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国外畜牧学（猪与禽） 2015年第8期35卷 54-56页

作者：肖昌何闪 Frans van Sambeek jeroen visscher Hendrix育种公司动物选育研究所

ISA(BV公司动物选育研究所)是世界领先的蛋鸡育种公司,本文将探讨ISA是如何一步步提高蛋鸡生产性能,保障其能够在2020年培育出适应各种恶劣环境,并能产出500枚高品质鸡蛋的蛋鸡品种。

关键词：育种计划蛋鸡品种育种公司蛋鸡生产性能选育研究育种价值 Gallus 蛋鸡饲养蛋白高度蛋

通过改善蛋鸡遗传性能和饲养管理生产优质食用蛋

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国外畜牧学（猪与禽） 2016年第2期36卷 49-51页

作者：姚俊峰(译) 周宗清(校) 罗静如(制图表) peter arts jeroen visscher julien fablet 不详 hendrix遗传公司isa分部

鸡蛋生产商和消费者对于优质蛋的定义都是一致的,那就是：一枚优质的蛋必须有合适的大小、高质量的蛋壳（外部品质）和内容物（内部品质）。食用蛋的品质是由遗传和饲养管理共同决定的。所以提高食用蛋的品质也需要在这二方面进行改进... 详细信息

鸡蛋生产商和消费者对于优质蛋的定义都是一致的,那就是：一枚优质的蛋必须有合适的大小、高质量的蛋壳（外部品质）和内容物（内部品质）。食用蛋的品质是由遗传和饲养管理共同决定的。所以提高食用蛋的品质也需要在这二方面进行改进：通过基因选择,使鸡蛋品质获得永久的提高;通过环境因素的影响,这其中主要与鸡蛋生产者采用的技术手段有关,须对每一批鸡群反复实施影响才能有效。

关键词：鸡蛋品质饲养管理家禽育种鸡蛋生产基因选择 lection 蛋壳质量蛋重环境因素蛋壳颜色

An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

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Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： Seol-Ha Jeong Jarno Hiemstra Patrick V.Blokzijl Rebeca Damian-Ferrara Danilo Martins dos Santos Jéssica H.L.da Fonseca Min-Ho Kang Jihyun Kim Dilara Yilmaz-Aykut Mei L.L.Cham-Pérez jeroen Leijten Su Ryon Shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leijten Lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

关键词： 3D bioprinting Bioink Colloidal gels Extrusion printing Oxygen-generating microparticle

Isotopic labelling experiments and enzymatic preparation of iso-casbenes with casbene synthase from Ricinus communis

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Organic Chemistry Frontiers 2022年第3期9卷 795-801页

作者： Heng Li jeroen S.Dickschat Kekulé-Institut für Organische Chemie und Biochemie Rheinische Friedrich-Wilhelms-Universität BonnGerhard-Domagk-Straße 153121 BonnGermany

Isotopic labelling experiments gave insights into the enzyme mechanism of casbene synthase from Ricinus communis,showing a clear stereochemical course for the cyclisation reaction,in agreement with the reported absolute configuration of *** oligoprenyl diphosphate analogs with shifted double bonds were synthesised and enzymatically converted with casbene synthase to yield casbene isomers.

关键词： enzymatic isomers bonds

Anti-fibrotic effect of adipose-derived stem cells on fibrotic scars

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World Journal of Stem Cells 2022年第2期14卷 200-213页

作者： Sophie Vanderstichele Jan jeroen Vranckx Master in Medicine KUL Leuven UniversityLeuven 3000Belgium Department of Plastic Reconstructive SurgeryKU-Leuven University HospitalsLeuven 3000Belgium

