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The role of peroxisome proliferator-activated receptor gamma in prostate cancer

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Asian Journal of Andrology 2018年第3期20卷 238-243页

作者： Catherine Elix Sumanta k.Pal jeremy O Jones Department of Medical Oncology City of Hope National Medical Center Duarte CA91010 USA.

Despite great progress in the detection and treatment of prostate cancer, this disease remains an incredible health and economic burden. Although androgen receptor （AR） signaling plays a k.y role in the development and progression of prostate cancer, aberrations in other molecular pathways also contribute to the disease, mak.ng it essential to identify and develop drugs against novel targets, both for the prevention and treatment of prostate cancer. One promising target is the peroxisome proliferator-activated receptor gamma （PPARy） protein. PPARy was originally thought to act as a tumor suppressor in prostate cells because agonist ligands inhibited the growth of prostate cancer cells; however, additional studies found that PPARy agonists inhibit cell growth independent of PPARy. Furthermore, PPARy expression increases with cancer grade/stage, which would suggest that it is not a tumor suppressor but instead that PPARy activity may play a role in prostate cancer development and/or progression. Indeed, two new studies, tak.ng vastly different, unbiased approaches, have identified PPARy as a target in prostate cancer and suggest that PPARy inhibition might be useful in prostate cancer prevention and treatment. These findings could lead to a new therapeutic weapon in the fight against prostate cancer.

关键词： androgen receptor PPAR gamma prevention prostate cancer warfarin

Molecular Phenomic Approaches to Deconvolving the Systemic Effects of SARS-CoV-2 Infection and Post-acute COVID-19 Syndrome

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Phenomics 2021年第4期1卷 143-150页

作者： jeremy k.Nicholson The Australian National Phenome Center and the Health Futures Institute Murdoch UniversityHarry Perkins BuildingRobert Warren DriveMurdoch PerthWA 6150Australia Institute of Global Health Innovation Imperial College LondonLevel 1Faculty Building South Kensington CampusLondon SW72NAUK

SARS COV-2 infection causes acute and frequently severe respiratory disease with associated multi-organ damage and systemic disturbances in many biochemical *** phenotyping provides deep insights into the complex immunopathological problems that drive the resulting COVID-19 disease and is also a source of novel metrics for assess-ing patient recovery.A multiplatform metabolic phenotyping approach to studying the pathology and systemic metabolic sequelae of COVID-19 is considered here,together with a framework.for assessing post-acute COVID-19 Syndrome(PACS)that is a major long-term health consequence for many *** sudden emergence of the disease presents a biological discovery challenge as we try to understand the pathological mechanisms of the disease and develop effective mitigation *** requires technologies to measure objectively the extent and sub-phenotypes of the disease at the molecular *** methods can reveal metabolic sub-phenotypes and new biomark.rs that can be monitored during the acute disease phase and *** approach is scalable and translatable to other pathologies and provides as an exem-plar strategy for the investigation of other emergent zoonotic diseases with complex immunological drivers,multi-system involvements and diverse persistent symptoms.

关键词： SARS COV-2 COVID-19 Post-acute COVID-19 Syndrome(PACS)lSpectroscopy Metabolic Phenoconversion Phenoreversion

Unintended consequences of rangeland conservation structures

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International Soil and Water Conservation Research 2021年第1期9卷 158-165页

作者： Mary H.Nichols jeremy R Shaw William k.Brandau Southwest Watershed Research Center USDA-ARS2000 E.Allen Rd.TucsonAZ85719USA Colorado State University Department of Forest&Rangeland Stewardship Fort CollinsCO80523-1472USA University of Arizona Cooperative Extension Service(retired) SaffordAZ85551USA

