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Bio-Design and manufacturing 2019年第3期2卷 145-152页

作者： Ivo Radice jeroen h.m.bergmann Department of Engineering Science Old Road Campus Research BuildingInstitute of Biomedical EngineeringUniversity of OxfordHeadingtonOxfordUK

Gripping devices help patients carry out everyday tasks and increase their ***,there seems to be a lack of bionic gripping technologies that can fully adapt to any possible shape,as the use of artificial fingers and predetermined grip settings limits the operating *** development of a more agile device,which is operated by a simple control paradigm,could greatly benefit *** electrorheological(ER)fluid system should be able to adapt to the shape of an object and then hold that *** aim of this study was to explore if a conceptual prototype of an ER system could hold a geometric shape when it is activated.A test rig was constructed with a moving part(set in different silicone oils)that could be displaced using a *** particles were dispersed in the silicone oils,and a field with a voltage of 4 kV mm?1 was generated to activate the *** results show that the developed system can support an increased force when activated and hold a simple geometric position without any noticeable *** outcome provides an initial proof of concept for a possible new(gravity-assisted)gripping approach using smart fluids,which could be developed with materials that are biocompatible and widely available.

关键词： Smart materials Prosthetics Exoskeleton Grasping manipulation Assistive technologies

Evaluation of large language models for the classification of medical device software

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Bio-Design and manufacturing 2024年第5期7卷 819-822页

作者： Yu han Aaron Ceross Florence Bourgeois Paulo Savaget jeroen h.m.bergmann Department of Engineering Science University of OxfordOld Road CampusOxford OX37QDUK harvard-mIT Center for Regulatory Science Harvard Medical SchoolBostonMAUSA Computational health Informatics Program(ChIP) Boston Children’s HospitalBostonMAUSA Department of Technology and Innovation The University of Southern DenmarkOdenseDenmark

Amidst the rapidly expanding integration of large language models(LLms)across various sectors(ranging from everyday applications to specialized fields demanding stringent regulatory adherence),our investigation seeks to determine how well these models can support medical device software *** device classification functions to systematically categorize devices according to their designated use,associated risk levels,and requisite regulatory oversight,thereby providing a structured framework for ensuring safety and efficacy as mandated by regulatory authorities.

关键词： everyday demanding thereby

The efficacy and effectiveness of machine learning for weaning in mechanically ventilated patients at the intensive care unit: a systematic review

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Bio-Design and manufacturing 2019年第1期2卷 31-40页

作者： man Ting Kwong Glen Wright Colopy Anika m.Weber Ari Ercole jeroen h.m.bergmann Department of Engineering Science University of OxfordParks Road. Oxford OXI 3PJ. UK snap40 Inc.125 Princess Street Edinburgh EH2 4AD UK CRUK/mRC Oxford Institute for Radiation Oncology.Roosevelt Drive Oxford OX3 7DQ. UK Division of Anaesthesia Addenbrooke's Hospital University of Cambridge Hills Road Cambridge CB2 0QQ. UK

Weani ng from mechanical ventilation in the in tensive care unit (ICU) is a complex clinical problem and relevant for future organ engineering. Prolonged mechanical ventilation (mV) leads to a range of medical complications that increases length of stay and costs as well as contributes to morbidity and even mortality and long-term quality of life. The need to reduce mV is both clinical and economical. Artificial intelligence or machine learning (mL) methods are promising opportunities to positively influence patient outcomes. mL methods have been proposed to enhance clinical decisions processes by using the large amount of digital information generated in the ICU setting. There is a particular interest in empirical methods (such as mL) to improve management of "difficult-to-wean" patients, due to the associated costs and adverse events associated with this population. A systematic literature search was performed using the OVID, IEEEXplore, Pubmed, and Web of Science databases. All publications that included (1) the application of mL to weaning from mV in the ICU and (2) a clinical outcome measurement were reviewed. A checklist to assess the study quality of medical mL publications was modified to suit the critical assessment of mL in mV weaning literature. The systematic search identified nine studies that used mL for weaning management from mV in critical care. The weaning management application areas included (1) prediction of successful spontaneous breathing trials (SBTs),(2) prediction of successful extubation,(3) prediction of arterial blood gases, and (4) ventilator setting and oxygenation-adjustment advisory systems. Seven of the nine studies scored seven out of eight on the quality index. The remaining two of the nine studies scored one out of eight on the quality index. This scoring may, in part, be explained by the publications' focus on technical novelty, and therefore focusing on issues most important to a technical audience, instead of issues most impor

