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Homocysteine and copper interact to promote type 5 phosphodiesterase expression in rabbit cavernosal smooth muscle cells

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Asian Journal of Andrology 2008年第6期10卷 905-913页

作者： Matthew Hotston Jamie Y. jeremy Jonathon Bloor Nick s. Greaves Raj Persad Gianni Angelini Nilima shukla Department of Urology University of BristoL Bristol Bs8 1TH UK Department of Cardiac surgery University of BristoL Bristol BS8 1TH UK

Aim： To study the effects of homocysteine and copper on type 5 phosphodiesterase （PDE5） expression in cavemosai vascular smooth muscle cells （CVsMCs） and to investigate superoxide （O2-） derived from nicotinamide adenine dinucleotide phosphate oxidase as homocysteine and copper generate O2-, and O2- upregulates PDE5 expression. Methods： CVsMCs derived from rabbit penis were incubated with homocysteine or copper chloride with or without superoxide dismutase （sOD）, catalase, sildenafil citrate, or apocynin （nicotinamide adenine dinucleotide phosphate inhibitor） for 16 h. The expression of PDE5 and of glyceraldehyde-3-phosphate dehydrogenase （internal standard） was assessed using Western blot analysis. In parallel, O2-was measured spectrophotometrically. Results： CuCl2 alone （up to 10 μmol/L） and homocysteine alone （up to 100 μmol/L） had no effect on O2- formation in CVsMCs compared to controls. In combination, however, homocysteine and CuCl2 markedly increased O2- formation, an effect blocked by sOD, catalase, apocynin, and sildenafil （1 μmol/L） when co-incubated over the same time course. PDE5 expression was also significantly increased in CVsMCs incubated with homocysteine and CuCl2, compared to controls. This effect was also negated by 16-h co-incubation with sOD, catalase, apocynin and sildenafil. Conclusion： This represents a novel pathogenic mechanism underlying ED, and indicates that the therapeutic actions of prolonged sildenafil use are mediated in part through inhibition of this pathway.

关键词： erectile dysfunction superoxide PDE5 sildenafil

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Abdominal tuberculosis: diagnosis and demographics, a 10-year retrospective review from a single centre

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World Journal of Clinical Cases 2016年第8期4卷 207-212页

作者： jeremy s Nayagam Claire Mullender Catherine Cosgrove Andrew Poullis Gastroenterology St George’s Hospital Clinical Infection Unit St George’s Hospital

AIM: To review all cases of abdominal tuberculosis(ATB) for demographic details, diagnostic work up and evidence of vitamin D ***: This was a retrospective analysis of all patients diagnosed with ATB from June 2003 to August 2013 at st George's Hospital, London. Demographic data was available from the local tuberculosis database. Further clinical information was collected from electronic patient records, including radiology, endoscopy, microbiology, histology, biochemistry and serology. Patients were classified as either confirmed ATB [if mycobacteria tuberculosis(MTB) was cultured from abdominal site] or presumed ATB(if suggestive findings or high clinical suspicion). subtypes of ATB were classified as tuberculosis(TB) peritonitis, luminal TB, solid organ TB or from a combination of ***: There were a total of 65 cases identified in this time period, with a mean of 6.5 cases per year(range 4-9). Mean age 42 years, 49.2% females. Fifty-two point three percent were south Asian, 38.5% African. Forty-nine point two percent had gastrointestinal endoscopy, 30.8% paracentesis and 24.6% surgery in order to obtain samples. Forty-seven point seven percent were defined as confirmed ATB with positive culture of MTB from abdominal sites, the rest were treated as presumed ATB. Twenty-four point six percent had co-existing sputum culture positive for MTB, and 30.8% had an abnormal chest X-ray. subtypes of ATB: 35.4% had TB peritonitis; 27.7% luminal TB; 3.1% solid organ TB; and 33.8% TB at a combination of abdominal sites. Thirteen point nine percent were human immunodeficiency virus positive, all with CD4 count less than 300 cells/μL. seventy point five percent had severe vitamin D deficiency, and 25% were vitamin D ***: ATB mainly affects young south Asian and African patients, with difficulties in confirming diagnosis despite a range of non-invasive and invasive diagnostic tests.

关键词： Abdominal gastrointestinal tuberculosis vitamin D human immunodeficiency virus

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Aggressive primary hepatic histiocytic sarcoma: case report and literature review

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Hepatoma Research 2016年第1期2卷 300-304页

作者： Guang Yang jeremy Deisch Haixia Qin Craig Zuppan Anwar s.Raza Department of Pathology Loma Linda University Medical CenterLoma LindaCA 92354USA Department of Medicine Loma Linda University Medical CenterLoma LindaCA 92354USA

Histiocytic sarcoma is an uncommon non-Langerhans histiocyte disorder of mature tissue *** authors presented an example of this rare tumor in a 14-year-old girl who presented with left upper quadrant pain,loss of appetite,and weight loss.A large 18 cm×10 cm heterogeneous solid and cystic enhancing mass was found in the left lobe of the *** on the histomorphology and positivity for histiocyte-specific markers in a needle biopsy,a diagnosis of histiocytic sarcoma was *** was initiated,but the tumor did not respond well,and she died about 7 weeks following initial diagnosis with multi-organ *** autopsy,the tumor showed extensive necrosis,with no evidence of metastatic *** conclusion,the diagnosis of histiocytic sarcoma is challenging,and requires a high index of suspicion,with an appropriate panel of confirmatory immunohistochemical *** of this rare tumor is important because of its poor response to chemotherapy and high mortality.

