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Comparing lignocaine-adrenaline-tetracaine gel with lignocaine infiltration for anesthesia during repair of lacerations:A randomized trial

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World Journal of Emergency Medicine 2013年第4期4卷 281-284页

作者： Jean MH Lee Nina Laxmikantha Marcus E H Ong Evelyn Wong jeremy cp wee Department of Emergency Medicine Singapore General Hospital169608 Singapore

BACKGROUND:This study aimed to compare the topical anesthetic lignocaine,adrenaline,and tetracaine(LAT)(4%lignocaine,1:2 000 adrenaline,1%tetracaine) with the conventional lignocaine infiltration(LI) for repair of minor lacerations,for the comfort of anesthetic administration,efficacy,adverse effects and ***:This was a prospective randomized clinical *** Asian patients who required toilet and suture for minor lacerations in the emergency department of the Singapore General Hospital over a 4-month *** patients were assigned randomly to 2 arms of *** first was the LAT gel group who had LAT gel applied to the laceration prior to *** second was the control group in whom the anesthetic administered was lignocaine infiltration(LI) via a *** pain of the process of administering anesthetic and efficacy of anesthesia were scored using the visual pain scale included *** efficacy of LAT *** infiltration as an anesthetic prior to the toilet and suture of minor lacerations and complications of ***:Twenty patients were randomized to LAT gel and 16 to LI on an intention to treat *** mean pain score by patients in the LAT gel group was 2.5(0.52 SE),and 2.5(0.58 SE)in the LI *** pain score for pain during application of the anesthetic was 1.5(0.40) in the LAT gel group,and 3.5(0.46) in the LI *** was no difference in complications between the LAT and LI ***:LAT gel prior to the toilet and suture of minor lacerations is proven to be as efficacious as LI in terms of patient comfort and effectiveness of *** complications are also comparable to those treated with LI.

关键词： Lignocaine infiltration Lacerations Emergency department Pain score

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T4 cervical esophageal cancer cured with modern chemoradiotherapy: A case report

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World Journal of Clinical Cases 2020年第10期8卷 1950-1957页

作者： Chia Ching Lee Chong Ming Yeo wee Khoon Ng Akash Verma jeremy CS Tey Department of Radiation Oncology National University Cancer InstituteNational University HospitalTan Tock Seng HospitalSingapore 119228Singapore Department of Medical Oncology Tan Tock Seng HospitalSingapore 308433Singapore Department of Gastroenterology and Hepatology Tan Tock Seng HospitalSingapore 308433Singapore Department of Respiratory and Critical Care Medicine Tan Tock Seng HospitalSingapore 308433Singapore

BACKGROUND T4 esophageal cancer portends a poor prognosis,particularly when it is complicated by a tracheoesophageal fistula(TEF)either resulting from disease or occurring as a complication of *** with TEF that occurs during treatment are commonly treated with palliative intent because fistula-associated treatment complications such as aspiration pneumonia and mediastinitis are associated with high morbidity and *** date,there is no clear evidence on the optimal treatment of T4 esophageal cancer,particularly when a TEF formation *** SUMMARY A 67-year-old gentleman who presented with dysphagia and weight *** and imaging revealed a T4N1M0 cervical esophageal squamous cell *** received image-guided intensity-modulated radiation therapy,with concurrent weekly carboplatin(area under curve 2 mg/mL per minute)and paclitaxel(50 mg/m2 of body surface area).One week after treatment initiation(16.2 Gy thus far),he developed cough on swallowing.A TEF was detected on image-guided radiation therapy using cone-beam computed tomography during the treatment course,for which a tracheal stent was *** discussing the risks and morbidity of continuing treatment,he resumed chemoradiotherapy with an additional radiation dose of 45 Gy in 25 *** months after completion of chemoradiotherapy,he developed an esophageal stricture that required esophageal stenting and *** patient remains cancer-free at two year on *** response of esophageal cancer was evident on post-treatment endoscopy and computed tomography imaging,with successful closure of *** This case highlights that successful curative treatment for esophageal cancer complicated by a TEF is possible using novel chemotherapeutic regimens and modern radiation technologies.

关键词： Esophageal cancer Chemoradiotherapy Fistula Stenting T4 Case report

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Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the cpG island methylator phenotype

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World Journal of Gastrointestinal Oncology 2017年第5期9卷 209-217页

作者： jeremy Stuart Williamson Huw Geraint Jones Namor Williams Anthony Paul Griffiths Gareth Jenkins John Beynon Dean Anthony Harris Department of General and Colorectal Surgery Singleton Hospital Department of Pathology Singleton Hospital Department of Life Sciences Swansea University

To identify whether cpG island methylator phenotype (CIMP) is predictive of response to neoadjuvant chemoradiotherapy (NACRT) and outcomes in rectal cancer. METHODSPatients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status (high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined upon histological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed. RESULTSThere were 160 patients analysed with a median follow-up time of 46.4 mo. Twenty-one (13%) patients demonstrated high levels of CIMP methylation (CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion (EMVI) compared with CIMP-L [8/21 (38%) vs 15/99 (15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival (P ween EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced “T” stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurre

关键词： Rectal cancer cpG islands Methylation

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