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Delivery of micro RNAs by plant virus-based nanoparticles to functionally alter the osteogenic differentiation of human mesenchymal stem cells

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Chinese Chemical Letters 2023年第1期34卷 215-220页

作者： Fei Xue jeroen J.L.m.Cornelissen Quan Yuan Shuqin Cao State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Department of molecules&materials MESA+Institute for NanotechnologyUniversity of TwenteEnschede AE 7500the Netherlands

micro RNA-26a(miR-26a)has been verified to promote osteogenic differentiation of mesenchymal stem cells in recent *** main obstacles to its application in bone regeneration are instability in the physiological environment and low efficiency of cellular membrane *** overcome these problems,we constructed a novel plant virus gene delivery system based on Cowpea chlorotic mottle virus(CCmV).By encapsulating miR-26a with purified capsid protein(CP)dimers derived from CCmV,CPmiR-26a(CP26a)virus-like particles(VLPs)were ***26a retained a structure similar to the native CCmV and protected miR-26a from digestion with its exterior ***,CP26a featured similar cellular uptake efficiency,osteogenesis promotion ability,and better biocompatibility compared with Lipofectamine2000-miR-26a(lipo26a),which indicated a promising prospect for CCmV as a novel gene delivery system.

关键词： VLPs Cowpea chlorotic mottle virus Gene delivery microRNAs Osteogenesis

TRADE-OFFS IN THE DESIGN OF SUSTAINABLE CROPPING SYSTEmS AT A REGIONAL LEVEL:A CASE STUDY ON THE NORTH CHINA PLAIN

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Frontiers of Agricultural Science and Engineering 2022年第2期9卷 295-308页

作者： jeroen C.J.GROOT Xiaolin YANG Farming Systems Ecology Wageningen University&ResearchP.O.Box 4306700 AK Wageningenthe Netherlands International maize and Wheat Improvement Center(CImmYT) Sustainable Intensification ProgramCarretera México-VeracruzKm.45El Batán56237 TexcocoMéxico Alliance of Bioversity International and CIAT PerformanceInnovation and Strategic Analysis for Impact unitVia di San Domenico 100153 RomeItaly College of Water Resources&Civil Engineering China Agricultural UniversityBeijing 100193China

Since the Green Revolution cropping systems have been progressively homogenized and intensified with increasing rates of inputs such as fertilizers,pesticides and *** has resulted in higher crop productivity but also a high environmental burden due to increased pollution and water *** identify opportunities for increasing the productivity and reducing the environmental impact of cropping systems,it is crucial to assess the associated *** paper presents a model-based analysis of how 30 different crop rotations practiced in the North China Plain could be combined at the regional level to overcome trade-offs between indicators of economic,food security,and environmental *** model uses evolutionary multi-objective optimization to maximize revenues,livestock products,dietary and vitamin C yield,and to minimize the decline of the groundwater *** modeling revealed substantial trade-offs between objectives of maximizing productivity and profitability versus minimizing ground water decline,and between production of livestock products and vitamin C *** strategies each defining a specific combination of cropping systems and contributing to different extents to the various objectives were *** of these six strategies could be used to find opportunities to mitigate the tradeoffs between *** was concluded that a holistic analysis of the potential of a diversity cropping systems at a regional level is needed to find integrative solutions for challenges due to conflicting objectives for food production,economic viability and environmental protection.

关键词： crop rotation food security multi-objective optimization water use

Conceptual exploration of a gravity-assisted electrorheological fluid-based gripping methodology for assistive technology

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Bio-Design and manufacturing 2019年第3期2卷 145-152页

作者： Ivo Radice jeroen H.m.Bergmann Department of Engineering Science Old Road Campus Research BuildingInstitute of Biomedical EngineeringUniversity of OxfordHeadingtonOxfordUK

