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One-dimensional Modeling of Sedimentation Impacts for the Mississippi River at the West Bay diversion

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Journal of Water Resource and Protection 2013年第9期5卷 16-29页

作者： jeremy A. Sharp Ronald E. Heath Nathan d. Clifton USACE Engineering Research and development Center Coastal and Hydraulics Lab Vicksburg USA

The Coastal Wetlands Planning, Protection and Restoration Act (CWPPRA) funded construction of the West Bay Sediment diversion Project (WBSd) on the west bank of the Mississippi River for the purpose of coastal restoration. A multi-tiered sediment study for the WBSd was conducted to determine impacts to the adjacent navigation channel and to the Pilottown Anchorage Area (PAA). One tier of the study is the implementation of HEC-6T, a one-dimensional (1-d) sediment model, to evaluate the regional impacts of the WBSd. The HEC-6T model results shows the long-term channel changes associated with the WBSd to be increasing shoaling in the adjacent areas on the order of 10% - 20%, as compared to the no WBSd condition. However, it is extremely difficult to isolate the impacts associated with a single diversion due to multiple diversions in the region. From a holistic vantage point, the 1-d model shows the necessity to examine, on a regional scale, the lower Mississippi River as a single congruent system on a regional scale.

关键词： diversion dredging Mississippi River Navigation Sediment

Genetic interactions between polycystin-1 and Wwtr1 in osteoblasts define a novel mechanosensing mechanism regulating bone formation in mice

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Bone Research 2023年第4期11卷 772-783页

作者： Zhousheng Xiao Li Cao Micholas dean Smith Hanxuan Li Wei Li jeremy C.Smith Leigh darryl Quarles department of Medicine University of Tennessee Health Science CenterMemphisTN 38163USA UT/ORNL Center for Molecular Biophysics Oak Ridge National LaboratoryOak RidgeTN 37830USA department of Biochemistry and Cellular and Molecular Biology The University of Tennessee-KnoxvilleKnoxvilleTN 37996-1939USA department of Pharmaceutical Sciences University of Tennessee Health Science CenterMemphisTN 38163USA

Molecular mechanisms transducing physical forces in the bone microenvironment to regulate bone mass are poorly ***,we used mouse genetics,mechanical loading,and pharmacological approaches to test the possibility that polycystin-1 and Wwtr1 have interdependent mechanosensing functions in *** created and compared the skeletal phenotypes of control Pkd1^(flox/)+;Wwtr1^(flox/)+,Pkd1^(Oc-cKO),Wwtr1^(Oc-cKO),and Pkd1/Wwtr1^(Oc-cKO)mice to investigate genetic *** with an interaction between polycystins and Wwtr1 in bone in vivo,Pkd1/Wwtr1^(Oc-cKO)mice exhibited greater reductions of BMd and periosteal MAR than either Wwtr1Oc-cKOor Pkd1^(Oc-cKO)***-CT 3d image analysis indicated that the reduction in bone mass was due to greater loss in both trabecular bone volume and cortical bone thickness in Pkd1/Wwtr1Oc-cKO mice compared to either Pkd1Oc-cKOor Wwtr1^(Oc-cKO)***1/Wwtr1^(Oc-cKO)mice also displayed additive reductions in mechanosensing and osteogenic gene expression profiles in bone compared to Pkd1Oc-cKOor Wwtr1^(Oc-cKO)***,we found that Pkd1/Wwtr1^(Oc-cKO)mice exhibited impaired responses to tibia mechanical loading in vivo and attenuation of loadinduced mechanosensing gene expression compared to control ***,control mice treated with a small molecule mechanomimetic,MS2 that activates the polycystin complex resulted in marked increases in femoral BMd and periosteal MAR compared to vehicle *** contrast,Pkd1/Wwtr1^(Oc-cKO)mice were resistant to the anabolic effects of *** findings suggest that PC1 and Wwtr1 form an anabolic mechanotransduction signaling complex that mediates mechanical loading responses and serves as a potential novel therapeutic target for treating osteoporosis.

关键词： mec impaired additive

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移动学习就在当下

中国远程教育 2012年第12期 89-92页

作者： clark Quinn.Ph.d 殷蕾(译) 不详北京广播电视大学

移动设备区分既然移动学习是基于移动设备的学习，那我们首先要考虑的就是人们如何使用这些设备。从功能性来看，现在的移动设备功能越来越综合了。

关键词：移动学习移动设备设备功能

Human germline editing: Insights to future clinical treatment of diseases

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Protein & Cell 2019年第7期10卷 470-475页

作者： Yanni Li Xiang Jin Kang jeremy Kah Sheng Pang Boon Seng Soh Yang Yu Yong Fan Key Laboratory for Major Obstetric diseases of Guangdong Province Center of Reproductive Medicine The Third Affiliated Hospital of Guangzhou Medical University Guangzhou 510150 China disease Modeling and Therapeutics Laboratory A*STAR Institute of Molecular and Cell Biology 61 Biopolis Drive Proteos Singapore 138673 Singapore Center of Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China

