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Phenomics 2021年第4期1卷 143-150页

作者： jer.my k.nicholson The Australian National Phenome Center and the Health Futures Institute Murdoch UniversityHarry Perkins BuildingRobert Warren DriveMurdoch PerthWA 6150Australia Institute of Global Health Innovation Imperial College LondonLevel 1Faculty Building South Kensington CampusLondon SW72NAUK

SARS COV-2 infection causes acute and frequently severe respiratory disease with associated multi-organ damage and systemic disturbances in many biochemical *** phenotyping provides deep insights into the complex immunopathological problems that drive the resulting COVID-19 disease and is also a source of novel metrics for assess-ing patient recovery.A multiplatform metabolic phenotyping approach to studying the pathology and systemic metabolic sequelae of COVID-19 is considered here,together with a framework for assessing post-acute COVID-19 Syndrome(PACS)that is a major long-term health consequence for many *** sudden emergence of the disease presents a biological discovery challenge as we try to understand the pathological mechanisms of the disease and develop effective mitigation *** requires technologies to measure objectively the extent and sub-phenotypes of the disease at the molecular *** methods can reveal metabolic sub-phenotypes and new biomarkers that can be monitored during the acute disease phase and *** approach is scalable and translatable to other pathologies and provides as an exem-plar strategy for the investigation of other emergent zoonotic diseases with complex immunological drivers,multi-system involvements and diverse persistent symptoms.

关键词： SARS COV-2 COVID-19 Post-acute COVID-19 Syndrome(PACS)lSpectroscopy Metabolic Phenoconversion Phenoreversion

Plasma lipidomics reveal systemic changes persistent throughout early life following a childhood burn injury

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Burns & Trauma 2023年第1期11卷 814-824页

作者： Eva kierath Monique Ryan Elaine Holmes jer.my k.nicholson Mark W.Fear Fiona M.Wood Luke Whiley Nicola Gray 无 Australian National Phenome Centre Health Futures InstituteMurdoch UniversityHarry Perkins Institute5 Robin Warren DriveMurdochPerthWA 6150Australia Fiona Wood Foundation Fiona Stanley HospitalFiona Wood FoundationFiona Stanley HospitalLevel 411 Robin Warren DriveMurdochWA 6150Australia Burn injury research unit School of Biomedical SciencesUniversity of Western Australia6 Verdun streetNedlandsWA 6009 Australia Department of Metabolism Digestion and ReproductionFaculty of MedicineImperial College LondonSir Alexander Fleming BuildingSouth KensingtonLondon SW72AZUK Centre for Computational Medicine Health Futures InstituteMurdoch University5 Robin Warren DriveMurdochPerthWA 6150Australia Medical School University of Western AustraliaHarry Perkins InstituteMurdochPerthWA 6150Australia Faculty of Medicine Institute of Global Health InnovationImperial College LondonLevel 1Faculty Building South Kensington CampusLondon SW72AZUK Burns Service of Western Australia WA Department of Health11 Robin Warren driveMurdochWA 6150Australia Perron Institute for Neurological and Translational Science NedlandsWAAustralia

Background:Non-severe paediatric burns can result in poor long-term health *** occurs even in cases with good acute burn-related outcomes,including minimal *** mechanisms that underpin the transition from non-severe burn to sustained negative long-term health impacts are currently ***,sustained metabolic and immune changes have been observed in paediatric burn studies,suggesting these changes may be *** plasma lipidome consists of a rich pool of bioactive metabolites that play critical roles in systemic processes including molecular signalling and *** hypothesised that changes in the plasma lipidome may reflect underlying changes in health status and be linked to long-term health after burn ***:This study analysed the lipidome in children who had previously experienced a non-severe burn,compared to non-injured ***-three participants were recruited between the ages of 5 and 8 years who had experienced a non-severe burn between the ages of 1 and 3 *** samples were also collected from a non-injured,healthy,age and gender matched control group(n=21).Plasma lipids were measured using reversed-phase liquid chromatographymass spectrometery(LC-MS).Results:In total 838 reproducible lipid species from 19 sub-classes passed quality control procedures and progressed to statistical *** of individual lipid metabolites showed significantly higher concentrations of lysophosphatidylethanolamines and phosphatidylethanolamines,and significantly lower concentrations in myristic,palmitic and palmitoleic acids in the plasma of those who had experienced burn injury compared to ***:Long-term changes in the lipid profile may give insight into the mechanisms underlying poor long-term health subsequent to non-severe burn *** work to investigate the relationship between long-term pathology and lipidomic changes may lead to a better understanding of the causes of seconda

