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CAR T-Cell therapies in lymphoma: current landscape, ongoing investigations, and future directions

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 497-510页

作者： J.Erika Haydu jeremy S.Abramson Center for Lymphoma Massachusetts General Hospital&Harvard Medical SchoolBostonMA 02114USA.

Chimeric antigen receptor(CAR)T-cell therapy has significantly improved outcomes for patients with relapsed/refractory large B-cell lymphoma,mantle cell lymphoma,and follicular lymphoma,with multiple FDA-approved CAR T products now commercially *** studies seek to move CAR T-cells to earlier lines of therapy and to characterize the efficacy and safety of CAR T-cell approaches in additional lymphoma histologies including relapsed/refractory follicular lymphoma and chronic lymphocytic *** areas of active research address CAR T in combination with other lymphoma-directed therapies,and mechanisms of CAR T *** review focuses on the FDA-approved anti-CD19 CAR T products for B-cell lymphomas,management of CAR T-cell-associated toxicities,approaches to bridging therapy,and ongoing clinical trials and future research directions across a broad range of lymphoma histologies.

关键词： CAR T-cells cell therapy adoptive immunotherapy non-Hodgkin lymphoma aggressive lymphoma indolent lymphoma mantle cell lymphoma diffuse large B-cell lymphoma

Effects of direct aging treatment on microstructure,mechanical properties and residual stress of selective laser melted AlSi10Mg alloy

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Journal of Materials Science & Technology 2023年第8期139卷 198-209页

作者： Huaping Tang Chaofeng Gao Yong Zhang Nannan Zhang Chuan Lei Yunjie Bi Ping Tang jeremy Heng Rao Institute of Advanced Additive Manufacturing Ji Hua LaboratoryFoshan 528200China Department of Materials Science and Engineering Monash UniversityClaytonVIC 3800Australia National Engineering Research Center of Light Alloy Net Forming and State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240China Hunan Farsoon High-Tech Co. LtdChangsha 410000China

Direct aging treatment is an important post-processing procedure,yet little research has been done on how it balances the mechanical properties and the stress removal for selective laser melted(SLMed)AlSi10Mg ***,we proposed a typical direct aging treatment on SLMed AlSi10Mg alloys,and studied the effects on their microstructure,properties and residual stress *** results indi-cate that the as-built microstructure is mainly composed of fine cellularα-Al and reticulated Si phases,and some pre-existing precipitates and dislocations are found in these *** direct aging treatment promotes the precipitation of nano-scaled Si phases and preserves a network-like Si ***,the strength of the peak-aged alloy increases while the ductility *** the aging temperature in-creases from 160 to 200℃,aging hardening behavior was accelerated *** at 160℃ for 4-9 h removes 32.0%-43.0%of the residual stress,which is attributed to the decomposition of the su-persaturatedα-Al matrix,the precipitation of the nano-Si phase and the exposure of low-angle grain boundaries(LAGBs).Considering the overal alloy performance obtained,over-aging at 160℃ for 4 h is the optimized heat treatment *** this condition,the yield strength(YS),ultimate tensile strength(UTS)and elongation(EL)of the alloy in the transverse and longitudinal direction are 309.5 MPa,464.4 MPa and 8.3%and 286.4 MPa,464.9 MPa and 5.1%,respectively.

关键词： Selective laser melting AlSi10Mg alloys Direct aging treatment Residual stress removal

Recent Unusual Consecutive Spring Tropical Cyclones in North Atlantic and Winter Oceanic Precursor Signals

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Journal of Meteorological Research 2023年第2期37卷 208-217页

作者： Hong HUANG jeremy Cheuk-Hin LEUNG Johnny CLCHAN Jimin LIU Weihong QIAN Banglin ZHANG College of Meteorology and Oceanography National University of Defense TechnologyChangsha410015 Guangzhou Institute of Tropical and Marine Meteorology/Guangdong Provincial Key Laboratory of Regional Numerical Weather Prediction China Meteorological AdministrationGuangzhou510640 School of Energy and Environment City University of Hong KongHong Kong999077 Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai519082 College of Atmospheric Sciences Lanzhou UniversityLanzhou730000 Shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030 Asia-Pacific Typhoon Collaborative Research Center Shanghai201306 Department of Atmospheric and Oceanic Sciences Peking UniversityBeijing100871

