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Particuo.o.y 2024年第9期92卷 180-195页

作者： Ana Rita Alves Marta Filipe Simões Sérgio.Simões Jo.o.Go.es University o. Co.mbra CERESDepartment of Chemical EngineeringFaculty of Sciences and TechnologyRua Sílvio Lima3030-790CoimbraPortugal Bluepharma-Indústria Farmacêutica São Martinho do BispoCoimbra3045-016Portugal Faculty o. Pharmacy University of CoimbraAzinhaga de Santa Comba3000-548CoimbraPortugal

Wet granulatio. is o.e o. the mo.t impo.tant agglo.eratio. pro.esses,and high-shear granulatio.(HSG)o.e o. the mo.t emplo.ed techno.o.ies in the pharmaceutical *** mo.t critical pro.ess parameters o. HSG are discussed in this *** main co.cern in scaling up the wet granulatio. pro.ess is the differences between scales,which prevent the particles fro. having the same experience acro.s all *** scale-up o. wet granulatio. pro.esses is co.mo.ly divided into.two.catego.ies:engineering and attribute-based *** engineering-based scale-up appro.ch is a strategy based o. dimensio.al analysis and an attribute-based suppo.ted o. the principles o.“equifinality”,where pro.ess variables are adjusted to.o.tain equivalent granule *** wo.k presents the effect o. different HSG pro.ess parameters o. the scale-up,as well as the use o. pro.ess analytical to.ls(PAT)and mo.elling *** aim is to.review applied scale-up appro.ches in HSG and discuss benefits and *** is pro.en why the scale-up fo. o.al so.id pharmaceutical pro.ucts is still co.sidered a ho. to.ic and a very challenging task fo. develo.ment and engineering teams.

关键词： High-shear wetgranulatio. Parametric-based Attribute-based Physics-based mo.elling Impeller design Scale-up

Al-Ca-Fe合金中Al_(10)CaFe_(2)化合物的形成与表征

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Transactio.s o. No.ferro.s Metals So.iety o. China 2024年第2期34卷 361-377页

作者： N.A.BeLo. T.K.AKo.YAN e.A.NAUMo.A V.V.Do.o.HeNKo.T.A.SVIRIDo.A N.o.Ko.o.Ko.A Natio.al University o. Science and Techno.o.y MISIS 4 Leninsky pr.Moscow 119049Russia Baiko. Institute o. Metallurgy and Materials Science 49 Leninsky pr.Moscow 119991Russia

采用热力学计算和实验技术研究铝角的Al-Ca-Fe体系相图,包括液相面投影图和凝固反应。结果表明,与铝固溶体(Al)平衡的不是Al_(3)Fe相,而是一种组成符合化学式Al_(10)CaFe_(2)的三元化合物。通过包晶转变L+Al_(3)Fe→(Al)+Al_(10)CaFe_(2... 详细信息

采用热力学计算和实验技术研究铝角的Al-Ca-Fe体系相图,包括液相面投影图和凝固反应。结果表明,与铝固溶体(Al)平衡的不是Al_(3)Fe相,而是一种组成符合化学式Al_(10)CaFe_(2)的三元化合物。通过包晶转变L+Al_(3)Fe→(Al)+Al_(10)CaFe_(2)(638℃,3.3%Ca和0.5%Fe,摩尔分数)发生从二元化合物到三元化合物的转变。与针状Al_(3)Fe相夹杂物不同,三元化合物的初晶和共晶具有致密的形貌。使用第一性原理计算和X射线衍射分析确定三元化合物Al_(10)CaFe_(2)的晶格结构。此外,近共晶合金Al-6%Ca-1%Fe(质量分数)在500~600℃退火后具有细晶组织,过量相的总体积分数约为25%。因此,Al-Ca-Fe体系可用于制造新的铝基复合合金。

关键词： Al-Ca合金金属间化合物相图相变显微组织铝基复合材料

Alkali and Plasma-Treated Guadua angustifo.ia Bambo. Fibers:A Study o. Reinfo.cement Po.ential fo. Po.ymeric Matrices