关键词： Artificial intelligence Patient-centred medicine Clinical trial Critical care Data science

An Accurate Cartesian method for Incompressible Flows with moving Boundaries

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Communications in Computational Physics 2014年第5期15卷 1266-1290页

作者： m.bergmann J.hovnanian A.Iollo Inria F-33400 TalenceFranceUniv.BordeauxIMBUMR 5251F-33400 TalenceFranceCNRSIMBUMR 5251F-33400 TalenceFrance.

An accurate cartesian method is devised to simulate incompressible viscous flows past an arbitrary moving *** Navier-Stokes equations are spatially discretized onto a fixed Cartesian *** body is taken into account via the ghost-cell method and the so-called penalty method,resulting in second-order accuracy in *** accuracy and the efficiency of the solver are tested through two-dimensional reference *** show the versatility of this scheme we simulate a threedimensional self propelled jellyfish prototype.

关键词： Viscous incompressible flow immersed boundary method penalty method cartesian grid self-propelled jellyfish.

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer m.Colón-mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose m.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis h.Pagan Rivera Jorge D.miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Statistical analysis and concentration of iron ore using Longi LGS 500 WhImS

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International Journal of mining Science and Technology 2016年第5期26卷 769-775页

作者： makhula m.J. Falcon R.m.S. bergmann C.P. Bada S.O. Department of mineral Processing Division Mintek Johannesburg 2125 South Africa School of Chemical and metallurgical Engineering University of the Witwatersrand Johannesburg 2050 South Africa

A Longi LGS 500 wet high intensity magnetic separator(WhImS) was used to concentrate a fine, low grade South African hematite ore. The ore was prepared into different size fractions and was subjected to changes in pulp density, magnetic field intensity and pulsation frequency which followed a 33 full factorial matrix. The concentrate mass yield and Fe grade were selected as the dependent responses to the changes. The analysis of variance(ANOVA) shows that the variables investigated are significant to the material's response to magnetic separation. This significance was in the order of magnetic field intensity followed by pulsation frequency and then pulp density. It was also noted that a single stage magnetic separation has a potential to upgrade a feed( 75 lm and 40% Fe) to a 55% Fe grade, as the pulsation frequency increases. In addition, the model predictions and actual data were in good agreement, reporting regression coefficients within acceptable ranges.

关键词： magnetic separation Longi LGS 500 hematite ANOVA

Spatial cluster mapping and environmental modeling in pediatric inflammatory bowel disease

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World Journal of Gastroenterology 2023年第23期29卷 3688-3702页

作者： mielle michaux Justin m Chan Luke bergmann Luis F Chaves Brian Klinkenberg Kevan Jacobson Department of Pediatrics Division of GastroenterologyHepatology and NutritionFaculty of MedicineBritish Columbia Children’s HospitalUniversity of British ColumbiaVancouver V6H 3V4British ColumbiaCanada British Columbia Children’s hospital Research Institute British Columbia Children’s HospitalVancouver V5Z 4H4British ColumbiaCanada Department of Geography University of British ColumbiaVancouver V6T 1Z2British ColumbiaCanada Department of Environmental and Occupational health School of Public HealthIndiana UniversityBloomingtonIN 47405United States Department of Cellular and Physiological Sciences University of British ColumbiaVancouver V6T 1Z3British ColumbiaCanada

