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Identification of Aristolactam Derivatives That Act as Inhibitors of Human Immunodeficiency Virus Type 1 Infection and Replication by Targeting Tat-Mediated Viral Transcription

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Virologica Sinica 2021年第2期36卷 254-263页

作者： Young Hyun Shin Chul min Park Hong Gi Kim Dong-Eun Kim min Suk Choi jeong-ah Kim Byeong-Sun Choi Cheol-Hee Yoon Division of Viral Disease Research Center for Infectious Disease ResearchKorea National Institute of HealthHeungdeok-guCheongju-siShungbuk 28159Republic of Korea Center for Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyYuseong-guDaejeon 34114Republic of Korea

Despite the success of antiretroviral therapy(ART),efforts to develop new classes of antiviral agents have been hampered by the emergence of drug ***-indole-bearing aristolactams are compounds that have been isolated from various plants species and which show several clinically relevant effects,including anti-inflammatory,antiplatelet,and antimycobacterial ***,the effect of these compounds on human immunodeficiency virus type 1(HIV-1)infection has not yet been *** this study,we discovered an aristolactam derivative bearing dibenzo[cd,f]indol-4(5 H)-one that had a potent anti-HIV-1 effect.A structure-activity relationship(SAR)study using nine synthetic derivatives of aristolactam identified the differing effects of residue substitutions on the inhibition of HIV-1 infection and cell *** the compounds tested,1,2,8,9-tetramethoxy-5-(2-(piperidin-1-yl)ethyl)-dibenzo[cd,f]indol-4(5 H)-one(Compound 2)exhibited the most potent activity by inhibiting HIV-1 infection with a half-maximal inhibitory concentration(IC50)of 1.03 lmol/L and a half-maximal cytotoxic concentration(CC50)of 16.91 lmol/L(selectivity index,16.45).The inhibitory effect of the compounds on HIV-1 infection was linked to inhibition of the viral replication ***-of-action studies showed that the aristolactam derivatives did not affect reverse transcription or integration;instead,they specifically inhibited Tat-mediated viral *** together,these findings show that several aristolactam derivatives impaired HIV-1 infection by inhibiting the activity of Tat-mediated viral transcription,and suggest that these derivatives could be antiviral drug candidates.

关键词： Human immunodeficiency virus type 1(HIV-1) Aristolactam Antiviral activity HIV-1 transcription

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Acute lower extremity arterial thrombosis after intraocular foreign body removal under general anesthesia: A case report and review of literature

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World Journal of Clinical Cases 2021年第27期9卷 8232-8241页

作者： Soeun Jeon jeong-min Hong Hyeon jeong Lee Eunsoo Kim Hyunju Lee Yesul Kim Hyun-Su Ri Jae Jung Lee Department of Anesthesia and Pain Medicine Pusan National UniversitySchool of MedicineBusan 49241South Korea Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea Department of Anesthesia and Pain Medicine Kyungpook National UniversitySchool of MedicineDaegu 41944South Korea Department of Ophthalmology College of MedicinePusan National UniversitySchool of MedicineYangsan 50612South Korea

BACKGROUND Surgery,which is a major risk factor for venous thrombosis,has rarely been considered a risk factor for arterial *** studies have suggested that venous and arterial thromboses share common risk factors and have a bidirectional ***,there is a growing interest in the risk of arterial thrombosis after *** report a case of acute bilateral lower extremity arterial thromboses that developed after a prolonged *** SUMMARY A 59-year-old man was hospitalized for intraocular foreign body removal *** was a heavy-drinking smoker and had untreated hypertension and varicose veins in both *** operation was unexpectedly prolonged,lasting 4 h and 45 *** after emergence from general anesthesia,the patient complained of extreme pain in both *** the surgical drape was removed,cyanosis was evident in both feet of the *** pulse was not palpable,and continuous-wave Doppler signals were inaudible in the bilateral dorsalis pedis and posterior tibial *** tomography angiography confirmed acute bilateral thrombotic occlusion of the popliteal arteries,proximal anterior tibial arteries,and tibioperoneal *** pulse returned in both lower limbs after 6 h of heparin *** patient was discharged on postoperative day 26 without any *** Acute lower extremity arterial thrombosis can occur after *** should pay particular attention to patients with risk factors for thrombosis.

