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open Journal of ophthalmology 2013年第3期3卷 73-75页

作者： Tuan A. Tran jeremy o’connor Xavier Fagan Tu Tran Dan Nguyen Department of Glaucoma Victorian Eye and Ear Hospital Melbourne Australia Department of Medical ophthalmology Victorian Eye and Ear Hospital Melbourne Australia. Department of Politecnico ophthalmology Sydney Eye Hospital Sydney Australia

Necrotizing scleritis is the most severe form of scleritis with a significant threat to vision and globe integrity. It can be infectious, surgically induced necrotizing scleritis (SINS) or systemic autoimmune associated. We report a case of necrotizing scleritis associated with 5-fluorouracil (5-FU) at the site of sub tenon’s block in a patient with previous trabeculectomy. To our knowledge, this is the first reported case of necrotizing scleritis associated with 5-FU. This may implicate alternative approaches to local anaesthetic techniques when using adjunctive 5-FU.

关键词： Necrotizing Scleritis 5-Fluorouracil Sub-Tenon’s Block Glaucoma

Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o’Dowd Antoinette o’connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

The electrochemical detection of bioterrorism agents: a review of the detection, diagnostics, and implementation of sensors in biosafety programs for Class A bioweapons

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Microsystems & Nanoengineering 2021年第1期7卷 21-39页

作者： connor o’Brien Kathleen Varty Anna Ignaszak Department of Chemistry University of New Brunswick30 Dineen DriveFrederictonNB E3B 5A3Canada

During the past year,disease has shown us the iron grip it can hold over a population of *** systems can be overwhelmed,economies can be brought into recession,and many people can be harmed or *** weaponized,diseases can be manipulated to create a detriment to health while becoming an economic burden on any *** is consequently prudent that easy detection of bioweapons is available to governments for protecting their *** sensing displays many distinct advantages,such as its low limit of detection,low cost to run,rapid generation of results,and in many instances *** therefore present a wide array of electrochemical sensing platforms currently being fabricated,a brief summary of Class A bioweapons,and the potential future of bioweapon detection and biosafety.

关键词： electrochemical instance programs

Integrative multi-omics and systems bioinformatics in translational neuroscience:A data mining perspective

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Journal of Pharmaceutical Analysis 2023年第8期13卷 836-850页

作者： Lance M.o'connor Blake A.o'connor Su Bin Lim Jialiu Zeng Chih Hung Lo College of Biological Sciences University of MinnesotaMinneapolisMN55455USA School of Pharmacy University of WisconsinMadisonWI53705USA Department of Biochemistry and Molecular Biology Ajou University School of MedicineSuwon16499South Korea Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore308232Singapore

Bioinformatic analysis of large and complex omics datasets has become increasingly useful in modern day biology by providing a great depth of information,with its application to neuroscience termed *** mining of omics datasets has enabled the generation of new hypotheses based on differentially regulated biological molecules associated with disease mechanisms,which can be tested experimentally for improved diagnostic and therapeutic targeting of neurodegenerative ***,integrating multi-omics data using a systems bioinformatics approach will advance the understanding of the layered and interactive network of biological regulation that exchanges systemic knowledge to facilitate the development of a comprehensive human brain *** this review,we first summarize data mining studies utilizing datasets from the individual type of omics analysis,including epigenetics/epigenomics,transcriptomics,proteomics,metabolomics,lipidomics,and spatial omics,pertaining to Alzheimer's disease,Parkinson's disease,and multiple *** then discuss multi-omics integration approaches,including independent biological integration and unsupervised integration methods,for more intuitive and informative interpretation of the biological data obtained across different omics *** further assess studies that integrate multi-omics in data mining which provide convoluted biological insights and offer proof-of-concept proposition towards systems bioinformatics in the reconstruction of brain ***,we recommend a combination of high dimensional bioinformatics analysis with experimental validation to achieve translational neuroscience applications including biomarker discovery,therapeutic development,and elucidation of disease *** conclude by providing future perspectives and opportunities in applying integrative multi-omics and systems bioinformatics to achieve precision phenotyping of neurodegenerative diseases and towards personaliz

