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Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype

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World Journal of Gastrointestinal Oncology 2017年第5期9卷 209-217页

作者： jeremy stuart williamson Huw Geraint Jones Namor Williams Anthony Paul Griffiths Gareth Jenkins John Beynon Dean Anthony Harris Department of General and Colorectal Surgery Singleton Hospital Department of Pathology Singleton Hospital Department of Life Sciences Swansea University

To identify whether CpG island methylator phenotype (CIMP) is predictive of response to neoadjuvant chemoradiotherapy (NACRT) and outcomes in rectal cancer. METHODSPatients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status (high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined upon histological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed. RESULTSThere were 160 patients analysed with a median follow-up time of 46.4 mo. Twenty-one (13%) patients demonstrated high levels of CIMP methylation (CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion (EMVI) compared with CIMP-L [8/21 (38%) vs 15/99 (15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival (P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation (P = 0.01). There were 14 (9%) patients with a pathological complete response (pCR) compared to 116 (73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pCR had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant (P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced “T” stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurre

关键词： Rectal cancer CpG islands Methylation

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Taking FAIR on the ChIN:The Chemistry Implementation Network

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Data Intelligence 2020年第1期2卷 131-138,310页

作者： Simon J.Coles jeremy G.Frey Egon L.Willighagen stuart J.Chalk School of Chemistry Faculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK Department of Bioinformatics Maastricht UniversityMaastrichtLimburg 6200 MDThe Netherlands Department of Chemistry University of North FloridaJacksonvilleFL 32224-7699USA

The Chemistry Implementation Network(ChIN)is focused on supporting the FAIR Data needs of the research community regarding chemical related *** Implementation Network is a consortium drawn from a community,in this case the chemistry discipline,committed to defining and constructing standards,materials and software in the spirit of the FAIR data principles and under the structure of the GO FAIR ***,as a core science the ChIN has to reach beyond the chemistry community and support the use of chemical information in other *** will be facilitated through connections in the GO FAIR ecosystem of Implementation *** of the FAIR chemical concepts that need to be supported include molecular and materials structures,chemical reactions,nomenclature and other chemical terminology and *** ChIN aims to drive forward the application of the FAIR Data Principles relating to the full range of chemistry concepts that are key to the transparent and efficient communication of chemical *** the goal of FAIR chemistry data will require a culture change across the *** this is best addressed once a critical mass of tools and approaches has been developed.

关键词： Chemistry Chemical information Chemistry data Chemical data standards Infrastructure Nomenclature Molecular structure Materials structure Chemical reactions Education Community engagement Endorsement and governance

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Detection of a possible superluminous supernova in the Epoch of Reionization

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Science Bulletin 2017年第10期62卷 675-678页

作者： jeremy Mould Tim Abbott Jeff Cooke Chris Curtin Antonios Katsianis Anton Koekemoer Edoardo Tescari Syed Uddin Lifan Wang stuart Wyithe Centre for Astrophysical & Supercomputing Swinburne University Hawthorn 3122 Australia Cerro Tololo lnteramerican Observatory NOAO La Serena Chile Space Telescope Science Institute Baltimore MD 21218 USA Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China Texas A&M University College Station 7X 77843 USA University of Melbourne School of Physics Melbourne 3010 Australia Departamento de Astronornia Universidad de Chile Los Condes Santiago. Chile

The Epoch of Reionization(EoR)poses a number of puzzles,including the sufficiency of ionizing radiation,the rapid production of supermassive black holes and the early appearance of abundant metals in larger *** the first of these,solutions focus on the main sequence evolution of massive stars,but the second and third puzzles involve the terminal phase of stellar evolution,

关键词：超新星再电离大质量恒星检测光度恒星演化电离辐射 EOR

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Objective assessment of bradykinesia in Parkinson’s disease using evolutionary algorithms:clinical validation

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Translational Neurodegeneration 2018年第1期7卷 167-174页

作者： Chao Gao Stephen Smith Michael Lones stuart Jamieson Jane Alty jeremy Cosgrove Pingchen Zhang Jin Liu Yimeng Chen Juanjuan Du Shishuang Cui Haiyan Zhou Shengdi Chen Department of Neurology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Electronic Engineering University of YorkYorkUK Department of Computer Science Heriot-Watt UniversityEdinburghUK Department of Neurology Leeds General InfirmaryLeeds Teaching Hospitals NHS TrustLeedsUK

Background:There is an urgent need for developing objective,effective and convenient measurements to help clinicians accurately identify *** purpose of this study is to evaluate the accuracy of an objective approach assessing bradykinesia in finger tapping(FT)that uses evolutionary algorithms(EAs)and explore whether it can be used to identify early stage Parkinson’s disease(PD).Methods:One hundred and seven PD,41 essential tremor(ET)patients and 49 normal controls(NC)were *** performed a standard FT task with two electromagnetic tracking sensors attached to the thumb and index *** from the sensors were transmitted to a tablet computer and subsequently analyzed by using *** output from the device(referred to as"PD-Monitor")scaled from−1 to+1(where higher scores indicate greater severity of bradykinesia).Meanwhile,the bradykinesia was rated clinically using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale(MDS-UPDRS)FT ***:With an increasing MDS-UPDRS FT score,the PD-Monitor score from the same hand side increased ***-Monitor score correlated well with MDS-UPDRS FT score(right side:r=0.819,P=0.000;left side:r=0.783,P=0.000).Moreover,PD-Monitor scores in 97 PD patients with MDS-UPDRS FT bradykinesia and each PD subgroup(FT bradykinesia scored from 1 to 3)were all higher than that in *** operating characteristic(ROC)curves revealed that PD-Monitor FT scores could detect different severity of bradykinesia with high accuracy(≥89.7%)in the right dominant ***,PD-Monitor scores could discriminate early stage PD from NC,with area under the ROC curve greater than or equal to ***,ET without bradykinesia could be differentiated from PD by PD-Monitor scores.A positive correlation of PD-Monitor scores with modified Hoehn and Yahr stage was found in the left hand ***:Our study demonstrated that a simple to use devic

关键词： Parkinson’s disease Bradykinesia Evolutionary algorithms Objective assessment Clinical validation

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大都市的绿色行动

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商业周刊（中文版） 2010年第7期 26-27页

作者：马克·斯科特（Mark Scott）杰里米·范卢恩（jeremy van Loon）斯图尔特·比格靳（stuart Biggs）马忠元（译）

洛杉矶：一个遍布高速公路、烟雾……还有自行车道的城市？这正是市长安东尼奥·维拉莱戈沙（Antonio Villaraigosa）为自己的城市设定的发展方向。在全球减少二氧化碳排放的行动中，为了这一不太可能实现的转型方案，洛杉矶市计划耗资2... 详细信息

洛杉矶：一个遍布高速公路、烟雾……还有自行车道的城市？这正是市长安东尼奥·维拉莱戈沙（Antonio Villaraigosa）为自己的城市设定的发展方向。在全球减少二氧化碳排放的行动中，为了这一不太可能实现的转型方案，洛杉矶市计划耗资2．3亿美元兴建1700英里长的自行车道。该项目的大部分将于2015年完成，其中包括由市政和民间合伙人经营的更衣室、沐浴室和自行车存车处。这一项目将优先上马，

关键词：绿色行动大都市二氧化碳排放洛杉矶市自行车高速公路安东尼奥转型方案

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