检索结果-南通市图书馆

Role of microbubble ultrasound contrast agents in the non-invasive assessment of chronic hepatitis C-related liver disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第22期12卷 3461-3465页

作者： Scott Grier Adrian KP Lim Nayna Patel jeremy fl cobbold Howard C Thomas Isobel J Cox Simon D Taylor-Robinson Liver Unit St Mary's Hospital Campus Faculty of MedicineImperial College LondonLondonUnited Kingdom Department of Imaging Sciences Hammersmith Hospital Campus Faculty of MedicineImperial College LondonLondonUnited Kingdom

长期地感染丙肝病毒的病人经常得长期的肝疾病，对肝损伤的严厉的评价在认为病毒的根除是治疗以前被要求。这篇文章检验从标准答案肝活体检视当前可得到的各种各样的评价方法到血清学的标记和成像。超声是在临床的实践的最广泛地使用的... 详细信息

长期地感染丙肝病毒的病人经常得长期的肝疾病，对肝损伤的严厉的评价在认为病毒的根除是治疗以前被要求。这篇文章检验从标准答案肝活体检视当前可得到的各种各样的评价方法到血清学的标记和成像。超声是在临床的实践的最广泛地使用的成像形式之一并且已经是为肝疾病的一个首要的诊断工具。Microbubble 超声对比代理人允许更高的分辨率要获得的图象和对要执行的微脉管的变化的功能的评价。在确定的这些代理人的角色肝的损害的状态作为与丙肝在病人决定肝疾病的阶段和等级的一个可行方法被讨论。尽管当前限制了到专家中心，提高对比的超声将不可避免地在临床的背景增加的微水泡的可获得性。

关键词：微泡超声检查丙型病毒肝炎病理机制临床

Use of second generation contrast-enhanced ultrasound in the assessment of focal liver lesions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第45期13卷 5963-5970页

作者： Stanislas HX Morin Adrian KP Lim eremy fl cobbold Simon D Taylor-Robinson Sciences Hammersmith Hospital Campus Faculty of Medicine Imperial College London London United Kingdom Liver Unit St Mary's Hospital Campus Faculty of Medicine Imperial College London London United Kingdom Liver Unit St Mary’s Hospital Campus Faculty of Medicine Imperial College London London United Kingdom

Ultrasound (US) is often the first imaging modality employed in patients with suspected focal liver lesions. The role of US in the characterisation of focal liver lesions has been transformed with the introduction of specific contrast media and the development of specialized imaging techniques. Ultrasound now can fully characterise the enhancement pattern of hepatic lesions, similar to that achieved with contrast enhanced multiphasic computed tomography (CT) and magnetic resonance imaging (MRI). US contrast agents are safe, well-tolerated and have very few contraindications. Furthermore, real-time evaluation of the vascularity of focal liver lesions has become possible with the use of the newer microbubble contrast agents. This article reviews the enhancement pattern of the most frequent liver lesions seen, using the second generation US contrast media. The common pitfalls for each type of lesion are discussed. The recent developments in US contrast media and specific imaging techniques have been a major advance and this technique, in view of the intrinsic advantages of US, will undoubtedly gain popularity in the years to come.

关键词：超声波检查肝损伤实验研究临床表现

Review and synthesis of the effects of climate change on amphibians

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2013年第2期8卷 145-161页

作者： Yiming LI jeremy M.COHEN Jason R.ROHR Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Department of Integrative Biology University of South FloridaTampaFLUSA