关键词： Lipidomics Lipids Burns Trauma Paediatric Children Mass spectrometry

苏格兰因佛内斯附近层状锰矿化——泥盆纪湖底热泉成因

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中国锰业 1991年第2期9卷 53-56页

作者： k.nicholson 杨子元

1 前言苏格兰东北部因佛内斯东南10km的达罗伊(Dalroy)产出一厚达4m的含锰层,其下伏地层为前寒武系格拉姆组片岩,泥盆系红色砂砾岩覆盖于上。锰矿物主要为细粒褐锰矿,含少量的蔷薇辉石。矿体下部发育空洞构造(与“平底晶洞构造”相似),... 详细信息

1 前言苏格兰东北部因佛内斯东南10km的达罗伊(Dalroy)产出一厚达4m的含锰层,其下伏地层为前寒武系格拉姆组片岩,泥盆系红色砂砾岩覆盖于上。锰矿物主要为细粒褐锰矿,含少量的蔷薇辉石。矿体下部发育空洞构造(与“平底晶洞构造”相似),并被重晶石、方解石或菱锰矿所充填。锰矿石的矿物组成和地球化学(富Ag、As、Ba、Bi、Pb、Sb、Sr和Zn)具有热液成因的特征。

关键词：锰矿床矿化热泉沉积成因泥盆纪

A Variational Approach to Norm Attainment of Some Operators and Polynomials

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Acta Mathematica Sinica,English Series 2010年第12期26卷 2259-2268页

作者： María D.ACOSTA jernimo ALAMINOS Domingo GARCA Manuel MAESTRE Departamento de Anlisis Matemtico Universidad de Granada Departamento de Anlisis Matemtico Universidad de Valencia

If X is an Asplund space, then every uniformly continuous function on Bx＊ which is holomorphic on the open unit ball, can be perturbed by a w＊ continuous and homogeneous polynomial on X＊ to obtain a norm attaining function on the dual unit ball. This is a consequence of a version of Bourgain-Stegall＇s variational principle. We also show that the set of N-homogeneous polynomials between two Banach spaces X and Y whose transposes attain their norms is dense in the corresponding space of N-homogeneous polynomials. In the case when Y is the space of Radon measures on a compact k, this result can be strengthened.

关键词： Banach space variational principle operator polynomial holomorphic function

基于NMR的代谢组学方法最新进展及应用(英文)

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波谱学杂志 2006年第1期23卷 101-127页

作者： LINDON J C HOLMES E nicholson J k Biological Chemistry Biomedical Sciences Division Imperial College London Sir Alexander Fleming Building South Kensington London SW7 2AZ UK

代谢组学的定义“对病理/生理刺激以及基因改变时生物体系动态的代谢响应进行多参数的定量测量”已被广泛接受.本文对代谢组学研究的最新进展及其在系统生物学中所发挥的作用进行了综述.在代谢组学方法研究方面,着重讨论了现代NMR技术... 详细信息

代谢组学的定义“对病理/生理刺激以及基因改变时生物体系动态的代谢响应进行多参数的定量测量”已被广泛接受.本文对代谢组学研究的最新进展及其在系统生物学中所发挥的作用进行了综述.在代谢组学方法研究方面,着重讨论了现代NMR技术的进展及其对代谢组学所产生的影响,同时也包括用于分离的HPLC及其与质谱的连用技术.对代谢组学广泛应用的概述,主要包括:对正常生理变化的新认识;药物和其他外源性化学物质的副作用;外源性物质对环境污染的影响以及逐渐增多的代谢组学方法在疾病检测中应用.

关键词：核磁共振液相色谱-质谱联用代谢物生物标记疾病检测毒性环境

Exploring the Relationship between Obstetrical Nurses’ Work and Pregnancy Outcomes

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Open Journal of Nursing 2016年第9期6卷 812-819页

作者： Jo Watson Monica nicholson kelly Dobbin karen Fleming Julia M. k. Alleyne Women and Babies Program Sunnybrook Health Sciences Centre Toronto Canada Lawrence S. Bloomberg Faculty of Nursing University of Toronto Toronto Canada College of Midwives of Ontario Toronto Canada Department of Family and Community Medicine Toronto Canada University Health Network Toronto Rehabilitation Institute Toronto Canada Department of Family and Community Medicine University of Toronto Toronto Canada

The Registered Nurses Association of Ontario Healthy Work Environments Best Practice Guideline recommends that employers promote safe, healthy workplaces. Healthy workplaces include addressing the unique needs of nurses who work while pregnant. The purpose of this descriptive study, summarizing information from 120 pregnancies reported by 95 nurses, was to determine if the workload of obstetrical nurses was associated with negative pregnancy outcomes, including preterm delivery and birth weight. Full-time obstetrical nursing work is a predictor of reduced birth weight, but not of preterm birth when compared to outcomes of obstetrical nurses working part time. One third of nurses reported pregnancy complications and most nurses experienced work-related and personal stress. Further research evaluating work modifications during pregnancy is indicated to improve birth outcomes.