关键词： Thromboembolism Thrombosis Arterial thrombosis Arterial occlusive diseases Peripheral occlusive artery disease Case report

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Engineered NiCo-LDH nanosheets- and ZnFe_(2)O_(4) nanocubes-decorated carbon nanofiber bonded mats for high-rate asymmetric supercapacitors

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Green Energy & Environment 2022年第6期7卷 1228-1240页

作者： Jae-Gyoung Seong Tae Hoon ko Danyun Lei Woong-Ki Choi Yun-Su Kuk min-Kang Seo Byoung-Suhk Kim Department of Organic Materials&Fiber Engineering Jeonbuk National University567 Baekje-daeroDeokjin-guJeonju-siJeollabuk-do54896Republic of Korea Department of BIN Convergency Technology Jeonbuk National University567 Baekje-daeroDeokjin-guJeonju-siJeollabuk-do54896Republic of Korea korea Institute of Carbon Convergence Technology Jeonju54852Republic of Korea Department of Environmental Biology and Water Engineering College of Urban ConstructionWuchang Shouyi UniversityWuhan430064China

In this work,we have prepared the hierarchically nanostructured core–shell NiCo layered double hydroxide(NiCo-LDH)nanosheets-and ZnFe_(2)O_(4) nanocubes-decorated polyacrylonitrile(PAN)/pitch-based carbon nanofibers(PPCNs)webs(NiCo-LDH@PPCNs as cathode and ZnFe_(2)O_(4)@PPCNs as anode materials)with the bonded network structure by a facile and scalable hydrothemal ***,the low-cost pitch with lower softening point(~90℃)as co-precursor was utilized to produce the PAN/pitch-based carbon nanofibers(PPCNs)with enhanced electrical *** obtained PPCNs with pitch content of 30%(PP30CNs)electrode material delivered higher specific capacitance(~67 F g^(-1))than that(~48 F g^(-1))of the PAN-based carbon nanofibers(PCNs)at 1 A g^(-1),due to the increased electrical conductivity and lower interfacial charge transfer resistance(RCT)of~0.16 ***,the NiCo-LDH-decorated PP30CNs(NiCoLDH@PP30CNs)as cathode material showed superior specific capacitance of 1162 F g^(-1) at 1.0 A g^(-1) and ultra-high retention rate of 91.56%at 10 A g^(-1).The ZnFe_(2)O_(4)@PP30CNs as anode material also showed higher specific capacitance of 282 F g^(-1) at 1 A g^(-1) and good rate capability with capacitance retention of 56.73%at 10 A g^(-1).The as-fabricated asymmetric NiCo-LDH@PP30CNs//ZnFe_(2)O_(4)@PP30CNs hybrid supercapacitor device delivered a specific capacitance of~98 F g^(-1) at 1 A g^(-1) and excellent capacitance retention of~88%after 5000 charge–discharge cycles.

关键词： Carbon nanofiber Pitch Asymmetric Rate capability Supercapacitor

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Paradoxical carbon dioxide embolism during laparoscopic hepatectomy without intracardiac shunt:A case report

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World Journal of Clinical Cases 2022年第9期10卷 2908-2915页

作者： Soeun Jeon jeong-min Hong Hyeon jeong Lee Yesul Kim Hyunjong Kang Boo-young Hwang Dowon Lee Young-hoon Jung Department of Anesthesia and Pain Medicine Pusan National UniversitySchool of MedicineBusan 49241South Korea Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Laparoscopic hepatectomy has recently become popular because it results in less bleeding than open ***,CO_(2)embolism occurs more *** CO_(2)embolisms during laparoscopic surgery are self-resolving and non-symptomatic;however,severe CO_(2)embolism may cause hypotension,cyanosis,arrhythmia,and cardiovascular *** particular,paradoxical CO_(2)embolisms are highly likely to cause neurological *** report a case of paradoxical CO_(2)embolism found on transesophageal echocardiography(TEE)during laparoscopic hepatectomy,although the patient had no intracardiac *** SUMMARY A 71-year-old man was admitted for laparoscopic left *** left hepatic vein ligation,the inferior vena cava was accidentally *** observed a sudden drop in oxygen saturation to 85%,decrease in systolic blood pressure(SBP)below 90 mm Hg,and reduction in end-tidal CO_(2)to 24 mm Hg.A“mill-wheel”murmur was auscultated over the *** fraction of inspired oxygen was increased to 100%with 5 cm H2O of positive end-expiratory pressure(PEEP)and hyperventilation was *** infusion was increased to maintain SBP above 90 mm Hg.A TEE probe was inserted,revealing gas bubbles in the right side of the heart,left atrium,left ventricle,and ascending *** surgeon reduced the pneumoperitoneum pressure from 17 to 14 mm Hg and repaired the damaged vessel ***,the patient’s hemodynamic status *** patient was transferred to the intensive care unit,recovering well without *** TEE monitoring is important to quickly determine the presence and extent of embolism in patients undergoing laparoscopic hepatectomy.