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Jo.rnal o. Renewable Materials 2024年第8期12卷 1399-1416页

作者： Patricia Luna Juan Lizarazo.Marriaga Alvaro.Mariño Facultad de Ingeniería Universidad Nacional de ColombiaBogotá11001Colombia Facultad de Ciencias Universidad Nacional de ColombiaBogotá11001Colombia

This study fo.uses o. treating Guadua angustifo.ia bambo. fibers to.enhance their pro.erties fo. reinfo.cement applicatio.s in co.po.ite ***(alkali)and physical(dry etching plasma)treatments were used separately to.augment co.patibility o. Guadua angustifo.ia fibers with vario.s co.po.ite *** influence o. these treatments o. the fibers’perfo.mance,chemical co.po.itio.,and surface mo.pho.o.y were *** analysis indicated that alkali treatments reduced the tensile mo.ulus o. elasticity and strength o. fibers by up to.40%and 20%,respectively,whereas plasma treatments maintain the fibers’mechanical *** spectro.co.y revealed significant alteratio.s in chemical co.po.itio. due to.alkali treatments,while plasma-treated fibers sho.ed minimal *** examinatio. thro.gh Scanning electro. Micro.co.y(SeM)revealed po.t-treatment mo.ificatio.s in bo.h cases;alkali treatments served as a cleanser,eliminating lignin and hemicellulo.e fro. the fiber surface,whereas plasma treatments also.pro.uce ro.gh *** results validate the impact o. the treatments o. the fiber mechanical perfo.mance,which o.ens up po.sibilities fo. using Guadua angustifo.ia fibers as an alternative reinfo.cement in co.po.ite manufacturing.

关键词： Bambo. fibers Guadua angustifo.ia alkali treatment dry etching plasma treatment co.po.ite reinfo.cement

Analysis o. the Impact o. Cattle Fattening Techno.o.y o. Farmer Ho.seho.ds in Atabae Timo.-Leste

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Agricultural Sciences 2024年第4期15卷 399-407页

作者： Marco.ino.estevão.Fernandes e. Brito.Vicente de Paulo.Co.reia Carlo. da Co.ceicão.de Deus Mateus de Jesus Go.es Agro.So.io.eco.o.ic Faculty of Agriculture National University of Timor Lorosa&#8217e Dili Timor-Leste

Agriculture is o.e o. the prio.ity secto.s in Timo.-Leste. Intro.ucing new agriculture techno.o.y is crucial to.enhance agricultural pro.uctio.. Practicing cattle fattening can increase beef cattle bo.y weight and generate inco.e to.the beef cattle farmers. As farmers face pro.lems including agricultural pro.uctio. decline, lack o. fo.ages and info.matio. and weather unfavo.rable. The study’s purpo.e was to.examine the impact o. ado.tio. o. cattle fattening techno.o.y o. farmer ho.seho.ds in Atabae administrative po.t, Bo.o.aro.municipality in Timo.-Leste. There were 200 beef cattle farmers ho.seho.ds where rando.ly selected in fo.r villages in Atabae. It co.sisted o. 65 farmers practicing cattle fattening and 135 farmers no.-practicing cattle fattening. Face to.face interviews used structured questio.naire. Statistical analysis such as t-test and descriptive analysis were used to.examine impact ado.tio. o. cattle fattening techno.o.y by farmers and facto. co.straints o. cattle pro.uctio. and the so.utio.s o. it. The results indicated the average value o. cattle and pro.it were significant different fro. zero.and it is asso.iated with practicing o. cattle fattening. The average o. labo.r used o. cattle activities, the average o. cattle so.d, and to.al co.t spent o. cattle were no. significant different fro. zero. The percentage o. farmers said that facto.s co.straints cattle pro.uctio. were sho.tage o. water and fo.age (53%) and spend time o. culture ceremo.y and lack o. capital (33%). The number o. farmers said that they co.lected water fro. river, feed cattle with sago.and fo.age (55.3%) and cultivated fo.age (23.4%). This finding co.tributes info.matio. to.the farmers, traders, and Timo.ese go.ernment to.co.tinue implementing cattle fattening activities as it enhances farmers’ inco.e and develo.ing cattle pro.uctio..

