induced changes in fatty acid metabolism have a major impact on both T cell fate and *** date,however,the molecular mechanisms that underlie the impact of fatty acid metabolism on T cell physiology and autoimmunity remain poorly ***,we report that stearoyl-coA desaturase-1(ScD1),an enzyme essential for the desaturation of fatty acids and highly regulated by dietary factors,acts as an endogenous brake on regulatory T-cell(Treg)differentiation and augments autoimmunity in an animal model of MS in a T cell-dependent *** by RNA sequencing and lipidomics analysis,we found that the absence of Scd1 in T cells promotes the hydrolysis of triglycerides and phosphatidylcholine through adipose triglyceride lipase(ATGL).ATGL-dependent release of docosahexaenoic acid enhanced Treg differentiation by activating the nuclear receptor peroxisome proliferator-activated receptor *** findings identify fatty acid desaturation by ScD1 as an essential determinant of Treg differentiation and autoimmunity,with potentially broad implications for the development of novel therapeutic strategies and dietary interventions for autoimmune disorders such as MS.

关键词： Regulatory T cells Autoimmunity Fatty acid metabolism Stearoyl-coA desaturase-1 Multiple sclerosis

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Synthesis, characterization and Biological Activity Evaluation of Schiff Bases Derived from 1,8-Diaminonaphtalène

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Open Journal of Physical chemistry 2023年第2期13卷 29-37页

作者： Niameke Jean Baptiste Kangah Nanou Tiéba Tuo Daouda Ballo Ahmont landry claude Kablan N’goran Etienne Kouame charles Guillaume Kodjo Nahossé Ziao Laboratoire de Thermodynamique et de Physico-chimie du Milieu UFR SFA Universite Nangui Abrogoua Abidjan C&ocircte d’Ivoire Laboratoire de chimie Organique Heterocyclique URAc 21 Pole de Competence Pharmacochimie Faculte des Sciences Universite’ Mohammed V Rabat Morocco Laboratoire de constitution et Reaction de la Matiere (LcRM) UFR Sciences des Structures de la Matiere et Technologie Universite Felix Houphouet-Boigny Abidjan C&ocircte d’Ivoire UFR Des Sciences Biologiques Universite Peleforo Gon Coulibaly de Korhogo Korhogo C&ocircte d’Ivoire

The compounds have been synthesized and characterized by routine MS, IR and NMR spectrometry methods. The compounds are all active on bacterial strains with the exception of Salmonella typhimirium, with a MIc value of 7.5 mg/mL. They show a percentage of anti-radical activity of 75.476 ± 5.070 for the compound DAN-S and of 68.142 ± 6.539 for the compound DAN-OV. The compounds are sensitive to the two champions used. DAN-S compound is then the most active.

关键词： Schiff Base Spectrometry Antioxidant Antimicrobial Activity Inhibition 1 8-Diaminonaphthalene

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植物体系非生物纳米载体的开发及生物分子递送应用

植物体系非生物纳米载体的开发及生物分子递送应用

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首届植物科学前沿学术大会

作者：张欢 Natalie Goh Markita landry 暨南大学化学与材料学院 University of california-Berkeley

植物基因工程是农业科技革命的关键技术,发展高效、安全的遗传转化技术是基因工程和遗传育种等领域的研究热点之一。传统的遗传转化技术(农杆菌转化法和基因枪法)存在物种受限、基因整合、组织损伤及效率低等问题,不能满足日益增长的植... 详细信息

植物基因工程是农业科技革命的关键技术,发展高效、安全的遗传转化技术是基因工程和遗传育种等领域的研究热点之一。传统的遗传转化技术(农杆菌转化法和基因枪法)存在物种受限、基因整合、组织损伤及效率低等问题,不能满足日益增长的植物遗传转化需求。本系列研究充分发挥DNA纳米技术的高度可设计性及可编程性,设计开发了DNA纳米结构以及纳米金等纳米载体,通过精确地调控纳米载体的物理化学性质,如尺寸、刚性等,系统的研究了纳米载体被植物细胞有效摄取的性能参数。结果标明,DNA纳米结构的尺寸及刚性是决定其是否可以有效摄取的两个关键指标。DNA纳米结构作为载体可以有效地将干扰小RNA(siRNA)递送到烟草植物叶片中发挥基因沉默功能,并且沉默效率和相对摄取量成正比。在此研究基础上,我们设计了不同尺寸(5-20 nm)和形状(球形和棒状)的核酸分子修饰的金纳米颗粒,进一步的系统研究纳米颗粒在植物叶片及细胞中的转运及摄取机理。研究结果发现,金纳米颗粒均可以被输送至细胞壁部位,和细胞壁发生一定的相互作用,但是只有棒状的金纳米颗粒可以被植物细胞摄取。进一步使用金纳米颗粒作为载体载带siRNA的结果却标明,10 nm的球形金纳米颗粒具有最优的基因沉默效率。基于此,本研究提出siRNA的载带并不需要纳米载体进入植物细胞,只要载体可以有效地保护siRNA且将其运送至植物细胞壁处,siRNA便可进入细胞发挥基因沉默作用。本系列研究为非生物纳米载体的设计及开发提供了理论指导,有望针对不同的功能生物分子开发定制的纳米载体,更好的服务基于基因编辑的新一代育种技术。