关键词： Carbon dioxide Embolism Laparoscopy Pneumoperitoneum Transesophageal echocardiography Case report

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Lithospheric thinning and ignition of a Cordilleran magmatic flare-up:Geochemical and O-Hf isotopic constraints from Cretaceous plutons in southern korea

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Geoscience Frontiers 2023年第1期14卷 327-345页

作者： Albert Chang-sik Cheong min-Ji Jung Hui JeJo jeongmin Kim Shinae Lee Youn-Joong jeong korea Basic Science Institute Ochang Center Cheongju 28119Republic of Korea Graduate School of Analytical Science and Technology Chungnam National UniversityDaejeon 34134Republic of Korea korea Institute of Geoscience and mineral Resources Daejeon 34132Republic of Korea

Northeast Asian continental margins contain the products of magma emplacement driven by prolonged subduction of the(paleo-)Pacific *** observed in many Cordilleran arcs,magmatic evolution in this area was punctuated by high-volume pulses amid background *** present study investigates the early evolution of the Cretaceous magmatic flare-up using new and published geochronological,geochemical,and O-Hf isotope data from plutonic rocks in the southern korean *** a long(~50 m.y.)magmatic hiatus and the development of the Honam Shear Zone through flat-slab subduction,the Cretaceous flare-up began with the intrusion of monzonites,granodiorites,and granites in the inboard Gyeonggi Massif and the intervening Okcheon *** to Jurassic granitoids formed during the former flare-up,Albian(~111 Ma)monzonites found in the Eopyeong area of the Okcheon Belt have distinctly higher zirconε_(Hf)(t)(-7.5±1.3)andδ^(18)O(7.78‰±0.25‰)values and lower wholerock La/Yb and Sr/Y *** voluminous coeval granodiorite and granite plutons in the Gyeonggi Massif are further reduced in Sr/Y and to a lesser extent,in La/Yb,and have higher zirconε_(Hf)(t)values(-13 to-19)than the Precambrian basement(ca.-30).These chemical and isotopic features indicate that Early Cretaceous lithospheric thinning,most likely resulting from delamination of tectonically and magmatically overthickened lithospheric keel that was metasomatized during prior subduction episodes,and consequent asthenospheric upwelling played vital roles in igniting the magmatic *** O-Hf isotopic ranges of synmagmatic zircons from the Albian plutons and their Paleoproterozoic and Jurassic inheritance attest to the involvement of lithospheric mantle and crustal basement in magma generation during this decratonization *** magmatism then migrated trenchward and culminated in the Late Cretaceous,yielding widespread granitoid rocks emplaced at shallow crustal *** early Late Cretaceous(94-8

关键词： Cordilleran arc Cretaceous flare-up korean Peninsula Lithospheric thinning Crustal rejuvenation

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Antipoisoning catalysts for the selective oxygen reduction reaction at the interface between metal nanoparticles and the electrolyte

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Carbon Energy 2023年第7期5卷 57-69页

作者： Sourabh S.Chougule A.Anto Jeffery Sreya Roy Chowdhury Jiho min Yunjin Kim Keonwoo ko Bathinapatla Sravani Namgee Jung Graduate School of Energy Science and Technology(GEST) Chungnam National UniversityYuseong-guDaejeonRepublic of Korea

One of the primary challenges in relation to phosphoric acid fuel cells is catalyst poisoning by phosphate anions that occurs at the interface between metal nanoparticles and the *** strong adsorption of phosphate anions on the catalyst surface limits the active sites for the oxygen reduction reaction(ORR),significantly deteriorating fuel cell ***,antipoisoning catalysts consisting of Pt-based nanoparticles encapsulated in an ultrathin carbon shell that can be used as a molecular sieve layer are rationally *** pore structure of the carbon shells is systematically regulated at the atomic level by high-temperature gas treatment,allowing O_(2) molecules to selectively react on the active sites of the metal nanoparticles through the molecular ***,the carbon shell,as a protective layer,effectively prevents metal dissolution from the catalyst during a long-term ***,the defect-controlled carbon shell leads to outstanding ORR activity and durability of the hybrid catalyst even in phosphoric acid electrolytes.