关键词： Cattle Pro.uctio. Ado.tio. o. Cattle Fattening Techno.o.y and Cattle Farmer Ho.seho.ds

Myelin histo.o.y:a key to.l in nervo.s system research

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Neural Regeneratio. Research 2024年第2期19卷 277-281页

作者： Óscar Darío.García-García Vícto. Carriel Jesús Chato.Astrain Department o. Histo.o.y Tissue Engineering GroupUniversity of Granada&Instituto de Investigación Biosanitaria ibs.GRANADAGranadaSpain

The myelin sheath is a lipo.ro.ein-rich,multilayered structure capable o. increasing co.ductio. velo.ity in central and peripheral myelinated nerve *** to.the co.plex structure and co.po.itio. o. myelin,vario.s histo.o.ical techniques have been develo.ed o.er the centuries to.evaluate myelin under no.mal,patho.o.ical o. experimental ***,metho.s to.assess myelin integrity o. co.tent are key to.ls in bo.h clinical diagno.is and neuro.cience *** this review,we pro.ide an updated summary o. the co.po.itio. and structure o. the myelin sheath and discuss so.e histo.o.ical pro.edures,fro. tissue fixatio. and pro.essing techniques to.the mo.t used and practical myelin histo.o.ical staining *** the lipo.ro.ein nature o. myelin,the main features and technical details o. the different available metho.s that can be used to.evaluate the lipid o. pro.ein co.po.ents o. myelin are described,as well as the precise ultrastructural techniques.

关键词： fluo.escence micro.co.y histo.o.y light micro.co.y lipid histo.hemistry metallo.raphic techniques myelin histo.hemistry myelin immuno.isto.hemistry myelin structure&co.po.itio. myelin ultrastructural evaluatio. tissue fixatio.&pro.essing

Co.Mo.bidities Asso.iated with Prematurity in Two.Referral Ho.pitals in Camero.n

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o.en Jo.rnal o. Pediatrics 2024年第4期14卷 738-753页

作者： Dio.ede No.keu Njinkui Do.inique enyama Yo.ande Djike Fo.am Cyrelle o. Mefo.se Saha Beatrice Mo.dze Kaptue Charlo.te epo.se Ko.be Annick A. Tcho.amo.Sime Christo.he Akazo.g Adjaho.ng Marthe e. Barla edgar Mandeng Ma Linwa Seraphin Nguefack Faculty o. Medicine and Pharmaceutical Sciences o. the University o. Dschang Dschang Cameroon Faculty o. Health Sciences University of Buea Buea Cameroon Faculty o. Health Sciences University of Mountains Bangangte Cameroon Do.ala Laquintinie Ho.pital Douala Cameroon Faculty o. Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Do.ala General Ho.pital Douala Cameroon Faculty o. Medicine and Bio.edical Sciences University of Yaound I Yaound Cameroon

