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Investigation on mechanical properties of aluminium 7075-boron carbide-coconut shell fly ash reinforced hybrid metal matrix composites

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China Foundry 2018年第6期15卷 449-456页

作者： Balasubramani Subramaniam Balaji Natarajan Balasubramanian Kaliyaperumal Samson jerold Samuel Chelladurai Department of Mechanical Engineering Sri Eshwar College of EngineeringCoimbatore-641202Tamilnadulndia Department of Mechanical Engineering Sri Krishna College of Engineering and TechnologyCoimbatore-641008India

The present research work reports the fabrication and evaluation of the mechanical properties of hybrid aluminium matrix composites(HAMC). Aluminium 7075(Al7075) alloy was reinforced with particles of boron carbide(B_4 C) and coconut shell fly ash(CSFA). Al7075 matrix composites were fabricated by stir casting method. The samples of Al7075 HAMC were fabricated with different weight percentages of(0, 3, 6, 9 and 12 wt.%) B_4 C and 3 wt.% of CSFA. The mechanical properties discussed in this work are hardness, tensile strength, and impact strength. Hardness of the composites increased 33% by reinforcements of 12 wt.% B_4 C and 3 wt.% CSFA in aluminium 7075 alloy. The tensile strength of the composites increased 66% by the addition of 9 wt.% B_4 C and 3 wt.% CSFA in aluminium 7075 alloy. Further addition of reinforcements decreased the tensile strength of the composites. Elongation of the composites decreased while increasing B_4 C and CSFA reinforcements in the matrix. The impact energy of the composites increased up to 2.3 J with 9 wt.% B_4 C and 3 wt.% CSFA addition in aluminium alloy. Further addition of reinforcement decreased the impact strength of the composites. The optical micrographs disclosed the homogeneous distribution of reinforcement particles(B_4 C and CSFA) in Al7075 matrix. The homogeneously distributed B_4 C and CSFA particles added as reinforcement in the Al7075 alloy contributed to the improvement of hardness, tensile strength, and impact strength of the composites.

关键词： aluminium 7075 boron carbide fly ash casting hardness tensile strength impact energy

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Dry sliding wear characterization of squeeze cast LM13/Fe Cu composite using response surface methodology

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China Foundry 2017年第6期14卷 525-533页

作者： Samson jerold Samuel Chelladurai Ramesh Arthanari Arunprasad Narippalayam Thangaraj Harishankar Sekar Department of Mechanical Engineering Sri Krishna College of Engineering and Technology Coimbatore 641008 India Department of Mechanical Engineering Sri Krishna College of Technology Coimbatore 641042 India

Dry sliding wear is one of the predominant factors to be considered while selecting material for automotive and aerospace applications. Researchers have been exploring novel aluminium matrix composites(AMC), which offer minimum wear rate for various tribological applications. In this present work, an attempt has been made to reinforce LM13 aluminium alloy with copper coated steel fibers(10 wt.%) using squeeze casting process and to perform dry sliding wear test using pin-on-disc tribometer. Microstructure of cast samples was examined using image analysis system to investigate the dispersion of reinforcement in matrix. Dry sliding wear test was performed by considering factors such as load(10–50 N), sliding velocity(1–5 m·s(-1)) and sliding distance(500–2,500 m). Wear test was performed according to the experimental design at room temperature. Three factors and five levels central composite design were used to design the experiments using response surface methodology. Based on the results of the experiments, a regression model was developed to predict the wear rate of composites and checked for its adequacy using significance tests, analyses of variance and confirmation tests. Worn surface of samples was investigated using field emission scanning electron microscope and reported with its mechanisms. Microstructure of cast samples revealed uniform dispersion of reinforcement throughout the matrix. Response surface plots revealed that wear rate of composites increases with increasing load up to 50 N with the velocity 1–5 m·s(-1) and a sliding distance up to 2,500 m. However wear rate decreasesd with increasing velocity at lower loads(up to 20 N) and increased after reaching transition velocity of 2 m·s(-1). Dry sliding wear process parameters were optimised for obtaining minimum wear rate and they were found to be a load of 18.46 N, velocity of 4.11 m·s(-1), sliding distance of 923 m. Worn surface of samples revealed a mild wear at lower loads(up to 30 N), and severe w

关键词： aluminium alloy casting response surface methodology microstructure wear

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A cross-sectional study to assess medication safety,knowledge,attitude,and practices regarding nutrition and medication among pregnant women

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Asian pacific Journal of Reproduction 2024年第3期13卷 115-119页

