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Two-color multiphoton in vivo imaging with a femtosecond diamond Raman laser

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Light(Science & Applications) 2017年第1期6卷 400-407页

作者： Evan P Perillo jeremy W Jarrett Yen-Liang Liu Ahmed Hassan daniel C Fernée John R Goldak Andrei Bonteanu david J Spence Hsin-Chih Yeh Andrew K dunn department of Biomedical Engineering The University of Texas at AustinTX 78712USA department of Physics The University of Texas at AustinTX 78712USA MQ Photonics Department of Physics and AstronomyMacquarie UniversitySydneyNSW 2109Australia

Two-color multiphoton microscopy through wavelength mixing of synchronized lasers has been shown to increase the spectral window of excitable fluorophores without the need for wavelength ***,most currently available dual output laser sources rely on the costly and complicated optical parametric generation *** this report,we detail a relatively simple and low cost diamond Raman laser pumped by a ytterbium fiber amplifier emitting at 1055 nm,which generates a first Stokes emission centered at 1240 nm with a pulse width of 100 *** two excitation wavelengths of 1055 and 1240 nm,along with the effective two-color excitation wavelength of 1140 nm,provide an almost complete coverage of fluorophores excitable within the range of 1000–1300 *** compared with 1055 nm excitation,two-color excitation at 1140 nm offers a 90%increase in signal for many far-red emitting fluorescent proteins(for example,tdKatushka2).We demonstrate multicolor imaging of tdKatushka2 and Hoechst 33342 via simultaneous two-color two-photon,and two-color three-photon microscopy in engineered 3d multicellular *** further discuss potential benefits and applications for two-color three-photon *** addition,we show that this laser system is capable of in vivo imaging in mouse cortex to nearly 1 mm in depth with two-color excitation.

关键词： microscopy nonlinear processes three-dimensional imaging ultrafast lasers

The LEAFY floral regulator displays pioneer transcription factor properties

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Molecular Plant 2021年第5期14卷 829-837页

作者： Xuelei Lai Romain Blanc-Mathieu Loïc GrandVuillemin Ying Huang Arnaud Stigliani jeremy Lucas Emmanuel Thevenon Jeanne Loue-Manifel Laura Turchi Hussein daher Eugenia Brun-Hernandez Gilles Vachon david Latrasse Moussa Benhamed Renaud dumas Chloe Zubieta François Parcy Laboratoire Physiologie Cellulaire et Vegetale Universite Grenoble AlpesCNRSCEAINRAEIRIG-DBSCI-LPCV17 avenue des martyrs38054GrenobleFrance Universite Paris-Saclay CNRSINRAEUniversite d'EvryInstitute of Plant Sciences Paris-Saclay(IPS2)91405OrsayFrance The Bioinformatics Centre Department of Biology and Biotech and Research Innovation CentreUniversity of CopenhagenOle Maalces Vej 5DK2200 Copenhagen NDenmark Laboratoire Reproduction et developpement des Plantes Universite de LyonENS de LyonUCB Lyon 1CNRSINRA69342 LyonFrance Institut de Biologie Structurale Universite Grenoble AlpesCEACNRSGrenobleFrance Universite de Paris Institute of Plant Sciences Paris-Saclay(IPS2)75006 ParisFrance

Pioneer transcription factors(TFs)are a special category of TFs with the capacity to bind to closed chromatin regions in which dNA is wrapped around histones and may be highly ***,pioneer TFs are able to modify the chromatin state to initiate gene *** plants,LEAFY(LFY)is a master floral regulator and has been suggested to act as a pioneer TF in ***,we demonstrate that LFY is able to bind both methylated and non-methylated dNA using a combination of in vitro genomewide binding experiments and structural *** between regions bound by LFY in vivo and chromatin accessibility data suggest that a subset of LFY bound regions is occupied by *** confirm that LFY is able to bind nucleosomal dNA in vitro using reconstituted ***,we show that constitutive LFY expression in seedling tissues is sufficient to induce chromatin accessibility in the LFY direct target genes APETALA1 and *** together,our study suggests that LFY possesses key pioneer TF features that contribute to launching the floral gene expression program.

关键词： flower development pioneer transcription factor gene regulation chromatin remodeling

Physiological benefits of ambient far infrared energy within the 4-24 micron range

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TMR Non-drug Therapy 2022年第3期5卷 29-34页

作者： jeremy Madvin Madiha Khalid MBA International Business The University of RedlandsCaliforniaUnited States Ph.d Pharmacy Sciences Humdard UniversityIslamabad CampusIslamabadPakistan

Far infrared(FIR)radiation(3-100µm)is an electromagnetic spectrum commonly studied for biological *** article aims to discuss using Far infrared radiation with sub-division(4-24µm)of this waveband to stimulate tissues and cells and is considered an effective therapeutic modality for specific medical *** IR application as a medical therapy has advanced rapidly in recent *** example,IR therapy like IR-emitting apparel and materials that can be run solely by body heat(does not need an external power supply)have been *** methods for providing FIR radiation to the human body have emerged due to technological *** saunas and lamps that emit pure FIR radiation have become effective,safe,and widely used therapeutic *** infused with thermide,FIR emitting ceramic nanomaterials and knitted into fabrics are used as clothes and apparel to produce FIR radiation and benefit from its effects.A deeper understanding of FIR's significant innovations and biological implications could aid in improving therapeutic efficacy or developing new methods that use FIR wavelengths.