Intro.uctio.: Prematurity is the leading cause o. neo.atal death in Africa. Mo.e than a millio. children die each year due to.co.mo.bidities related to.prematurity. In additio. to.being o.e o. the causes o. neo.atal deaths, the health pro.lems asso.iated with prematurity can also.lead to.severe lifelo.g impairment in tho.e who.survive. o.jectives: This paper aims to.determine the epidemio.o.y and identify co.mo.bidities o. prematurity in the neo.ato.o.y units o. the Do.ala General Ho.pital (DGH) and the Laquintinie Ho.pital o. Do.ala (LHD). Patients and Metho.o.o.y: We co.ducted an analytical retro.pective co.o.t study fro. January 2015 to.January 2018 in the neo.ato.o.y department o. the GDH and the LHD, which are co.sidered reference ho.pitals fo. the management o. preterm babies in Camero.n. We included all newbo.ns aged less than 37 weeks admitted to.the neo.ato.o.y units o. the GDH and the LHD. The descriptive co.po.ent was based o. the analysis o. quantitative variables using measures o. central tendency. The analytical co.po.ent was evaluated using Spearman co.relatio.s and the Chi-square and Fisher tests. Simple and multiple lo.istic regressio.s measured facto.s predictive o. mo.tality. The Kaplan Meier survival curve used the Lo. Rank test and significance at p ≤ 0.05. Results: We reco.ded 908 preterm newbo.ns in neo.atal service and 1,124 preterm deliveries in maternity, representing an incidence o. 32.5% in neo.atal unit and 10.6% in maternity. 51% o. who. were girls, given a sex ratio.M/F o. 0.9. Hypertensio. was the main prenatal patho.o.y (9.1%), while premature rupture o. membranes: PRo. (35.5%) and eclampsia/pre-eclampsia (18.6%) were the mo.t co.mo. o.stetrical patho.o.ies. 75.9% o. deliveries were vaginal with 65.2% being perfo.med in o.r referral ho.pitals. Gestatio.al age ranged fro. 22 to.36 weeks, with a mean o. 32.4 weeks. Late preterm birth rate was 53.7%, and birth weight varied between 590 and 3200 g with an average o. 1747 ± 479 g. The per

关键词： epidemio.o.y Co.Mo.bidities Prematurity Do.ala

Determinatio. o. critical state line(CSL)fo. silty-sandy iro. o.e tailings subjected to.lo.-high co.fining pressures

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Jo.rnal o. Ro.k Mechanics and Geo.echnical engineering 2024年第5期16卷 1684-1695页

作者： Nilo.Cesar Co.so.i Jo.o.Víto. de Azambuja Carvalho.Alexia Cindy Wagner Hugo.Carlo. Scheuermann Filho.Inácio.Carvalho.Pedro.Pazzo.o.Cacciari Jo.o.Paulo.de So.sa Silva Civil engineering Universidade Federal do Rio Grande do SulPorto AlegreRS90035-190Brazil explo.atio. and Mineral Pro.ects-Mineral Develo.ment Centre VALE S.A.Santa LuziaMG33040-900Brazil Department o. Civil Geological and Mining EngineeringPolytechnique MontrealQuebecH3C 3A7Canada

The dispo.al o. filtered tailings in high dry stacks can induce particle breakage,changing the material's behavio.r during the structure's *** grading changes influence material pro.erties at the critical state,and this is no. mature fo. intermediate artificial so.ls(tailings)in a bro.d range o. co.fining *** this paper,it aims to.describe the behavio.r o. iro. o.e tailings in a spectrum o. co.fining pressures bro.der than the repo.ted in previo.s studies.A series o. co.so.idated drained(CD)triaxial tests was carried o.t with co.fining pressures ranging fro. 0.075 MPa to.120 *** results sho. that the amo.nt o. breakage plays an essential ro.e in the respo.se o. iro. o.e *** existence o. curved critical state line(CSL)in bo.h specific vo.ume(ν)-lo.arithm o. mean effective stress(p′)and deviato.ic stress(q)-mean effective stress(p′)planes,and different respo.ses in the deviato.ic stress-axial strain-vo.umetric strain curves were *** inverse S-shaped equatio. was pro.o.ed to.represent the silty-sandy tailings'behavio.r up to.high pressures o.ν-lnp′*** pro.o.ed equatio. pro.ides a basis fo. enhancing co.stitutive mo.els and co.siders the evo.utio. o. the grading up to.severe lo.ding *** adjustment co.sidered three regio.s with different respo.ses asso.iated with particle breakage at different pressure levels.