关键词： Histiocytic sarcoma hepatic neoplasms liver

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silicone matrices for controlled dexamethasone release:toward a better understanding of the underlying mass transport mechanisms

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Regenerative Biomaterials 2023年第1期10卷 498-509页

作者： Thitiphorn Rongthong Adam Qnouch Maria Maue Gehrke Laurent Paccou Paulo Oliveira Florence Danede jeremy Verin Christophe Vincent Jean-Francois Willart Florence siepmann Juergen siepmann Univ.Lille INSERMCHU LilleU1008F-59000 LilleFrance Univ.Lille UMR CNRS 8207UMETF-59655 Villeneuve d’AscqFrance

Dexamethasone-loaded silicone matrices offer an interesting potential as innovative drug delivery systems,*** the treatment of inner ear diseases or for ***,very long drug release periods are targeted:several years/*** renders the development and optimization of novel drug products cumbersome:experimental feedback on the impact of the device design is obtained very slowly.A better understanding of the underlying mass transport mechanisms can help facilitating research in this field.A variety of silicone films were prepared in this study,loaded with amorphous or crystalline *** polymorphic drug forms were investigated,the film thickness was altered and the drug optionally partially/completely exchanged by much more water-soluble dexamethasone‘phosphate’.Drug release studies in artificial perilymph,scanning electron microscopy,optical microscopy,differential scanning calorimetry,X-ray diffraction and Raman imaging were used to elucidate the physical states of the drugs and polymer,and of the systems’structure as well as dynamic changes thereof upon exposure to the release *** particles were initially homogeneously distributed throughout the *** hydrophobicity of the matrix former very much limits the amounts of water penetrating into the system,resulting in only partial drug *** mobile drug molecules diffuse out into the surrounding environment,due to concentration ***,Raman imaging revealed that even very thin silicone layers(s of *** physical state of the drug(amorphous,crystalline)did not affect the resulting drug release kinetics to a noteworthy extent.

关键词： silicone matrix drug release mechanism dexamethasone dexamethasone phosphate Raman imaging

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China's Media Morphosis From new content to new media, communication is more profitable than ever in China

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Beijing Review 2006年第41期49卷 40-41页

作者： sUNNIE WONG jeremy WANG

Insiders weigh in on minimizing risk and maximizing return in the new venture capital marketIn an exquisitely renovated office in a luxury office building on Nanjing Xilu, in downtown shanghai, Wu Meng was on the phon... 详细信息

关键词： Media China’s Media Morphosis From new content to new media communication is more profitable than ever in China

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Computer Aided Modeling and Dynamic Analysis of A New surgical Instrument

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surgical science 2012年第5期3卷 242-244页

作者： jeremy (Zheng) Li school of Engineering University of Bridgeport Bridgeport USA

One major difference among surgical instruments is the level of bodily disruption and tissue trauma that surgical devices might cause the patients. This newly designed and developed surgical instrument aims at minimally invasive therapy procedure, more reliable and durable function, less operational force, and reduced manufacturing cost. The computer aided modeling and simulation have been applied to help this new instrument design and analysis. This improved new surgical instrument is designed to use in general surgery to prevent patient's vessels and tissues from being damaging due to reliable motion control of surgical clips with no unexpected clip drop. It can also be applied to surgical education purpose to educate medical students for their future surgical careers. The prototype testing indicated that the handle operational force to close surgical clips is lower than current surgical clip instruments, product manufacturing is cost-effective due to less dimensional tolerance control of this new instrument design, more reliable instrument function, and good mechanical advantage.

关键词： surgical Instrument Mechanical Advantage suture Occluding

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Angola’s Awakening

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ChinAfrica 2011年第7期3卷 30-32页

作者： simon Freemantle jeremy stevens the standard Bank

BRIC is dominant in Angola’s economic awakening,with China a special and prominent partner since the end of the civil war in 2002, Angola has moved from the fringe to the center of African economic ***,Angola accounts for 6 percent of Africa’s GDP,10 percent of its trade and 5 percent of continental-wide investment flows. Importantly,Angola’s economic awakening has occurred in tandem with the resurgence of BRIC(Brazil,Russia,India and China) commercial interest in *** such,Angola is,

关键词： Angola’s Awakening CITIC

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Factors influencing communication of traditional Chinese medicine use between patients and doctors:A multisite cross-sectional study

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Journal of Integrative Medicine 2019年第6期17卷 396-403页

