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却英多吉笔下的罗汉——以丽江市博物馆藏《释迦牟尼与十六罗汉》为例

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西藏艺术研究 2023年第1期 48-58,127页

作者：白玛央金北京大学外国语学院南亚系西藏大学文学院

罗汉画一直以来是汉藏佛教艺术的经典主题。自2003年,却英多吉作品在芝加哥艺术学院公开展出以来,却英多吉(1604—1674)迥异于西藏传统绘画的艺术风格受到了国内外研究西藏艺术史的专家学者的高度关注,尤其是其创作的一套《释迦牟尼与... 详细信息

罗汉画一直以来是汉藏佛教艺术的经典主题。自2003年,却英多吉作品在芝加哥艺术学院公开展出以来,却英多吉(1604—1674)迥异于西藏传统绘画的艺术风格受到了国内外研究西藏艺术史的专家学者的高度关注,尤其是其创作的一套《释迦牟尼与十六罗汉》组画。多年来,国内外已有数位学者围绕这套组画进行了多角度的研究,但多以分析画作整体风格为主,少有以画作主题(罗汉)作为着手的。本文将以“罗汉”这一却英多吉绘画作品中的永恒主题作为切入点,以《释迦牟尼与十六罗汉》组画为例,辅以相关传记资料,通过对汉藏两地传统罗汉画与却英多吉组画中的罗汉形象进行对比,分析却英多吉笔下罗汉形象的特殊之处。

关键词：却英多吉十六罗汉组画罗汉形象

MicroRNA expression in inflammatory bowel disease-associated colorectal cancer

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World Journal of Gastrointestinal Oncology 2021年第9期13卷 995-1016页

作者： Thais Gagno Grillo Ana Elisa Valencise Quaglio Rodrigo Fedatto Beraldo Talles Bazeia Lima Julio Pinheiro baima Luiz Claudio Di stasi Ligia Yukie sassaki Department of Internal Medicine São Paulo State University(Unesp)Medical SchoolBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology São Paulo State University(Unesp)Institute of BiosciencesBotucatu 18618-689São PauloBrazil

MicroRNAs(miRNAs)are non-coding RNA molecules composed of 19–25 nucleotides that regulate gene expression and play a central role in the regulation of several immune-mediated disorders,including inflammatory bowel diseases(IBD).IBD,represented by ulcerative colitis and Crohn’s disease,is characterized by chronic intestinal inflammation associated with an increased risk of colorectal cancer(CRC).CRC is one of the most prevalent tumors in the world,and its main risk factors are obesity,physical inactivity,smoking,alcoholism,advanced age,and some eating habits,in addition to chronic intestinal inflammatory processes and the use of immunosuppressants administered to IBD *** studies have identified miRNAs associated with an increased risk of developing CRC in this *** identification of miRNAs involved in this tumorigenic process could be useful to stratify cancer risk development for patients with IBD and to monitor and assess ***,the present review aimed to summarize the role of miRNAs as biomarkers for the diagnosis and prognosis of IBD-associated *** the future,therapies based on miRNA modulation could be used both in clinical practice to achieve remission of the disease and restore the quality of life for patients with IBD,and to identify the patients with IBD at high risk for tumor development.

关键词： MicroRNA Colorectal cancer Inflammatory bowel disease Crohn's disease Ulcerative colitis Cancer Diagnosis Prognosis Targets

Treatment of acute severe ulcerative colitis using accelerated infliximab regimen based on infliximab trough level:A case report

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World Journal of Clinical Cases 2021年第13期9卷 3219-3226页

作者： Ana Lorena sousa de Vasconcelos Garate Thiara Barcelos Rocha Luciana Rocha Almeida Rodrigo Quera Jaqueline Ribeiro Barros Julio Pinheiro baima Rogerio saad-Hossne Ligia Yukie sassaki Department of Internal Medicine São Paulo State University(Unesp)Medical SchoolBotucatu 18618687São PauloBrazil Inflammatory Bowel Disease Program GastroenterologyMedicine DepartmentClínica Universidad de los AndesSantiago 7550000Chile