关键词： far-infrared radiation FIR emitting ceramics and fibers infrared sauna radiant heat far infrared for health far infrared for wellness

适用于SWaP受限应用的小像元间距、高清晰度MWIR和SWIR/MWIR双波段成像传感器

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云光技术 2023年第2期55卷 75-82页

作者： Andrew d.Hood Edward K.Huang Kai Yang dustin Hibberd Vince Loung Mitchell Oleson Randall Lott Carson Pratt jeremy Thomas Michael Costolo Michael Macdougal 徐睿驹(译) Attollo Engineering 160 Camino RuizCamarilloCAUSA 93012 不详

无人机载和单兵的能力需求继续推动缩小尺寸、重量和功率(SWaP)和高灵敏度红外(IR)成像的应用,在以前,这些应用不切实际。现在,为了满足这些需求,Attollo工程公司开发了一款1280×1024、5mm像元间距的制冷中波红外(MWIR)传感器,在像元... 详细信息

无人机载和单兵的能力需求继续推动缩小尺寸、重量和功率(SWaP)和高灵敏度红外(IR)成像的应用,在以前,这些应用不切实际。现在,为了满足这些需求,Attollo工程公司开发了一款1280×1024、5mm像元间距的制冷中波红外(MWIR)传感器,在像元间距方面取得了突破,此外还开发了1280×1024、10mm像元的双波段传感器,在短波红外(SWIR)中具有更高的灵敏度,以利用SWIR现象,其中包括激光定位(laser see spot)功能。这两种传感器都提供MWIR传感功能,但也能够利用Attollo探测器设计的各个方面,实现不同程度的SWIR传感。这类制冷小像元、单波段和双波段红外传感器技术代表了传感器设计和开发的各个方面的进步,我们将讨论Attollo为实现这一能力所做的创新,包括基于III-V族化合物半导体的外延探测器设计、探测器阵列和焦平面阵列制造、低噪声设计、双波段CTIA/dI读出集成电路(ROIC)、真空杜瓦封装、电子和固件设计。在本文中,我们将介绍高清晰度小像元间距MWIR和双波段SWIR/MWIR成像技术在Attollo的现状,它涉及到上述传感器,包括设计和测量数据及成像。

关键词： SWIR MWIR 双波段 SLS 定位 IdCA ROIC ALPd

苏格兰猛禽监测计划:目标、前四年取得的成果以及未来发展计划

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AMBIO－人类环境杂志 2008年第6期37卷 442-446页

作者： Chris V. Wernham Brian Etheridge Mark Holling Gordon Riddle Helen T. Riley Patrick K.Stirling-Aird david Stroud des B.A.Thompson jeremy d.Wilson 静莹英国鸟类信托协会苏格兰鸟类学家俱乐部南斯爵斯克莱德猛禽研究小组苏格兰自然遗产保护协会苏格兰猛禽研究小组英国联合自然保护委员会苏格兰猛禽监测计划英国皇家保护鸟类学会研究部

苏格兰猛禽监测计划(SRMS)于2002年制定,包含7个合作机构。其动因是:1)英国政府所出版的《猛禽工作组报告》中提出了加强猛禽监测的建议;2)对应用资料的需求(比如选点所需的资料)越来越多;3)对某些物种现状的关注。苏格兰猛禽监测计划有... 详细信息

苏格兰猛禽监测计划(SRMS)于2002年制定,包含7个合作机构。其动因是:1)英国政府所出版的《猛禽工作组报告》中提出了加强猛禽监测的建议;2)对应用资料的需求(比如选点所需的资料)越来越多;3)对某些物种现状的关注。苏格兰猛禽监测计划有3个主要目标:1)促进各方之间的合作;2)通过分析猛禽数量、活动范围、存活率,繁育生产力的趋势并了解其变化原因,提供有关苏格兰猛禽种群的稳定而丰富的信息;3)在资料的收集、整理、审核、分析以及信息的报告方面保持高标准和统一标准。文中主要收集了19种猛禽的资料:14种昼行猛禽,4种鸮以及1种鸦科鸟类——渡鸦。本文将介绍监测计划的发展、面临的挑战、前4年所取得的成果、所收集资料的性质和价值以及未来的计划。

