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Delivery of nitric oxide-releasing silica nanoparticles for in vivo revascularization and functional recovery after acute peripheral nerve crush injury

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Neural Regeneration Research 2022年第9期17卷 2043-2049页

作者： Jung Il lee Ji Hun Park Yeong-Rim Kim Kihak Gwon Hae Won Hwang Gayoung Jung Joo-Yup lee jeong-Yun Sun Jong Woong Park Jae Ho Shin Myoung-Ryul ok Department of Orthopedic Surgery College of MedicineKorea UniversitySeoulRepublic of Korea Medical Sensor Biomaterial Research Institute Kwangwoon UniversitySeoulRepublic of Korea Center for Biomaterials Korea Institute of Science&TechnologySeoulRepublic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea Department of Orthopedic Surgery College of MedicineCatholic UniversitySeoulRepublic of Korea Department of Chemistry Kwangwoon UniversitySeoulRepublic of Korea

Nitric oxide(NO)has been shown to promote revascularization and nerve regeneration after peripheral nerve ***,in vivo application of NO remains challenging due to the lack of stable carrier materials capable of storing large amounts of NO molecules and releasing them on a clinically meaningful time ***,a silica nanoparticle system capable of reversible NO storage and release at a controlled and sustained rate was *** this study,NO-releasing silica nanoparticles(NO-SNs)were delivered to the peripheral nerves in rats after acute crush injury,mixed with natural hydrogel,to ensure the effective application of NO to the *** using a polymer dye and immunohistochemical staining for the detection of CD34(a marker for revascularization)results showed that NO-releasing silica nanoparticles increased revascularization at the crush site of the sciatic *** sciatic functional index revealed that there was a significant improvement in sciatic nerve function in NO-treated *** and anatomical analyses showed that the number of myelinated axons in the crushed sciatic nerve and wet muscle weight excised from NO-treated rats were ***,muscle function recovery was improved in rats treated with *** together,our results suggest that NO delivered to the injured sciatic nerve triggers enhanced revascularization at the lesion in the early phase after crushing injury,thereby promoting axonal regeneration and improving functional recovery.

关键词： crush injury nerve injury,nerve regeneration nitric oxide peripheral nerve revascularization silica nanoparticles

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Evaluation of Heavy Rainfall Model Forecasts over the Korean Peninsula Using Different Physical Parameterization Schemes and Horizontal Resolution

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Advances in Atmospheric Sciences 2011年第6期28卷 1233-1245页

作者： jeong-Gyun PARK Dong-Kyou lee Atmospheric Sciences Program School of Earth and Environmental Sciences Seoul National University Seoul 151-747 Korea

In this study, the accuracy of a Pennsylvania State University–National Center for Atmospheric Research mesoscale model （PSU/NCAR MM5） for predicting heavy summer precipitation over the Korean Peninsula was investigated. A total of 1800 simulations were performed using this model for 30 heavy rainfall events employing four cumulus parameterization schemes （CPS）, two grid-scale resolvable precipitation schemes （GRS）, and two planetary boundary layer （PBL） schemes in three model resolutions （90 km, 30 km, and 10 km）. The heavy rainfall events were mesoscale convective systems developed under the influence of mid-latitude baroclinic systems with low-level moisture transport from the ocean. The predictive accuracy for maximum rainfall was approximately 80% for 10-km resolution and was 60% for 30-km resolution. The predictive accuracy for rainfall position extended to ～150 km from the observed position for both resolutions. Simulated rainfall was most sensitive to CPS, then to PBL schemes, and then to GRS. In general, the Grell （GR） scheme and the Anthes and Kuo （AK） scheme showed a better prediction capability for heavy rainfall than did the Betts-Miller （BM） scheme and the Kain-Fritsch （KF） scheme. The GR scheme also performed well in the 24-h and 12-h precipitation predictions： the parameterized convective rainfall in GR is directly related to synoptic-scale forcing. The models without CPS performed better for rainfall amounts but worse for rainfall position than those with CPS. The MM5 model demonstrated substantial predictive capacity using synoptic-scale initial conditions and lateral boundary data because heavy summer rainfall in Korea occurs in a strong synoptic-scale environment.