BACKGROUND Acute severe ulcerative colitis (AsUC) is a complication of ulcerative colitisassociated with high levels of circulating tumor necrosis factor alpha, due to theintense inflammation and faster stool clearance of anti-tumor necrosis factordrugs. Dose-intensified infliximab treatment can be beneficial and is associatedwith lower rates of colectomy. The aim of the study was to present a case of apatient with AsUC and megacolon, treated with hydrocortisone and acceleratedscheme of infliximab that was monitored by drug trough *** sUMMARYA 22-year-old female patient diagnosed with ulcerative colitis, presented withdiarrhea, rectal bleeding, abdominal pain, vomiting, and distended *** investigation, a positive toxin for Clostridium difficile and colonic dilatationof 7 cm consistent with megacolon were observed. she was treated with oralvancomycin for pseudomembranous colitis and intravenous hydrocortisone forsevere colitis, which led to the resolution of megacolon. Due to the persistentsevere colitis symptoms, infliximab 5 mg/kg was prescribed, monitored by drugtrough level (8.8 μg/mL) and fecal calprotectin of 921 μg/g (sed onthe low infliximab trough level after one week from the first infliximab dose, thepatient received a second infusion at week 1, consistent with the acceleratedregimen (infusions at weeks 0, 1, 2 and 6). We achieved a positive clinical andendoscopic response after 6 mo of therapy, without the need for a *** accelerated infusions can be beneficial in AsUC unresponsive to thetreatment with intravenous corticosteroids. Longitudinal studies are necessary todefine the best therapeutic drug monitoring and treatment regimen for thesepatients.

关键词： Infliximab Acute severe ulcerative colitis Toxic megacolon Ulcerative colitis Inflammatory bowel disease Case report

中国固体废物中镉检测能力现状与检测方法分析

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中国环境监测 2023年第3期39卷 32-40页

作者：白玛旺堆吴晓凤齐炜红吕怡兵西藏自治区生态环境监测中心西藏拉萨850000 中国环境监测总站国家环境保护环境监测质量控制重点实验室北京100012 邯郸市环境监控中心河北邯郸056002

2020年9月,新修订的《固体废物污染环境防治法》正式生效,固体废物污染防治相关制度进一步完善。为了解和掌握国内环境检测实验室固体废物检测能力水平,为环境管理部门提供客观准确的数据支撑,该研究组织了31个省(自治区、直辖市)各级... 详细信息

2020年9月,新修订的《固体废物污染环境防治法》正式生效,固体废物污染防治相关制度进一步完善。为了解和掌握国内环境检测实验室固体废物检测能力水平,为环境管理部门提供客观准确的数据支撑,该研究组织了31个省(自治区、直辖市)各级各类生态环境检验检测机构共计368家实验室开展了固体废物中镉实验室间比对研究,利用稳健统计技术统计分析比对结果。结果显示:省级站、地市级以上站和社会化检测机构检测合格率分别为97.0%、89.8%、81.0%,整体合格率为87.5%,表明目前国内环境监测领域各级各类实验室固体废物中镉的整体检测能力较好。对实验室使用的检测方法进行分析比较,结果表明使用电感耦合等离子体质谱法的比对结果合格率最高(96.0%),其次为石墨炉原子吸收法(84.4%)、电感耦合等离子体法(83.9%),而火焰原子吸收法的合格率仅为57.9%,建议实验室应慎重选择使用火焰原子吸收法检测固体废物中低浓度的镉。

关键词：固体废物中镉实验室比对检测能力检测方法

血清IgG唾液酸化修饰在肝棘球蚴病诊断中的应用研究

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中国寄生虫学与寄生虫病杂志 2023年第4期41卷 434-439,445页

作者：封晓晓白玛央金张颋陆豪杰魏黎明西藏自治区疾病预防控制中心国家卫生健康委员会棘球蚴病预防控制重点实验室拉萨850000 复旦大学生物医学研究院化学系&国家卫生健康委糖复合物研究重点实验室上海200032 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心) 国家卫生健康委员会寄生虫病原与媒介生物学重点实验室(中国疾病预防控制中心寄生虫病预防控制所)上海200025

