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Matched or nonmatched interventions based on the transtheoretical model to promote physical activity.A meta-analysis of randomized controlled trials

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Journal of Sport and Health Science 2018年第1期7卷 50-57页

作者： Ahmed jerome Romain Catherine Bortolon Mathieu Gourlan Marion Carayol Emmanuelle Decker Olivier Lareyre Grégory Ninot Julie Boiché Paquito bernard EA4556 Laboratory Epsylon-Dynamics of Human Abilities and Health Behaviours University of Montpellier Montpellier 34000 France Challenge for the Change of Behaviour (CCB) Group Montpellier 34000 France University of Montreal Hospital Research Centre Montreal Quebec H2X OA9 Canada Unit of Adult Psychiatry La colombiere University Hospital of Montpellier Montpellier 34295 France Prevention Department of institut Regional du Cancer de Montpellier Epidaure Montpellier 34298 France Research Centre of the University Hospital of Quebec Quebec GIR 2J6 Canada Cancer Research Centre University of LavaL Quebec G1R 3S3 Canada School of Psychology University of Laval Quebec G1C OA6 Canada

Purpose: The aim of this study was to examine whether the efficacy of transtheoretical model(TTM)-based interventions on physical activity(PA)varied according to the following criteria:(1) interventions targeted the actual stages of change(SOCs) or did not;(2) participants were selected according to their SOC or were not; and(3) its theoretical constructs(decisional balance, temptation, self-efficacy, processes of change).Methods: Thirty-three randomized controlled trials assessing TTM-based interventions promoting PA in adults were systematically ***: The between-group heterogeneity statistic(Qb) did not reveal any differential efficacy either in interventions targeting the actual SOC compared with those that did not(Qb = 1.48, p = 0.22) or in interventions selecting participants according to their SOC compared with those that did not(Qb = 0.01, p = 0.91). TTM-based interventions enhanced PA behavior whether they targeted the actual SOC(Cohen's d = 0.36; 95%confidence interval(CI): 0.22–0.49) or not(d = 0.23; 95%CI: 0.09–0.38) and whether they selected their participants according to their SOC(d = 0.33; 95%CI: 0.13–0.53) or not(d = 0.32; 95%CI: 0.19–0.44). The moderators of the efficacy of TTM-based interventions were the number of theoretical constructs used to tailor the intervention(Qb = 8.82, p = 0.003), the use of self-efficacy(Qb = 6.09, p = 0.01), and the processes of change(Qb = 3.51, p = 0.06).Conclusion: TTM-based interventions significantly improved PA behavior, and their efficacy was not moderated by SOC but by the TTM theoretical constructs.

关键词：随机化物理试用控制模特儿匹配 SOC TTM

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Effects of improved sanitation on diarrheal reduction for children under five in Idiofa,DR Congo:a cluster randomized trial

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Infectious Diseases of Poverty 2017年第1期6卷 1215-1226页

作者： Seungman Cha JaeEun Lee DongSik Seo Byoung Mann Park Paul Mansiangi Kabore bernard Guy jerome Nkay Mulakub-Yazho Honore Minka Famasulu Korea International Cooperation Agency 825 Daewangpangyo-roSujeong-guSeongnam-siGyeongi-doRepublic of Korea Department of Disease Control Faculty of Infectious and Tropical DiseaseLondon School of Hygiene&Tropical MedicineKeppel Street London WC1E 7HTLondonUK Korea Environment Corporation 42 Hwangyeong-roSeo-guIncheonRepublic of Korea Kinshasa University 18 Denis streetYolo-Sud QuarterKalamu ZoneKinshasaDemocratic Republic of the Congo Water and Sanitation for Africa Ouaga 03Secteur 27441Rue NabaKiibaBoulsaOuagadougouBurkina Faso Service National d’Hydraulique Rurale Av.Colonel Lukusa No.111-112 C/GombeKinshasaDemocratic Republic of the Congo