关键词： carbon shell catalyst poisoning effect molecular sieve effect oxygen reduction reaction phosphate anions phosphoric acid fuel cells

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Role of a wireless surface electromyography in dystonic gait in functional movement disorders: A case report

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World Journal of Clinical Cases 2020年第2期8卷 313-317页

作者： min-Kyun Oh Hyeong Seop Kim Yun jeong Jang Chang Han Lee Department of Rehabilitation Medicine Gyeongsang National University School of Medicine and Gyeongsang National University Hospital

BACKGROUND Dystonic gait(DG) is one of clinical symptoms associated with functional dystonia in the functional movement disorders(FMDs). Dystonia is often initiated or worsened by voluntary action and associated with overflow muscle activation. There is no report for DG in FMDs caused by an abnormal pattern in the ankle muscle recruitment strategy during *** SUMMARY A 52-year-old male patient presented with persistent limping gait. When we requested him to do dorsiflexion and plantar flexion of his ankle in the standing and seating positions, we didn’t see any abnormality. However, we could see the DG during the gait. There were no evidences of common peroneal neuropathy and L5 radiculopathy in the electrodiagnostic study. Magnetic resonance imaging of the lumbar spine, lower leg, and brain had no definite finding. No specific finding was seen in the neurologic examination. For further evaluation, a wireless surface electromyography(EMG) was performed. During the gait, EMG amplitude of left medial and lateral gastrocnemius(GCM) muscles was larger than right medial and lateral GCM muscles. When we analyzed EMG signals for each muscle, there were EMG bursts of double-contraction in the left medial and lateral GCM muscles, while EMG analysis of right medial and lateral GCM muscles noted regular bursts of single contraction. We could find a cause of DG in *** We report an importance of a wireless surface EMG, in which other examination didn’t reveal the cause of DG in FMDs.

关键词： Gait disorders Dystonic gait Surface electromyography Functional movement disorders Case report

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Highly Concentrated,Conductive,Defect-free Graphene Ink for Screen-Printed Sensor Application

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Nano-Micro Letters 2021年第6期13卷 17-30页

作者： Dong Seok Kim Jae-min jeong Hong Jun Park Yeong Kyun Kim Kyoung G.Lee Bong Gill Choi Department of Chemical Engineering Kangwon National UniversitySamcheokGangwon-do 25913Republic of Korea Resources Utilization Research Center Korea Institute of Geoscience and Mineral ResourcesDaejeon 34132Republic of Korea Center for Nano Bio Development National Nanofab CenterDaejeon 34141Republic of Korea

Conductive inks based on graphene materials have received significant attention for the fabrication of a wide range of printed and flexible ***,the application of graphene fillers is limited by their restricted mass production and the low concentration of their *** this study,a highly concentrated and conductive ink based on defect-free graphene was developed by a scalable fluid dynamics process.A high shear exfoliation and mixing process enabled the production of graphene at a high concentration of 47.5 mg mL^(−1)for graphene *** screen-printed graphene conductor exhibits a high electrical conductivity of 1.49×10^(4)S m^(−1)and maintains high conductivity under mechanical bending,compressing,and fatigue *** on the as-prepared graphene ink,a printed electrochemical sodium ion(Na^(+))sensor that shows high potentiometric sensing performance was ***,by integrating a wireless electronic module,a prototype Na^(+)-sensing watch is demonstrated for the real-time monitoring of the sodium ion concentration in human sweat during the indoor exercise of a *** scalable and efficient procedure for the preparation of graphene ink presented in this work is very promising for the low-cost,reproducible,and large-scale printing of flexible and wearable electronic devices.