Considerable progress has been made in understanding the responses of amphibians to climate change,with successful research carried out on climate change-associated shifts in amphibian phenology,elevational distributions and amphibian-parasite *** review and synthesize the literature on this topic,emphasizing acutely lethal,sublethal,indirect and positive effects of climate change on amphibians,and major research *** instance,evidence is lacking on poleward shifts in amphibian distributions and on changes in body sizes and morphologies of amphibians in response to climate *** have limited information on amphibian thermal tolerances,thermal preferences,dehydration breaths,opportunity costs of water conserving behaviors and actual temperature and moisture ranges amphibians *** when much of this information is available,there remains little evidence that climate change is acutely lethal to *** suggests that if climate change is contributing to declines,it might be through effects that are not acutely lethal,indirect,or both,but evidence in support of this suggestion is *** fact,evidence that climate change is directly contributing to amphibian declines is weak,partly because researchers have not often ruled out alternative hypotheses,such as chytrid fungus or climate-fungus ***,we recommend that amphibian-climate research shift from primarily inductive,correlational approach as to studies that evaluate alternative hypotheses for *** additional rigor will require interdisciplinary collaborations,estimates of costs and benefits of climate change to amphibian fitness and populations,and the integration of correlative field studies,experiments on‘model’amphibian species,and mathematical and functional,physiological models.

关键词： amphibian decline Batrachochytrium dendrobatidis breeding date climate-linked epidemic hypothesis global warming

Structural and biomechanical characterizations of acellular porcine mitral valve scaffolds:anterior leaflets,posterior leaflets,and chordae tendineae

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineered Regeneration 2022年第4期3卷 374-386页

作者： Bo Wang Leslie N.Sierad jeremy J.Mercuri Agneta Simionescu Dan T.Simionescu Lakiesha N.Williams Ryan Vela Pietro Bajona Matthias Peltz Sharan Ramaswamy Yi Hong Jun Liao Department of Bioengineering University of Texas at ArlingtonArlingtonTX 76010United States Joint Department of Biomedical Engineering Medical College of Wisconsin and Marquette UniversityMilwaukeeWI 53226United States Department of Bioengineering Clemson UniversityClemsonSC 29634United States Department of Biomedical Engineering Florida International UniversityMiamiFL 33174United States Department of Biomedical Engineering University of FloridaGainesvilleFL 32611United States Department of Cardiovascular and Thoracic Surgery University of Texas Southwestern Medical CenterDallasTX 75390United States Allegheny Health Network-Drexel University College of Medicine PittsburghPA 15212United States

Mitral valve(MV)tissue engineering is still in its early stage,and one major challenge in MV tissue engineering is to identify appropriate scaffold *** the potential of acellular MV scaffolds being demonstrated recently,it is important to have a full understanding of the biomechanics of the native MV components and their acellular *** this study,we have successfully characterized the structural and mechanical properties of porcine MV components,including anterior leaflet(AL),posterior leaflet(PL),strut chordae,and basal chordae,before and after *** DNA assay showed more than 90%reduction in DNA content,and Griffonia simplicifolia(GS)lectin immunohistochemistry confirmed the complete lack of porcine𝛼-Gal antigen in the acellular MV *** the acellular AL and PL,the atrialis,spongiosa,and fibrosa trilayered structure,along with its ECM constitutes,i.e.,collagen fibers,elastin fibers,and portion of GAGs,were ***-theless,the ECM of both AL and PL experienced a certain degree of disruption,exhibiting a less dense,porous ECM *** overall anatomical morphology of the strut and basal chordae were also maintained af-ter decellularization,with longitudinal morphology experiencing minimum disruption,but the cross-sectional morphology exhibiting evenly-distributed porous *** the acellular AL and PL,the nonlinear anisotropic biaxial mechanical behavior was overall preserved;however,uniaxial tensile tests showed that the removal of cellular content and the disruption of structural ECM did result in small decreases in maximum tensile modulus,tissue extensibility,failure stress,and failure strain for both MV leaflets and chordae.