关键词： heavy rainfall mesoscale convection mesoscale model evaluation convective parameterization

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A Delayed Stochastic Volatility Correction to the Constant Elasticity of Variance Model

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Acta Mathematicae Applicatae Sinica 2016年第3期32卷 611-622页

作者： Min-Ku lee jeong-Hoon KIM Department of Mathematics Kunsan National University Department of Mathematics Yonsei University

The Black-Scholes model does not account non-Markovian property and volatility smile or skew although asset price might depend on the past movement of the asset price and real market data can find a non-flat structure of the implied volatility surface. So, in this paper, we formulate an underlying asset model by adding a delayed structure to the constant elasticity of variance （CEV） model that is one of renowned alternative models resolving the geometric issue. However, it is still one factor volatility model which usually does not capture full dynamics of the volatility showing discrepancy between its predicted price and market price for certain range of options. Based on this observation we combine a stochastic volatility factor with the delayed CEV structure and develop a delayed hybrid model of stochastic and local volatilities. Using both a martingale approach and a singular perturbation method, we demonstrate the delayed CEV correction effects on the European vanilla option price under this hybrid volatility model as a direct extension of our previous work [12].

关键词： constant elasticity variance , delay stochastic volatility martingale option pricing

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Prediction of Monthly Mean Surface Air Temperature in a Region of China

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Advances in Atmospheric Sciences 2007年第3期24卷 503-508页

作者： jeong-Hyeong lee Keon-Tae SOHN Division of Management Information Science Dong-A University Busan 604-714Korea Department of Statistics Pusan National University Busan 609-735Korea

In conventional time series analysis, a process is often modeled as three additive components： linear trend, seasonal effect, and random noise. In this paper, we perform an analysis of surface air temperature in a region of China using a decomposition method in time series analysis. Applications to the National Centers for Environmental Prediction/the National Center for Atmospheric Research （NCEP/NCAR） Collaborative Reanalysis data in this region of China are discussed. The main finding was that the surface air temperature trend estimated for January 1948 to February 2006 was not statistically significant at 0.5904℃ （100 yr）^-1. Forecasting aspects are also considered.

关键词： Chinese region surface air temperature time series decomposition method regression

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Mismatching between nest volume and clutch volume reduces egg survival and fledgling success in black-tailed gulls

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Current Zoology 2016年第5期62卷 451-456页

作者： Who-Seung lee jeong-Chil Yoo Korea Institute of Ornithology and Department of Biology Kyung Hee University Seoul 02447 Korea Center for Stock Assessment Research University of California Santa Cruz Santa Cruz CA 95080 USA

A longstanding suggestion posits that parents prefer to match nest volume and clutch size （clutch volume）, but few studies have tested this in colonial seabirds that nest in the open. Here, we demonstrate the effects of nest-clutch volume matching on egg survival, hatching, and fledgling success in black-tailed gulls Larus crassirostris on Hongdo Island, Korea. We show that the volume mismatch, defined as the difference between nest volume and total egg volume （the sum of all eggs＇ volume in the clutch）, was positively related to egg and chick mortality caused by predation, but was not significantly related to hatching success incurred by insulation during the incubation period. Although nest volume was negatively related to laying date, we found that the mismatch was positively related to laying date. Our results support the claim that well-matched nest-clutch volume may contribute to survival of eggs and chicks, and ultimately breeding success.

关键词： black-tailed gulls clutch size egg survival fledgling success nest volume.