BACKGROUND Sustained injury,through radiotherapy,burns or surgical trauma,can result in fibrosis,displaying an excessive deposition of extracellular matrix(ECM),persisting inflammatory reaction,and reduced *** increasing recognition of fibrosis as a cause for disease and mortality,and increasing use of radiotherapy causing fibrosis,stresses the importance of a decent anti-fibrotic *** To obtain an in-depth understanding of the complex mechanisms underlying fibrosis,and more specifically,the potential mechanisms-of-action of adiposederived stomal cells(ADSCs)in realizing their anti-fibrotic *** A systematic review of the literature using PubMed,Embase and Web of Science was performed by two independent *** The injection of fat grafts into fibrotic tissue,releases ADSC into the ***’capacity to directly differentiate into key cell types(e.g.,ECs,fibroblasts),as well as to secrete multiple paracrine factors(e.g.,hepatocyte growth factor,basis fibroblast growth factor,IL-10),allows them to alter different mechanisms underlying fibrosis in a combined *** favor ECM degradation by impacting the fibroblast-to-myofibroblast differentiation,favoring matrix metalloproteinases over tissue inhibitors of metalloproteinases,positively influencing collagen organization,and inhibiting the pro-fibrotic effects of transforming growth factor-β***,they impact elements of both the innate and adaptive immune response system,and stimulate angiogenesis on the site of injury(through secretion of pro-angiogenic cytokines like stromal cell-derived factor-1 and vascular endothelial growth factor).CONCLUSION This review shows that understanding the complex interactions of ECM accumulation,immune response and vascularization,is vital to fibrosis treatments’effectiveness like fat *** details how ADSCs intelligently steer this complex system in an anti-fibrotic or pro-angiogenic direction,without falling in

关键词： Fibrosis Fat grafting Adipose-derived stem cells Angiogenesis Anti-fibrotic effect Immunomodulation

Assessment of ship maneuvering simulation with different propeller models

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Journal of Hydrodynamics 2022年第3期34卷 422-433页

作者： Ganbo Deng Patrick Queutey jeroen Wackers Michel Visonneau Emmanuel Guilmineau Alban Leroyer LHEEA Lab Ecole Centrale de NantesNantesFrance

This paper is devoted to the assessment of ship maneuvering simulation using different propeller models with the focus on a simplified propeller model that represents the action of the propeller by body force and uses propeller performance curve to determine propeller loading during ship *** are also performed with an actual propeller approach with which the propeller rotation is simulated directly with the Reynolds averaged Navier-Stokes equation(RANSE)*** time accurate simulations using sliding grid and rotating frame approximations have been performed for *** zigzag and turning circle maneuvers in calm water have been simulated for two different ship models,namely the ONR tumblehome(ONRT)test case and the KRISO(Korea Research Institute of Ship and Ocean)Container Ship(KCS)test *** ship motion is compared with measurement data to assess the accuracy of the numerical prediction using RANSE computations with different propeller models.

关键词： Ship zigzag and turning circle motion simplified propeller model with body force actual propeller approach

Solving PDEs with a Hybrid Radial Basis Function:Power-Generalized Multiquadric Kernel

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Advances in Applied Mathematics and Mechanics 2022年第5期14卷 1161-1180页

作者： Cem Berk Senel jeroen van Beeck Atakan Altinkaynak von Karman Institute for Fluid Dynamics Belgium Istanbul Technical University Mechanical Engineering DepartmentIstanbulTurkey

Radial Basis Function(RBF)kernels are key functional forms for advanced solutions of higher-order partial differential equations(PDEs).In the present study,a hybrid kernel was developed for meshless solutions of PDEs widely seen in several engineering *** kernel,Power-Generalized Multiquadric-Power-GMQ,was built up by vanishing the dependence of e,which is significant since its selection induces severe problems regarding numerical instabilities and convergence *** drawback of e-dependency is that the optimal e value does not exist in *** present the Power-GMQ kernel which combines the advantages of Radial Power and Generalized Multiquadric RBFs in a generic ***-GMQ RBF was tested in higher-order PDEs with particular boundary conditions and different ***-Finite Difference(RBF-FD)discretization was also implemented to investigate the characteristics of the proposed *** results revealed that our proposed kernel makes similar or better estimations as against to the Gaussian and Multiquadric kernels with a mild increase in computational ***-QR method may achieve better accuracy in some cases with considerably higher computational *** using Power-GMQ RBF,the dependency of solution on e was also substantially relaxed and consistent error behavior were obtained regardless of the selected e accompanied.