Although the North Atlantic(NA)hurricane season has been reported to start increasingly early,historical longterm changes in NA spring tropical cyclone(TC)activity have not been examined in previous *** find that spring TCs have become more frequent and intense,and they have more closely approached the US coastline over the past four decades,thus increasing the probability of landfall.A long-term increase in the NA sea surface temperature(SST)and northward incursion of warm water may be responsible for the increasing number,intensity,and northward shift of spring *** addition,the interdecadal winter NA SST tripole mode may induce a North Atlantic Oscillation(NAO)-like atmospheric response in the following spring,which controls spring TC tracks via modulating the strength and position of the NA subtropical high(or the Bermuda high).The superposition of the interdecadal positive winter SST tripole on the NA warming trend has contributed to the anomalous enhancement and northward shift of spring TC activity,increasing the spring TC risks in the US in the past six years.

关键词： hurricane climate change spring tropical cyclone preseason storm

Instructor''s resource CD-ROM for Environmental geology and Earth matters / jeremy Dunning, Larry Onesti, Lawrence J Onesti.

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Instructor''s resource CD-ROM for Environmental geology and ...

Longitudinal changes in cardiac function in the very elderly: the Jerusalem longitudinal cohort study

1998年

作者： Dunning jeremy.

来源：畅想之星图书光盘版（南... 评论

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Journal of Geriatric Cardiology 2019年第11期16卷 800-805页

作者： David Leibowitz Irit Stessman-Lande Hend Sliman jeremy M Jacobs Jochanan Stessman Dan Gilon Jerusalem Institute of Aging Research Hadassah-Hebrew University Medical CenterMount-ScopusJerusalemIsrael Coronary Care Unit Hadassah–Hebrew University Medical CenterMount-ScopusJerusalemIsrael Department of Geriatrics and Rehabilitation Hadassah-Hebrew University Medical CenterMount-ScopusJerusalemIsrael

Background People over the age of 85 are a rapidly growing age group with a high incidence of congestive heart failure(CHF),in particular heart failure with preserved ejection fraction(HFp EF).The diagnosis of CHF is challenging and longitudinal data assessing cardiac structure and function are necessary to distinguish physiologic from pathologic cardiac *** objective of the study was to determine longitudinal changes in cardiac struture and function from ages 85 to 94 years using home *** Subjects were recruited from the Jerusalem Longitudinal Cohort *** three members of the initial cohort(32 F,31 M)who underwent home echocardiography at age 85 were the subjects of the current study and underwent repeat home 2-D and Doppler echocardiographic assessment at age *** There were no significant longitudinal changes in left ventricular mass index(LVMI),however LV end-diastolic volume significantly decreased from 113.4±30 to 103.6±35.5 m L(P<0.02).Ejection fraction(EF)remained stable,however longitudinal systolic function significantly decreased with age from 7.9±1.8 to 6.6±1.4 cm/s2(P<0.0001).Diastolic function as assessed by increased E:e’(11.2±3.4 to 16±7.5,P<0.0001)and increased left atrial volume index(34.1±11.3 to 42.4±13.7 m L/m^2,P<0.0001)was reduced with *** This study demonstrated preserved EF with decreased longitudinal systolic function and diastolic function without significant change in LV *** in LV function in the very elderly may be independent of changes in LV geometry.