作者： Gauthami R Bipin Shaji Twinkle MJS Krishnapriya Radhakrishnan Reshma Kolar Juno jerold Joel Nitte(Deemed to be University) NGSM Institute of Pharmaceutical Sciences(NGSMIPS)Department of Pharmacy PracticeDeralakatteMangaluruIndia Nitte(Deemed to be University) KS Hegde Medical Academy(KSHEMA)Department of Obstetrics and GynaecologyDeralakatteMangaluruIndia AJ Institute of Medical Sciences and Research Centre Department of Community MedicineMangaluruKarnatakaIndia

Objective:To assess pregnant women's knowledge,attitude,and practice regarding nutrition and medication usage,analyse the prescribing pattern,and categorize them based on the Food and Drug Administration(FDA)***:A cross-sectional study was conducted with 264 pregnant women in the obstetrics and gynaecology department of a tertiary care hospital from October 2022 to August 2023.A knowledge,attitude,and practice(KAP)questionnaire was prepared in English language by the researchers and validated by an expert panel consisting of 12 *** validated questionnaire was then translated into regional languages,Kannada and *** reliability of the questionnaire was assessed with test-retest method with a representative sample population of 30 subjects(10 subjects for each language).The subjects'knowledge,attitude,and practice were evaluated using the validated KAP *** safety of the medication was assessed using the FDA drug safety classification for ***:The mean scores for nutritional and medication usage knowledge,attitude,and practice were 4.14±1.15,4.50±1.09,and 3.00±1.47,*** 30 prescribed medications,3 belong to category A(no risk in human studies),8 belong to category B(no risk in animal studies),18 belong to category C(risk cannot be ruled out)and 1 drug is not classified.A significant association was observed between medication knowledge and practice(r=0.159,P=0.010).Conclusions:Most of the study population knows the need to maintain good dietary and medication practices during *** pregnant women regarding diet and medication usage is crucial in maternal care.

关键词： Pregnancy Nutrition Medication Knowledge Practice Safe medication

The effect of Heterozygous deletion of Lpar1 in cardiac remodeling after myocardial infarction

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中国循环杂志 2016年第Z1期31卷 -页

作者： Lin Cai Guangpu Fan Tiewei Li Si Liu Fang Wang jerold Chun Xiangfeng Cong Xi Chen State Key Laboratory of Cardiovascular Disease FuwaiHospital NationalCenter for Cardiovascular Diseases Chinese Academy of MedicalSciences and Peking Union MedicalColege Beijing China. Department of Cardiovascular Surgery Peking University People’s Hospital Beijing China. Molecular and Celular Neuroscience Department Dorris Neuroscience Center The Scripps Research Institute La Jola USA

Atrial Arrhythmias Including Atrial Fibrillation in Congenital Heart Disease:Mechanisms,Substrate Identifi cation and Interventional Approaches

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Cardiovascular Innovations and Applications 2018年第B05期3卷 41-59页

作者： jerold S.Shinbane Philip M.Chang Division of Cardiovascular Medicine Keck School of Medicine of the University of Southern California1510 San Pablo StreetSuite 32290033 Los AngelesCAUSA Congenital Heart Center Departments of Pediatrics and Internal MedicineUniversity of Florida College of Medicine1600 SW Archer RoadPO Box 10029632610 GainesvilleFLUSA

Atrial arrhythmias,including atrial fibrillation,in the setting of congenital heart disease(CHD)are epidemiologically and mechanistically different from those encountered in the general *** arrhythmias occur at younger ages in patients with CHD,and are frequently degenerative and *** epidemiology,incidence,and prevalence of the spectrum of atrial arrhythmias,including atrial fibrillation,vary according to the specific CHD type,prior treatment,and residual and ongoing structural and functional *** combined impact of incisional scars,abnormal hemodynamics,atrial chamber dilatation,and increases in atrial wall thickness and distribution of fi brosis results in a highly dynamic and continuously changing atrial substrate that is highly predisposed to *** the multiple substrates,individualized therapeutic plans can include pharmacologic therapy,catheter-based ablation,and surgical therapies performed concomitantly with primary surgical intervention for hemodynamically significant sequelae of *** imaging with CT or MRI can provide valuable information for decision making and procedural *** of novel therapeutic technologies and pharmacologic agents necessitates special considerations when applied to the CHD population and requires greater study in specific subsets of CHD patients.

