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绵羊妊娠期暴露于双酚A和双酚s会导致胎儿骨骼肌肥大

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绵羊妊娠期暴露于双酚A和双酚S会导致胎儿骨骼肌肥大

富s-Cl岩浆对斑岩铜矿成矿的约束:以加拿大Red Chris斑岩Cu-Au矿床为例

中国毒理学会第九次全国毒理学大会

作者：景炅婕蒲勇 jeremy Gingrich Almudena Veiga-Lopez 山西农业大学动物科技学院 Department of Animal science Michigan State University Department of Pharmacology and Toxicology Michigan State University

目的妊娠期暴露于内分泌干扰物双酚A(BPA)可导致后代产生胰岛素抵抗。虽然骨骼肌是维持体内胰岛素平衡的一个重要能量代谢组织,但是,妊娠期暴露于双酚A或其类似物双酚s(BPs)是否会损害骨骼肌的发育尚不清楚。本研究假设妊娠期暴露于双... 详细信息

目的妊娠期暴露于内分泌干扰物双酚A(BPA)可导致后代产生胰岛素抵抗。虽然骨骼肌是维持体内胰岛素平衡的一个重要能量代谢组织,但是,妊娠期暴露于双酚A或其类似物双酚s(BPs)是否会损害骨骼肌的发育尚不清楚。本研究假设妊娠期暴露于双酚类化合物会影响胎儿肌肉发育,导致胰岛素抵抗。材料和方法怀孕绵羊(n=7-8/组)从妊娠日30至100天,分别皮下注射玉米油,BPA或BPs,剂量为0.5 mg·kg/天。在妊娠日120天,采集胎儿腿部骨骼肌组织,使用苏木精-伊红染色法对组织切片进行染色,检测肌纤维大小变化。使用荧光定量PCR检测肌纤维类型和炎症相关基因表达。使用Western blotting检测肌纤维类型相关蛋白表达。此外,分离纯化绵羊原代骨骼肌细胞,检测对其增殖和分化的影响。结果与对照组相比,BPA和BPs处理组胎儿(公胎羊和母胎羊)肌纤维横截面显著增加。肌纤维类型相关基因表达的研究显示,BPA组的母胎羊MYH1(IIX型快速糖酵解纤维)表达量显著增加,而BPs组的MYH2和MYH7(IIA型快速氧化/糖酵解和Ⅰ型缓慢氧化纤维)的表达量更高;同时,肌肉发育调节因子(Myf5、Myog、MyoD和MRF4)的m RNA表达量也增加,这些变化在公胎羊中均没有观察到差异。体外对骨骼肌细胞研究显示,妊娠期BPA或BPs暴露后,胎儿(公胎羊和母胎羊)肌细胞增殖没有改变,但分化后的肌管面积和直径增加。另外,在所有处理组中,母胎羊的肌纤维横截面和分化后的肌管都比公胎羊大。结论妊娠期暴露于BPA或BPs会导致胎儿骨骼肌纤维肥大,并能以性别特异性方式改变纤维类型分布。

关键词：双酚A 双酚s 绵羊骨骼肌骨骼肌肥大

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富S-Cl岩浆对斑岩铜矿成矿的约束:以加拿大Red Chris斑岩Cu-Au矿...

中国矿物岩石地球化学学会第17届学术年会

作者：朱经经 jeremy Richards 胡瑞忠毕献武中国科学院地球化学研究所矿床地球化学国家重点实验室 Laurentian University

大量的研究表明,高氧逸度(ΔFMQ=1～2)、富水(>4wt.%)、富硫(>1000×10)的岩浆对斑岩铜矿成矿十分关键,上述任一条件的缺失均可阻碍矿床的形成。此外,与长期演化(可达10Ma)的斑岩复式侵入体相比,Cu-Au成矿时限相对短得多(数万年),且成...

大量的研究表明,高氧逸度(ΔFMQ=1～2)、富水(>4wt.%)、富硫(>1000×10)的岩浆对斑岩铜矿成矿十分关键,上述任一条件的缺失均可阻碍矿床的形成。此外,与长期演化(可达10Ma)的斑岩复式侵入体相比,Cu-Au成矿时限相对短得多(数万年),且成矿往往与较晚阶段的斑岩体相关(Richards,2003)。然而,目前其成因尚不明确。加拿大Red Chris斑岩Cu-Au矿床位于stikinia岛弧北部,为太平洋板块于晚三叠世东

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木质素功能化在新材料生产中的应用

腐植酸 2023年第4期 27-35页

作者： stefania Bertella jeremy s.Luterbacher 钱孙逸豪(译) 覃羽彤(译) 亢淑含(译) 孟爽(译) 王靖瀚(译) 赵嘉琳(译) 乔英云(译) 瑞士洛桑联邦理工学院化学科学与工程研究所可持续与催化加工实验室洛桑10152 中国石油大学(华东)重质油国家重点实验室青岛266580

木质素是木质纤维生物质的主要组分,是生成腐植酸的主要物质,也是芳香族分子最大的天然来源,因此是一种有吸引力的可再生化工生产原料。将分离的木质素直接掺入材料中,因其想法的简单性和方案潜在的高原子经济性,长期以来一直被研究。然... 详细信息

