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Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling

Signal Transduction and Targeted Therapy 2023年第11期8卷 5404-5416页

作者： Catarina Macedo-Silva Vera Miranda-Gonçalves Nuno Tiago Tavares Daniela Barros-Silva joana Lencart joão Lobo Ângelo Oliveira Margareta PCorreia Lucia Altucci Carmen jerónimo Cancer Biology&Epigenetics Group Research Center of IPO Porto(CI-IPOP)/CI-IPOP@RISE(Health Research Network)Portuguese Oncology Institute of Porto(IPO-Porto)/Porto Comprehensive Cancer Center Raquel Seruca(Porto.CCC)R.Dr.António Bernardino de Almeida4200-072PortoPortugal Department of Precision medicine University of Campania“Luigi Vanvitelli”80138NaplesItaly Department of Pathology and Molecular Immunology ICBAS-School of Medicine&Biomedical SciencesUniversity of PortoR.Jorge de Viterbo Ferreira 2284050-313PortoPortugal medical Physics Radiobiology and Radiation Protection Group-Research Center of IPO Porto(CI-IPOP)/CI-IPOP@RISE(Health Research Network)Portuguese Oncology Institute of Porto(IPO-Porto)/Porto Comprehensive Cancer Center Raquel Seruca(Porto.CCC)R.Dr.António Bernardino de Almeida4200-072PortoPortugal Department of medical Physics Portuguese Oncology Institute of Porto4200-072PortoPortugal Department of Pathology Portuguese Oncology Institute of PortoPortoPortugal Department of Radiation Oncology Portuguese Oncology Institute of PortoPortoPortugal BIOGEM Molecular Biology and Genetics Research Institute83100AvellinoItaly IEOS Institute of Endocrinology and Oncology80100NaplesItaly

External beam radiotherapy(RT)is a leading first-line therapy for prostate cancer(PCa),and,in recent years,significant advances have been ***,RT resistance can arise and result in long-term recurrence or disease progression in the worst-case ***,making crucial the discovery of new targets for PCa ***,we generated a radioresistant PCa cell line,and found p53 to be highly expressed in radioresistant PCa cells,as well as in PCa patients with recurrent/disease progression submitted to *** dissection revealed that RT could promote p53 expression via epigenetic ***,a decrease of H3K27me3 occupancy at TP53 gene promoter,due to increased KDM6B activity,was observed in radioresistant PCa ***,p53 is essential for efficient DNA damage signaling response and cell recovery upon stress induction by prolonged fractionated ***,KDM6B inhibition by GSK-j4 significantly decreased p53 expression,consequently attenuating the radioresistant phenotype of PCa cells and hampering in vivo 3D tumor ***,this work contributes to improve the understanding of p53 as a mediator of signaling transduction in DNA damage repair,as well as the impact of epigenetic targeting for PCa radiosensitization.

关键词： TP53 damage cancer

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Investigations on Fill-Factor Drop of Microcrystalline Silicon P-I-N Solar Cells Deposited onto Highly Surface-textured ZnO Substrates

Investigations on Fill-Factor Drop of Microcrystalline Silic...

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第十五届国际光伏科学与工程大会

作者： Luc Feitknecht jer.me Steinhauser Romain Schlüchter Sylvie Fa■ Didier Dominé Evelyne Vallat-Sauvin Fanny meillaud Christophe Ballif Arvind Shah Institute for Microtechnology (IMT) University of Neuchatel rue A.-L.Breguet 2 CH-2000 Neuchatel Switzerland

Various Zinc Oxide (ZnO) films deposited by Low-Pressure Chemical Vapour Deposition (LP-CVD) serving as front-contacts of μc-Si:H solar cells are fabricated. Special interest is drawn on the light-trapping performance of such front-contacts for a series of identically deposited p-i-n type solar cell devices. The surface-roughness of these front-contacts consisting of LP-CVD ZnO range from an rms value of 20 nm (low surface-roughness) up to 120 nm (highly textured ZnO surface) by varying the boron doping of the ZnO. The goal here is, to compare the influence of the substrate’s surface roughness on device characteristics while keeping other factors as constant as possible. Two clear trends were thereby observed: (a) an increase of j with increasing surface roughness and increasing haze factor, (b) a decrease in Fill-Factor (FF) at the same time. Values of open-circuit voltage (V) remain more or less stable for various front-TCO roughness. An explanation for trend (b) is given by (1) a reduced Raman crystallinity for devices deposited onto highly textured front-ZnO;and (2) a linear increase of defect density of the device’s absorber layers in function of the surface-texture of the front-ZnO.

关键词： Microcrystalline silicon thin-film solar cell devices Surface textured LP-CVD ZnO substrates Light-trapping

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Early-diverging fungal phyla:taxonomy,species concept,ecology,distribution,anthropogenic impact,and novel phylogenetic proposals

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Fungal Diversity 2021年第4期109卷 59-98页

作者： Kerstin Voigt Timothy Y.james Paul M.Kirk AndréL.C.M.de A.Santiago Bruce Waldman Gareth W.Griffith Minjie Fu Renate Radek jürgen F.H.Strassert Christian Wurzbacher Gustavo Henrique jerônimo David R.Simmons Kensuke Seto Eleni Gentekaki Vedprakash G.Hurdeal Kevin D.Hyde Thuong T.T.Nguyen Hyang Burm Lee jena Microbial Resource Collection Leibniz Institute for Natural Product Research and Infection BiologyAdolf-Reichwein-Straße 2307745 JenaGermany Institute of Microbiology Faculty of Biological SciencesFriedrich Schiller University JenaNeugasse 2507743 JenaGermany Department of Ecology and Evolutionary Biology University of MichiganAnn ArborMI 48109USA Biodiversity Informatics and Spatial Analysis Jodrell LaboratoryRoyal Botanic Gardens KewSurrey TW93DSUK Department of Mycology Federal University of PernambucoAv.Da Engenharias/nRecifePE 50740-4600Brazil School of Biological Sciences Seoul National UniversitySeoul 08826South Korea Department of Integrative Biology Oklahoma State UniversityStillwaterOK 74078USA Institute of Biological Environmentaland Rural Sciences(IBERS)Aberystwyth UniversityAberystwyth SY233DDWalesUK Institute of Biology/Zoology Evolutionary BiologyFreie Universität Berlin14195 BerlinGermany Leibniz Institute of Freshwater Ecology and Inland Fisheries Ecosystem Research12587 BerlinGermany Department of Civil Geo and Environmental EngineeringTechnical University of MunichGarchingGermany School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Environmental Microbiology Lab Department of Agricultural Biological ChemistryCollege of Agriculture&Life SciencesChonnam National UniversityGwangju 61186South Korea

The increasing number of new fungal species described from all over the world along with the use of genetics to define taxa,has dramatically changed the classification system of early-diverging fungi over the past several *** number of phyla established for non-Dikarya fungi has increased from 2 to ***,to date,both the classification and phylogeny of the basal fungi are still *** this article,we review the recent taxonomy of the basal fungi and re-evaluate the relationships among early-diverging lineages of fungal *** also provide information on the ecology and distribu-tion in Mucoromycota and highlight the impact of chytrids on amphibian *** concepts in Chytridiomycota,Aphelidiomycota,Rozellomycota,Neocallimastigomycota are discussed in this *** preserve the current application of the genus Nephridiophaga(Chytridiomycota:Nephridiophagales),a new type species,Nephridiophaga blattellae,is proposed.

关键词： Early-diverging fungi Evolution Nuclear large subunit(LSU/28S) Nuclear small subunit(SSU/18S) Molecular phylogeny

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