关键词： Obstetrical Nurse Pregnancy Outcomes Preterm Birth Birth Weight

Spatial Variation of Nutrient Concentrations (NH+4and Cl-) in the Dudhkoshi River Basin, Sagarmatha National Park, Nepal

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Journal of Water Resource and Protection 2020年第7期12卷 577-589页

作者： Jessique Ghezzi-Haeft k. nicholson k. Neumann L. Wood S. Acharya S. Sharma Environment Geology and Natural Resources Ball State University Muncie USA Department of Earth Sciences Indiana University-Purdue University Indianapolis USA Aquatic Ecology Laboratory Kathmandu University Dhulikhel Nepal

The Sagarmatha National Park (SNP) in Nepal is home to unique natural beauty and cultural significance. While the SNP has a relatively small local population, it has drawn thousands of visitors since Edmund Hillary and Tenzing Norgay reached the peak of Mt Everest in 1953. Importantly, the tourists and their concurrently generated refuse have caused massive anthropogenic pressure with serious environmental consequences for the unique SNP and SNP Buffer Zone ecosystems. This study aimed to understand the spatial variation of nutrient concentrations in stream water and drinking water (primarily shallow springs) using analyses of nitrogen as NH+4 and chlorine (Cl-) concentrations. Sampling occurred in April 2017 during the pre-monsoon dry season in the upper Dudhkoshi River Basin, SNP. Dissolved inorganic nitrogen (NH+4) concentrations in both drinking water and stream water were low with average concentrations in drinking water of 0.016 mg/L (±0.010) and 0.033 mg/L (±0.031) in stream water. Similarly, Cl- concentrations were also low with average concentrations of 0.185 mg/L (±0.045) and 0.124 mg/L (±0.051) in stream and drinking water, respectively. Importantly, nitrogen in stream waters exhibits a decreasing trend with altitude whereas Cl- values decrease with altitude in both drinking water and streams. The observed spatial variations of nitrogen and chlorine concentrations are attributed primarily to the significant variations in land use/land cover from the highest portions of the drainage basin to the lowest elevations, which are outside of the SNP boundary and therefore allow more agricultural development. Our results demonstrated that although the quality of stream water in the upper reach of Dudhkoshi River Basin meets WHO standards for drinking water, there is significant surface water contamination in the form of agricultural run-

关键词： Sagarmatha Nutrients Nitrogen LULC Water Quality Nepal

Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5404-5416页

作者： Catarina Macedo-Silva Vera Miranda-Gonçalves Nuno Tiago Tavares Daniela Barros-Silva Joana Lencart João Lobo Ângelo Oliveira Margareta PCorreia Lucia Altucci Carmen jerónimo Cancer Biology&Epigenetics Group Research Center of IPO Porto(CI-IPOP)/CI-IPOP@RISE(Health Research Network)Portuguese Oncology Institute of Porto(IPO-Porto)/Porto Comprehensive Cancer Center Raquel Seruca(Porto.CCC)R.Dr.António Bernardino de Almeida4200-072PortoPortugal Department of Precision Medicine University of Campania“Luigi Vanvitelli”80138NaplesItaly Department of Pathology and Molecular Immunology ICBAS-School of Medicine&Biomedical SciencesUniversity of PortoR.Jorge de Viterbo Ferreira 2284050-313PortoPortugal Medical Physics Radiobiology and Radiation Protection Group-Research Center of IPO Porto(CI-IPOP)/CI-IPOP@RISE(Health Research Network)Portuguese Oncology Institute of Porto(IPO-Porto)/Porto Comprehensive Cancer Center Raquel Seruca(Porto.CCC)R.Dr.António Bernardino de Almeida4200-072PortoPortugal Department of Medical Physics Portuguese Oncology Institute of Porto4200-072PortoPortugal Department of Pathology Portuguese Oncology Institute of PortoPortoPortugal Department of Radiation Oncology Portuguese Oncology Institute of PortoPortoPortugal BIOGEM Molecular Biology and Genetics Research Institute83100AvellinoItaly IEOS Institute of Endocrinology and Oncology80100NaplesItaly

