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Gestational heat stress alters skeletal muscle gene expression profiles and vascularity in fetal pigs in a sexually dimorphic manner

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Journal of Animal Science and Biotechnology 2022年第6期13卷 1785-1798页

作者： Weicheng Zhao Mark P.Green Christina d.Marth Fan Liu Hieu H.Le Gordon S.Lynch Alan W.Bell Brian J.Leury Frank R.dunshea jeremy J.Cottrell School of Agriculture and Food Faculty of Veterinary and Agricultural SciencesThe University of MelbourneParkvilleVIC 3010Australia School of BioSciences Faculty of ScienceThe University of MelbourneParkvilleVIC 3010Australia Melbourne Veterinary School Faculty of Veterinary and Agricultural SciencesThe University of MelbourneWerribeeVIC 3030Australia Rivalea Australia Pty Ltd CorowaNSW 2646Australia Centre for Muscle Research Department of Anatomy and PhysiologyThe University of MelbourneParkville 3010Australia department of Animal Science Cornell UniversityIthacaNY 14853-4801USA Faculty of Biological Sciences The University of LeedsLeeds LS29JTUK

Background: There is evidence that sow heat stress(HS) during gestation affects fetal development with implications for impaired muscle growth. We have previously demonstrated that maternal HS during early to midgestation compromised muscle fibre hyperplasia in developing fetal pigs. Thus, we hypothesised these phenotypic changes are associated with a change in expression of genes regulating fetal skeletal muscle development and metabolism. To test this, at d 60 of gestation, RNA sequencing and immunohistochemistry were performed on fetal longissimus dorsi(Ld) muscle biopsies collected from pregnant gilts that had experienced either thermoneutral control(CON, 20 ℃, n = 7 gilts, 18 Ld samples) or controlled HS(cyclic 28 to 33 ℃, n = 8 gilts, 23 Ld samples)conditions for 3 ***: A total of 282 genes were differentially expressed between the HS and CON groups in female Ld muscles(false discovery rate(FdR) ≤ 0.05), whereas no differentially expressed genes were detected in male Ld muscles between the two groups(FdR > 0.05). Gestational HS increased the expression of genes associated with transcription corepressor activity, adipogenesis cascades, negative regulation of angiogenesis and pro-inflammatory signalling in female Ld muscles. Immunohistochemical analyses revealed a decreased muscle vascularity density in fetuses from HS group for both sexes compared to those from the CON group(P = 0.004).Conclusions: These results reveal gilt HS during early to mid-gestation altered gene expression profiles in fetal Ld muscles in a sexually dimorphic manner. The molecular responses, including transcription and angiogenesis repressions and enhanced adipogenesis cascades, were exclusively observed in females. However, the associated reductions in muscle vascularity were observed independently of sexes. Collectively this may indicate female fetal pigs are more adaptive to gestational HS in terms of gene expression changes, and/or there may be sexually dimorphic differences

关键词： Adipogenesis Angiogenesis Fetal pig Gestation Heat stress Sexual dimorphism Skeletal muscle Sows

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早产儿视网膜病变3期治疗后和阈下3期自然转归的比较:对3个月和3年病变活动性、屈光力和解剖学变化的研究

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 23-24页

作者： Sahni J. Subhedar N.V. clark d. 王永强 department of Ophthalmology Walton Hospital Rice Lane Liverpool L9 IAE United Kingdom