关键词：苏格兰猛禽监测收集资料统一标准英国政府活动范围工作组

In the name of the rose:a roadmap for rose research in the genome era

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Horticulture Research 2019年第1期6卷 948-964页

作者： Marinus J.M.Smulders Paul Arens Peter M.Bourke Thomas debener Marcus Linde Jan de Riek Leen Leus Tom Ruttink Sylvie Baudino Laurence Hibrant Saint-Oyant jeremy Clotault Fabrice Foucher Plant Breeding Wageningen University and ResearchP.O.Box 3866700 AJ WageningenThe Netherlands Faculty of Natural Sciences Institute for Plant GeneticsMolecular Plant BreedingLeibniz University of HannoverHerrenhäuser Strasse 230419 HannoverGermany ILVO Plant Sciences UnitFlanders Research Institute for AgricultureFisheries and FoodCaritasstraat 399090 MelleBelgium BVpam CNRS FRE 3727UJM-Saint-ÉtienneUniv.LyonSaint-EtienneFrance IRHS Agrocampus-OuestINRAUniversitéd’AngersSFR 4207 QuaSaV42 rue Georges Morel BP 6005749071 BeaucouzéFrance

The recent completion of the rose genome sequence is not the end of a process,but rather a starting point that opens up a whole set of new and exciting *** to a high-quality genome sequence other genomic tools have also become available for rose,including transcriptomics data,a high-density single-nucleotide polymorphism array and software to perform linkage and quantitative trait locus mapping in *** cultivars are highly heterogeneous and *** vast diversity in cultivated roses can be explained through the genetic potential of the genus,introgressions from wild species into commercial tetraploid germplasm and the inimitable efforts of historical *** can now investigate how this diversity can best be exploited and refined in future breeding work,given the rich molecular toolbox now available to the rose breeding *** paper presents possible lines of research now that rose has entered the genomics era,and attempts to partially answer the question that arises after the completion of any draft genome sequence:‘Now that we have“the”genome,what’s next?’.Having access to a genome sequence will allow both(fundamental)scientific and(applied)breeding-orientated questions to be *** outline possible approaches for a number of these questions.

关键词： breeding cultivar linkage

Wnt5a对大鼠牙囊细胞成骨向分化作用研究

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Wnt5a对大鼠牙囊细胞成骨向分化作用研究

Einstein Probe discovery of EP240408a:A peculiar X-ray transient with an intermediate timescale

2014年第九次全国牙体牙髓病学学术会议

作者：项露赛贺玲杜宇张新春周晨 Mao J jeremy 凌均棨中山大学光华口腔医学院·附属口腔医院广东省口腔医学重点实验室

目的:探讨Wnt5a在出生后牙囊组织中的表达及其对牙囊细胞的调控作用。方法:分离出生后1d到11d的大鼠下颌骨。免疫组化法观察Wnt5a在牙槽骨、牙周膜和发育中的成釉细胞层和成牙本质细胞层中的表达;分离培养出生后7d的大鼠第一磨牙牙囊细... 详细信息

目的:探讨Wnt5a在出生后牙囊组织中的表达及其对牙囊细胞的调控作用。方法:分离出生后1d到11d的大鼠下颌骨。免疫组化法观察Wnt5a在牙槽骨、牙周膜和发育中的成釉细胞层和成牙本质细胞层中的表达;分离培养出生后7d的大鼠第一磨牙牙囊细胞,采用慢病毒载体过表达Wnt5a,通过实时定量PCR,Western Blot和免疫荧光探讨其对增殖、成骨向分化和细胞迁移能力的影响。结果:Wnt5a在出生后1d到11d大鼠牙周组织中持续表达。出生后7d牙囊细胞在培养14天后未见明显矿化组织形成,在成骨诱导液处理下牙囊细胞表现出中等矿化能力,300-ng/ml的Wnt5a蛋白和成骨诱导液共同处理时,其矿化作用增强,但不显著。Wnt5a和100-ng/ml BMP2协同作用时显著提高Runx2,Col1a1,Ocn的表达,Alp的表达无明显增高。进一步研究发现Wnt5a蛋白作用7d时RANKL表达明显增高,表明Wnt5a可能通过调节破骨细胞向分化参与牙槽骨改建。Wnt5a过表达细胞P-JNK1/2信号增强,在SP600125(JNK抑制剂)作用下,Runx2、Col1a1和Ocn的表达减弱,表明Wnt5a通过JNK通路调节牙囊细胞骨分化作用。Wnt5a过表达后显著降低细胞增殖能力,同时促进迁移运动。结论:本研究阐明了Wnt5a对大鼠牙囊细胞的骨分化调节作用,为牙周病、牙齿萌出和牙槽骨改建提供研究基础。

关键词： Wnt5a 牙囊干细胞骨分化 JNK BMP2

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Science China(Physics,Mechanics & Astronomy) 2024年