关键词： Mitral valve tissue engineering Heart valve biomechanics Valve leaflets Chordae tendineae Decellularization

Taking FAIR on the ChIN:The Chemistry Implementation Network

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Data Intelligence 2020年第1期2卷 131-138,310页

作者： Simon J.Coles jeremy G.Frey Egon L.Willighagen Stuart J.Chalk School of Chemistry Faculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK Department of Bioinformatics Maastricht UniversityMaastrichtLimburg 6200 MDThe Netherlands Department of Chemistry University of North FloridaJacksonvilleFL 32224-7699USA

The Chemistry Implementation Network(ChIN)is focused on supporting the FAIR Data needs of the research community regarding chemical related *** Implementation Network is a consortium drawn from a community,in this case the chemistry discipline,committed to defining and constructing standards,materials and software in the spirit of the FAIR data principles and under the structure of the GO FAIR ***,as a core science the ChIN has to reach beyond the chemistry community and support the use of chemical information in other *** will be facilitated through connections in the GO FAIR ecosystem of Implementation *** of the FAIR chemical concepts that need to be supported include molecular and materials structures,chemical reactions,nomenclature and other chemical terminology and *** ChIN aims to drive forward the application of the FAIR Data Principles relating to the full range of chemistry concepts that are key to the transparent and efficient communication of chemical *** the goal of FAIR chemistry data will require a culture change across the *** this is best addressed once a critical mass of tools and approaches has been developed.

关键词： Chemistry Chemical information Chemistry data Chemical data standards Infrastructure Nomenclature Molecular structure Materials structure Chemical reactions Education Community engagement Endorsement and governance

Deductions from the Quaternion Form of Maxwell’s Electromagnetic Equations

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Physics 2020年第9期11卷 1361-1371页

作者： jeremy Dunning-Davies Richard Lawrence Norman Departments of Mathematics and Physics (retd) University of Hull Kingston upon Hull England Institute for Basic Research Palm Harbor FL USA Thunder Energies Corporation Palm Harbor FL USA

It is often claimed that Maxwell’s electromagnetic equations were originally written in terms of quaternions. Once returned to that form and treated with left and right hand operators as in the mathematics of P. M. Jack, a new seventh scalar electromagnetic field component emerges with possible relations to clean energy extraction and gravitation. It is the purpose here to examine this approach afresh and see how it might link up with other fairly recent, but little known, work in the field. Again, as with the usual form of Maxwell’s equations, a new scalar wave equation is derived but, on this occasion, due to the presence of the scalar component of the quaternion, that equation exhibits a wave speed greater than the speed of light. Historical and present uses within military and humanitarian contexts are considered briefly.

关键词： Electromagnetic Field Quaternion Gravity Maxwell Energy Scalar Wave

A global review of the ecological significance of symbiotic associations between birds and fungi

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fungal Diversity 2019年第5期98卷 161-194页

作者： Todd F.Elliott Michelle A.Jusino James M.Trappe Heino Lepp Guy-Anthony Ballard jeremy J.Bruhl Karl Vernes Ecosystem Management School of Environmental and Rural ScienceUniversity of New EnglandArmidaleNSW 2351Australia Department of Plant Pathology University of FloridaGainesvilleFL 32611USA Department of Forest Ecosystems and Society Oregon State UniversityCorvallisOR 97331USA Forestry Sciences Laboratory Pacific Northwest Research StationU.S.Forest ServiceCorvallisOR 97331USA Honorary Scientific Associate Australian National Botanic GardensCanberraACTAustralia School of Environmental and Rural Sciences University of New EnglandArmidaleNSW 2351Australia Vertebrate Pest Research Unit Biosecurity NSWNSW Department of Primary IndustriesUniversity of New EnglandPO Box U86Armidale 2351NSWAustralia Botany School of Environmental and Rural ScienceUniversity of New EnglandArmidaleNSW 2351Australia

Symbiotic associations between mammals and fungi have been well documented and are widely regarded as vital to ecosystem functions around the *** between birds and fungi are also ecologically vital but have been far less thoroughly *** manuscript is the first to review a wide range of symbiotic associations between birds and *** compile the largest list to date of bird species reported to eat fungi(54 bird species in 27 families)and follow up with a discussion of these symbioses and suggestions for how future studies can determine the prevalence of associations between birds and *** review the importance of fungi for cavity-excavating birds and show that at least 30 bird species in three families form varying levels of associations with fungi for cavity *** also review the use of fungal rhizomorphs in nest construction and show that 176 bird species in 37 families use fungal material in their *** of these interactions have wide-reaching ecosystem implications,particularly in regard to fungal dispersal and biogeography,plant health,ecosystem function,bird nutrition/fitness and bird behaviour.