关键词： Meshfree collocation methods Radial Basis Function(RBF) partial differential equations(PDEs)

Delivery of Micro RNAs by plant virus-based nanoparticles to functionally alter the osteogenic differentiation of human mesenchymal stem cells

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Chinese Chemical Letters 2023年第1期34卷 215-220页

作者： Fei Xue jeroen J.L.M.Cornelissen Quan Yuan Shuqin Cao State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Department of Molecules&Materials MESA+Institute for NanotechnologyUniversity of TwenteEnschede AE 7500the Netherlands

Micro RNA-26a(miR-26a)has been verified to promote osteogenic differentiation of mesenchymal stem cells in recent *** main obstacles to its application in bone regeneration are instability in the physiological environment and low efficiency of cellular membrane *** overcome these problems,we constructed a novel plant virus gene delivery system based on Cowpea chlorotic mottle virus(CCMV).By encapsulating miR-26a with purified capsid protein(CP)dimers derived from CCMV,CPmiR-26a(CP26a)virus-like particles(VLPs)were ***26a retained a structure similar to the native CCMV and protected miR-26a from digestion with its exterior ***,CP26a featured similar cellular uptake efficiency,osteogenesis promotion ability,and better biocompatibility compared with Lipofectamine2000-miR-26a(lipo26a),which indicated a promising prospect for CCMV as a novel gene delivery system.

关键词： VLPs Cowpea chlorotic mottle virus Gene delivery MicroRNAs Osteogenesis

Muscle recruitment patterns and saddle pressure indexes with alterations in effective seat tube angle

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Sports Medicine and Health Science 2022年第1期4卷 29-37页

作者： Reece McDonald Wendy Holliday jeroen Swart Department of Human Biology Faculty of Health SciencesUniversity of Cape TownSouth Africa

Alteration of the effective seat tube angle(ESTA)may affect muscle activation patterns of the lower limbs in *** is conflicting evidence due to inadequate kinematic controls in previous *** primary aim of this study was to determine the muscle activity of seven lower limb muscles during alterations of the ESTA by altering the position of both the handlebars and saddle forwards or backwards by 3 cm while ensuring controlled ***,to determine the effect on the saddle pressure *** participants performed two 5 min electromyography(EMG)trials at 70%of peak power output(PPO)for three consecutive *** was a significant increase in muscle activity in the biceps femoris,gluteus maximus,and medial gastrocnemius with reductions in ESTA while a significant increase in tibialis anterior with increases in ESTA was *** pressure indices demonstrated a significant change in frontal versus back pressure as well as mean pubic pressure with changes in *** in the ESTA affects muscle activity in some,but not all of the lower limb *** research needs to be conducted to adequately understand the mechanism behind the differences in muscle activation.

关键词： EMG Muscle recruitment Seat tube angle Pressure mapping

TRADE-OFFS IN THE DESIGN OF SUSTAINABLE CROPPING SYSTEMS AT A REGIONAL LEVEL:A CASE STUDY ON THE NORTH CHINA PLAIN

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Frontiers of Agricultural Science and Engineering 2022年第2期9卷 295-308页

作者： jeroen C.J.GROOT Xiaolin YANG Farming Systems Ecology Wageningen University&ResearchP.O.Box 4306700 AK Wageningenthe Netherlands International Maize and Wheat Improvement Center(CIMMYT) Sustainable Intensification ProgramCarretera México-VeracruzKm.45El Batán56237 TexcocoMéxico Alliance of Bioversity International and CIAT PerformanceInnovation and Strategic Analysis for Impact unitVia di San Domenico 100153 RomeItaly College of Water Resources&Civil Engineering China Agricultural UniversityBeijing 100193China

Since the Green Revolution cropping systems have been progressively homogenized and intensified with increasing rates of inputs such as fertilizers,pesticides and *** has resulted in higher crop productivity but also a high environmental burden due to increased pollution and water *** identify opportunities for increasing the productivity and reducing the environmental impact of cropping systems,it is crucial to assess the associated *** paper presents a model-based analysis of how 30 different crop rotations practiced in the North China Plain could be combined at the regional level to overcome trade-offs between indicators of economic,food security,and environmental *** model uses evolutionary multi-objective optimization to maximize revenues,livestock products,dietary and vitamin C yield,and to minimize the decline of the groundwater *** modeling revealed substantial trade-offs between objectives of maximizing productivity and profitability versus minimizing ground water decline,and between production of livestock products and vitamin C *** strategies each defining a specific combination of cropping systems and contributing to different extents to the various objectives were *** of these six strategies could be used to find opportunities to mitigate the tradeoffs between *** was concluded that a holistic analysis of the potential of a diversity cropping systems at a regional level is needed to find integrative solutions for challenges due to conflicting objectives for food production,economic viability and environmental protection.

关键词： crop rotation food security multi-objective optimization water use