External beam radiotherapy(RT)is a leading first-line therapy for prostate cancer(PCa),and,in recent years,significant advances have been ***,RT resistance can arise and result in long-term recurrence or disease progression in the worst-case ***,making crucial the discovery of new targets for PCa ***,we generated a radioresistant PCa cell line,and found p53 to be highly expressed in radioresistant PCa cells,as well as in PCa patients with recurrent/disease progression submitted to *** dissection revealed that RT could promote p53 expression via epigenetic ***,a decrease of H3k27me3 occupancy at TP53 gene promoter,due to increased kDM6B activity,was observed in radioresistant PCa ***,p53 is essential for efficient DNA damage signaling response and cell recovery upon stress induction by prolonged fractionated ***,kDM6B inhibition by GSk-J4 significantly decreased p53 expression,consequently attenuating the radioresistant phenotype of PCa cells and hampering in vivo 3D tumor ***,this work contributes to improve the understanding of p53 as a mediator of signaling transduction in DNA damage repair,as well as the impact of epigenetic targeting for PCa radiosensitization.

关键词： TP53 damage cancer

大气悬浮颗粒的长途输送及其对台湾空气质量的影响(英文)

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干旱区资源与环境 2004年第S1期18卷 153-156页

作者： Shaw C. Liu Charles C.-k. Chou Saint-jer Huang Chung-Ming Liu Chea-Yuan Young Institute of Earth Sciences Academia Sinica Taipei Taiwan ROCInstitute of Earth Sciences Academia Sinica Taipei Taiwan ROCInstitute of Earth Sciences Academia Sinica Taipei Taiwan ROCDepartment of Atmospheric Science National Taiwan University Taiwan ROCEnvironmental Protection Agency Taipei Taiwan ROC

On the cratonization of the Arabian-Nubian Shield: Constraints from gneissic granitoids in south Eastern Desert, Egypt

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Geoscience Frontiers 2021年第4期12卷 215-243页

作者： Ali A.khudeir Jean-Louis Paquette kirsten nicholson Åke Johansson Tyrone O.Rooney Sadiq Hamid Mohamed A.El-Fadly Loretta Corcoran Shawn J.Malone Mohamed Ali Abu El-Rus Geology Department Faculty of ScienceAssiut University71516Egypt UniversitéClermont Auvergne CNRSIRDOPGCLaboratoire Magmas et VolcansF-63000 Clermont-FerrandFrance Ball-State University Department of EnvironmentGeology and Natural Resources117 Fine Art BuildingMuncieIN 47306USA Department of Geosciences Swedish Museum of Natural HistoryBox 50007SE-10405 StockholmSweden Department of Earth and Environmental Sciences Michigan-State UniversityEast LansingMI 48824USA Notre Dame University Department of Civil and Environmental Engineering and Earth Sciences156 Fitzpatrick HallNotre DameIN 46556USA

The Shaitian granite complex(SGC)spans more than 80 Ma of crustal growth in the Arabian–Nubian Shield in southeast *** is a voluminous composite intrusion(60 km2)comprising a host tonalite massif intruded by subordinate dyke-like masses of trondhjemite,granodiorite and *** host tonalite,in turn,encloses several,fine-grained amphibolite enclaves.U-Pb zircon dating indicates a wide range of crystallization ages within the SGC(800±18Ma for tonalites;754±3.9 Ma for trondhjemite;738±3.8 Ma for granodiorite;and 717±3.2 Ma for monzogranite),suggesting crystallization of independent magma *** high positiveεNdi(+6–+8)indicate that the melting sources were dominated by juvenile material without any significant input from older *** of zircon saturation geothermometry indicates increasing temperatures during the generation of melts from 745±31℃ for tonalite to 810±25℃ for trondhjemite;840±10℃ for granodiorite;and 868±10℃ for *** pressure of partial melting is loosely constrained to be below the stability of residual garnet(kbar)as inferred fromthe almost flat HREE pattern((Gd/Lu)N=0.9–1.1),but>3 kbar for the stability of residual amphibole as inferred from the significantly lower NbN and TaN compared with LREEN and the sub-chondrite Nb/Ta ratios exhibited by the granitic *** inverse relation between the generation temperatures and the ages estimates of the granitoid lithologies argue against a significant role of fractional *** major and trace element contents indicate the emplacement of the SGC within a subduction zone *** lacks distinctive features for melt derived from a subducted slab(*** Sr/Y and high(La/Yb)N ratios),and the relatively low MgO and Ni contents in all granite phases within the SGC suggest melting within the lower crust of an island arc overlying a *** melts produced during melting experiments indicates an amphibolite of basaltic composition is th

关键词： Arabian-Nubian Shield(ANS) Cratonization Fractional crystallization Partial melting Subduction zones Tonalite-Trondhjemite-granodiorite(TTG)