关键词：纳米载体基因沉默生物分子递送植物

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Endoscopic ultrasound-guided portal pressure gradient identifies patients with previously undiagnosed clinically significant portal hypertension

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Portal Hypertension & cirrhosis 2024年第2期3卷 67-74页

作者： jerome c.Edelson Scott F.D.Edelson John G.Quiles cyrus V.Edelson Eric M.Montminy christian L.Horn John P.Magulick Don c.Rockey Department of Gastroenterology and Hepatology Brooke Army Medical CenterFort Sam HoustonTexasUSA Department of Medicine Uniformed Services University of the Health SciencesBethesdaMarylandUSA Department of Medicine Brooke Army Medical CenterFort Sam HoustonTexasUSA John H.Stroger Jr.Hospital of cook county ChicagoIllinoisUSA Digestive Disease Research center Medical University of South CarolinaCharlestonSouth CarolinaUSA

Aims:Portal hypertension(PH)is a complication of cirrhosis that leads to hepatic *** the portal pressure gradient(PPG)provides valuable information for disease assessment,staging,and *** this study,we aimed to report the utilization of endoscopic ultrasound(EUS)-guided PPG(EUS-PPG)measurements in a real-world ***:This retrospective analysis included patients at a tertiary care center who underwent EUS-PPG between February 2021 and May *** most common indication was to establish or exclude the diagnosis of cirrhosis,followed by an assessment of surgical risk in the setting of suspected *** demographic and clinical data were collected,and statistical analysis was performed using the Student's t ***:Eighteen patients underwent *** success was achieved in 17 of the 18 *** complications were *** mean scores of child-Pugh,Model for End-Stage Liver Disease-Sodium,and Fibrosis-4 scores were 5.1±0.5,9.0±3.0,and 3.7±4.5,*** the 18 patients,two presented with esophageal varices and six with portal hypertensive *** mean PPG was 5.8±4.5 mmHg,and five patients exhibited clinically significant PH(cSPH).Of the 18 patients,15 underwent concurrent EUS-liver biopsy,which was 100%successful and provided diagnostic histology for all *** PPG data led to changes in the clinical management of 17 ***:EUS-PPG is safe and technically *** child-Pugh score did not correlate well with the presence of cSPH;however,PPG measurements resulted in changes in the management of almost all *** studies correlating EUS-PPG with other assessments of liver diseases are required.

关键词： EUS portal hypertension portal pressure gradient

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cyberMax ValueMax c5 200+ MMX,HiQ 6x86MX PowerStation,NEc PowerMate Professional,Tri-Star StarStationⅡ——cyrix M2挑战300MHz PentiumⅡ

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电子与电脑 1997年第11期4卷 40-41页

作者： Marty jerome 唐宏

随着cyrix首次推出大家期待已久的M2处理器,市场上涌现出的大量新cPU使用户做出购买决定变得很困难。与此同时,Intel公司也将其Pentium Ⅱ处理器的主频提升到300MHz。这些新产品的陆续问世的确令人困惑,但我们对四种新系统进行预览后发... 详细信息

随着cyrix首次推出大家期待已久的M2处理器,市场上涌现出的大量新cPU使用户做出购买决定变得很困难。与此同时,Intel公司也将其Pentium Ⅱ处理器的主频提升到300MHz。这些新产品的陆续问世的确令人困惑,但我们对四种新系统进行预览后发现,Windows NT的能力在这些系统中比以前得到了更充分的发挥。低标价 cyrix这种最新版处理器芯片的正式名称为6x86MX,有两种型号:200MHz和233MHz,它们主要针对Pentium Ⅱ。

关键词：微处理器 M2 PentiumⅡ

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A rare case of giant solitary spinal B cell lymphoblastic lymphoma

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chinese Neurosurgical Journal 2016年第4期2卷 245-248页