关键词： Mycorrhizae Fungal dispersal Ornithomycological associations Bird nutrition Mycophagy Rhizomorphs Cavity-nesting Tree hollows

Trampoline Troubles: Serious Traumatic Injuries in Children from a Trampoline Park, a Case Series

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Clinical Medicine 2019年第9期10卷 452-461页

作者： jeremy Smith Brendan Williams Tricia B. Swan College of Medicine University of Florida Gainesville FL USA Department of Orthopaedics The Children’s Hospital of Philadelphia Philadelphia PA USA

Background: Trampoline use is one of the most common causes of recreational injury in children. In recent years, trampoline parks have grown in popularity and may be altering the spectrum of the trampoline-related injuries that occur. These parks create increased opportunity for injuries that appear uniquely different from accident patterns seen with home trampoline use. Recent work has suggested this may result in injuries occurring in greater frequency and with increased severity that may result in a greater need of hospital admission and procedural management by subspecialty services. Case Series Presentation: This case series presents three such examples occurring after the opening of a trampoline park in our local community: 1) A displaced forearm fracture requiring closed reduction and orthopedic follow-up;2) An ankle fracture necessitating operative reduction and fixation;and 3) A facial injury with tooth avulsion prompting oral surgery consultation and endodontic follow-up. Conclusions: These cases demonstrate the complexity and severity of injury that can occur from trampoline park participation and should serve to increase awareness among health care providers of these risks to provide appropriate parental counseling and advocate for preventative measures.

关键词： Trampoline Injury Pediatrics Trampoline Parks Trauma Children

Targeting KRAS in pancreatic adenocarcinoma:Progress in demystifying the holy grail

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界临床肿瘤学杂志:英文版 2023年第8期14卷 285-296页

作者： Ahmed Elhariri Ahmed Alhaj Daniel Ahn Mohamad Bassam Sonbol Tanios Bekaii-Saab Christina Wu Michael Scott Rutenberg John Stauffer Jason Starr Umair Majeed jeremy Jones Mitesh Borad Hani Babiker Division of Hematology-Oncology Department of MedicineMayo Clinic FloridaMayo Clinic Cancer CenterJacksonvilleFL 32224United States Division of Hematology-Oncology Department of MedicineMayo Clinic ArizonaMayo Clinic Cancer CenterPhoenixAZ 85054United States Department of Radiation-Oncology Mayo Clinic FloridaMayo Clinic Cancer CenterJacksonvilleFL 32224United States Department of Surgical Oncology Hepatopancreatobiliary SurgeryMayo Clinic FloridaJacksonvilleFL 32224United States

Pancreatic cancer(PC)remains one of the most challenging diseases,with a very poor 5-year overall survival of around 11.5%.Kirsten rat sarcoma virus(KRAS)mutation is seen in 90%-95%of PC patients and plays an important role in cancer cell proliferation,differentiation,metabolism,and survival,making it an essential mutation for targeted *** extensive efforts in studying this oncogene,there has been little success in finding a drug to target this pathway,labelling it for decades as“undruggable”.In this article we summarize some of the efforts made to target the KRAS pathway in PC,discuss the challenges,and shed light on promising clinical trials.

关键词： Kirsten rat sarcoma virus Targeted therapy Pancreatic cancer Drug resistance Next generation sequencing Clustered regularly interspaced short palindromic repeats