Gripping devices help patients carry out everyday tasks and increase their ***,there seems to be a lack of bionic gripping technologies that can fully adapt to any possible shape,as the use of artificial fingers and predetermined grip settings limits the operating *** development of a more agile device,which is operated by a simple control paradigm,could greatly benefit *** electrorheological(ER)fluid system should be able to adapt to the shape of an object and then hold that *** aim of this study was to explore if a conceptual prototype of an ER system could hold a geometric shape when it is activated.A test rig was constructed with a moving part(set in different silicone oils)that could be displaced using a *** particles were dispersed in the silicone oils,and a field with a voltage of 4 kV mm?1 was generated to activate the *** results show that the developed system can support an increased force when activated and hold a simple geometric position without any noticeable *** outcome provides an initial proof of concept for a possible new(gravity-assisted)gripping approach using smart fluids,which could be developed with materials that are biocompatible and widely available.

关键词： Smart materials Prosthetics Exoskeleton Grasping manipulation Assistive technologies

较大直肠腺瘤中经肛门内镜显微手术与内镜下黏膜切除术的随机对照试验(TREND研究)

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英国医学杂志中文版 2018年第11期21卷 676-676页

作者： Renee m Barendse Gijsbert D musters Eelco J R de Graaf Frank J C van den Broek Esther C J Consten Pascal G Doornebosch James C Hardwick Ignace H J T de Hingh Chrisiaan Hoft jeroen m jansen A W marc van milligen de Wit George P van der Schelling Erik J Schoon matthijs P Schwartz Bas L A m Weusten marcel G Dijkgraaf Paul Fockens Willem A Bemelman Evelien Dekker TREND研究小组李佳宁(译) 吴东(校) 不详北京协和医院消化科

摘要目的非随机研究表明内镜下黏膜切除术(endoscopic mucosal resection,EmR)在切除直肠较大腺瘤时与经肛门内镜显微手术(transanal endoscopic microsurgery,TEm)同样有效,但EmR可能更具成本效益且相对安全。本试验旨在对比摘除较... 详细信息

摘要目的非随机研究表明内镜下黏膜切除术(endoscopic mucosal resection,EmR)在切除直肠较大腺瘤时与经肛门内镜显微手术(transanal endoscopic microsurgery,TEm)同样有效,但EmR可能更具成本效益且相对安全。本试验旨在对比摘除较大直肠腺瘤时EmR与TEm的临床结局与成本效益。

关键词：随机对照试验显微手术切除术内镜黏膜肛门肠腺成本效益

Impedancemetry of multiplexed quantum devices using an on-chip cryogenic complementary metal-oxide-semiconductor active inductor

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Chip 2023年第4期2卷 133-141页

作者： L.Le Guevel G.Billiot S.De Franceschi A.morel X.Jehl A.G.m.jansen *** UniversitéGrenoble Alpes CEALETIGrenoble F-38000France UniversitéGrenoble Alpes CEAGrenoble INPIRIGPHELIQSGrenoble F-38000France Department of Electrical and Computer Engineering University ofMassachusetts-AmherstMA 01003USA UniversitéSavoie mont Blanc SYMMEAnnecy F-74000France

In the pursuit for scalable quantum processors,significanteffort has been devoted to the development of cryogenic classical hardware for the control and readout of a growingnumber of *** current work presented a novelapproach called impedancemetry that is suitable for measuringthe quantum capacitance of semiconductor qubits connected toa resonant *** impedancemetry circuit exploits theintegration of a complementary metal-oxide-semiconductor(CmOS)active inductor in the resonator with tunable resonance frequency and quality factor,enabling the optimizationof readout sensitivity for quantum *** realized cryogenic circuit allows fast impedance detection with a measuredcapacitance resolution down to 10 aF and an input-referrednoise of 3.7 aF/Hz *** 4.2 K,the power consumption of theactive inductor amounts to 120μW,with an additional dissipation for on-chip current excitation(0.15μW)and voltageamplification(2.9 mW)of the impedance *** to the commonly used schemes based on dispersiveRF reflectometry which require millimeter-scale passive inductors,the circuit exhibits a notably reduced footprint(50μm360μm),facilitating its integration in a scalable quantumclassical *** impedancemetry method has been applied at 4.2 K to the detection of quantum effects in the gatecapacitance of on-chip nanometric CmOS transistors that areindividually addressed via multiplexing.