关键词： Graphene ink Fluid dynamics Screen printing Ion sensor Real-time monitoring

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CO_(2)-adsorbent spongy electrode for non-aqueous Li–O_(2) batteries

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Journal of Energy Chemistry 2022年第2期31卷 646-653页

作者： Yiseul Yoo Giseung Lee min-Gi jeong Hun-Gi Jung Sunghee Shin Dongjin Byun Taeeun Yim Hee-Dae Lim Center for Energy Storage Research Korea Institute of Science and Technology(KIST)Hwarang-ro 14-gil 5Seongbuk-guSeoul 02792Republic of Korea Department of Materials Science and Engineering Korea University145 Anam-roSeongbuk-guSeoul 02841Republic of Korea Department of Chemistry Incheon National University119 Academy-roYeonsu-guIncheon 22012Republic of Korea Department of Chemical and Biological Engineering Korea UniversitySeoul 02841Republic of Korea

Regulation of the Li_(2)CO_(3) byproduct is the most critical challenge in the field of non-aqueous Li–O_(2) *** considerable efforts have been devoted to preventing Li_(2)CO_(3) formation,no approaches have suggested the ultimate solution of utilizing the clean Li_(2)O_(2) reaction instead of that of Li_(2)CO_(3).Even if extremely pure O_(2) is used in a Li–O_(2) cell,its complete elimination is impossible,eventually generating CO_(2) gas during *** this paper,we present the new concept of a CO_(2)-adsorbent spongy electrode(CASE),which is designed to trap the evolved CO_(2) using adsorption *** candidates composed of amine functional groups(–NH2)for capturing CO_(2) were screened,with quadrapurebenzylamine(QPBZA)exhibiting superior CO_(2)-adsorbing ability among the proposed ***,we fabricated the CASE by sandwiching QPBZA between porous carbon layers,which facilitated the transport of gaseous *** new electrode was demonstrated to effectively capture the evolved CO_(2) during charge,therefore altering the reaction pathways to the ideal *** is highly advantageous to mitigate the undesirable CO_(2) incorporation in the next discharge,resulting in improved *** novel concept of a CO_(2)-sponging electrode provides an alternative route to the realization of practically meaningful Li–O_(2) batteries.

关键词： Li-O_(2)battery Benzylamine CO_(2)adsorption Li_(2)CO_(3) Li_(2)O_(2) CO_(2)-sponging electrode

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Point-defect engineering of nanoporous CuBi_(2)O_(4) photocathode via rapid thermal processing for enhanced photoelectrochemical activity

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Journal of Energy Chemistry 2022年第8期31卷 201-209,I0007页

作者： Li Qu Runfa Tan Arumugam Sivanantham min Je Kang Yoo Jae jeong Dong Hyun Seo Sungkyu Kim In Sun Cho Department of Materials Science&Engineering Ajou UniversitySuwon 16499South Korea Department of Energy Systems Research Ajou UniversitySuwon 16499South Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006South Korea

Engineering point defects such as metal and oxygen vacancies play a crucial role in manipulating the electrical,optical,and catalytic properties of oxide semiconductors for solar water ***,we synthesized nanoporous CuBi_(2)O_(4)(np-CBO)photocathodes and engineered their surface point defects via rapid thermal processing(RTP)in controlled atmospheres(O_(2),N_(2),and vacuum).We found that the O_(2)-RTP treatment of np-CBO increased the charge carrier density effectively without hampering the nanoporous morphology,which was attributed to the formation of copper vacancies(VCu).Further analyses revealed that the amounts of oxygen vacancies(Vo)and Cu^(1+)were reduced simultaneously,and the relative electrochemical active surface area increased after the O_(2)-RTP ***,the point defects(VC_(u),Cu^(1+),and Vo)regulated np-CBO achieved a superb water-splitting photocurrent density of-1.81 m A cm^(-2) under simulated sunlight illumination,which is attributed to the enhanced charge transport and transfer properties resulting from the regulated surface point ***,the reversibility of the formation of the point defects was checked by sequential RTP treatments(O_(2)-N_(2)-O_(2)-N_(2)),demonstrating the strong dependence of photocurrent response on the RTP ***,the surface point defect engineering via RTP treatment in a controlled atmosphere is a rapid and facile strategy to promote charge transport and transfer properties of photoelectrodes for efficient solar water-splitting.

关键词： Nanoporous Copper bismuth oxide Rapid thermal processing Copper vacancy Charge transport

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