Aim: To compare the visual acuity (VA), spherical equivalent refractive error, motility, and anatomical outcomes in children with treated regressed threshold stage3 retinopathy of prematurity (ROP) and those with spontaneously regressed subthreshold stage3 ROP. Method: 6 month and 3 year data collected from infants examined between 1989 and 1999 with regressed stage3 ROP, with or without treatment were retrospectively reviewed. Results: 85 infants were included in this study. 40 eyes received cryotherapy, 81 eyes laser photocoagulation, and 34 eyes had spontaneously regressed subthreshold stage3 ROP. Grating acuity score ≥ 2 cycles/degree (c/d) at 6 months was predictive of optotype acuity ≥ 6/9 in 69% of eyes and a score d at 6 months was predictive of acuity d stage3 ROP were twice as likely to haveVA of 6/9 or better at 36 months than the treated eyes. The mean spherical equivalent refractive error at 36 months was-6.5 dioptres (d) (-21.5d to + 1.38d) in cryotherapy treated eyes,-2.4d (-13d to + 4d) in the laser group, and-0.22d (-9d to + 2.25d) in the subthreshold group. Eyes within the treated groups were more myopic than the eyes within the spontaneously regressed group (P=0.005). At 36 months, 42 out of the 85 infants (that is, 49% ) had strabismus (44% in the cryotherapy group, 26% in the laser group, and 25% in the subthreshold group). There was a statistically significant association between the presence of strabismus and anisometropia (P=0.016) and strabismus and intraventricular haemorrhage (IVH) (P=0.005). There was a statistically significant difference in the incidence of strabismus between mild and moderate and severe grade IVH (P=0.01). Eight out of 40 eyes in the cryotherapy group and six out of the 81 eyes in the laser group developed macular ectopia. None of the eyes in the spontaneously regressed group had macular dragging. Conclusions: In this study, the grating acuity at 6 months was a good pred

关键词：病变活动屈光力自然转归激光治疗组黄斑异位等量球镜激光光凝术近视程度屈光不正屈光参差

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Experimental Study on Performance and Combustion Analysis of a diesel Engine Fueled with diesel and Jatropha Oil Blended with Heptane

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Energy and Power Engineering 2021年第1期13卷 1-16页

作者： Yomi Woro Gounkaou Tizane daho Ali diane Gilles Vaitilingom Bruno Piriou jeremy Valette Oumar Sanogo Antoine Béré département de Physique Université Joseph KI-ZERBO Ouagadougou Burkina Faso Biomasse Bois Energie Bioproduits Montpellier France Centre National de la Recherche Scientifique et Technologique Ouagadougou Burkina Faso

This work focuses on blending Jatropha oil with diesel fuel and heptane to improve its physico-chemical characteristics for production of blends and their use as fuel in a diesel engine. The influence of the heptane content was evaluated by comparing the results obtained from the engine (performance and combustion parameters) with those of the diesel fuel and straight Jatropha oil. The results obtained show an improvement in engine performance especially at low loads. Specifically, a reduction in the specific fuel consumption of the engine is obtained when the heptane content in the mixture is around 10% compared to that obtained with pure Jatropha oil. The best results were obtained with the blend containing 70% Jatropha oil, 20% diesel fuel and 10% heptane (J70G20H10). Overall engine efficiency and exhaust gas temperatures are comparable for all fuels tested. Engine combustion parameters are improved with J70G20H10. The results obtained with J70G20H10 are close to those of the engine operating on diesel fuel. The cyclic dispersion is low with coefficients of variation of the indicated mean effective pressure (COVIMEP) whose values are less than 10%. The lowest values of the COVIMEP are obtained with the blend J70G20H10.

关键词： diesel Engine Jatropha Oil Heptane Blends Engine Performance Cyclic dispersion

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历史超新星

历史超新星

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作者： d.H.·克拉克(d.H. clark) F.R.·斯蒂芬森(F.R. Stephenson)

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A hybrid organic-inorganic polariton LEd

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Light(Science & Applications) 2019年第1期8卷 475-485页

作者： Rahul Jayaprakash Kyriacos Georgiou Harriet Coulthard Alexis Askitopoulos Sai K.Rajendran david M.Coles Andrew J.Musser Jenny clark Ifor d.W.Samuel Graham A.Turnbull Pavlos G.Lagoudakis david G.Lidzey department of Physics and Astronomy The University of SheffieldHicks BuildingHounsfield RoadSheffield S37RHUK department of Physics and Astronomy University of SouthamptonSouthampton SO171BJUK Skolkovo Institute of Science and Technology MoskvaRussia Organic Semiconductor Centre SUPASchool of Physics and AstronomyUniversity of St AndrewsSt.AndrewsFife KY169SSUK Baker Laboratory Cornell University259 East AvenueIthacaNY 14850USA

Polaritons are quasi-particles composed of a superposition of excitons and photons that can be created within a strongly coupled optical ***,we describe a structure in which a strongly coupled microcavity containing an organic semiconductor is coupled to a second microcavity containing a series of weakly coupled inorganic quantum *** show that optical hybridisation occurs between the optical modes of the two cavities,creating a delocalised polaritonic *** electrically injecting electron–hole pairs into the inorganic quantum-well system,we are able to transfer energy between the cavities and populate organic-exciton *** approach represents a new strategy to create highly efficient devices for emerging‘polaritonic’technologies.

