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Brain physiome:A concept bridging in vitro 3D brain models and in silico models for predicting drug toxicity in the brain

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Bioactive Materials 2022年第7期7卷 135-148页

作者： Yoojin Seo Seokyoung Bang jeongtae son Dongsup Kim Yong Jeong Pilnam Kim Jihun Yang Joon-Ho Eom Nakwon Choi Hong Nam Kim Brain Science Institute Korea Institute of Science and Technology(KIST)Seoul02792Republic of Korea Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon34141Republic of Korea Next&Bio Inc. Seoul02841Republic of Korea Medical Device Research Division National Institute of Food and Drug Safety EvaluationCheongju28159Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea School of Mechanical Engineering Yonsei UniversitySeoul03722Republic of Korea Yonsei-KIST Convergence Research Institute Yonsei UniversitySeoul03722Republic of Korea

In the last few decades,adverse reactions to pharmaceuticals have been evaluated using 2D in vitro models and animal ***,with increasing computational power,and as the key drivers of cellular behavior have been identified,in silico models have *** models are time-efficient and cost-effective,but the prediction of adverse reactions to unknown drugs using these models requires relevant experimental ***,the physiome concept has emerged to bridge experimental datasets with in silico *** brain physiome describes the systemic interactions of its components,which are organized into a multilevel *** of the limitations in obtaining experimental data corresponding to each physiome component from 2D in vitro models and animal models,3D in vitro brain models,including brain organoids and brain-on-a-chip,have been *** this review,we present the concept of the brain physiome and its hierarchical organization,including cell-and tissue-level *** also summarize recently developed 3D in vitro brain models and link them with the elements of the brain physiome as a guideline for dataset *** connection between in vitro 3D brain models and in silico modeling will lead to the establishment of cost-effective and time-efficient in silico models for the prediction of the safety of unknown drugs.

关键词： Brain physiome In vitro 3D platform Brain organoid Brain-on-a-chip In silico model

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