Last year, the first attempt to genetically modify human embryos in the United States was reported and sparked a huge debate (Ma et al., 2017). Although the first human germline modification was only performed two years ago, the study showed that rapid adva nces in tech no logy has allowed the rate of off-target effects and mosaicism to be reduced considerably (Liang et al., 2015). Recently, Vertex and CRISPR therapeutics collaborated and developed CTX001, the first CRISPR/Cas9-based therapy, targeting patients with P-thalassemia and have begun phase 1/2 clinical trials. With policies and technologies regarding genome editing both developing rapidly, explorations into the possibility of clinical gene editing for hundreds of hereditary diseases are starting to become achievable. Here, we address the progress of huma n embryo editi ng tech no logies so far and its promise and risks in advancing therapy for hereditary diseases.

关键词： Human germline editing Insights diseases

Response of life-history traits to artificial and natural selection for virulence and nonvirulence in a drosophila parastitoid, Asobara tabida

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Insect Science 2018年第2期25卷 317-327页

作者： Joffrey Moiroux Joan van Baaren Mathilde Poyet Aude Couty Patrice Eslin Genevieve Prevost jeremy Sguin Vincent Le Roux FRE 3498 EdYSAN CNRS-Universite de Picardie Jules Verne 33 rue St Leu Amiens Cedex France UMR 6553 ECOBIO CNRS- Universite Rennes 1 Campus de Beaulieu avenue du G~n~ral Leclerc Rennes Cedex France UMR 7263 IMBE AMU - CNRS - IRD - UAPV Universite d＇Avignon et des Pays de Vaucluse 301 rue Baruch de Spinoza 84916 Avignon Cedex 09 Franc

Co-evolution of host-parasitoid interactions is determined by the costs of host resistance, which received empirical evidence, and the costs ofparasitoid virulence, which have been mostly hypothesized. Asobara tabida is a parasitoid, which mainly parasitizes drosophila melanogaster and d. subobscura, the first species being able to resist to the parasitoid development while the second species is not. To parasitize resistant hosts, including d. melanogaster, A. tabida develops sticky eggs, which prevent encapsulation, but this virulence mechanism may be costly. Interindividual and interpopulation variation in the proportion of sticky eggs respectively allowed us to （i） artificially select and compare life-history traits of a virulent and a nonvirulent laboratory strain, and （ii） compare a virulent and a nonvirulent field strain, to investigate the hypothetical costs of virulence. We observed strong differences between the 2 laboratory strains. The nonvirulent strain invested fewer resources in reproduction and walked less than the virulent one but lived longer. Concerning the field strains, we observed that the nonvirulent strain had larger wings while the virulent one walked more and faster. All together, our results suggest that virulence may not always be costly, but rather that different life histories associated with different levels of virulence may coexist at both intra- and interdodulation levels.

关键词： encapsulation geographic variation host resistance trade-offs

Trans-Gulf of Mexico loop migration of tree swallows revealed by solar geolocation

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Current Zoology 2014年第5期60卷 653-659页

作者： david W. BRAdLEY Robert G. clark Peter O. dUNN Andrew J. LAUGHLIN Caz M. TAYLOR Carol VLECK Linda A. WHITTINGHAM david W. WINKLER d. Ryan NORRIS department of Integrative Biology University of Guelph Guelph Ontario N1G 2W 1 Canada Bird Studies Canada Port Rowan Ontario N0E 1M0 Canada Environment Canada. Saskatoon. Saskatchewan S7N 0X4. Canada Behavioral and Molecular Ecology Group Department of Biological Sciences University of Wisconsin Milwaukee Wisconsin 53201 USA department of Ecology and Evolutionary Biology Tulane University New Orleans Louisiana 70118 USA department of Ecology Evolution and Organismal Biology Iowa State University Ames IA 50011-1020 USA department of Ecology and Evolutionary Biology Museum of Vertebrates and Lab of Ornithology Comell University Ithaca New York 14853 USA

One of the greatest feats of avian migration is the non-stop crossing of extensive areas of inhospitable habitat such as deserts and seas. differences in spring and autumn migration routes have been reported in species that cross such barriers, and are thought to have evolved in response to seasonal variation in prevailing wind direction. We tested the hypothesis that migration routes vary seasonally with respect to the Gulf of Mexico in the tree swallow Tachycineta bicolor using solar geolocators attached and retrieved at 4 breeding sites in central North America. We found that 100 % of birds （n = 10） made a trans-Gulf flight of 〉850 km from Louisiana south to their wintering grounds in the Yucatan Peninsula in 12-36 hours, achieving minimum ground speeds as high as 32 m/s. Although most days during autumn migration were characterized by unfavorable headwinds blowing to the northwest, migration over the Gulf mostly occurred on days with strong winds blowing to the south. In contrast, in 8 of 9 （88 %） birds on spring migration returned from the wintering grounds towards Louisiana following a clockwise loop pat- tern flying over land to the west around the Gulf. during this spring period there were few days with prevailing winds from the south to assist northward migration. Results suggest that, despite being up to three times further （ca. 2,700 kin）, a coastal circum-Gulf spring migration represents the less risky route when wind conditions are not favorable. These findings also help to resolve a long-standing dispute in the literature concerning migration patterns between the US Gulf coast and Mexico, and provide insight into the factors shaping migration strategies of small songbirds migrating across large bodies of water [Current Zoology 60（5）： 653-559, 2014].

