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Evaluation of quality of clinical management of neuroendocrine tumors

Cancer Innovation 2022年第4期1卷 305-315页

作者： Hannah Bloemen Kristien Kneepkens Karen Deraedt Anna Ivanova Gregory Sergeant jeroen mebis Kurt Van der Speeten Department of Medicine Faculty of Medicine and Life Sciences(LCRC)Hasselt UniversityDiepenbeekBelgium Department of Pathology and Department Future Health Ziekenhuis Oost-LimburgGenkBelgium Department of Abdominal Surgery and Department Jessa&Science Jessa HospitalHasseltBelgium Department of Medical Oncology and Department Jessa&Science Jessa HospitalHasseltBelgium Department of Surgical Oncology and Department Future Health Ziekenhuis Oost-LimburgGenkBelgium

Background:Neuroendocrine tumors(NETs)are a group of biologically and clinically heterogeneous neoplasms predominantly found in the gastrointestinal and bronchopulmonary *** a rising incidence,implementation of evidence-based standardized care for this heterogenous group remains *** European Neuroendocrine Tumor Society regularly reviews guidelines regarding diagnostic and treatment strategies for *** aim of this study is to shed light on the care of patients with a NET in Belgian Limburg,to provide data as a basis for future studies and to check whether data and results are according to consensus guidelines and outcomes described in ***:Our study concerned a detailed observational data collection of two large Belgian hospitals(Jessa Hospital Hasselt and Hospital Oost-Limburg Genk)with special interest in patient profile,quality of pathology reports,use of diagnostic imaging,and overall *** on 188 patients were assembled between January 2010 and December 2014 with follow-up until June 2016(median follow-up:33.6 months).Results:Fifty percent of patients were *** were located mainly in the digestive tract(63.8%)and lung(20.2%).Appendiceal NETs were diagnosed at a significantly younger age than other tumors(41.3 vs.64.0 years).Overall,a mean pathology report quality score of 3.0/5 was observed with the highest scores for small bowel *** and nuclear imaging was performed in 74.5%and 29.8%of cases,***-four percent of the population survived until the end of the observation period with highest survival rates for appendiceal and small bowel ***:Overall,epidemiological results were comparable with findings in the *** NETs met most of the requirements of qualitative pathology reporting and diagnostic imaging as listed in the European Neuroendocrine Tumor Society consensus ***,consensus with regard to bronchopulmonary NETs is still scarce

关键词： neuroendocrine tumors epidemiology quality pathology report Ki67 overall survival guidelines

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