作者： Wen Qiang Lee jeremy Teoh Pei Zheng Kenneth Lee Zhi Xiong Gerard Low Xueling sim Foong Fong Mary Chong Norbert Ludwig Wagner Yong Loo Lin school of Medicine National University of Singapore117597Singapore saw swee Hock school of Public Health National University of Singapore117549Singapore

Objective: In singapore, the use of traditional Chinese medicine(TCM) alongside Western medicine(WM)is common. There are risks of adverse herb-drug interactions when taken concurrently. Current literature suggests that TCM use is not regularly reported to WM doctors in singapore, but the underlying reasons are not ***: A cross-sectional study was conducted across singapore by administering questionnaires to TCM-using patients and WM-practising general practitioners(GPs). The questionnaire examined the following themes:(1) demographics and TCM use pattern;(2) respondents'(patients and GPs) knowledge and beliefs about TCM and the factors influencing the discussion of TCM during the WM consultation;and(3) respondents' qualitative suggestions to increase disclosure ***: A total of 484 patients and 334 GPs were surveyed. Factors associated with patients' initiation of TCM discussion include length of consultation(odds ratio [OR]: 2.1;P scussing TCM(OR: 1.6;P scussion(OR: 1.4;P = 0.017). Doctor's initiation of discussion(74%) was the top patient-ranked factor influencing their discussion of TCM. For doctors,knowledge of TCM indications(OR: 2.2;P scussion(OR: 2.1;P scussing TCM(OR: 1.9;P = 0.001) were associated with their initiation of TCM use discussion. Possible WM-TCM interactions(58%) was the top doctor-ranked factor influencing their discussion of ***: The discussion of TCM in a WM setting is multifactorial. Interventions include doctors' active screening for TCM use in patients and equipping doctors with TCM knowledge. Improving communication between patients and doctors is key to avoiding harmful herb-drug interactions.

关键词： Traditional Chinese medicine Western medicine Patient-provider communication Primary care General practice Public health

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Deductions from the Quaternion Form of Maxwell’s Electromagnetic Equations

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Journal of Modern Physics 2020年第9期11卷 1361-1371页

作者： jeremy Dunning-Davies Richard Lawrence Norman Departments of Mathematics and Physics (retd) University of Hull Kingston upon Hull England Institute for Basic Research Palm Harbor FL USA Thunder Energies Corporation Palm Harbor FL USA

It is often claimed that Maxwell’s electromagnetic equations were originally written in terms of quaternions. Once returned to that form and treated with left and right hand operators as in the mathematics of P. M. ... 详细信息

stify"> It is often claimed that Maxwell’s electromagnetic equations were originally written in terms of quaternions. Once returned to that form and treated with left and right hand operators as in the mathematics of P. M. Jack, a new seventh scalar electromagnetic field component emerges with possible relations to clean energy extraction and gravitation. It is the purpose here to examine this approach afresh and see how it might link up with other fairly recent, but little known, work in the field. Again, as with the usual form of Maxwell’s equations, a new scalar wave equation is derived but, on this occasion, due to the presence of the scalar component of the quaternion, that equation exhibits a wave speed greater than the speed of light. Historical and present uses within military and humanitarian contexts are considered briefly.

关键词： Electromagnetic Field Quaternion Gravity Maxwell Energy scalar Wave

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RegCM3对东亚环流和中国气候模拟能力的检验

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热带气象学报 2007年第5期23卷 444-452页

作者：张冬峰欧阳里程高学杰赵宗慈 PAL jeremy s GIORGI Filippo 中国科学院大气物理研究所广州国际专业气象台国家气候中心 The Abdus salamInternational Centre for Theoretical Physics 34100 TriesteItaly

使用RegCM3区域气候模式,嵌套ERA40再分析资料,对东亚地区进行了15年（1987～2001年）时间长度的数值积分试验,分析了模式对东亚平均环流及中国地区气温和降水的模拟。结果表明,模式对东亚平均环流的特征和中国地区降水、地面气温的年... 详细信息

使用RegCM3区域气候模式,嵌套ERA40再分析资料,对东亚地区进行了15年（1987～2001年）时间长度的数值积分试验,分析了模式对东亚平均环流及中国地区气温和降水的模拟。结果表明,模式对东亚平均环流的特征和中国地区降水、地面气温的年、季地理分布和季节变化特征均具有一定的模拟能力,对气温和降水年际变率的模拟也较好。此外模式模拟在测站稀少地区,可以提供局地如降水分布更可靠的信息。模式对气温的模拟存在1-3℃的系统性冷偏差;对中国地区降水地理分布的模拟也存在一定偏差,如对年平均降水的模拟中,降水最大值位置与观测有一定差距,特别是对冬季降水中心的模拟存在较大偏差。模式模拟的夏季降水,在中国北方地区总体偏大100-200 mm,南方总体偏小100-200 mm。模式对地面气温的模拟效果好于降水。

关键词：区域气候模式气候模拟检验东亚地区中国

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