BACKGROUND Geographical(geospatial)clusters have been observed in inflammatory bowel disease(IBD)incidence and linked to environmental determinants of disease,but pediatric spatial patterns in North America are *** hypothesized that we would identify geospatial clusters in the pediatric IBD(PIBD)population of British Columbia(BC),Canada and associate incidence with ethnicity and environmental *** To identify PIBD clusters and model how spatial patterns are associated with population ethnicity and environmental *** One thousand one hundred eighty-three patients were included from a BC Children’s hospital clinical registry who met the criteria of diagnosis with IBD≤age 16.9 from 2001–2016 with a valid postal code on file.A spatial cluster detection routine was used to identify areas with similar *** ecological analysis employed Poisson rate models of IBD,Crohn’s disease(CD),and ulcerative colitis(UC)cases as functions of areal population ethnicity,rurality,average family size and income,average population exposure to green space,air pollution,and vitamin-D weighted ultraviolet light from the Canadian Environmental health Research Consortium,and pesticide *** hot spots(high incidence)were identified in metro Vancouver(IBD,CD,UC),southern Okanagan regions(IBD,CD),and Vancouver Island(CD).Cold spots(low incidence)were identified in Southeastern BC(IBD,CD,UC),Northern BC(IBD,CD),and on BC’s coast(UC).No high incidence hot spots were detected in the densest urban *** results were represented as incidence rate ratios(IRR)with 95%*** risk factors for PIBD included fine particulate matter(Pm2.5)pollution(IRR=1.294,CI=1.113-1.507,Pm oil to orchards and grapes(IRR=1.135,CI=1.007-1.270,P=0.033).South Asian population(IRR=1.020,CI=1.011-1.028,Pmily size(IRR=0.467,CI=0.268-0.81

关键词： Inflammatory bowel diseases Crohn disease Ulcerative colitis Pesticides Air pollution South Asian people

Free vibration and buckling analysis of polymeric composite beams reinforced by functionally graded bamboo fbers

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Applied mathematics and mechanics(English Edition) 2024年第3期45卷 543-562页

作者： h.m.FEIZABAD m.h.YAS Department of mechanical Engineering Razi UniversityKermanshah ***Iran

Natural fibers have been extensively researched as reinforcement materials in polymers on account of their environmental and economic advantages in comparison with synthetic fibers in the recent *** fibers are renowned for their good mechanical properties,abundance,and short cycle *** beams are one of the fundamental structural components and are susceptible to mechanical loads in engineering applications,this paper performs a study on the free vibration and buckling responses of bamboo fiber reinforced composite(BFRC)beams on the elastic *** different functionally graded(FG)layouts and a uniform one are the considered distributions for unidirectional long bamboo fibers across the *** elastic properties of the composite are determined with the law of *** hamilton’s principle,the governing equations of motion are *** generalized differential quadrature method(GDQm)is then applied to the equations to obtain the *** achieved outcomes exhibit that the natural frequency and buckling load values vary as the fiber volume fractions and distributions,elastic foundation stiffness values,and boundary conditions(BCs)and slenderness ratio of the beam ***,a comparative study is conducted between the derived analysis outcomes for BFRC and homogenous polymer beams to examine the effectiveness of bamboo fibers as reinforcement materials,demonstrating the significant enhancements in both vibration and buckling responses,with the exception of natural frequencies for cantilever beams on the Pasternak foundation with the FG-◇fiber ***,the obtained analysis results of BFRC beams are also compared with those for carbon nanotube reinforced composite(CNTRC)beams found in the literature,indicating that the buckling loads and natural frequencies of BFRC beams are lower than those of CNTRC beams.

关键词： bamboo fiber free vibration buckling analysis functionally graded(FG)beam elastic foundation generalized differential quadrature method(GDQm)

Functional attributes： Compacting vs decompacting earth- worms and influence on soil structure

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Current Zoology 2012年第4期58卷 556-565页

作者： Arnauth martinezGUEI Yannick BAIDAI Jerome Ebagnerin TONDOh jeroen hUISING Universit6 Abobo-Adjam6 Sciences de la Nature/Centre de Recherche en Ecologie 08 BP 109 Abidjan 08 C6te d'Ivoire CIAT-TSBF Institut d'Economie Rurale CRRA de Sotuba Laboratoire Sol-Eau-Plante c/o Icraf Sahel BPE 5118 B amako Mali CIAT-TSBF Nairobi c/o ICRAF United Nations Avenue P.O. Box 30677-00100 Nairobi Kenya