Background:The lack of safe water and sanitation contributes to the rampancy of diarrhea in many developing ***:This study describes the design of a cluster-randomized trial in Idiofa,the Democratic Republic of the Congo,seeking evidence of the impact of improved sanitation on diarrhea for children under *** the 276 quartiers,18 quartiers were randomly allocated to the intervention or control *** hundred and-twenty households were sampled and the youngest under-four child in each household was registered for this *** primary endpoint of the study is diarrheal incidence,prevalence and duration in children under ***:Material subsidies will be provided only to the households who complete pit digging plus superstructure and roof construction,regardless of their income *** study employs a Sanitation Calendar so that the mother of each household can record the diarrheal episodes of her under-four child on a daily *** diary enables examination of the effect of the sanitation intervention on diarrhea duration and also resolves the limitation of the small number of clusters in the *** addition,the project will be monitored through the‘Sanitation Map’,on which all households in the study area,including both the control and intervention arms,are *** avoid information bias or courtesy bias,photos will be taken of the latrine during the household visit,and a supervisor will determine well-equipped latrine uptake based on the *** reduces the possibility of recall bias and under-or over-estimation of diarrhea,which was the main limitation of previous *** registration:The study was approved by the Institutional Review Board of the School of Public Health,Kinshasa University(ESP/CE/040/15;April 13,2015)and registered as an International Standard Randomized Controlled Trial(ISRCTN:10,419,317)on March 13,2015.

关键词： Sanitation Diarrhea Well-equipped latrine Sanitation calendar

Fluorometric Viability Assessment of Capacitated and Acrosome-Reacted Boar Spermatozoa by Flow Cytometry

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Optics and Photonics Journal 2013年第1期3卷 40-44页

作者： Reyna Fierro Humberto Gonzalez-Marquez Rocio Ortiz jerome Chevrier bernard Foliguet Departamento de Ciencias de la Salud Universidad Autonoma Metropolitana-IztapalapaMexico CityMexico Laboratoire d’Histologie Embryologie et Microscopie ElectroniqueUniversite LorraineNancyFrance

Sperm capacitation involves functional changes, such as the removal or appearance of specific molecules and changes in the plasma membrane;the acrosome reaction (AR) is an exocytotic event induced by calcium influx, enabling the spermatozoa to penetrate the zona pellucida. These processes can be achieved only if the spermatozoa have good viability;indeed, determination of sperm viability is used for the assessment of semen quality. Membrane integrity and mitochondrial activity are important viability parameters of spermatozoa and fluorescent techniques based on membrane permeability to dyes have been developed to determine these parameters. The aim of this work was to determine the viability of boar sperm (fresh, one hour of capacitation induction and 20 min of AR induction) by flow cytometry using propidium iodide (PI) (1.25 μg/mL) and rhodamine 123 (R123) (0.20 μg/mL). Aliquots of 5 × 105 sperm were incubated with each fluorochrome separately and simultaneously for 10 or 20 min, respectively, at 38℃. The proportion of labeled spermatozoa and their fluorescence intensities were measured using a flow cytometer. The fluorescence index (FI) with PI gradually increased during the incubation and we found significant differences between all the groups. With R123, the FI increased in the capacitated sperm but decreased in the acrosome-reacted sperm, with significant differences between the fresh and capacitated spermatozoa. Our results suggest that the increase in the R123 fluorescence intensity in capacitated spermatozoa is due to changes in the mitochondrial membrane activity because the spermatozoa experienced changes in membrane fluidity and flagellar activation during capacitation. The use of fluorochromes and flow cytometry is a good tool for monitoring many markers of sperm function. Although capacitation and AR processes have been well studied, there is still much information to be elucidated with regard to these complex processes.

关键词： Boar Sperm Flow Cytometry Propidium Iodide Rhodamine 123 Viability

Neuronal networks in mental diseases and neuropathic pain:Beyond brain derived neurotrophic factor and collapsin response mediator proteins

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World Journal of Psychiatry 2016年第1期6卷 18-30页

作者： Tam T Quach Jessica K Lerch jerome Honnorat Rajesh Khanna Anne-Marie Duchemin Department of Neuroscience Center for Brain and Spinal Cord Repairthe Ohio State University Lyon Neuroscience Research Center French Reference Center on Paraneoplastic Neurological Syndrome Hospices Civils de LyonH?pital Neurologique Université de Lyon Université Claude Bernard Lyon 1 Department of Pharmacology College of Medicinethe University of Arizona Department of Psychiatry College of Medicinethe Ohio State University