关键词： Ecological Barrier Geolocation Gulf of Mexico Tachycineta bicolor Tree swallow Migration

do Your Students Notice Anything?(I)

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基础教育外语教学研究 2019年第1期 31-32页

作者： jeremy Harmer 不详

What Role does Noticing Play in Language Acquisition?Should teachers trust theorists?‘Noticing' for example,is a key concept in language *** not all of its suppose d attributes are universal *** this article jeremy Harmer looks at what noticing is and what,perhaps,it is not Where does it fit in Task based learning-and does TBL itself justify the claims made for it?

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Current and future applications of in vitro magnetic resonance spectroscopy in hepatobiliary disease

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World Journal of Gastroenterology 2006年第30期12卷 4773-4783页

作者： I Jane Cox Amar Sharif jeremy FL Cobbold Howard C Thomas Simon d Taylor-Robinson Imaging Sciences department Division of Clinical Sciences Imperial College London Hammersmith Hospital Campus Du Cane Road London W12 OHS United Kingdom department of Medicine Division of Medi-cine Imperial College London St Mary's Campus London W2 United Kingdom

Nuclear magnetic resonance spectroscopy allows the study of cellular biochemistry and metabolism, both in the whole body in vivo and at higher magnetic field strengths in vitro. Since the technique is non-invasive and non-selective, magnetic resonance spectroscopy methodologies have been widely applied in biochemistry and medicine. In vitro magnetic resonance spectroscopy studies of cells, body fluids and tissues have been used in medical biochemistry to investigate pathophysiologi- cal processes and more recently, the technique has been used by physicians to determine disease abnormalities in vivo. This highlighted topic illustrates the potential of in vitro magnetic resonance spectroscopy in studying the hepatobiliary system. The role of in vitro proton and phosphorus magnetic resonance spectroscopy in the study of malignant and non-malignant liver disease and bile composition studies are discussed, particularly with reference to correlative in vivo whole-body magnetic resonance spectroscopy applications. In summary, magnetic resonance spectroscopy techniques can provide non-invasive biochemical information on disease severity and pointers to underlying pathophysiological processes. Magnetic resonance spectroscopy holds potential promise as a screening tool for disease biomarkers, as well as assessing therapeutic response.

关键词： Magnetic resonance spectroscopy Liver Hepatobiliary disease Membrane metabolism

Phosphorylation of MtRopGEF2 by LYK3 mediates MtROP activity to regulate rhizobial infection in Medicago truncatula

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Journal of Integrative Plant Biology 2021年第10期63卷 1787-1800页

作者： Mingxing Wang Huan Feng Peng Xu Qiujin Xie Jinpeng Gao Yanzhang Wang Xiaowei Zhang Jun Yang jeremy dMurray Fengli Sun Chunyan Wang Ertao Wang Nan Yu College of Life and Environment Sciences Shanghai Normal UniversityShanghai 200234China National key Laboratory of Plant Molecular Genetics Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and Ecologythe Chinese Academy of SciencesShanghai 200032China University of Chinese Academy of Sciences Beijing 100039China College of Forestry Northwest A&F UniversityYangling 712100China College of Agronomy Northwest A&F UniversityYangling 712100China

The formation of nitrogen-fixing no dules on legume roots requires the coordination of infection by rhizobia at the root epidermis with the initiation of cell divisions in the root *** infection,rhizobia attach to the tip of elongating root hairs which then curl to entrap the ***,the mechanism of root hair deformation and curling in response to symbiotic signals is still ***,we found that small GTPases(MtRac1/MtROP9 and its homologs)are required for root hair development and rhizobial infection in Medicago *** results show that the Nod factor receptor LYK3 phosphorylates the guanine nucleotide exchange factor MtRopGEF2 at S73 which is critical for the polar growth of root *** turn,phosphorylated MtRopGEF2 can activate *** MtRac1 was found to localize at the tips of root hairs and to strongly interact with LYK3 and *** together,our results support the hypothesis that MtRac1,LYK3,and NFP form a polarly localized receptor complex that regulates root hair deformation during rhizobial infection.

关键词： guanine nucleotide exchange factor ROP GTPase root hair deformation rhizobial infection