关键词： Echocardiography The elderly Ventricular function

Designing a locating-routing three-echelon supply chain network under uncertainty

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International Journal of Intelligent Computing and Cybernetics 2022年第4期15卷 562-588页

作者： Leila Hashemi Armin Mahmoodi Milad Jasemi Richard C.Millar jeremy Laliberte Department of Industrial Management Islamic Azad University South Tehran BranchTehranIslamic Republic of Iran Department of Industrial Management Islamic Azad University ofMasjid-i-SoliemanMasjid-i-SoliemanIslamic Republic of Iran Stephens College of Business University of MontevalloMontevalloAlabamaUSA Department of Engineering Management and Systems Engineering The George Washington UniversityWashingtonDistrict of ColumbiaUSA Department of Mechanical and Aerospace Engineering Carleton UniversityOttawaCanada

Purpose-In the present research,location and routing problems,as well as the supply chain,which includes manufacturers,distributor candidate sites and retailers,are *** goal of addressing the issue is to reduce delivery times and systemcosts for retailers so that routing and distributor locationmay be ***/methodology/approach-By adding certain unique criteria and limits,the issue becomes more *** expect simultaneous deliveries and pickups,and retail service start times have soft and hard time *** expenses,noncompliance with the soft time window,distributor construction,vehicle purchase or leasing,andmanufacturing costs are all part of the system *** problem’s conceptual model is developed and modeled first,and then General Algebraic Modeling System software(GAMS)and Multiple Objective Particle Swarm Optimization(MOPSO)and non-dominated sorting genetic algorithm II(NSGAII)algorithms are used to solve it in small ***-According to the mathematical model’s solution,the average error of the two suggested methods,in contrast to the exact answer,is less than 0.7%.In addition,the performance of algorithms in terms of deviation from the GAMS exact solution is pretty satisfactory,with a divergence of 0.4%for the biggest problem(N 5100).As a result,NSGAII is shown to be superior to *** limitations/implications-Since this paper deals with two bi-objective models,the priorities of decision-makers in selecting the best solution were not taken into account,and each of the objective functions was given an equal weight based on the weighting *** model has not been compared or studied in both robust and deterministic *** is because,with the exception of the variable that indicates traffic mode uncertainty,all variables are deterministic,and the uncertainty character of demand in each level of the supply chain is *** implications-The suggested model’s conclusions

关键词： Metaheuristic algorithms Time windows Supply chain management Robust optimization Location-routing problems

A comparison of cyanoacrylate to sutures for wound closure following acoustic transmitter insertion in rainbow trout

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Aquaculture and Fisheries 2021年第5期6卷 513-518页

作者： jeremy Kientz Nathan Huysman Michael E.Barnes South Dakota Department of Game Fish and Parks4130 Adventure TrailRapid CitySD57702USA South Dakota Department of Game Fish and ParksMcNenny State Fish Hatchery19619 Trout LoopSpearfishSD57783USA

Tag retention,wound healing,wound closure,and tagged fish survival are critically important after surgical implantation of acoustic transmitters in *** study compared the use of sutures to cyanoacrylate adhesives and bandages for post-surgery wound *** rainbow trout Oncorhynchus mykiss were assigned to one of seven treatments:a control group where fish were only handled,two suture groups(tagged with dummy acoustic transmitters or non-tagged),and four cyanoacrylate adhesive groups(non-tagged,tagged with adipose fin applied as a biological bandage,tagged with anal fin applied,and non-tagged with water-proof bandage).Tag retention was significantly improved in adhesive with anal fin(89%)and tagged suture(78%)treatments when compared to only 11%tag retention in the adhesive with adipose fin *** redness severity increased over the 14 weeks of the study in the tagged and sutured fish,and in those receiving the waterproof *** redness severity was also significantly higher in the waterproof bandage and tagged and sutured treatments than both tagged adhesive treatments at the end of the *** gape was significantly more severe in the adhesive with adipose treatment than in the control,suture,tagged suture,and adhesive treatments,but no significant differences were observed between the adhesive with adipose treatment and the adhesive with anal fin or bandage *** gape never completely closed in the adhesive with adipose group,while both the tagged suture treatment and tagged adhesive with anal treatment wounds completely closed between four-and six-weeks *** results of this study indicate that cyanoacrylate adhesive used in conjunction with anal fin tissue is a suitable post-surgical treatment.