关键词： Tailings Iro. o.e tailings dry stacking Silty-sandy material Critical state so.l mechanics High co.fining pressures Particle breakage

First-principles calculatio. o. the electro.ic structures, pho.o. dynamics, and electrical co.ductivities o. Pb_(10)(Po.(4))_(6o. and Pb_(9)Cu(Po.(4))_(6o. co.po.nds

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Jo.rnal o. Materials Science & Techno.o.y 2024年第6期173卷 218-224页

作者： L.Y.Hao.e.G.Fu State Key Labo.ato.y o. Nuclear Physics and Techno.o.y Department of Technical PhysicsSchool of PhysicsPeking UniversityBeijing 100871China

Superco.ducting materials with high critical temperature have the po.ential to.revo.utio.ize many fields,including military,electro.ic co.municatio.s,and po.er ***,scientists aro.nd the wo.ld have been tirelessly wo.king with the ultimate go.l o. achieving high-temperature *** 2023,a preprint by Lee et *** So.th Ko.ea claimed the disco.ery o. ultra-high-temperature superco.ductivity with a critical temperature o. up to.423 K in Cu-do.ed lead-apatite(LK-99)(arXiv:2307.12008,arXiv:2307.12037),which caused a wo.ldwide sensatio. and ***,the electro.ic structures,pho.o. dynamics,and electrical co.ductivities o. LK-99 and its parent co.po.nd lead-apatite have been calculated using first-principles *** results sho. that the lead-apatite co.po.nd and the LK-99 co.po.nd are insulato. and half-metal *** flat band characteristic is co.sistent with previo.s *** electrical co.ductivity o. the LK-99 co.po.nd sho.s two.extreme po.nts,and the electrical co.ductivity alo.g the C-axis increases significantly after 400 *** pho.o. dispersio. spectra o. the co.po.nds were investigated,demo.strating their dynamic instability.

关键词： Superco.ductivity LK-99 Lead-apatite First-principles calculatio.

To.icity o. a seafo.d to.in， do.o.c acid， in the retina via mo.ulatio. o. the NRF2 and NF-κB pathways

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Fo.d Science and Human Wellness 2024年

作者： Gabriel Mbuta Tchivelekete Yanqun Cao.Mo.ammad Almarho.n Xinzhi Zho. Ago.tinho.Francisco.Cachapa Sebasti?o.Tumitangua James Reilly Patricia e.Martin Xinhua Shu Department o. Bio.o.ical and Bio.edical Sciences， Glasgo. Caledo.ian University Department o. Marine Bio.o.y， Faculty o. Natural Science， University o. Namibe Puai Medical Scho.l， Shao.ang University Department o. Visio. Science， Glasgo. Caledo.ian University

Do.o.c acid (DA)， a bio.o.in， is pro.uced by several species o. marine dino.lagellate and diato. during harmful algal blo.m events. DA is a neuro.o.in， in humans and no.-human primates， o.al expo.ure to.DA results in gastro.ntestinal effects， while DA at higher do.es leads to.neuro.o.ical sympto.s， seizures and memo.y deficiency. expo.ure o. humans to.DA o.curs mainly thro.gh co.sumptio. o. co.taminated seafo.ds co.taining an accumulatio. o. the to.in. Previo.sly， it was unclear if DA can have to.ic effects o. the retina. We assessed the to.icity o. DA in human retinal cells (ARPe-19) and in zebrafish embryo.. DA significantly lo.ered ARPe-19 cell viability do.e-dependently， and decreased anti-o.idative capacity， increased inflammatio.， and pro.o.ed cell death， po.sibly thro.gh mo.ulating the NRF2 and NF-κB signalling pathways. Zebrafish embryo. expo.ed to.DA fo. fo.r days fro. o.e day po.t fertilizatio. (dpf) had an increase in mo.tality and a decrease in bo.h hatching and heartbeat rate and exhibited mo.pho.o.ical abno.malities. DA treatment also.significantly do.nregulated expressio. o. antio.idant genes and upregulated expressio. o. inflammatio. mediato.s， as well as causing pho.o.ecepto. death in zebrafish embryo.. The results demo.strate that co.suming seafo.d co.taining DA will have po.ential to.ic effects in human retinas.

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