木质素是木质纤维生物质的主要组分,是生成腐植酸的主要物质,也是芳香族分子最大的天然来源,因此是一种有吸引力的可再生化工生产原料。将分离的木质素直接掺入材料中,因其想法的简单性和方案潜在的高原子经济性,长期以来一直被研究。然而,由于其高化学反应性,木质素在不经过控制的缩合和再聚合的情况下很难分离出来,这极大地阻碍了它与聚合物和其他材料的结合。因此,可控化学改性已经或正在开发中,以提高木质素与现有材料的相容性。本文综述了木质素提取和功能化的最新进展及其在提高木质素基材料生产方面的潜力。

关键词：木质素化学改性功能化材料聚合物绿色化学

The LEAFY floral regulator displays pioneer transcription factor properties

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Molecular Plant 2021年第5期14卷 829-837页

作者： Xuelei Lai Romain Blanc-Mathieu Loïc GrandVuillemin Ying Huang Arnaud stigliani jeremy Lucas Emmanuel Thevenon Jeanne Loue-Manifel Laura Turchi Hussein Daher Eugenia Brun-Hernandez Gilles Vachon David Latrasse Moussa Benhamed Renaud Dumas Chloe Zubieta François Parcy Laboratoire Physiologie Cellulaire et Vegetale Universite Grenoble AlpesCNRSCEAINRAEIRIG-DBSCI-LPCV17 avenue des martyrs38054GrenobleFrance Universite Paris-saclay CNRSINRAEUniversite d'EvryInstitute of Plant Sciences Paris-Saclay(IPS2)91405OrsayFrance The Bioinformatics Centre Department of Biology and Biotech and Research Innovation CentreUniversity of CopenhagenOle Maalces Vej 5DK2200 Copenhagen NDenmark Laboratoire Reproduction et Developpement des Plantes Universite de LyonENS de LyonUCB Lyon 1CNRSINRA69342 LyonFrance Institut de Biologie structurale Universite Grenoble AlpesCEACNRSGrenobleFrance Universite de Paris Institute of Plant Sciences Paris-Saclay(IPS2)75006 ParisFrance

Pioneer transcription factors(TFs)are a special category of TFs with the capacity to bind to closed chromatin regions in which DNA is wrapped around histones and may be highly ***,pioneer TFs are able to modify the chromatin state to initiate gene *** plants,LEAFY(LFY)is a master floral regulator and has been suggested to act as a pioneer TF in ***,we demonstrate that LFY is able to bind both methylated and non-methylated DNA using a combination of in vitro genomewide binding experiments and structural *** between regions bound by LFY in vivo and chromatin accessibility data suggest that a subset of LFY bound regions is occupied by *** confirm that LFY is able to bind nucleosomal DNA in vitro using reconstituted ***,we show that constitutive LFY expression in seedling tissues is sufficient to induce chromatin accessibility in the LFY direct target genes APETALA1 and *** together,our study suggests that LFY possesses key pioneer TF features that contribute to launching the floral gene expression program.

关键词： flower development pioneer transcription factor gene regulation chromatin remodeling

CEO的“明日鸿沟”企业和社会——威胁CEO的社会问题

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中国企业家 2008年第3期44卷 137-140页

作者： sheila Bonini Jieh Greeney Lenny Mendonca jeremy Oppenheim 汤潇洵（翻译）

一个警告：CEO如果无视社会政治热点问题，将可能把企业置于险境。这并非危言耸听，在麦肯锡最近的一次全球商业社会调查中，一些社会热点问题成为CEO们探讨的热点，他们甚至认为，这些社会问题将影响到股东价值。看看一组数据：84％认... 详细信息

一个警告：CEO如果无视社会政治热点问题，将可能把企业置于险境。这并非危言耸听，在麦肯锡最近的一次全球商业社会调查中，一些社会热点问题成为CEO们探讨的热点，他们甚至认为，这些社会问题将影响到股东价值。看看一组数据：84％认为公司给投资人的高回报应与为公众利益做贡献并行不悖；只有16％的受访者认为公司只应关注投资人的利益。

关键词：社会问题 CEO 企业社会热点问题公众利益社会政治

Precision grounding augments the therapeutic benefits of simultaneous topical essential oil application

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TMR Non-Drug Therapy 2023年第3期6卷 11-15页

作者： Madiha Khalid jeremy Madvin Department of Pharmacy sciences Humdard UniversityIslamabad CampusIslamabad 44000Pakistan Department of International Business The University of RedlandsCalifornia 91361United States

Grounding or earthing involves making physical contact with the Earth's surface by walking barefoot on natural surfaces or using grounding devices that simulate direct contact with the *** Grounding is believed to balance the electrical charge in the human body and has potential physical and psychological benefits,including reduced inflammation,improved sleep quality,and decreased anxiety and depression *** earthing therapy with essential oils is gaining popularity as a natural and effective therapeutic *** oils contain antioxidants and anti-inflammatory chemicals that complement the benefits of earthing *** study aims to highlight a novel method for reducing inflammation by combining essential oils with precision grounding and to emphasize the significance of the duration and intensity of grounding on inflammation and *** findings indicate that essential oils combined with precision grounding can reduce pain and alter the levels of neutrophils,lymphocytes,and inflammation-related chemicals in *** review underscores the potential of earthing with essential oils as a simple and widely available clinical intervention with potentially significant therapeutic *** Grounding therapy is safe and theoretically beneficial for most people,but medical advice should be sought before beginning any new wellness practice.