关键词： state. inorganic polar

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脱除SO_2并回收硫磺的冶炼烟气处理工艺

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硫酸工业 2006年第3期 40-45页

作者： L.Micucci A.danieletto P.d.clark N.I.dowling 胡小云 Siirtec Nigi公司 Alberta硫研究有限责任公司

介绍用甲烷(天然气)直接还原技术使冶炼烟气中SO2生成元素硫的工艺研究。SO2直接还原法分2 步:在高温下用甲烷将部分SO2还原成S和H2S,然后未反应的SO2和H2S发生Claus转化反应生成S。研究发现, 在工业装置中还原反应器宜采用分批甲烷法进... 详细信息

介绍用甲烷(天然气)直接还原技术使冶炼烟气中SO2生成元素硫的工艺研究。SO2直接还原法分2 步:在高温下用甲烷将部分SO2还原成S和H2S,然后未反应的SO2和H2S发生Claus转化反应生成S。研究发现, 在工业装置中还原反应器宜采用分批甲烷法进料,以避免烟灰的生成;另需严格控制各种物料的相对比例,以确保位于Claus转化系列的硫冷凝器排出的尾气中的H2S／SO2为2,从而优化工艺性能。另外试验发现,在不同的停留时间下,SO2转化率与反应温度的关系曲线变化趋势是相反的,因此必须根据具体的现场条件选择停留时间。Siirtec Nigi公司和Albera硫研究有限责任公司联合开发了一种CH4／SO2还原／Claus／HCRTM工艺,其总硫回收率可达到99％以上。试验确定了一组有价值的化学工程数据,可用于该工艺的工业装置设计。

关键词：冶炼烟气脱除SO2 回收硫磺试验研究工业装置

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克劳斯催化过程的实际情况

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硫酸工业 2006年第4期 21-28页

作者： P.d.clark[加拿大] N.I.dowling[加拿大] M.Huang[加拿大] 瑾（译）阿尔伯塔硫研究有限公司加拿大不详

结合现场操作情况,考查了在克劳斯催化剂上H2S／SO2转化反应的基本化学原理。结果表明,在缺氧条件下硫酸盐在催化剂表面的形成是克劳斯催化过程中的一种基本情况,也是降低CS2转化率和导致催化剂因BTX降解而结垢的原因。结合催化剂表面... 详细信息

结合现场操作情况,考查了在克劳斯催化剂上H2S／SO2转化反应的基本化学原理。结果表明,在缺氧条件下硫酸盐在催化剂表面的形成是克劳斯催化过程中的一种基本情况,也是降低CS2转化率和导致催化剂因BTX降解而结垢的原因。结合催化剂表面天然硫酸盐的生成,对更换催化剂和高比值浸润问题进行论述。最后考查了亚露点操作的催化剂设计问题。

关键词：克劳斯反应化学原理硫酸盐化 BTX 亚露点催化剂

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WHO叶状肿瘤三级分类预后意义及与新加坡中央医院列线图的相关性

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诊断病理学杂志 2023年第4期30卷 405-405,F0003页

作者： Bedi d clark BZ Carter GJ 方三高(译) 于丽娟(校) 不详迈杰转化医学研究(苏州)有限公司病理中心苏州215123

叶状肿瘤(PT)是上皮和间质成分双相分化为特征的纤维上皮性肿瘤,间质富于细胞且伴叶状生长。按基质细胞丰富程度、细胞学非典型、每10个高倍视野核分裂数、伴或不伴间质过度生长、病变边界类型(光滑还是浸润)和异源性成分是否存在等组... 详细信息