目的探索血清IgG唾液酸化修饰在肝棘球蚴病诊断及鉴别中的应用价值。方法采集西藏自治区、甘肃省、四川省、青海省2014—2016年的98例肝细粒棘球蚴病患者和29例肝多房棘球蚴病患者血样,广西医科大学附属医院2017年1—12月的30例肝癌住... 详细信息

目的探索血清IgG唾液酸化修饰在肝棘球蚴病诊断及鉴别中的应用价值。方法采集西藏自治区、甘肃省、四川省、青海省2014—2016年的98例肝细粒棘球蚴病患者和29例肝多房棘球蚴病患者血样,广西医科大学附属医院2017年1—12月的30例肝癌住院患者血样,广西医科大学体检科22份健康体检者血样。提取各组血样的血清,每份50μl,采用基于荧光色谱的糖组学技术对血清中IgG的唾液酸化修饰进行定量分析。使用Protein G琼脂糖纯化试剂盒分离纯化血清中的IgG。取50μg纯化后的IgG样品,在25 mmol/L二硫苏糖醇溶液和50 mmol/L碘乙酰胺溶液中进行还原烷基化反应后加入1μl N‑糖苷酶缓冲液,酶解后采用石墨化碳小柱进行糖链的富集并将其冷冻干燥后溶于二甲基亚砜和冰醋酸的7∶3(v/v)混合溶液中,快速加入5 mmol/L的2‑氨基苯酰胺溶液和10 mmol/L氰基硼氢化钠溶液各50μl,反应2 h后,使用石墨碳小柱纯化。将标记后的糖链在Waters Acquity UPLC(H‑Class)系统上进行亲水色谱柱分离,荧光检测器设置的激发和发射波长分别为330 nm和420 nm,分析样品的单唾液酸化修饰、双唾液酸化修饰以及总唾液酸化修饰。采用Empower 3软件进行数据收集和处理,sPss 25进行数据统计分析,数据的比较采用D’Agostino&Pearson omnibus正态分布检验(P1值)与单因素方差分析检验(P2值),两两之间的比较采用Tukey’s multiple comparisons test分析(P3值)。结果IgG糖链的色谱图共检测到21个IgG糖链峰,其中单唾液酸化修饰糖链5种,分别为FA2BG1s1(17.79 min)、A2G2s1(19.02 min)、A2BG2s1(20.02 min)、FA2G2s1(20.27 min)和FA2BG2s1(21.13 min);双唾液酸化修饰糖链4种,分别为A2G2s2(22.70 min)、A2BG2s2(23.29 min)、FA2G2s2(23.78 min)和FA2BG2s2(24.26 min)。各组血清样品各类唾液酸化修饰的含量均具有正态分布特性(P1>0.1)。肝细粒棘球蚴病组、肝多房棘球蚴病组血清IgG单唾液酸化修饰含量分别为(14.15±2.89)%和(10.24±2.97)%,双唾液酸化修饰含量分别为(3.02±0.98)%和(1.92±0.65)%,总唾液酸化修饰含量分别为(17.25±3.69)%和(12.27±3.65)%,均低于健康对照组的(16.55±2.95)%、(3.71±1.04)%和(20.26±3.79)%(F=23.70、11.14、22.98,均P2<0.0001)。其中肝细粒棘球蚴病组与肝多房棘球蚴病组相比,单唾液酸化修饰、双唾液酸化修饰和总唾液酸化修饰含量差异有统计学意义(t=6.352、4.701、6.392,P3<0.0001)。利用受试者工作曲线(ROC)进行了IgG唾液酸化修饰潜在诊断性能的评估,肝细粒棘球蚴病组与肝多房棘球蚴病组间AUC为0.829(95%CI:0.738~0.921),灵敏度和特异性分别为82.7%和87.7%。肝癌组的血清IgG的单唾液酸化修饰、双唾液酸化修饰和总唾液酸化修饰含量分别为(15.09±2.68)%、(3.28±1.30)%和(18.37±3.69)%,与肝多房棘球蚴病组的差异有统计学意义(t=6.587、4.318、6.372,P3<0.0001),肝多房棘球蚴病组和肝癌组间IgG总唾液酸化修饰ROC的AUC为0.881(95%CI:0.793~0.963),灵敏度和特异性分别为86.7%和93.1%。结论本研究发现了血清IgG唾液酸化修饰可能与肝棘球蚴病的发病机制有关,在肝棘球蚴病诊断,肝细粒棘球蚴病与肝多房棘球蚴病、肝癌与肝多房棘球蚴病的鉴别研究中具有一定的应用价值。