关键词： aromatherapy CAM earthing essential oils grounding inflammation pain

Highly Efficient and Linear Class E siGe Power Amplifier Design

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Highly Efficient and Linear Class E SiGe Power Amplifier Des...

Physiological benefits of ambient far infrared energy within the 4-24 micron range

2006 8th International Conference on solid-state and Integrated Circuit Technology

作者： Donald Y.C.Lie jeremy D.Popp Jason F.Rowland Annie H.Yang Feipeng Wang Don Kimball Dynamic Research Corporation(DRC) San DiegoCA sPAWAR system Center San DiegoCA Department of Electrical and Computer Engineering University of CaliforniaSan Diego(UCSD)La JollaCA

ISBN: (纸本)1424401607

＜正＞This paper discusses the design of monolithic RF broadband Class E siGe power amplifiers（PAs） that are highly efficient and ***-pull measurement data on IBM 7HP siGe power devices have been made at 900MHz and 2.4GHz and monolithic class E PAs have been designed using these devices to achieve highest power-added-efficiency（PAE） at these *** is found that high PAE can be achieved for monolithic single-stage Class E PAs designed using high-breakdown siGe transistors at～65%（900MHz） and～40%（2.4GHz）, respectively,which are roughly～10%lower than the device’s maximum PAE values obtained by load-pull tests under optimal off-chip matching *** have also demonstrated that monolithic siGe class E PAs can be successfully linearized using an open-loop envelope tracking（ET） technique as their output spectra pass the stringent EDGE transmit mask with margins, achieving overall PAE of 44.4%for the linearized PA system that surpasses the ＜30%PAE with commercially available GaAs Class AB PAs for EDGE applications. These promising results indicate the feasibility of realizing true single-chip wireless transceivers with on-chip RF siGe PAs for spectrally-efficient non-constant-envelope modulation schemes.

关键词： silicon germanium protactinium load-pull MONOLITHIC Power amplifiers PUBLIC ADDREss sYsTEM telecommunication standards cellular radio

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TMR Non-Drug Therapy 2022年第3期5卷 29-34页

作者： jeremy Madvin Madiha Khalid MBA International Business The University of RedlandsCaliforniaUnited States Ph.D Pharmacy sciences Humdard UniversityIslamabad CampusIslamabadPakistan

Far infrared(FIR)radiation(3-100µm)is an electromagnetic spectrum commonly studied for biological *** article aims to discuss using Far infrared radiation with sub-division(4-24µm)of this waveband to stimulate tissues and cells and is considered an effective therapeutic modality for specific medical *** IR application as a medical therapy has advanced rapidly in recent *** example,IR therapy like IR-emitting apparel and materials that can be run solely by body heat(does not need an external power supply)have been *** methods for providing FIR radiation to the human body have emerged due to technological *** saunas and lamps that emit pure FIR radiation have become effective,safe,and widely used therapeutic *** infused with thermide,FIR emitting ceramic nanomaterials and knitted into fabrics are used as clothes and apparel to produce FIR radiation and benefit from its effects.A deeper understanding of FIR's significant innovations and biological implications could aid in improving therapeutic efficacy or developing new methods that use FIR wavelengths.

关键词： far-infrared radiation FIR emitting ceramics and fibers infrared sauna radiant heat far infrared for health far infrared for wellness

Design and Characterization of an Aerosol Test Chamber for Emergency Response Patient Contamination Control simulation and Research

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Occupational Diseases and Environmental Medicine 2023年第1期11卷 78-96页

作者： Megan L. steele Emily M. spatz George P. Lemmer Jacob M. Denney jeremy M. slagley Casey W. Cooper Robert M. Eninger Fenic Ltd. Dayton USA Department of systems Engineering and Management Air Force Institute of Technology Wright-Patterson Air Force Base Montgomery County USA Air Force Materiel Command Office of the Command Surgeon Wright-Patterson Air Force Base Montgomery County USA

Contaminated or infected patients present a risk of cross-contamination for emergency responders, attending medical personnel and medical facilities as they enter a treatment facility. The controlled conditions of an aerosol test chamber are required to examine factors of contamination, decontamination, and cross-contamination. This study presents the design, construction, and a method for characterizing an aerosol test chamber for a full-sized manikin on a standard North Atlantic Treaty Organization litter. The methodology combined air velocity measurements, aerosol particle counts and size distributions, and computational fluid dynamics modeling to describe the chamber’s performance in three dimensions. This detailed characterization facilitates future experimental design by predicting chamber performance for a variety of patient-focused research.

关键词： Test Chamber Characterization Aerosol Generation Exposure Chamber Design Air Velocity Mapping spatial Variability CFD Modeling Patient Decontamination