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纤溶酶基因多态性与缺血性卒中

世界核心医学期刊文摘(神经病学分册) 2006年第2期 53-53页

作者： Jood K. Ladenvall P. Tjrnlund-Wolf A. c.jern 刘凯 Institute of clinical Neuroscience Sahlgrenska Academy at Gteborg University Sahlgrenska University Hospital/-Sahlgrenska S-413 45 Gteborg Sweden.Dr

Background and Purpose -The tissue-type plasminogen activator (tPA) -7351c > T and the plasminogen activator inhibitor type 1 (PAI-1) -675 4G >5G polymorphisms influence transcriptional activity. Both variants have been associated with myocardial infarction, with increased risk for the T and 4G allele, respectively. In this study we investigated the possible association between these polymorphisms, the respective plasma protein levels, and ischemic stroke. Methods -In the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS), 600 patients with acute ischemic stroke aged 18 to 69 years and 600 matched community controls were recruited. Stroke subtype was determined using Trial of Org 10172 in Acute Trea tment criteria. Results -There were no associations between individual genetic variants and ischemic stroke. The multivariate-adjusted odds ratio for overall ischemic stroke was 1.11 (95%cI 0.87 to 1.43) for tPA T allele carriers, and 0. 84 (95%cI, 0.64 to 1.11) for subjects homozygous for the PAI-1 4G allele. When genotypes were combined, a protective effect for the tPA cc/PAI-1 4G4G genotyp e combination was observed (odds ratio 0.65, 95%cI 0.43 to 0.98; P ciated with overall ischemic stroke. tPA-antigen differed by stroke subtype and was h ighest among those with large-vessel disease and cardioembolic stroke. conclusi ons -Neither the tPA -7351c > T nor the PAI-1 to 675 4G >5G polymorphism show ed significant association with ischemic stroke. For the tPA cc/PAI-1 4G4G geno type combination, a protective effect was observed. collectively, these results are consistent with a more complex role for tPA and PAI-1 in the brain as compa red with the heart.

关键词：缺血性卒中基因多态性遗传多态性卒中亚型

Mode-locked fiber laser in the c-band region for dual-wavelength ultrashort pulses emission using a carbon nanotube saturable absorber

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chinese Optics Letters 2019年第5期17卷 30-33页

作者： Kuen Yao Lau Pin jern Ker Ahmad Fauzi Abas Mohammed Thamer Alresheedi Mohd Adzir Mahdi Electronics Research Group. Institute of Power Engineering Uni ver sit i Tenaga Nasional43000 Kajang SelangorMalaysia Department of Electrical Engineering College of EngineeringKing Saud UniversityRiyadh 11421Kingdom of Saudi Arabia Wireless and Photonics Networks Research centre Faculty of EngineeringUniversiti Putra Alalaysia43400 UPM Ser dangSelangorJMalaysia

A saturable absorber is commonly employed to generate an ultrashort laser with a mode-locking scheme. In an erbium-doped fiber laser system, the laser regimes of either 1530 or 1550 nm wavelength are procured based on the absorption profile of the erbium-doped fiber. The absorption of the erbium-doped fiber is designed to emit at both wavelengths by controlling the net gain of the laser cavity. Subsequently, simultaneous erbium-doped fiber laser emission is attained at 1533.5 and 1555.1 nm with the pulse duration of 910 and 850 fs, ***, this work maximizes the output portfolios of a mode-locking fiber laser for dual-wavelength ultrashort pulses emission.

关键词： mode-locking scheme c-band region dual-wavelength ultrashort pulses emission using

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Socio-Environmental Impact of Water Pollution on the Mid-canal (<i>Meda Ela</i>), Sri Lanka

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Journal of Water Resource and Protection 2012年第7期4卷 451-459页

作者： K. B. S. N. Jinadasa S. K. I. Wijewardena Dong Qing Zhang Richard M. Gersberg c. S. Kalpage Soon Keat Tan Jing Yuan Wang Wun jern Ng Department of chemical and Process Engineering University of Peradeniya Peradeniya Sri Lanka Department of civil Engineering University of Peradeniya Peradeniya Sri Lanka Graduate School of Public Health San Diego State University Hardy Tower Campanile San Diego USA Nanyang Environment & Water Research Institute (NEWRI) Nanyang Technological University Singapore City Singapore Nanyang Environment & Water Research Institute (NEWRI) Nanyang Technological University Singapore Singapore Works Department Kandy Municipal Council Kandy Sri Lanka

Unplanned urban population growth in developing countries such as Sri Lanka exert pressures on the sectors of water supply, sewage disposal, waste management, and surface drainage in the cities as well as their surrounding areas. The Mid-canal is considered the most polluted surface water body in the Kandy district of Sri Lanka and contributes significantly to pollution of the Mahaweli River. Health problems in the nearby population may well be associated with environmental degradation and related to deteriorated water quality. The overall objectives of this study were to identify the socio-economic status of the community settled along the Meda Ela banks, and to examine the current water quality status of the Meda Ela and possible impacts of the nearby residents on water quality. Additionally, we propose remedial measures concerning wastewater and solid waste disposal to improve environmental conditions in this area.

关键词： Meda Ela Sri Lanka Environment Pollution Water Quality

抗高血压治疗期间逆转心电图左室肥厚和主要心血管事件的预测

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世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 18-19页

作者： Okin P.M. Devereux R. B. jern S. 王亭忠 cornell University Medical center 525 E 68th St New York NY 10021 United States Dr.

context: Electrocardiographic left ventricular hypertrophy (LVH) is a strong p redictor of cardiovascular(cV) morbidity and mortality. However, the predictive value of changes in the magnitude of electrocardiographic LVH criteria during an tihypertensive therapy remains unclear. Objective: To test the hypothesis that l esser severity of electrocardiographic LVH during antihypertensive treatment is associated with decreased cV morbidity and mortality, independent of blood press ure levels and reduction and treatment modality. Design, Setting, and Participan ts: Double-blind, randomized, parallel-group study conducted in 1995-2001 amo ng 9193 men and women with hypertension aged 55 through 80 years(mean, 67 years) , with electrocardiographic LVH by cornell volt-age-duration product or Sokolo w-Lyon voltage criteria and enrolled in the Losartan Intervention For Endpoint Reduction in Hypertension(LIFE) study. Interventions: Losartan-or atenolol-bas ed treatment regimens, with follow-up assessments for at least 4(mean, 4.8 [SD, 0.9]) years. Main Outcome Measure: composite end point of cV death, myocardial infarction(MI), or stroke in relation to severity of electrocardiographic LVH de termined at baseline and on subsequent electrocardiograms obtained at 1 or more annual revisits. Results: cardiovascular death, nonfatal MI, or stroke occurred in 1096 patients (11.9%). In cox regression models controlling for treatment ty pe, baseline Framingham risk score, baseline and in-treatment blood pressure, a nd severity of baseline electrocardiographic LVH by cornell product and Sokolow -Lyon voltage, less-severe in-treatment LVH by cornell product and Sokolow-L yon voltage were associated with 14%and 17%lower rates, respectively, of the c omposite cV end point(adjusted hazard ratio[HR], 0.86; 95%confidence interval[c I], 0.82-0.90; Pcrease in cornell produ ct; and HR, 0.83; 95%cI, 0.78-0.88; Pcrease in Sokolow-

关键词：抗高血压治疗左室肥厚心血管事件 cornell 电压标准复合终点预测价值终点事件双盲随机洛沙坦

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