关键词：棘球蚴病糖组学技术唾液酸化修饰

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Heart failure as an adverse effect of infliximab for Crohn's disease: A case report and review of the literature

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World Journal of Clinical Cases 2021年第33期9卷 10382-10391页

作者： Thais Gagno Grillo Luciana Rocha Almeida Rodrigo Fedatto Beraldo Mariana Barros Marcondes Diego Aparecido Rios Queiróz Daniel Luiz da silva Rodrigo Quera Julio Pinheiro baima Rogerio saad-Hossne Ligia Yukie sassaki Department of Internal Medicine São Paulo State University(Unesp)Medical SchoolBotucatu 18618687São PauloBrazil Department of Pathology São Paulo State University(Unesp)Medical SchoolBotucatu 18618687São PauloBrazil Inflammatory Bowel Disease Program Digestive Disease Center Clínica Universidad de los AndesSantiago 7550000Chile

BACKGROUND Anti-tumor necrosis factor agents were the first biologic therapy approved for the management of Crohn's disease(CD).Heart failure(HF)is a rare but potential adverse effect of these *** objective of this report is to describe a patient with CD who developed HF after the use of *** sUMMARY A 50-year-old woman with a history of hypertension and diabetes presented with abdominal pain,diarrhea,and weight *** and enterotomography showed ulcerations,areas of stenosis and dilation in the terminal ileum,and thickening of the intestinal *** patient underwent ileocolectomy and the surgical specimen confirmed the diagnosis of stenosing *** patient started infliximab and azathioprine treatment to prevent post-surgical *** 6 mo after initiating infliximab therapy,the patient complained of dyspnea,orthopnea,and paroxysmal nocturnal dyspnea that gradually *** revealed biventricular dysfunction,moderate cardiac insufficiency,an ejection fraction of 36%,and moderate pericardial effusion,consistent with *** cardiac disease was considered an infliximab adverse effect and the drug was *** patient received treatment with diuretics for HF and showed improvement of symptoms and cardiac ***,the patient is using anti-interleukin for CD and is *** This reported case supports the need to investigate risk factors for HF in inflammatory bowel disease patients and to consider the risk-benefit of introducing infliximab therapy in such patients presenting with HF risk factors.

关键词： Heart failure Infliximab Anti-tumor necrosis factor therapy Crohn's disease Inflammatory bowel disease Case report

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复发性多软骨炎诊疗规范

中华内科杂志 2022年第5期61卷 525-530页

作者：徐健王丹丹石桂秀白玛央金张烜赵岩昆明医科大学第一附属医院风湿免疫科昆明650032 南京大学医学院附属鼓楼医院风湿免疫科南京210008 厦门大学附属第一医院风湿免疫科厦门361000 西藏自治区人民医院风湿免疫科拉萨850000 北京医院国家老年医学中心国家老年疾病临床医学研究中心中国医学科学院临床免疫中心北京100730 中国医学科学院北京协和医学院北京协和医院风湿免疫科国家皮肤与免疫疾病临床医学研究中心疑难重症及罕见病国家重点实验室风湿免疫病学教育部重点实验室北京100730

复发性多软骨炎(RP)是一种免疫介导的全身炎症性疾病,主要累及软骨及富含蛋白聚糖成分的组织,特征性表现为耳和鼻软骨炎症、畸形。为提高临床医生对RP的认识和诊疗水平,中华医学会风湿病学分会在借鉴目前国内外经验和指南的基础上,制定... 详细信息

复发性多软骨炎(RP)是一种免疫介导的全身炎症性疾病,主要累及软骨及富含蛋白聚糖成分的组织,特征性表现为耳和鼻软骨炎症、畸形。为提高临床医生对RP的认识和诊疗水平,中华医学会风湿病学分会在借鉴目前国内外经验和指南的基础上,制定了本规范,总结了RP的临床表现、诊断及疾病活动评估,旨在规范RP临床治疗方案,改善RP患者预后。

关键词：多软骨炎,复发性诊断治疗

Two-year measurements of surface ozone at Dangxiong, a remote highland site in TibetanPlateau, China

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Two-year measurements of surface ozone at Dangxiong, a remot...