关键词： Impedancemetry Qubit readout Cryogenic circuit Activeinductor CmOS

Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility

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Genes & Diseases 2023年第2期10卷 381-384页

作者： jeroen Vierstraete Charlotte Fieuws David Creytens Jo Van Dorpe Andy Willaert Anne Vral Kathleen Bm Claes Center for medical Genetics Department of Biomolecular MedicineGhent University Hospital and Ghent University9000 GhentBelgium Department of Human Structure and Repair Ghent University9000 GhentBelgium Cancer Research Institute Ghent (CRIG) Ghent University and Ghent University Hospital9000 GhentBelgium Department of Pathology Ghent University and Ghent University Hospital9000 GhentBelgium

Biallelic loss-of-function variants in ATm (Ataxia Telangiectasia mutated) cause Ataxia Telangiectasia (AT), a rare disorder associated with cerebellar degeneration and ataxia, cancer predisposition, infertility, growth retardation, etc. ATm is a phosphoinositide 3-kinase-related kinase (PIKK) with a role in DNA repair and maintenance of genome stability. Studying a multisystem genetic disease like AT requires animal models to ascertain its pathogenesis at the level of tissues, organs and the organism. Due to its small size, cheap maintenance, large progeny, rapid development and initial transparency, zebrafish (Danio rerio) is an increasingly popular vertebrate model organism, suitable for genetic modifications and large-scale in vivo therapeutic screens as embryos are chemically permeable to small compounds. Currently, no zebrafish model for AT exists.1 We generated atm knock-outs through CRIPSR-Cas9 mutagenesis. We show that atm conserved its function as a tumour suppressor gene and is involved in gametogenesis and fertility. Therefore, this mutant is of great value for further studies investigating the role of atm in reproduction and tumorigenesis.

关键词： ATm function transparency

Introducing 3D-potting:a novel production process for artificial membrane lungs with superior blood flow design

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Bio-Design and manufacturing 2022年第1期5卷 141-152页

作者： Fellx Hesselmann Jannls m.Focke Peter C.Schlansteln NIklas B.Steuer Andreas Kaesler Sebastlan D.Relnartz Thomas Schmltz-Rode Ulrlch SteInselfer Sebastlan V.jansen Jutta Arens Department of Cardiovascular Engineering Instituteof Applied Medical EngineeringHelmholtz.InstituteRWTH Aachen UniversityPauwelsstrasse 2052074 AachenGermany Department of Diagnostic and Interventional Radiology Uniklinik RWTH AachenPauwelsstrasse 3052074 AachenGermany Department of Biomechanical Engineering Faculty of EngineeringTechnology University of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands

Currently,artificial-membrane lungs consist of thousands of hollow fiber membranes where blood flows around the fibers and gas flows inside the fibers,achieving diffusive gas *** both ends of the fibers,the interspaces between the hollow fiber membranes and the plastic housing are filled with glue to separate the gas from the blood *** a uniaxial centrifugation process,the glue forms the“potting.”The shape of the cured potting is then determined by the centrifugation process,limiting design possibilities and leading to unfavorable stagnation zones associated with blood *** this study,a new multiaxial centrifugation process was developed,expanding the possible shapes of the potting and allowing for completely new module designs with potentially superior blood flow guidance within the potting ***-phase simulations of the process in conceptual artificial lungs were performed to explore the possibilities of a biaxial centrifugation process and determine suitable parameter sets.A corresponding biaxial centrifugation setup was built to prove feasibility and experimentally validate four conceptual designs,resulting in good agreement with the *** summary,this study shows the feasibility of a multiaxial centrifugation process allowing greater variety in potting shapes,eliminating inefficient stagnation zones and more favorable blood flow conditions in artificial lungs.

