检索结果-南通市图书馆

Peginterferon Lambda-1a, a New Therapeutic for Hepatitis C Infection, from bench to Clinic

作者：托尼·迈尔斯(Tony myers)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2013年第2期1卷 116-124页

作者： Henrik Andersen Jeff Meyer jeremy Freeman Sean E.Doyle Kevin Klucher Dennis M.Miller Diana Hausman Jan L.Hillson ZymoGenetics/bristol-myers Squibb Seattle WA 98102 USA EMD Serono Billerica MA USA Oncothyreon Inc. Seattle WA USA CPTxbio Woodinville WA USA

Chronic infection with hepatitis C virus (HCV) is estimated to affect approximately 3% of the world's population and cause 350,000 deaths each *** number of years,the standard of care has been combination therapy with recombinant alfa interferons—originally as native proteins but more recently as polyethyleneglycol-modified derivatives—and ribavirin,with the recent addition of an NS3 protease inhibitor for HCV genotype ***,therapeutic alfa interferons are associated with a significant burden of treatment-limiting adverse events,including musculoskeletal and influenza-like symptoms,hematologic cytopenias,autoimmune disease,fatigue,and other neurologic *** 2003,a team at ZymoGenetics (now a fully owned subsidiary of bristol-myers Squibb) and a second,independent group simultaneously identified a new class of interferons—the type Ⅲ lambda interferons—with near-identical activity to the type Ⅰ alfa interferons in hepatocytes but with an unrelated and less ubiquitous *** evaluation of the type Ⅲ interferon system demonstrated antiviral activity against HCV in vitro with limited activity in peripheral blood mononuclear cells and other nonhepatocyte cell types,supporting its development as a potentially better-tolerated therapy for viral *** lambda-1a (Lambda) is an investigational type Ⅲ therapeutic agent originally developed at ZymoGenetics that is currently in Phase 3 studies for the treatment of *** this review,we describe the selection of the Lambda molecule and its preclinical and early clinical development,and how the resulting data have helped to establish the differentiated safety profile for Lambda—with fewer influenza-like and musculoskeletal symptoms and less hematologic toxicity than the alfa interferons—that was seen in later studies.

关键词： Discovery HCV Interferonλ

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

重新发现欧洲

2020年

作者： (英)杰里米·布莱克(jeremy black)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

板块运动控制着弧后扩张

地震地质译丛

地震地质译丛 1987年第3期 26-29页

作者： jeremy b.Fein Donna M.Jurdy 章振铨

引言活跃扩张的弧后盆地是俯冲带的瞬时特征,它只出现在某些活动的俯冲带的后面,最长的扩张期达20百万年。Karig 首先确定出了这些边缘盆地的扩张性质,认为岩石圈俯冲时的摩擦产生了具浮力的热底辟,这种底辟引起了扩张。另一个模式认为... 详细信息

引言活跃扩张的弧后盆地是俯冲带的瞬时特征,它只出现在某些活动的俯冲带的后面,最长的扩张期达20百万年。Karig 首先确定出了这些边缘盆地的扩张性质,认为岩石圈俯冲时的摩擦产生了具浮力的热底辟,这种底辟引起了扩张。另一个模式认为,俯冲板块引起它上面的软流楔形成一个对流室,从而生成了发生扩张所必需的张应力。然而这两个局部模式未能解释可观察到的边缘海的分布和年龄。一个包含了全球板块的相互影响的第三类模式可以说

关键词：板块运动上覆俯冲板块地球动力学下冲板块弧后扩张洋底扩张地壳运动海底扩张边缘盆地

The total cross sections of the ^(11)b(α,n)^(14N) and the ^(10)b(α,n)^(13)N reactions between 2 and 6 MeV

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2017年第8期28卷 111-116页

作者： R. M. Prior M. C. Spraker R. H. France S. Stave M. W. Ahmed H. J. Karwowski J. M. Mueller L. S. myers H. R. Weller University of North Georgia Dahlonega GA 30597 USA Georgia College & State University MilledgevilleGA 31061 USA Duke University Durham NC 27708 USA Triangle Universities Nuclear Laboratory DurhamNC 27708 USA University of North Carolina Chapel Hill NC 27599 USA Present Address: bluffton University Bluffton OH 45817USA