关键词： Multi-omics integration Systems bioinformatics Data mining Human brain profile reconstruction Translational neuroscience

Role of radiation therapy in gastric adenocarcinoma

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World Journal of Gastroenterology 2006年第10期12卷 1511-1520页

作者： Lisa Hazard John o'connor Courtney Scaife Departments of Radiation oncology University of Utah School of Medicine Salt Lake CityUTUnited States Department of Radiation oncology Tulane University New OrleansLAUnited States Departments of Surgery University of Utah School of Medicine Salt Lake CityUTUnited States

outcomes in patients with gastric cancer in the United States remain disappointing, with a five-year overall survival rate of approximately 23%. Given high rates of local-regional control following surgery, a strong rationale exists for the use of adjuvant radiation therapy. Randomized trials have shown superior local control with adjuvant radiotherapy and improved overall survival with adjuvant chemoradiation. The benefit of adjuvant chemoradiation in patients who have undergone D2 lymph node dissection by an experienced surgeon is not known, and the benefit of adjuvant radiation therapy in addition to adjuvant chemotherapy continues to be defined. In unresectable disease, chemoradiation allows long-term survival in a small number of patients and provides effective palliation. Most trials show a benefit to combined modality therapy compared to chemotherapy or radiation therapy alone. The use of pre-operative, intra-operative, 3D conformal, and intensity modulated radiation therapy in gastric cancer is promising but requires further study. The current article reviews the role of radiation therapy in the treatment of resectable and unresectable gastric carcinoma, focusing on current recommendations in the United States.

关键词： Radiation therapy Gastric cancer Stomach cancer Chemoradiation Adjuvant therapy Neoadjuvant therapy Intra-operative radiation therapy 3D conformal radiation therapy Intensity modulated radiation therapy

Fabrication and in vivo 2-photon microscopy validation of transparent PEDoT:PSS microelectrode arrays

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Microsystems & Nanoengineering 2022年第4期8卷 183-190页

作者： Gerwin Dijk Attila Kaszas Jolien Pas Rodney Philip o’connor Mines Saint-Etienne Centre CMPDepartment of BioelectronicsGardanne 13541France Panaxium SAS Aix-en-Provence 13100France

Transparent microelectrode arrays enable simultaneous electrical recording and optical imaging of neuronal networks in the *** made of the conducting polymer poly(3,4-ethylenedioxythiophene)doped with polystyrene sulfonate(PEDoT:PSS)are transparent;however,device fabrication necessitates specific processes to avoid deterioration of the organic ***,we present an innovative fabrication scheme for a neural probe that consists of transparent PEDoT:PSS electrodes and demonstrate its compatibility with 2-photon *** electrodes show suitable impedance to record local field potentials from the cortex of mice and sufficient transparency to visualize GCaMP6f-expressing neurons underneath the PEDoT:PSS *** results validate the performance of the neural probe,which paves the way to study the complex dynamics of in vivo neuronal activity with both a high spatial and temporal resolution to better understand the brain.

关键词： material. transparent microelectrode

Numerical investigation into water entry problems of a flat plate with air pockets

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Journal of ocean Engineering and Science 2023年第4期8卷 386-400页

作者： Casey o’connor Saeed Mohajernasab Nagi Abdussamie National Centre for Maritime Engineering and Hydrodynamics Australian Maritime CollegeUniversity of TasmaniaLauncestonTasmaniaAustralia

Computational Fluid Dynamics(CFD)investigations into water entry problems of a rigid flat plate with air pockets were systematically *** Volume of Fluid(VoF)model was utilised to capture localised slamming phenomena that occur during,and post-impact *** model’s geometry was modified to include a pocket on the slamming impact surface to investigate the effect of air entrapment on the magnitude and distribution of slamming forces and pressures.A parametric study was conducted on the geometric parameters of the modelled pocket by altering its area,depth,and volume to exam-ine the response of slamming force and pressure loading under several impact *** numerical results of slamming forces and pressures were in good agreement with experimental drop test measure-ments(with relative error of-6%and 7%for the magnitude of slamming force and pressure,respectively).The numerical results proved that the peak pressure is proportional to the magnitude of impact velocity squared(p maxαv^(2)).