关键词： congenital heart disease arrhythmia atrial fibrillation

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探讨除菌级过滤器的重复使用（上）

流程工业 2009年第5期 48-50页

作者： jerold Martin

专为液体和气体灭菌而设计的膜式过滤器在许多生产工艺中被广泛使用。随着经济和市场因素的影响，医药、生物技术和疫苗产业开始寻求降低操作成本、提高收益率的新方法，其中人们可能会考虑除菌级过滤器的重复使用。虽然液体除菌级过滤... 详细信息

专为液体和气体灭菌而设计的膜式过滤器在许多生产工艺中被广泛使用。随着经济和市场因素的影响，医药、生物技术和疫苗产业开始寻求降低操作成本、提高收益率的新方法，其中人们可能会考虑除菌级过滤器的重复使用。虽然液体除菌级过滤器一般设计和建议只在单一的批次或者周期生产中使用，但是在许多应用中可能会涉及到多次使用（重复使用）。本文作者在上半篇中总结了可能被定义为重复使用的不同工艺过程，讨论了除菌级过滤器能否重复使用的决定因素，并将在下半篇中提供一个综述重复使用过程中的潜在风险和工艺验证的案例研究，对此作更加翔实的说明。

关键词：重复使用过滤器除菌生产工艺气体灭菌市场因素操作成本生物技术

探讨除菌级过滤器的重复使用（下）——除菌级过滤器能否重复使用的决定因素及案例研究

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流程工业 2009年第9期 42-45页

作者： jerold Martin

本文在上篇中总结了液体灭菌应用中重复使用的适宜性问题最终取决于特定的应用、厂商过滤产品的核心验证研究和终端用户过滤工艺的验证。这项评估包括重复使用的风险评估和对过滤器完全除菌能力及工艺流体除菌效率的影响评估。在不兼容... 详细信息

本文在上篇中总结了液体灭菌应用中重复使用的适宜性问题最终取决于特定的应用、厂商过滤产品的核心验证研究和终端用户过滤工艺的验证。这项评估包括重复使用的风险评估和对过滤器完全除菌能力及工艺流体除菌效率的影响评估。在不兼容的重复使用条件下，膜有可能发生降解并危及到过滤器的细菌截留性质，但这种情况往往被忽视。过滤器厂商的核心验证研究没有对这种膜老化的情况进行模拟；使用在通常模型状态下与截留相关联的普通的产品完整性试验根本无法检测膜老化过程。本文以一个综述重复使用过程中潜在风险和工艺验证的案例研究充分说明了这个观点。

关键词：重复使用过滤器除菌案例过滤工艺过滤产品影响评估老化过程

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广泛采用一次性技术所面对的挑战

流程工业 2014年第13期 48-51页

作者：董巍 jerold Martin 颇尔中国生命科学制药部

随着生物制药工艺中一次性技术的日趋广泛采用，尤其是商业化生产批次中采用一次性生产方式，针对这个相对较新且还在不断进化中的技术平台，各种担忧和关注被医药监管当局、制药工业界和行业组织所提出。这些关注主要集中在安全性和商... 详细信息

随着生物制药工艺中一次性技术的日趋广泛采用，尤其是商业化生产批次中采用一次性生产方式，针对这个相对较新且还在不断进化中的技术平台，各种担忧和关注被医药监管当局、制药工业界和行业组织所提出。这些关注主要集中在安全性和商业供应相关的两个方面。本文将就这两个方面目前国际上的讨论、共识和进展进行介绍。

关键词：技术平台一次性商业化生产制药工艺生产方式行业组织工业界安全性

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海洋放射性污染的危险

海洋科技资料 1972年第2期 33-35页

作者： jerold M.Lowenstein 一美国加里福尼亚大学放射性研究中心医学院临床付教授加里福尼亚圣弗兰西斯海洋协会董事会成员

最近,在罗马召开的联合国粮食和农业组织的会议上有报告称,在海洋中除放射性物质少量增加外,各种类型的污染物正在不断地增加。报告在新闻报导中广泛地传播,大概使千百万关心环境放射性危害的人安心了。但是,核试验和运转中的核能设施... 详细信息

最近,在罗马召开的联合国粮食和农业组织的会议上有报告称,在海洋中除放射性物质少量增加外,各种类型的污染物正在不断地增加。报告在新闻报导中广泛地传播,大概使千百万关心环境放射性危害的人安心了。但是,核试验和运转中的核能设施及核能舰船的数目不断增加,使这种趋势将很快改变。在这一代内,我们可以逐渐看到海洋生态学和人类健康严重的辐射影响。

关键词：海洋放射性污染放射性废物放射性废弃物放射性物质