作者： Hermann Adonis N'da Kporou landry Drogba Louis Derou Slim Alban Mbende Dominique N'dri Oka Vincent Ba Zézé Service de Neurochirurgie CHU de Yopougon Abidjan C(o)te d'lvoire 21 BP 632 Abidjan C(o)te d'lvoire

Background:common B cell lymphoma locations are lymph nodes,skin,bone,mediastinum and it accounts for 2 ％ of *** solitary spinal B-LBL has not yet been *** presentation:A 15-years old boy was admitted for a painful swelling of the thoracolumbar spine and *** showed a voluminous mass of the thoracolumbar *** treatment consisted of surgical decompression and stabilization,followed by chemotherapy and *** examination showed a *** quality of life improved ***:To the best of our knowledge,this is the first case of giant solitary spinal B-LBL ever *** to choose a treatment method over another should weigh on individual *** should be considered as initial treatment option in this atypical lesion.

关键词： B Lymphoblastic lymphoma Spinal tumour Spine surgery

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RAPD标记基因鉴别小花型观赏月季品种及其辐射育种突变系的研究

RAPD标记基因鉴别小花型观赏月季品种及其辐射育种突变系的研究

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中国科学技术协会第二届青年学术年会

作者：李荣旗 Marchard M．c．桑贺田 landry B．S 北京市林业科学院果树研究所 Agriulture canada Research Station 430 Bird Gonin St-Jean-Su-Richelieu Queoce canada J3B3E6

利用RAPD(Random Amplyiied Poly noiphil DNA)标记基因,随机选用19个10个碱基的寡聚核苷酸引物印迹了五个小花型月季品种以及由这5个品种经过辐射方法获得的19个突变系,共探测453个基因位点。RAPD标记基因可以将5个品种以及5个家系准... 详细信息

利用RAPD(Random Amplyiied Poly noiphil DNA)标记基因,随机选用19个10个碱基的寡聚核苷酸引物印迹了五个小花型月季品种以及由这5个品种经过辐射方法获得的19个突变系,共探测453个基因位点。RAPD标记基因可以将5个品种以及5个家系准确地鉴别开来,但对每个家系内亲本和后代的鉴别十分困难。有意义的是,引物OP-ALL探测到MT-258有一条比其亲本MT以及其他姐妹系具有同一分子量,但较其同一位点的DNA片段为弱,十分稳定的DNA 片段,为进一步研究利用RAPD标记基因鉴别无性系变异的可能提供了参考。

关键词： RAPD 月季辐射育种

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Left Ventricular Diastolic Dysfunction and Silent Myocardial Ischemia amongst Asymptomatic Type 2 Diabetic Patients in Two Referral Hospitals in cameroon

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World Journal of cardiovascular Diseases 2022年第7期12卷 374-381页

作者： Joshua Njimbuc Walinjom jerome Boombhi Martine Etoa collins chenwi Ambe Emerentia Eho Alain Menanga Samuel Kingue Faculty of Medicine and Biomedical Sciences (FMBS) University of Yaoundé I Yaoundé Cameroon Medical and cardiology Unit General Hospital Yaoundé Yaoundé Cameroon central Hospital Yaoundé Yaoundé Cameroon Mvangan District Hospital Mvangan Cameroon

Background: cardiovascular events, the leading cause of death among diabetic patients, are usually under-diagnosed due to subclinical presentation. Methods: We conducted a cross-sectional study from March-2019 to September-2020, in two reference hospitals in Yaoundé, cameroon, to assess the prevalence of asymptomatic Left Ventricular Diastolic Dysfunction (LVDD) and Silent Myocardial Infarction (SMI) and potentially associated factors. Results: Out of 95 participants (mean age ± SD: 43 ± 7 years;M/F sex-ratio 1.6), 22 (23.1%;95% cI: 15.8% - 32.6%) had LVDD and fewer (n = 13, 13.6%;95% cI: 8.2% - 22.0%) had SMI, p = 0.86. Though not statistically significant, patients with ≥5 years diabetes duration, as well as patients with HbA1c ≥ 7.5% had two-fold increased risk of LVDD (p = 0.22 and p = 0.15 respectively). LVDD was significantly higher in patients with SMI (29% vs 6.3%, p conclusion: The significant presence of asymptomatic cardiovascular manifestations in this population entails mandatory preventive screening, especially, in patients with long standing diabetes and poor glycemic control, to allow timely detection and management.