关键词： Surgery Acoustic transmitter Cyanoacrylate Rainbow trout Oncorhynchus mykiss

Plasmon-directed polymerization:Regulating polymer growth with light

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Nano Research 2018年第12期11卷 6384-6390页

作者： Yunxia Wang Shuangshuang Wang Shunping Zhang Oren A.Scherman jeremy J.Baumberg Tao Ding Hongxing Xu Key Laboratory of Artificial Micro-and Nano-structures Of Ministry of Education of China School of Physics and Technologywuhan UniversityWuhan 430072China Nanophotonics Centre Cavendish LaboratoryUniversity of CambridgeCambridgeCB30HEUK Department of Chemistry University of CambridgeLensfield RoadCambridgeCB2I EWUK

Plasmon-induced polymerization can facilitate the site-selectivity and orientation of polymer growth, which enriches the toolbox of polymerization and nanofabrication. Here, we demonstrate plasmon-induced polymerization, accomplished by low-power laser excitation of gold nanoparticles (NPs). We selectively control the growth of polymers around single plasmonic NPs while monitoring the polymerization using dark field spectroscopy and subsequent scanning electron microscopy. This plasmon-induced polymerization, generated by hot electron initiation, not only precisely controls the thickness and composition of the polymer coatings but also regulates the location and orientation of the growth, which are strongly influenced by the laser polarization and near-field distribution around the plasmonic NPs. A saturation increase in the polymer thickness provides a strong support for our mechanism. This facile approach of nanoscale polymerization directed by light not only provides new opportunities in nanosynthesis and nanofabrication for functional devices, but also opens many routes for polymer physics and chemistry at the nanoscale level.

关键词： hot electrons plasmons polarization selective growth

Coastal protection using building with nature concept:A case study from Chongming Dongtan Shoal,China

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Acta Oceanologica Sinica 2021年第10期40卷 152-166页

作者： Zhentao Chong Min Zhang Jiahong Wen Luyang Wang Jie Mi jeremy Bricker Stanley Nmor Zhijun Dai School of Environmental and Geographical Sciences Shanghai Normal UniversityShanghai 200234China State Key Laboratory of Estuarine and Coastal Research(East China Normal University) Shanghai 200241China Department of Hydraulic Engineering Delft University of Technology2628 CN DelftThe Netherlands Department of Civil&Environmental Engineering University of MichiganAnn ArborMI 48109USA Department of Estuarine and Delta Systems Royal Netherlands Institute for Sea Research4400 AC YersekeThe Netherlands

With climate change and rising sea levels,the coastal zone’s flood risk is *** researches have shown a gradually degrading capacity of traditional hard engineering structures(e.g.,seawall,dikes)on flood mitigation due to problems such as land subsidence and insufficient *** remedy the defects,the"building with nature concept"for coastal protection with saltmarshes was examined by combining field measurements and numerical *** advantages of saltmarsh over traditional seawall on flood protection was demonstrated from the perspective of both flood area mitigation and economic gain,based on scenario *** show that tidal wetlands are essential in mitigating significant wave heights(Hs)and current velocities even during storm *** storm wave and current velocity reduction ratio(RRw and RRc)by saltmarshes on Chongming Dongtan Shoal(CMDS)during Typhoon 9711 is approximately 11%and 51%,*** wave and current mitigation by Scirpus mariqueter are more efficient than Spartina alterniflora and Phragmites australis during measurements in 2010,which were approximately 0.3 m and 0.2 m/s,0.125 m and 0.155 m/s,0.086 m and 0.128 m/s per kilometer width,*** summer saltmarsh area 54.2 km2 on CMDS protects approximately 32 km^(2)land area behind the seawall from being flooded,equivalent to the seawall heightening of approximately 0.42 m on equivalent flood *** performance of cost-and-benefit analysis shows a relatively higher(by 3%–7%)net present value(NPV)and a higher(by 1.5 times)benefit-cost ratio(BC)of nature-based solution(i.e.,saltmarsh restoration)compared with traditional hard engineering solution(i.e.,seawall construction).Thus,building seawall with nature,such as a hybrid flood protection measure,should be implemented in the future coastal redesign and maintenance.

关键词： nature-based flood protection storm wave mitigation numerical simulation cost-benefit analysis Chongming Dongtan Shoal