叶状肿瘤(PT)是上皮和间质成分双相分化为特征的纤维上皮性肿瘤,间质富于细胞且伴叶状生长。按基质细胞丰富程度、细胞学非典型、每10个高倍视野核分裂数、伴或不伴间质过度生长、病变边界类型(光滑还是浸润)和异源性成分是否存在等组织学特征,WHO将PT分为良性(病灶局限;间质异型性极小或无;核分裂<5个/10HPFs;间质过度生长缺乏)、交界性(介于良恶性之间)及恶性(间质异型性常明显、间质过度生长;核分裂≥10个/10HPFs)。为进一步研究,作者分析了新加坡中央医院(SGH)2005年~2019年所有的PT病例,基于细胞学异型性、核分裂、间质过度生长三项组织学标准加上手术切缘状态的AMOS标准,制成列线图(“nomogram”诺模图或诺模预测模型)作为其无复发生存期风险评估工具,研究了WHO分类的预后意义及其与SGH列线图的相关性.

关键词：新加坡中央医院预后意义叶状肿瘤间质成分高倍视野病灶局限列线图核分裂

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子宫内膜增生的治疗:对现行治疗方法的评价

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世界核心医学期刊文摘（妇产科学分册） 2006年第9期2卷 36-37页

作者： clark T.J. Neelakantan d. Gupta J.K. 党慧敏 Academic department of Obstetrics and Gynaecology Birmingham Women's Hospital Birmingham B15 2TG United Kingdom

Objective: To identify current management practices and evaluate subsequent outcomes of treatment for women diagnosed with endometrial hyperplasia. Study design: All women with a histological diagnosis of endometrial hyperplasia at the Birmingham Women s Hospital were identified between October 1998 and September 2000. A retrospective case note review was performed for each woman using a standardised data abstraction sheet. Baseline characteristics including clinical presentation and treatment strategywere obtained. Results of subsequent endometrial tissue examinations were used to assess histological response to treatment and the need and indication for hysterectomy was used to assess clinical response. Results: There were 351 women diagnosed with endometrial hyperplasia during the study period of which 84% presented with symptoms of abnormal uterine bleeding and 54% were postmenopausal. Complex endometrial hyperplasia was the most common diagnosis accounting for 60% of all cases. Eighty percent of women with atypical endometrial hyperplasia were treated by hysterectomy compared with 30% without evidence of cytological atypia (relative hysterectomy rate of 2.6, 95% CI 2.0- 3.3). Hysterectomy was avoided in 138/172 (80% , 95% CI 74- 86% ) women managed conservatively during the study period. Overall 35/108 (36% , 95% CI 27- 46% ) of women managed conservatively had persistent or progressive disease identified (mean follow up 36 months). 20/143 (14% ) women initially diagnosed with endometrial hyperplasia who subsequently underwent hysterectomy were found to have endometrial cancer, the majority of whom had been diagnosed with atypical disease (14/20, 70% ). Conclusion( s): The majority of women with atypical endometrial hyperplasia were managed by hysterectomy and the substantial risk of diagnostic under-call supports this approach to treatment. In contrast, there is no consensus regarding the initial management of women with endometrial hyperplasia without cytolog

关键词：子宫内膜增生治疗方法子宫内膜非典型增生组织学诊断子宫切除术子宫内膜组织异常子宫出血病例研究

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石油行业2004年的发现和开发成本剧增

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国外石油动态 2005年第13期 96-98页

作者： JudyR．clark 谢力

美国银行证券(BAS)4月18日在一项报告中宣布，根据由12家综合国际石油公司和60家美国独立石油公司组成的研究小组调查，2004年的全负荷总发现和开发(F&d)成本比2003年有显著增加(见图)。BAS称，引起这些增加的原因是兼并和服务成本剧增... 详细信息

美国银行证券(BAS)4月18日在一项报告中宣布，根据由12家综合国际石油公司和60家美国独立石油公司组成的研究小组调查，2004年的全负荷总发现和开发(F&d)成本比2003年有显著增加(见图)。BAS称，引起这些增加的原因是兼并和服务成本剧增以及储量增加和净负储量修正较少。

关键词： 2004年开发成本石油行业国际石油公司 2003年储量增加服务成本 BAS 美国证券银行兼并

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