关键词： Asymptomatic cardiovascular Manifestations Left ventricular Diastolic Dysfunction Silent Myocardial Ischemia Type 2 Diabetes cameroon

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Anti-hepatitis c virus potency of a new autophagy inhibitor using human liver slices model

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World Journal of Hepatology 2016年第21期8卷 902-914页

作者： Sylvie Lagaye Sonia Brun Jesintha Gaston Hong Shen Ruzena Stranska claire camus clarisse Dubray Géraldine Rousseau Pierre-Philippe Massault jerome courcambeck Firas Bassisi Philippe Halfon Stanislas Pol Institut Pasteur INSERM Institut cochin INSERM U1016CNRS UMR8104Universite Paris Descartes(UMR S1016) Genoscience Pharma KU Leuven Rega Institute Laboratoire Alphabio APHP Groupe Hospitalier La Pitie Salpe-triereService de Chirurgie digestive et Hepato bilio pancreatique APHP Groupe Hospitalier CochinService de Chirurgie digestiveHepato-biliaire et Endocrinienne Universite Paris Descartes APHP Groupe Hospitalier CochinUnite d’Hepatologie Institut Pasteur Departement de Recherche TranslationnelleINSERM

AIM: To evaluate the antiviral potency of a new antihepatitis c virus(HcV) antiviral agent targeting the cellular autophagy machinery. METHODS: Non-infected liver slices, obtained from human liver resection and cut in 350 μm-thick slices(2.7 × 106 cells per slice) were infected with cell culture-grown HcV con1b/c3 supernatant(multiplicity of infection = 0.1) cultivated for up to ten days. HcV infected slices were treated at day 4 post-infection with GNS-396 for 6 d at different concentrations. HcV replication was evaluated by strand-specific real-time quantitative reverse transcription- polymerase chain reaction. The infectivity titers of supernatants were evaluated by foci formation upon inoculation into naive Huh-7.5.1 cells. The cytotoxic effect of the drugs was evaluated by lactate dehydrogenase leakage assays. RESULTS: The antiviral efficacy of a new antiviral drug, GNS-396, an autophagy inhibitor, on HcV infection of adult human liver slices was evidenced in a dosedependent manner. At day 6 post-treatment, GNS-396 Ec50 was 158 nmol/L without cytotoxic effect(compared to hydroxychloroquine Ec50 = 1.17 μmol/L).cONcLUSION: Our results demonstrated that our ex vivo model is efficient for evaluation the potency of autophagy inhibitors, in particular a new quinoline derivative GNS-396 as antiviral could inhibit HcV infection in a dosedependent manner without cytotoxic effect.

关键词： Host antiviral therapy Hepatitis c virus Tissue culture Autophagy Quinoline derivative

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Assessment of the Drafting Quality of Request Forms Submitted to the Malaria and Parasitology Units at the Institut Pasteur de cote d’Ivoire

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Journal of Biosciences and Medicines 2024年第5期12卷 330-339页

作者： Yao Serge-Stéphane Ako Ako Bérenger Aristide Sylvain Beourou Ouattara Yacouba N’Guessan Tiacoh landry N’Dri Kouadio Thierry-Borel Toure André Offianan Malaria Unit Institut Pasteur de Cote d&#8217Ivoire Abidjan Cote d&#8217Ivoire Parasitology Unit Institut Pasteur de Cote d&#8217Ivoire Abidjan Cote d&#8217Ivoire

Biological tests provide information on the medical analysis requested by both the patient and the prescriber. It is a communication link between the prescriber and the laboratory staff. The lack of some information on request forms not only affects the drafting quality of the test and patient care, but could also make thousands of data produced by healthcare centers unusable. The aim of this study was to assess the drafting quality of request forms submitted to the Malaria and Parasitology Units at the Institut Pasteur de côte d’Ivoire. Methods: It was a descriptive cross-sectional study to assess the drafting quality of request forms of various prescribers received at the Institut Pasteur de côte d’Ivoire. This study was conducted at the Malaria and Parasitology Units, department of Parasitology and Mycology (Institut Pasteur de côte d’Ivoire), from 6th December 2020 to 6th December 2021. The information on each request forms was recorded on a data collection form designed for this purpose. Each data collection form corresponds to a request forms and each test to a patient. Results: Out of a total of 1990 request forms received, the patient’s age and sex were missing on 18% and 26.8% of the tests respectively. More than half (51.80%) of request forms did not indicate the patient’s place of residence. clinical information was not provided on 45.90% of the tests. Prescribers omitting their signatures were 51%, stamps were 50.3% and contacts were 71.2%. Only 5.4% of request forms were of good drafting quality. Providing all the required information on the forms could facilitate the use and analysis of data and samples.

关键词： Laboratory Quality Request Forms Information

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