By the 1930's vast areas of the western US were severely degraded by overgrazing and *** response,Congress authorized conservation work.including the construction of erosion control and water storage,distribution,and conveyance *** of structures such as check.dams,water spreaders,and contour berms were built during the 1930s and 40s to control water and sediment in an attempt to restore degraded ***,across most of the western US,these soil and water conservation measures were implemented without the benefit of local hydrologic data or technical design *** of the established conservation practices had been developed for humid regions and were untested for use in semiarid areas that are characterized by highly variable rainfall and flash *** a result,many structures proved ineffective and were subsequently *** in cases where structures were effective,many never received maintenance after their initial *** structurally compromised,abandoned and unmaintained structures continue to alter surface runoff patterns and can greatly exacerbate *** sites in Arizona,USA were selected to charac-terize the multi-decadal impacts of conservation *** have formed in 100%of contour berms(n=67)while 96%of water spreader berms(n=26)were *** failures in these structures has created concentrated flow paths that reorganized routing of runoff and sediment thus transforming sheetflow regimes to concentrated flow *** study emphasizes the unin-tended legacy impacts of soil and water conservation structures and highlights their role as a potential constraint on contemporary resource management.

关键词： Contour berm Erosion Human altered landscape Restoration Semiarid Water spreader

Comparing the Effect of Pruning on a Best Path and a Na?ve-approach Black.oard Solver

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International Journal of Automation and computing 2015年第5期12卷 503-510页

作者： jeremy Straub Department of Computer Science University of North DakotaGrand Forks North Dakota 58202 USA

A na?ve solver is one approach that can be used to identify prospective solutions based on data on(or projected to be on) a Black.oard Architecture’s black.oard. The na?ve solver approach doesn t implement heuristics or other techniques to determine what solution paths to attempt first. Instead, it runs the black.oard forward(simulating what would occur if data were gradually added to the black.oard at a faster-than-real time rate). The approach doesn t guarantee that an optimal solution will be found and will need to be run repetitively to create multiple solutions for comparison. This paper assesses the effect of pre-pruning the black.oard’s facts and rules to remove those that are not relevant(e.g., facts that cannot be asserted, rules that cannot be triggered) or which produce irrelevant facts and pruning actions that produce irrelevant facts(and/or trigger other similarly useless actions). It describes the Black.oard implementation and its utility, explains the pruning process used and presents quantitative and qualitative assessment of the utility of pruning to a na?ve solver’s operations. This value is extrapolated to facilitate consideration of a more robust pruning process which also removes low-value facts, actions and rules in addition to those being removed due to their uselessness.

关键词： Black.oard Architecture black.oard maintenance con

Placental accommodations for transport and metabolism during intra-uterine crowding in pigs

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Journal of Animal Science and Biotechnology 2015年第2期6卷 163-176页

作者： Jeffrey L Vallet Anthony k.Mc Neel jeremy R Miles Bradley A Frek.ng U.S. Department of Agriculture Agricultural Research Service U.S. Meat Animal Research CenterState Spur 18D Clay Center NE 68933 USA

Litter size and birth weights are limited by uterine capacity, defined as the ability of the uterus to maintain the appropriate development of some number of conceptuses. Uterine capacity is the result of the combined effects of uterine, placental and embryo/fetal function. The number of living conceptuses that the uterus is capable of supporting is greater during early gestation compared to later gestation. Plots of log fetal weight versus log placental weight also indicate that fetal weights are less sensitive to reduced placental weight （and therefore reduced intrauterine space） in early gestation compared to late gestation. However, even in late gestation, mechanisms still exist that maintain fetal growth when the size of the placenta is reduced. One such mechanism is lik.ly to be improved development of the folded placental-epithelial/maternal-epithelial bilayer. Fold depth, and therefore the maternal fetal interactive surface, increases as gestation advances and is greater in placenta from smal fetuses. On the fetal side of the placenta, the epithelial bilayer is embedded in stromal tissue. Glycosaminoglycans are major components of stroma, including hyaluronan and heparan sulfate. Hyaluronidases and heparanases are present within placental tissues, and lik.ly play roles in modification of stromal components to facilitate fold development. Glycosaminoglycans are polymers of forms of glucose （glucosamine, glucuronic acid, iduronic acid） suggesting that glycosaminoglycan synthesis may compete with the glucose needs of the developing fetus. Pig conceptuses are fructogenic, such that a substantial portion of glucose transferred from mother to fetus is converted to fructose. Fructose is an intermediate product in the synthesis of glucosamine from glucose, and glucosamine is link.d to regulation of trophoblast cell proliferation through regulation of mTOR. These findings suggest a link.between glucose, fructose, glucosamine synthesis, GAG production, and placental m