A short term field mesocosm experiment was performed in semi-deciduous forest areas of Ivory Coast to assess the impact of a decompacting （hyperiodrilus africanus, Eudrilidae） and two compacting （millsonia omodeoi and Dichogaster terrae nigrae, Acanthodrilidae） earthworm species on soil properties. These species have been selected for their predominance in the re- gion and their contrasting impact on soil structure. The experimental design consisted of a treatment without worms （control）, and treatments with one, two or three species of earthworms. Both compacting and decompacting earthworms increased water infil- tration rate in all treatments, with marked impact in h. africanus and m. omodeoi＋D, terraenigrae treatments. Interactions be- tween compacting and decompacting species resulted in more large aggregates in comparison to when the compacting species D. terraenigrae was alone. This may be accounted for by their compacting attribute as compacting earthworms are responsible for producing the highest number of large aggregates. The low values of mean weight diameter in treatments combining decompact-ing and compacting earthworms compared with compacting ＂m. omodeoi＂ one also confirmed the trend of decline in soil com-paction in the presence of the decompacting species. These results showed positive impact of species richness on soil structure regulation, which is crucial in ecosystem productivity and support consequently the insurance hypothesis. In fact, this study showed that the preservation of earthworm species belonging to these two contrasting functional groups is essential for the main-tenance of stable soil structure regulation in agro-tropical ecosystems.

关键词： Earthworms Physical properties Compacting and decompacting species mesocosms

histological and magnetic resonance imaging assessment of Liqoseal in a spinal in vivo pig model

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Animal models and Experimental medicine 2023年第1期6卷 74-80页

作者： Emma m.h.Slot Wilhelmina bergmann Ahmet Kinaci Bart de Boer Nizar moayeri Saskia Redegeld Sander van Thoor Tristan P.C.van Doormaal Department of Neurology and Neurosurgery University Medical Center UtrechtUtrechtthe Netherlands Department of Translational Neuroscience Brain CenterUniversity Medical Center UtrechtUtrechtthe Netherlands Department of Biomolecular health Sciences Division of PathologyFaculty of Veterinary MedicineUtrecht UniversityUtrechtthe Netherlands Department of Neurosurgery Elizabeth TweeSteden ziekenhuisTilburgthe Netherlands Brain Technology Institute Utrechtthe Netherlands Department of Neurosurgery Clinical Neuroscience CenterUniversity Hospital ZurichZurichSwitzerland

Background:Liqoseal (Polyganics,B.V.) is a dural sealant patch for preventing postoperative cerebrospinal fluid (CSF) *** has been extensively tested preclinically and CE (Conformite Européenne) approved for human use after a first cranial in-human ***,the safety of Liqoseal for spinal application is still *** aim of this study was to assess the safety of spinal Liqoseal application compared with cranial application using histology and magnetic resonance imaging ***:Eight female Dutch Landrace pigs underwent laminectomy,durotomy with standard suturing and Liqoseal *** control animals underwent the same procedure without sealant *** histological characteristics and imaging characteristics of animals with similar survival times were compared to data from a previous cranial porcine ***:Similar foreign body reactions were observed in spinal and cranial *** foreign body reaction consisted of neutrophils and reactive fibroblasts in the first3 days,changing to a chronic granulomatous inflammatory reaction with an increasing number of macrophages and lymphocytes and the formation of a fibroblast layer on the dura by day *** Liqoseal plus dura thickness reached a maximum of 1.2mm(range 0.7-2.0mm) at day ***:The spinal dural histological reaction to Liqoseal during the first 7days was similar to the cranial dural *** did not swell significantly in both application areas over *** the current lack of a safe and effective dural sealant for spinal application,we propose that an in-human safety study of Liqoseal is the logical next step.

关键词： reaction resonance magnetic