关键词： Potting process Flow design membrane lung Artificial lung Hollow fiber membrane module manufacturing

Biocompatibility and degradation comparisons of four biodegradable copolymeric osteosynthesis systems used in maxillofacial surgery: A goat model with four years follow-up

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Bioactive materials 2022年第11期7卷 439-456页

作者： Barzi Gareb Nico Bvan Bakelen Leon Driessen Pieter Buma jeroen Kuipers Dirk W.Grijpma Arjan Vissink Ruud R.m.Bos Baucke van minnen University of Groningen University Medical Center GroningenDepartment of Oral and Maxillofacial SurgeryHanzeplein 19713 GZP.O.Box 300019700 RBGroningenthe Netherlands Radboud University medical Center Radboud Institute for Molecular Life SciencesOrthopaedic Research LabHoutlaan 46525 XZP.O.Box 91026500 HCNijmegenthe Netherlands University of Groningen University Medical Center GroningenDepartment of Biomedical Sciences of Cells and SystemsHanzeplein 19713 GZP.O.Box 300019700 RBGroningenthe Netherlands University of Twente TechMed CentreDepartment of Biomaterials Science and TechnologyDrienerlolaan 57522 NBP.O.Box 2177500 AEEnschedethe Netherlands

pplying biodegradable osteosyntheses avoids the disadvantages of titanium osteosyntheses. However, foreign-body reactions remain a major concern and evidence of complete resorption is lacking. This study compared the physico-chemical properties, histological response and radiographs of four copolymeric biodegradable osteo-synthesis systems in a goat model with 48-months follow-up. The systems were implanted subperiosteally in both tibia and radius of 12 Dutch White goats. The BioSorb FX [poly(70LLA-co-30DLLA)], Inion CPS [poly([70–78.5] LLA-co-[16–24]DLLA-co-4TmC)], SonicWeld Rx [poly(DLLA)], LactoSorb [poly(82LLA-co-18GA)] systems and a negative control were randomly implanted in each extremity. Samples were assessed at 6-, 12-, 18-, 24-, 36-, and 48-month follow-up. Surface topography was performed using scanning electron microscopy (SEm). Differential scanning calorimetry and gel permeation chromatography were performed on initial and explanted samples. Histological sections were systematically assessed by two blinded researchers using (polarized) light microscopy, SEm and energy-dispersive X-ray analysis. The SonicWeld Rx system was amorphous while the others were semi-crystalline. Foreign-body reactions were not observed during the complete follow-up. The SonicWeld Rx and LactoSorb systems reached bone percentages of negative controls after 18 months while the BioSorb Fx and Inion CPS systems reached these levels after 36 months. The SonicWeld Rx system showed the most predictable degradation profile. All the biodegradable systems were safe to use and well-tolerated (i.e., complete implant replacement by bone, no clinical or histological foreign body reactions, no [sterile] abscess formation, no re-interventions needed), but nanoscale residual polymeric fragments were observed at every system’s assessment.

关键词： Biocompatible materials Absorbable implants Polymers Orthopaedic fixation devices Reconstructive surgical procedures Fracture fixation

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FRAmE STORE

现代装饰 2014年第7期 106-111页

作者： jaspar jansen jeroen Dellensen 姜敏华 i29 interiorar chitects

全球顶尖店面设计杂志FRAmE与阿姆斯特丹FOAm摄影博物馆携手,在一栋具有历史意义的Felix meritis大楼内带来一次极富创造力的设计碰撞。项目位于阿姆斯特丹Keizersgracht324号,一个创新性平台由此开启。在这里,未来将举办更多由FRAmE杂... 详细信息

全球顶尖店面设计杂志FRAmE与阿姆斯特丹FOAm摄影博物馆携手,在一栋具有历史意义的Felix meritis大楼内带来一次极富创造力的设计碰撞。项目位于阿姆斯特丹Keizersgracht324号,一个创新性平台由此开启。在这里,未来将举办更多由FRAmE杂志与FOAm博物馆联手组织的一系列活动和展览,同时,FRAmE还规划了两个零售空间,由荷兰空间建筑事务所i29 interior architects进行设计。

关键词：建筑装饰室内装饰装饰材料环保材料

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