作者： Wenda Zhang Weimin Yuan Zhixing Ling Yong Chen Nanda Rea Arne Rau Zhiming Cai Huaqing Cheng Francesco Coti Zelati Lixin dai Jingwei Hu Shumei Jia Chichuan Jin dongyue Li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng Wang Lei Yang Bing Zhang Chen Zhang Shuang-Nan Zhang Yonghe Zhang Jie An david Buckley Alexis Coleiro Bertrand Cordier Liming dou Rob Eyles-Ferris Zhou Fan Hua Feng Shaoyu Fu Johan P. U. Fynbo Lluis Galbany Saurabh W. Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong Li Bifang Liu Mingjun Liu Xing Liu Yuan Liu Zhu Liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra jeremy Sanders Roberto Soria Lian Tao Junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu Xuefeng Wu dong Xu Yanjun Xu Suijian Xue Yongquan Xue Zijian Zhang Zipei Zhu Hu Zou Congying Bao Fansheng Chen Houlei Chen Tianxiang Chen Wei Chen Yehai Chen Yifan Chen Chenzhou Cui Weiwei Cui Yanfeng dai dongwei Fan Ju Guan dawei Han dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge Jin Chengkui Li Junfei Li Longhui Li Maoshun Li Wei Li Zhengda Li Tianying Lian Congzhan Liu Heyang Liu Huaqiu Liu Fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan Liming Song Hui Sun Yunyin Tan Qingjun Tang Yihan Tao Hao Wang Juan Wang Lei Wang Wenxin Wang Yilong Wang Yusa Wang Qinyu Wu Haitao Xu Jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin Xue Yulong Xue Ailiang Yan Haonan Yang Xiongtao Yang Yanji Yang Juan Zhang Mo Zhang Wenjie Zhang Zhen Zhang Zhen Zhang Ziliang Zhang donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan Zhou Yilin Zhou Yuxuan Zhu Zhencai Zhu Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation Academy for Microsatellites Chinese Academy of Sciences department of Physics University of Hong Kong School of Physics and Astronomy University of Leicester School of Physics and Astronomy Sun Yat-sen University National Astronomical Observatories department of Physics Anhui Normal University Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics department Tsinghua University Nevada Center for Astrophysics University of Nevada Las Vegas department of Physics and Astronomy University of Nevada Las Vegas Chinese Academy of Sciences South African Astronomical Observatory department of Astronomy University of Cape Town department of Physics University of the Free State Universite' Paris Cite' CNRS Astroparticule et Cosmologie Universite' Paris Cite' CEA Paris-Saclay School of Astronomy and Space Sciences IRFU/dAp-AIM department of Astronomy Guangzhou University Cosmic dawn Center (dAWN) Niels Bohr Institute University of Copenhagen department of Physics and Astronomy Rutgers the State University of New Jersey Institute for Cosmic Ray Research University of Chinese Academy of Sciences The University of Tokyo ESA/ESTEC Noordwijk 2201 AZ The Netherlands department of Astronomy School of Physics Huazhong University of Science and Technology INAF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics Key Laboratory of Particle Astrophysics The University of Sydney department of Astronomy Xiamen University Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University department of Astronomy University of Science and Technology Hefei School of Astronomy and Space Sciences University of Science and Technology of China Institute of High Energy Physics Institute of deep Space Sciences deep Space Exploration Laboratory department of Astronomy School of Physics and Astronomy Yunnan University Shanghai Astronomical Observatory Chinese Academy of Science

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GRONd,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 keV,300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 keV,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for4d,followed by a steep decay till becoming undetectable10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

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《智取威虎山》难道这是武侠片?

东方电影 2014年第12期 98-98页

作者： jeremy

拍摄《智取威虎山》是徐克的夙愿,多年前徐克曾被谢晋导演问及＂什么是最想在内地拍摄的电影＂时,他不假思索地同答是《智取威虎山》。拍革命样板戏题材对徐克导演来说是一次全新的尝试,历经多年思考与筹备,此片终于在2013年12月开机,... 详细信息

拍摄《智取威虎山》是徐克的夙愿,多年前徐克曾被谢晋导演问及＂什么是最想在内地拍摄的电影＂时,他不假思索地同答是《智取威虎山》。拍革命样板戏题材对徐克导演来说是一次全新的尝试,历经多年思考与筹备,此片终于在2013年12月开机,他率领张涵予、梁家辉、林更新、余男、佟丽娅、韩庚、陈晓、谢苗、吴旭东在内的规模达1100人的摄制团队,深入零下30度的东北林海雪原,历时130天、饱尝风雪拍摄3d谍战动作大片。

关键词：《智取威虎山》徐克谢晋导演余男林海雪原梁家辉革命样板戏韩庚陈晓自我评价