1981-2010年西藏霜冻日数的变化特征

创新驱动发展提高气象灾害防御能力——第30届中国气象学会年会

作者： Lin Weili Xu Xiaobin Zheng Xiangdong Jaxi Dawa Ciren baima Zhang Jiushan Centre for Atmosphere Watch & services Meteorological Observation Centre China Meteorological Administration Key Laboratory for Atmospheric Chemistry Chinese Academy of Meteorological Sciences China Meteorological Administration Dangxiong Meteorological Bureau Lhasa Meteorological Bureau

We present a two-year measurement results of surface ozone at Dangxiong (30.48 o N, 91.10 o E, 4187m), a remote highland site in a southern valley of Nyainqêntanglha Mountains, Tibetan Plateau, China. The monthly mean ozone mixing ratios range 29.1-59.4 ppbv with a mean value plus or minus standard deviation of 38.5±7.5 ppbv. If only are the data for12:00-17:00 local time considered, the monthly mean ozone mixing ratios are 37.5-63.5 ppbv with a mean value plus or minus standard deviation of 49.8±7.8 ppbv. The maximum ozone value is found to occur in May, in accordance with the spring ozone maximum phenomenon in the Northern Hemisphere. The average diurnal cycle of O3 concentration shows the minima in the early morning and the maxima in the afternoon. The O3 mixing ratio maintained an high and flat level for hours from the late morning to the afternoon, which is very consistent with the variation of surface wind velocity. Ozone increases with an increase of wind speed at relatively low wind speed and it keeps much smooth when the wind speed increases above a level (about 2.5 m/s in cold months and 3.0 m/s in warm months). The significant correlation of surface ozone with the column ozone from satellite data, along with the very similar day-to-day and week-to-week temporal fluctuations of surface ozone with those measured at another site in the northern side of Nyainqêntanglha Mountains, suggests a good regional representativeness of surface ozone observed at Dangxiong. The characteristics of air in the afternoon are strong wind, higher ozone, lower CO and lower relative humidity (RH), being the distinct features of the free atmosphere. The significant negative correlations of O3 -CO and O3 -RH in most months indicate a significant influence of air masses from the upper troposphere and lower stratosphere. 5-day backward trajectory analysis shows that air masses coming from the south of the site have a negative contribution to surface ozone, humidity and a positive co

关键词： surface ozone Tibetan Plateau Background atmosphere Diurnal ozone cycles seasonal ozone cycles

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地理学报 2014年第5期69卷 690-696页

作者：拉巴次仁索朗加措白玛西藏自治区气象信息与网络中心拉萨850001

利用西藏38个气象站点1981-2010年的逐日最低气温资料，采用气候倾向率、累积距平、信噪比和R／s分析等气候统计方法，分析了霜冻日数的年际、年代际、异常、突变等气候变化特征。结果表明：西藏霜冻日数都表现为不同程度的减少趋势，... 详细信息

利用西藏38个气象站点1981-2010年的逐日最低气温资料，采用气候倾向率、累积距平、信噪比和R／s分析等气候统计方法，分析了霜冻日数的年际、年代际、异常、突变等气候变化特征。结果表明：西藏霜冻日数都表现为不同程度的减少趋势，减幅为3．3～14．6d／10a（37个站P〈0．01）；随着海拔高度的升高，霜冻日数减幅在增大。在10a年际变化尺度上，大部分站点霜冻日数20世纪80年代为正距平、21世纪初为负距平；90年代霜冻日数以正距平居多。有8个站点霜冻日数存在突变点，发生在20世纪90年代，以1997年居多。特多霜冻日数发生频数为0～3次，多发生在20世纪80年代；特少霜冻日数频数介于0-4次，以21世纪初居多。特多霜冻日数发生频次与经度、纬度和海拔高度的关系不密切，而特少霜冻日数发生频次与海拔高度呈极显著的负相关。

关键词：霜冻日数年际和年代际变化异常突变西藏