The brain is a complex network system that has the capacity to support emotion, thought, action, learning and memory, and is characterized by constant activity, constant structural remodeling, and constant attempt to compensate for this remodeling. The basic insight that emerges from complex network organization is that substantively different networks can share common key organizational principles. Moreover, the interdependence of network organization and behavior has been successfully demonstrated for several specific tasks. From this viewpoint, increasing experimental/clinical observations suggest that mental disorders are neural network disorders. On one hand, single psychiatric disorders arise from multiple, multifactorial molecular and cellular structural/functional alterations spreading throughout local/global circuits leading to multifaceted and heterogeneous clinical symptoms. On the other hand, various mental diseases may share functional deficits across the same neural circuit as reflected in the overlap of symptoms throughout clinical diagnoses. An integrated framework including experimental measures and clinical observations will be necessary to formulate a coherent and comprehensive understanding of how neural connectivity mediates and constraints the phenotypic expression of psychiatric disorders.

关键词： Neuron Network Synapse Schizophrenia Bipolar Depression Stress Pain Collapsin response mediator proteins

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广州博物馆

城市环境设计 2016年第1期 184-190页

作者： bernard Tschumi Nianlai Zhong Christopher Lee Joel Rutten Pierre-Yves Kuhn jerome Hafered Dora Felekou Pedro Camara Bart-Jan Polman Shaoyi Liang Nate Oppenheim Jessica Myers Michael Haddy

基于"罗盘"的设计概念将周遭城市的景象充分融入博物馆的体验之中,把比邻的赤岗塔吸收成为方案的基本组成部分。博物馆的外墙形状则呼应了广州古城区的原有轮廓,并以如"丝印"其上般的历史浮雕石刻呈现这座历史名城的风貌。我们在屋顶上... 详细信息

基于"罗盘"的设计概念将周遭城市的景象充分融入博物馆的体验之中,把比邻的赤岗塔吸收成为方案的基本组成部分。博物馆的外墙形状则呼应了广州古城区的原有轮廓,并以如"丝印"其上般的历史浮雕石刻呈现这座历史名城的风貌。我们在屋顶上的退台处理营造出现代博物馆的感觉,北向天窗、景观水体和植栽退台的结合将建筑变成了

关键词：博物馆博物院文化机构贮藏室厕所中央大厅倒影池广州广东

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天津滨海探索博物馆

现代装饰 2019年第4期 78-83页

作者： bernard Tschumi Joel Rutten Nianlai Zhong Christopher Lee Pierre-Yves Kuhn jerome Haferd Bart-Jan Polman Dora Felekou Pedro Camara Shayi Liang Nate Oppenheim Kate Scott Clinton Peterson Olga Jitariouk Sung Yu Kris Provoost 李薇 bernard Tschumi Architects 不详

天津滨海探索博物馆,占地3.3万平方米,预计201 9年秋季对外开放。博物馆将通过大规模的当代技术展示天津工业史上的各种人工制品,包括用于太空研究的壮观火箭。该项目是城市滨海文化中心的一部分,除了展览和文化活动设施外,还包括画廊... 详细信息

天津滨海探索博物馆,占地3.3万平方米,预计201 9年秋季对外开放。博物馆将通过大规模的当代技术展示天津工业史上的各种人工制品,包括用于太空研究的壮观火箭。该项目是城市滨海文化中心的一部分,除了展览和文化活动设施外,还包括画廊、办公室、餐厅和零售空间等。

关键词：探索博物馆天津滨海

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天津滨海城市与工业探索馆

城市环境设计 2016年第1期 232-235页

作者： bernard Tschumi Nianlai Zhong Joel Ruten Christopher Lee Joel Rutten Pierre-Yves Kuhn jerome Hafered Bart-Jan Polman Dora Felekou Pedro Camara Shayi Liang Nate Oppenheim Kate Scott Clinton Peterson Olga Jitariouk Sung Yu

我们将探索馆定义为一座过去、现在与未来之馆。馆内空间将城市和工业组织到了一起,展示出二者相互联系和贯通的关系。一系列锥形的体量成为贯穿探索馆的建筑语言,并在探索馆内创造出一系列内室。部分锥体是访客可以进入的真实三维空间... 详细信息