There is considerable interest in potential aneutronic fusion reactors. One possible reaction is^(11)b(p,a)***, the emitted alpha particles are energetic enough to generate neutrons by interacting with boron inside the reactor through the ^(11)b(α,n)^(14N) and ^(10)b(α,n)^(13)N *** aid in evaluating neutron production within this potential aneutronic reactor, the total cross sections were measured for the ^(11)b(α,n)^(14N) reaction between 2 and 6 MeV and for the ^(10)b(α,n)^(13)N reaction between 2 and 4.8 MeV. The results are presented and compared with previously reported results.

关键词：聚变反应堆 MeV 总截面核反应堆中子反应器 α粒子电子

维普期刊数据库

Kinetic Characterization of Na,K-ATPase Inhibition by the Acetaminophen Metabolite N-Acetylbenzoquinoneimine

在线全文

学校读者我要写书评

暂无评论

Open Journal of Molecular and Integrative Physiology 2015年第1期5卷 1-17页

作者： Jeff b. Helms Lauren P. Saunders Jamie Meyer Charles J. Costa Eric Plowman Nick Williford Matthew Corbitt jeremy P. Holden Craig Gatto Department of biology Upper Iowa University Fayette IA USA Division of Neuroscience and Physiology Department of Biological Science Illinois State University Normal IL USA Department of Internal Medicine University of Wisconsin-Madison Medical Center Madison WI USA

N-acetylbenzoquinoneimine (NAbQI) is a toxic metabolite of the common analgesic acetaminophen (APAP). NAbQI is an electrophilic intermediate formed via the oxidation of APAP within the cytochrome P450 system. Within the normally recommended low-dose use of APAP, NAbQI is a minor metabolite which is either quickly reduced back to APAP or conjugated to Glutathione (GSH) producing an innocuous by-product. However, with overdose or prolonged high-dose usage of acetaminophen, GSH levels can become depleted and the bioactive NAbQI is thought to form adducts with proteins and oxidize protein sulfhydryls producing intra- and intermolecular disulfide bridges in proteins. In this work we investigated the effect of NAbQI on purified kidney Na,K-ATPase to see if the clinical renal insufficiencies seen in APAP overdose may be linked to inhibition of the Na,K-ATPase. Our work has shown that NAbQI does indeed inhibit the Na,K-ATPase in a dose dependent (IC50 = 19.8 ± 2.9 μM) and irreversible manner. Interestingly, brief storage of NAbQI at -20°C eliminates the irreversible effects of the compound, and leads to a product that remains a potent reversible inhibitor of the Na,K-ATPase (IC50 = 58.7 ± 19.5 μM). Further, the reversible inhibition produced by stored NAbQI competes with para-nitrop.

关键词： Na K-ATPase Paracetamol N-Acetylbenzoquinoneimine Overdose Renal Electrophillic

Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica b 2022年第10期12卷 3905-3923页

作者： Aneesh V.Karkhanis Gopalakrishnan Venkatesan Ryuichi Kambayashi Jacqueline Wen Hui Leow Marcus Qingrui Han Hiroko Izumi-Nakaseko Ai Goto jeremy Kah Sheng Pang boon Seng Soh Pipin Kojodjojo Atsushi Sugiyama Eric Chun Yong Chan Department of Pharmacy Faculty of ScienceNational University of SingaporeSingapore 117543Singapore Department of Pharmacology Faculty of MedicineToho UniversityTokyo 143-8540Japan Institute of Molecular and Cell biology Agency for ScienceTechnology and ResearchSingapore 138673Singapore Department of biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117558Singapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore

Cytochrome P4502J2(CYP2J2)metabolizes arachidonic acid(AA)to cardioprotective epoxyeicosatrienoic acids(EETs).Dronedarone,an antiarrhythmic drug prescribed for treatment of atrial fibrillation(AF)induces cardiac adverse effects(AEs)with poorly understood *** previously demonstrated that dronedarone inactivates CYP2J2 potently and irreversibly,disrupts AA-EET pathway leading to cardiac mitochondrial toxicity rescuable via EET *** this study,we investigated if mitigation of CYP2J2 inhibition prevents dronedarone-induced cardiac *** first synthesized a deuterated analogue of dronedarone(termed poyendarone)and demonstrated that it neither inactivates CYP2J2,disrupts AA-EETs metabolism nor causes cardiac mitochondrial toxicity in *** patch-clamp experiments demonstrated that pharmacoelectrophysiology of dronedarone is unaffected by ***,we show that dronedarone treatment or CYP2J2 knockdown in spontaneously beating cardiomyocytes indicative of depleted CYP2J2 activity exacerbates beat-to-beat(bTb)variability reflective of proarrhythmic *** contrast,poyendarone treatment yields significantly lower bTb variability compared to dronedarone in cardiomyocytes indicative of preserved CYP2J2 ***,poyendarone and dronedarone display similar antiarrhythmic properties in the canine model of persistent AF,while poyendarone substantially reduces beat-to-beat variability of repolarization duration suggestive of diminished proarrhythmic *** findings prove that deuteration of dronedarone prevents CYP2J2 inactivation and mitigates dronedarone-induced cardiac AEs.

关键词： Arachidonic acid Atrial fibrillation CYP2J2 Drug-induced proarrhythmia Epoxyeicosatrienoic acids Mechanism-based inactivation Dronedarone

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

英国简史

2016年

作者： (英)杰里米·布莱克(jeremy black)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

钟冠报春苣苔(苦苣苔科)的分类鉴定

广西植物 2020年第10期40卷 1393-1401页

作者：洪欣 KEENE jeremy 单皖粤 DO Van Truong 温放安徽大学资源与环境工程学院中国合肥230601 广西喀斯特植物保育与恢复生态学重点实验室广西壮族自治区中国科学院广西植物研究所中国广西桂林541000 格伦威尔州立大学美国西弗吉尼亚州格伦威尔市越南国家自然博物馆越南科学技术研究院越南河内10072 中国科学院华南植物园植物资源保护与可持续利用重点实验室中国广州510650 中国科学院桂林植物园中国苦苣苔植物保育中心中国广西桂林541006

原唇柱苣苔属(Chirita buch.-Ham. ex D. Don)为一个人为界定的属,2011年在分子系统学研究的基础上对该属及其近缘属开展了系统发育重建工作,其中绝大部分的原唇柱苣苔属唇柱苣苔组(*** C. b. Clark)的物种被并入了广义报春苣苔属(Primu... 详细信息

原唇柱苣苔属(Chirita buch.-Ham. ex D. Don)为一个人为界定的属,2011年在分子系统学研究的基础上对该属及其近缘属开展了系统发育重建工作,其中绝大部分的原唇柱苣苔属唇柱苣苔组(*** C. b. Clark)的物种被并入了广义报春苣苔属(Primulina Hance)。然而,由于历史原因和早期经典分类学在研究方法上的局限性以及对现报春苣苔属部分物种的营养器官与生殖器官的认知不够,该属下一些物种的分类仍存在一些问题,亟待深入研究。比如,在对中国和越南分布的苦苣苔科植物开展研究的过程中,作者发现两个报春苣苔属的物种——广布于中国西南和华南直至中南半岛中部的钟冠报春苣苔[Primulina swinglei (Merr.) Mich. MÖller&A. Weber]命名人和原被认为是中国与广西特有种的疏花报春苣苔[P. laxiflora(W. T. Wang) Yin. Z. Wang]之间的鉴定存在分类学问题,需要进一步厘清两者之间的关系。该文对这两个物种进行了形态比较,同时通过对这两种植物的原始描述对比、植物标本检查、栽培观察以及野外实地观察,确定疏花报春苣苔是钟冠报春苣苔的异名。此外,还明确了钟冠报春苣苔的后选指定模式标本。

关键词：唇柱苣苔属后选模式指定新异名疏花报春苣苔分类学

维普期刊数据库

Fundamentals of corporate finance 3rd ed. 3rd ed.

在线全文

学校读者我要写书评

暂无评论