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Risk of ischaemic stroke in patients with transient global amnesia: a propensity-matched cohort study

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Stroke & Vascular Neurology 2022年第2期7卷 101-107页

作者： Sang Hun lee Keon-Yeup Kim jeong-Woo lee So-jeong Park Jin-Man Jung Department of Neurology Korea University Ansan HospitalKorea University College of MedicineAnsanRepublic of Korea Data Science Team Hanmi Pharm.Co.LtdSeoulRepublic of Korea Korea University Zebrafish Translational Medical Research Center AnsanRepublic of Korea

Background The exact pathophysiological mechanism of transient global amnesia(TGA)is *** is debatable whether TGA is a risk factor for ***,here we investigated the possibility of TGA as a risk factor for stroke in a real-world setting using large-scale nationwide health claims *** We used health claims data from the Korean National Health Insurance Service(NHIS).Patients diagnosed with TGA between 2007 and 2013 were *** initially extracted patients without TGA who were preferentially matched for age and sex with the patients with TGA at a ratio of 10:1 from the whole ***,we performed 1:2 propensity score matching analysis to balance the baseline characteristics between the two *** the propensity score-matched dataset,we performed multivariable Cox regression analysis to investigate the association between TGA and stroke type,including ischaemic,haemorrhagic and all stroke *** Patients with TGA(n=14673)were selected from the NHIS *** extracting from the whole database(n=140486)and propensity score matching their data at a 1:2 ratio,a total of 10448 and 20442 patients were finally assigned to the TGA and control groups,*** multivariable Cox regression analysis demonstrated that the TGA group had a higher risk of ischaemic stroke and all types of stroke(adjusted HR=1.194;95%CI:1.043 to 1.368;and HR=1.197;95%CI:1.056 to 1.357,respectively).Conclusions Analysis of the nationwide claims database showed that TGA could be an important risk factor for stroke,especially for ischaemic stroke.

关键词： patients matched transient

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Parameterization and Application of Storm Surge/Tide Modeling Using a Genetic Algorithm for Typhoon Periods

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Advances in Atmospheric Sciences 2011年第5期28卷 1067-1076页

作者： Sung Hyup YOU Yong Hee lee Woo jeong lee Marine Meteorology Division Observation Infrastructure Bureau/KMA Korea Forecast Research Laboratory National Institute of Meteorological Research/KMA Korea Global Environment System Research Laboratory National Institute of Meteorological Research/KMA Korea

A genetic algorithm was used to optimize the parameters of the two-dimensional Storm Surge/Tide Operational Model （STORM） to improve sea level *** genetic algorithm was applied to nine typhoons that affected the Korean Peninsula during *** following model parameters were used：the bottom drag coefficient,the background horizontal diffusivity,Smagorinski＇s horizontal viscosity,and the sea level pressure ***,the simulation results using the optimized,mean,and median parameter values improved sea level *** four estimated parameters improved the sea level prediction by 76% and 54% in the bias and root mean square error for Typhoon Kalmaegi （0807） in 2008,***-month simulations of February and August 2008 were also improved using the estimated *** study demonstrates that parameter optimization on STORM can improve sea level prediction.

关键词： genetic algorithm STORM sea level typhoon

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Effects of TiC on the microstructure refinement and mechanical property enhancement of additive manufactured Inconel 625/TiC metal matrix composites fabricated with novel core-shell composite powder

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Journal of Materials Science & Technology 2023年第33期164卷 13-26页

作者： Taegyu lee Wonjong jeong SeungHyeok Chung Ho Jin Ryu Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyYu Seong-GuDae Hak-Ro 29134141 DaejeonRepublic of Korea Department of Nuclear and Quantum Engineering Korea Advanced Institute of Science and TechnologyYu Seong-GuDae Hak-Ro 29134141 DaejeonRepublic of Korea

The flexible product shape of additive manufacturing(AM)is attractive,but the process suffers from a lack of material property diversity due to a limited number of printable alloys and post-processing *** overcome this problem,the AM of metal matrix composites(MMCs)is a highly suitable solution because the properties of MMC can be tailored using various ***,extensive research has been conducted on the AM of MMCs;however,the major huddle for this process has been the difficulties in preparing feedstock powder and operating the AM *** study introduces an easily synthesizable core-shell composite powder,which was fabricated by a recently developed process called the SMART *** core-shell powder has a novel morphology,consisting of a metal core and composite shell,distinguishing it from the powders used in conventional AM *** 625/TiCp composites were fabricated using the core-shell composite powder,with various fractions of TiCp up to 10 vol.%.Compared to additive-manufactured Inconel 625,the additive-manufactured MMCs showed enhanced strength with significantly fewer *** results of this study may accelerate the application of MMC fabricated by AM,which offers superior properties and reliability compared to casting and powder metallurgy due to the higher degree of dislocation density and reinforcement dispersion.