关键词： Marine structures Slamming Air entrapment Computationalﬂuid dynamics Drop tests

Consciousness, Free Will, and the Sciences of the Mind

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Frontiers of Philosophy in China 2018年第3期13卷 394-401页

作者： Timothy o'connor Department of Philosophy Indiana University Bloomington IN 47405 USA

In his review of the trio of philosopher-scientist dialogues on the nature and capacities of the human mind, Paul Thagard （2018） advocates clearly and forcefully for a fairly extreme position, which he advances as preferable to an equally extreme alternative. I will suggest a middle path that becomes attractive when one attends not just to the range of data now pouring forth from the sciences of mind but also to our own experience as minded individuals.

关键词： consciousness free will emergence qualia dualism cognitivescience first-person perspective

The role of peroxisome proliferator-activated receptor gamma in prostate cancer

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Asian Journal of Andrology 2018年第3期20卷 238-243页

作者： Catherine Elix Sumanta K Pal jeremy o Jones Department of Medical oncology City of Hope National Medical Center Duarte CA91010 USA.

Despite great progress in the detection and treatment of prostate cancer, this disease remains an incredible health and economic burden. Although androgen receptor （AR） signaling plays a key role in the development and progression of prostate cancer, aberrations in other molecular pathways also contribute to the disease, making it essential to identify and develop drugs against novel targets, both for the prevention and treatment of prostate cancer. one promising target is the peroxisome proliferator-activated receptor gamma （PPARy） protein. PPARy was originally thought to act as a tumor suppressor in prostate cells because agonist ligands inhibited the growth of prostate cancer cells; however, additional studies found that PPARy agonists inhibit cell growth independent of PPARy. Furthermore, PPARy expression increases with cancer grade/stage, which would suggest that it is not a tumor suppressor but instead that PPARy activity may play a role in prostate cancer development and/or progression. Indeed, two new studies, taking vastly different, unbiased approaches, have identified PPARy as a target in prostate cancer and suggest that PPARy inhibition might be useful in prostate cancer prevention and treatment. These findings could lead to a new therapeutic weapon in the fight against prostate cancer.

关键词： androgen receptor PPAR gamma prevention prostate cancer warfarin

Brain-derived neurotrophic factor and inflammation in depression:Pathogenic partners in crime?

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World Journal of Psychiatry 2022年第1期12卷 77-97页

作者： Grace A Porter Jason C o’connor Department of Pharmacology UT Health San AntonioSan AntonioTX 78229United States Department of Pharmacology University of Texas Health San AntonioSan AntonioTX 78229United States Audie L.Murphy VA Hospital South Texas Veterans Health SystemSan AntonioTX 78229United States

Major depressive disorder is a debilitating disorder affecting millions of people each ***-derived neurotrophic factor(BDNF)and inflammation are two prominent biologic risk factors in the pathogenesis of depression that have received considerable *** clinical and animal studies have highlighted associations between low levels of BDNF or high levels of inflammatory markers and the development of behavioral symptoms of ***,less is known about potential interaction between BDNF and inflammation,particularly within the central nervous *** evidence suggests that there is bidirectional regulation between these factors with important implications for the development of depressive symptoms and antidepressant *** levels of inflammatory mediators have been shown to reduce expression of BDNF,and BDNF may play an important negative regulatory role on inflammation within the *** this interaction more fully within the context of neuropsychiatric disease is important for both developing a fuller understanding of biological pathogenesis of depression and for identifying novel therapeutic *** we review these two prominent risk factors for depression with a particular focus on pathogenic implications of their interaction.

关键词： Brain-derived neurotrophic factor Microglia Neuroinflammation Growth factors Depression