关键词： Glycosaminoglycans Nutrient transport Placenta

Waveguide-based augmented reality displays: a highlight

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Light(Science & Applications) 2024年第1期13卷 10-12页

作者： Jannick.P.Rolland jeremy Goodsell Institute of Optics University of Rochester480 Intercampus DriveRochesterNY14627USA Center for Freeform Optics University of RochesterRochesterNY14627USA Center for Visual Science University of RochesterRochesterNY14627USA

Augmented reality(AR),which emerged in the 1960s,remains a focal point of interest given its capacity to overlay the real world with digitally presented information through optical *** prevalent combiner,commonly k.own as the waveguide in the AR literature,is prized for its compact design and generous eyebox—essential elements in human-centric ***,these combiners encounter unique challenges in meeting various other requirements of the human visual *** paper highlights a recent review of technological advancements and presents a forward-look.ng perspective on the future of AR technology.

关键词： waveguide Waveguide look.ng

Lobular capillary hemangioma of the liver

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Hepatobiliary & Pancreatic Diseases International 2009年第3期8卷 323-325页

作者： Faisal Abaalk.ail Mathieu Castonguay David k.Driman jeremy Parfitt Paul Marotta London Health Sciences Centre University of Western Ontario

BACk.ROUND: Lobular capillary hemangioma (LCH) is a benign vascular tumor that is rare in adults and has never been reported in the liver. This vascular lesion usually presents on the sk.n or mucous membranes, and predominantly affects children. METHODS: LCH as a large asymptomatic hepatic mass was seen in a 35-year-old female. Imaging and pathologic characteristics of the mass are reviewed, and the relevant literature is also reviewed. RESULTS: A large vascular hepatic lesion was observed in an asymptomatic 35-year-old female. Pathologic examination after surgical resection revealed typical features of LCH. CONCLUSIONS: This is the first case of lobular capillary hemangioma seen as a liver lesion in an adult. Large vascular hepatic lesions pose significant difficulties in discerning benign from potentially malignant conditions. In this report we describe the pitfalls and radiological uncertainties with interpreting vascular lesions of the liver. (Hepatobiliary Pancreat Dis Int 2009; 8: 323-325)

关键词： lobular capillary hemangioma benign

For cancers there is more to life than a longer G-strand

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Asian Journal of Andrology 2010年第6期12卷 779-782页

作者： jeremy D. Henson Children＇s Medical Research Institute Sydney NSW 2154 Australia University of Sydney NSW 2154 Australia

Three recent studies from the Wright [1], Chai [2] and de Lange [3] labs have elucidated previously neglected aspects of cancer cell telomere maintenance. Because inhibiting telomere maintenance can selectively k.ll cancer cells without harming normal cells [4, 5], this new understanding of the mechanism and dynamics involved may provide useful new strategies for treating cancer. Until recently,

关键词： Maintenance Cancer (genus) Neoplasms Cells Lymphocytes

Neither Ghost nor Machine:The Emergence and Nature of Selves

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学术界 2019年第11期 185-196页

作者： jeremy Sherman University of California

Every generation marvels at what prior generations did not not k.ow,the mysteries they had not not yet solved,perhaps had not not even *** might,therefore,wonder what future generations will regard as our biggest blind *** central mystery have not not we solved yet and perhaps even do not not recognize to be a mystery?Here,I will propose a lik.ly candidate:Scientists have yet to explain the emergence and nature of striving selves.I will also summarize a new explanation developed by biologist Terrence *** selves,I mean all living beings ever,here on earth or anywhere in the *** go by different names- agents,individuals,living beings,organisms.I will simply refer to them as selves and refer to all inanimate objects and processes as non-selves.

关键词： self emergence self-organization Autogen