关键词： Powder treatment Composite powder Metal matrix composite Additive manufacturing Nickel-based superalloy Directed energy deposition

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Improved Photoresponse of UV Photodetectors by the Incorporation of Plasmonic Nanoparticles on Ga N Through the Resonant Coupling of Localized Surface Plasmon Resonance

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Nano-Micro Letters 2020年第7期12卷 175-190页

作者： Sundar Kunwar Sanchaya Pandit Jae-Hun jeong Jihoon lee Department of Electronic Engineering College of Electronics and InformationKwangwoon University

Very small metallic nanostructures,i.e.,plasmonic nanoparticles(NPs),can demonstrate the localized surface plasmon resonance(LSPR)e ect,a characteristic of the strong light absorption,scattering and localized electromagnetic field via the collective oscillation of surface electrons upon on the excitation by the incident *** LSPR of plasmonic NPs can significantly improve the photoresponse of the *** this work,significantly enhanced photoresponse of UV photodetectors is demonstrated by the incorporation of various plasmonic NPs in the detector *** size and elemental composition of monometallic Ag and Au NPs,as well as bimetallic alloy Ag Au NPs,are fabricated on Ga N(0001)by the solid-state dewetting *** photoresponse of various NPs are tailored based on the geometric and elemental evolution of NPs,resulting in the highly enhanced photoresponsivity of 112 A W-1,detectivity of 2.4×1012 Jones and external quantum e ciency of 3.6×104%with the high Ag percentage of Ag Au alloy NPs at a low bias of 0.1 *** Ag Au alloy NP detector also demonstrates a fast photoresponse with the relatively short rise and fall time of less than 160 and 630 ms,*** improved photoresponse with the Ag Au alloy NPs is correlated with the simultaneous e ect of strong plasmon absorption and scattering,increased injection of hot electrons into the Ga N conduction band and reduced barrier height at the alloy NPs/Ga N interface.

关键词： UV photodetection NP-based photodetectors Nanoparticles Plasmonic enhancement

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Inhibition of poly(ADP-Ribose)polymerase:A promising strategy targeting pancreatic cancer with BRCAness phenotype

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World Journal of Gastrointestinal Oncology 2021年第11期13卷 1544-1550页

作者： Keun-Yeong jeong Haejun lee R&D Center Metimedi PharmaceuticalsIncheon 22006South Korea Department of Nuclear Medicine Gil Medical CenterIncheon 21565South Korea

The use of chemotherapeutic regimens for the treatment of pancreatic cancer is still limited because pancreatic cancer is usually diagnosed at an advanced stage as a refractory disease in which symptoms are difficult to recognize in the early ***,at advanced stages,there are important challenges to achieve clinical benefit and symptom resolution,even with the use of an expanded spectrum of anticancer ***,a point of reduced susceptibility to conventional chemotherapies by breast cancer susceptibility gene(BRCA)mutations led to a new perspective for overcoming the resistance of pancreatic cancer within the framework of increased genome ***(ADP-Ribose)polymerase(PARP)-1 is an enzyme that can regulate intrinsic functions,such as response to DNA ***,in an environment where germline mutations in BRCAs(BRCAness)inhibit homologous recombination in DNA damage,resulting in a lack of DNA damage response,a key role of PARP-1 for the adaptation of the genome instability could be further ***,we summarized the key functional role of PARP-1 in genomic instability of pancreatic cancer with the BRCAness phenotype and listed clinical applications and outcomes of PARP-1 inhibitors to highlight the importance of targeting PARP-1 activity.

关键词： Pancreatic cancer BRCAness Poly(ADP-Ribose)polymerase-1 PARylation Poly(ADP-Ribose)polymerase-1 inhibitor

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