我们将探索馆定义为一座过去、现在与未来之馆。馆内空间将城市和工业组织到了一起,展示出二者相互联系和贯通的关系。一系列锥形的体量成为贯穿探索馆的建筑语言,并在探索馆内创造出一系列内室。部分锥体是访客可以进入的真实三维空间,而另一部分锥体则是虚拟的,象征着全新的未来城市和工业类型。

关键词：平面图图(数学) very

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萝实国际学校萝实音乐厅

城市环境设计 2016年第1期 200-211页

作者： bernard Tschumi Kate Scott Joel Rutten Christopher Lee Jocelyn Froimovich Bart-Jan Polman jerome Haferd Paul-Arthur Heller Clinton Peterson Emmanuel Desmazèires Nianlai Zhong Olga Jitariouk Colin Spoelman Kim Starr Grégoire Giot Dustin Brugmann Taylor Burgess Sheena Garcia Sung Yu Pierre-Yves Kuhn Alison McIlvride Jessica Myers

项目任务是为瑞士最负盛名的教育学院设计一所新的表演艺术设施,项目设有可容纳1 000名观众的音乐厅、黑盒剧场、几间会议室、彩排和练习空间、图书馆兼学习中心、餐厅、咖啡厅、学生休息区以及其他设施。宽敞的圆顶内部支撑结构十分简... 详细信息

项目任务是为瑞士最负盛名的教育学院设计一所新的表演艺术设施,项目设有可容纳1 000名观众的音乐厅、黑盒剧场、几间会议室、彩排和练习空间、图书馆兼学习中心、餐厅、咖啡厅、学生休息区以及其他设施。宽敞的圆顶内部支撑结构十分简单,便于灵活排布各项功能。自然光透过所有需要外界视线的地方侧向进入建筑内部。建筑核心部分是一个全木制的体量,其

关键词：音乐厅剧场建筑物文化机构黑盒

手术后应用氯胺酮降低腹部外科手术患者的吗啡用量：一项前瞻性、随机、双盲、对照研究

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麻醉与镇痛 2009年第6期5卷 81-87页

作者： jerome Zakine David Samarcq Emmanuel Lorne Mona Moubarak Philippe Montravers Sadek Beloucif Herve Dupont 侯磊(译) 陈卫民(校) Department of Anesthesiology and Critical Care University Hospital of Amiens France Department of Anesthesiology and Surgical Critical Care APHP Bichat-Claude Bernard University Hospital Paris France Department of Anesthesiology and Critical Care APHP Avicenne University Hospital Bobigny France 不详

背景氯胺酮能够降低手术后吗啡的用量，但给药的适合剂量及持续时间仍然不是很清楚。在这项研究中，我们比较了仅在手术中给予氯胺酮和持续到手术后48小时对吗啡用量影响的差异。方法81例拟行腹部外科手术的患者在双盲的条件下被随机分... 详细信息

背景氯胺酮能够降低手术后吗啡的用量，但给药的适合剂量及持续时间仍然不是很清楚。在这项研究中，我们比较了仅在手术中给予氯胺酮和持续到手术后48小时对吗啡用量影响的差异。方法81例拟行腹部外科手术的患者在双盲的条件下被随机分为3组：（1）PERI组的患者在手术中及手术后48小时给予氯胺酮（单次给予0．5mg／kg后持续给予2μg·kg^-1·h^-1）。（2）INTRA组的患者只在手术中给予氯胺酮（单次给予0．5mg／kg后持续给予2μg·kg^-1·h^-1）。（3）CTRL组的患者给予安慰剂。记录手术后48小时的吗啡用量，视觉模拟评分（VAS）及副作用（镇静评分、恶心及呕吐评分、梦魇、精神障碍或幻想）。结果手术后24小时的吗啡累积用量在PERI组（中位数27mg，四分位距为[19]）显著低于INTRA组（48mg[41．5]）和CTRL组（50mg[21]）（P〈0．005）。手术后VAS评分PERI组和INTRA组显著低于CTRL组（P〈0．001）。恶心的发生率CTRL组显著高于PERI组（27％与4％，P=0．005）。镇静评分和精神障碍在各组间没有观察到差异。结论手术后48小时持续给予低剂量氯胺酮能够改善手术后的疼痛，显著降低吗啡的用量，且呕吐的发生率较低，也没有氯胺酮副作用的发生。

关键词：腹部外科手术累积用量氯胺酮外科手术患者吗啡术后应用随机双盲